Influence of administration route on the biotransformation of amoxicillin in the pig

Journal of Veterinary Pharmacology and Therapeutics

Volumn 32, Issue 3, 2009, Pages 241-248

  Reyns, T ^a   De Boever, S ^a   Schauvliege, S ^a   Gasthuys, F ^a   Meissonnier, G ^b   Oswald, I ^b   De Backer, P ^a   Croubels, S ^a  

^a GHENT UNIVERSITY   (Belgium)

^b CEMAGREF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; AMOXICILLIN DIKETOPIPERAZINE 2',5' DIONE; AMOXICILLOIC ACID; BETA LACTAM; DRUG METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DEGRADATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG TRANSFORMATION; FEMALE; GLOMERULUS FILTRATION; KIDNEY PROXIMAL TUBULE; NONHUMAN; PRIORITY JOURNAL; SWINE;

ADMINISTRATION, ORAL; AMOXICILLIN; ANIMALS; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; FEMALE; GASTROINTESTINAL TRACT; HALF-LIFE; INJECTIONS, INTRAVENOUS; KIDNEY; LIVER; NETHERLANDS; SWINE;

SUIDAE;

EID: 65949102758     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2008.01033.x     Document Type: Article

References (57)

1. Adam, D., De Visser, I. Koeppe, P. (1982) Pharmacokinetics of amoxicillin and clavulanic acid administered alone and in combination. Antimicrobial Agents and Chemotherapy, 22, 353 357. (Pubitemid 13241690)
2. Agersø, H. Friis, C. (1998) Bioavailability of amoxicillin in pigs. Journal of Veterinary Pharmacology and Therapeutics, 21, 41 44.
3. Anfossi, P., Zaghini, A., Grassigli, G., Menotta, S. Fedrizzi, G. (2002) Relative oral bioavailability of microgranulated amoxicillin in pigs. Journal of Veterinary Pharmacology and Therapeutics, 25, 329 334. (Pubitemid 35370030)
4. Barragry, T.B. (1994) Beta-lactam antibiotics. In Veterinary Drug Therapy. Ed. Cann, C., pp. 220 262. Lea & Febiger Press, Pennsylvania, USA.
5. Barza, M. Weinstein, L. (1976) Pharmacokinetics of the penicillins. Clinical Pharmacokinetics, 1, 297 308.
6. Cardaci, G., Lambrecht, J.R., King, R.G., Onishi, N. Midolo, P. (1995) Reduced amoxicillin uptake into human gastric mucosa when gastric juice pH is high. Antimicrobial Agents and Chemotherapy, 39, 2084 2087.
7. Chesa-Jiménez, J., Peris, J.S., Torres-Molina, F. Granero, L. (1994) Low bioavailability of amoxicillin in rats as a consequence of presystemic degradation in the intestine. Antimicrobial Agents and Chemotherapy, 38, 842 847. (Pubitemid 24114028)
8. Cole, M., Kenig, M.D. Hewitt, V.A. (1973) Metabolism of penicillins to penicilloic acids and 6-aminopenicillanic acid in man and its significance in assessing penicillin absorption. Antimicrobial Agents and Chemotherapy, 3, 463 468.
9. Connor, S.C., Everett, J.P., Jennings, K.R., Nicholson, J.K. Woodnutt, G. (1994) High resolution 1H NMR spectroscopic studies of the metabolism and excretion of amipicillin and amoxicillin in rats and humans. Journal of Pharmacy and Pharmacology, 46, 128 134. (Pubitemid 24070842)
10. Craft, J.C., Feldman, W.E. Nelson, J.D. (1979) Clinicopharmacological evaluation of amoxicillin and probenecid against bacterial meningitis. Antimicrobial Agents and Chemotherapy, 16, 346 352. (Pubitemid 10224030)
11. Dorrestein, G.M., Van Gogh, H., Rinzema, J.D. Buitelaar, M.N. (1986) Bioavailability and pharmacokinetics of ampicillin and amoxycillin from tablets, capsules and long-acting preparations in the homing pigeon (Columba livia). Journal of Veterinary Pharmacology and Therapeutics, 9, 394 401.
12. El-Sooud, K.A., Khammas, W. Kadri, M.N. (2007) Pharmacokinetics of imipenem in sheep with special reference to its hepato-renal effects. Chemotherapy, 53, 169 172. (Pubitemid 46591330)
13. Ensink, J.M., Klein, W.R., Mevius, D.J., Klarenbeek, A. Vulto, A.G. (1992) Bioavailability of oral penicillins in the horse: a comparison between pivampicillin and amoxicillin. Journal of Veterinary Pharmacology and Therapeutics, 15, 221 230.
14. Escudero, E., Carceles, C.M. Vicente, S. (1996) Pharmacokinetics of amoxicillin/clavulanic acid combination and of both drugs alone after intravenous administration to goats. British Veterinary Journal, 152, 551 559. (Pubitemid 126783284)
15. Eshelman, F.N. Spyker, D.A. (1978) Pharmacokinetics of amoxicillin and ampicillin: crossover study of the effect of food. Antimicrobial Agents and Chemotherapy, 14, 539 543. (Pubitemid 9028417)
16. Galtier, P., Battaglia, A., More, J. Franc, M. (1983) Impairment of drug metabolism by the liver in experimental fascioliasis in the rat. Journal of Pharmacy and Pharmacology, 35, 729 733. (Pubitemid 14234175)
17. Gasthuys, F., Baert, K. De Backer, P. (1999) Repetitive intravenous catheterisation for pharmacokinetic studies in pigs. Vlaams Diergeneeskundig Tijdschrift, 68, 85 90. (Pubitemid 129639101)
18. Gasthuys, F., De Boever, S., Schauvliege, S., Reyns, T., Levet, T., Cornillie, P., De Backer, P. Croubels, S. (2008) Transsplenic portal catheterisation combined with a jugular double lumen catheter for pharmacokinetic and presystemic metabolisation studies in pigs. Journal of Veterinary Pharmacology and Therapeutics, in press.
19. Gibaldi, M. Schwartz, M.A. (1968) Apparent effect of probenecid on the distribution of penicillin in man. Clinical Pharmacology and Therapeutics, 9, 345 349.
20. Haruta, S., Iwasaki, N., Ogawara, K.-I., Higaki, K. Kimura, T. (1998) Absorption behaviour of orally administered drug in rats treated with propantheline. Journal of Pharmaceutical Sciences, 87, 1081 1085. (Pubitemid 28452107)
21. Hernandez, E., Rey, R., Puig, M., Gercia, M.A., Solans, C. Bregante, M.A. (2005) Pharmacokinetics and residues of a new amoxicillin formulation in piglets: a preliminary study. The Veterinary Journal, 170, 237 242. (Pubitemid 41212960)
22. Hikida, M., Kawashima, K., Yoshida, M. Mitsuashi, S. (1992) Inactivation of new carbapenem antibiotics by dehydropeptidase-I from porcine and human renal cortex. Journal of Antimicrobial Chemotherapy, 30, 129 134.
23. Jewell, C., Bennet, P., Mutch, E., Ackermann, C. Williams, F.M. (2007) Inter-individual variability in esterases in human liver. Biomedical Pharmacology, 74, 932 939. (Pubitemid 47214626)
24. Kahan, F.M., Kropp, H., Sundelof, J.G. Birnbaum, J. (1983) Thienamycin: development of imipenem-cilastin. Antimicrobial Agents and Chemotherapy, 12 (Suppl. D 1S 35S.
25. Küng, K. Wanner, M. (1994) Bioavailability of different forms of amoxicillin administered orally to dogs. The Veterinary Record, 135, 552 554. (Pubitemid 24371288)
26. Lashev, L. (1986) Comparative pharmacokinetic research on amoxicillin in domestic animals. Veterinarno Medicinski Nauki, 23, 76 82.
27. Lennernas, H., Nylander, S. Ungell, A.L. (1997) Jejunal permeability: a comparison between the using chamber technique and the single-pass perfusion in humans. Pharmaceutical Research, 14, 667 671. (Pubitemid 27220288)
28. 1) receptor inhibition in an experimental model of heart failure. Journal of the American College of Surgeons, 194, 603 609. (Pubitemid 34496655)
29. Martinez-Larrañaga, M.R., Anadon, A., Martinez, M.A., Diaz, M.J., Frejo, M.T., Castellano, V.J., Isea, G. De La Crez, C.O. (2004) Pharmacokinetics of amoxicillin and the rate of depletion of its residues in pigs. The Veterinary Record, 154, 627 632. (Pubitemid 38744497)
30. Messonnier, G.M., Laffitte, J., Loiseau, N., Benoit, E., Raymond, I., Pinton, P., Cossalter, A.-M., Bertin, G., Oswald, I.P. Galtier, P. (2007) Selective impairement of drug-metabolizing enzymes in pig liver during subchronic dietary exposure to aflatoxin B1. Food and Chemical Toxicology, 45, 2145 2150. (Pubitemid 47451569)
31. Morita, E., Mizuno, N., Nishikata, M. Takahashi, K. (1992) Effect of gastrointestinal maturation on absorption of β-lactam antibiotics. Journal of Pharmaceutical Sciences, 81, 337 340.
32. Nägele, E. Moritz, R. (2005) Structure elucidation of degradation products of the antibiotic amoxicillin with ion trap MSn and accurate mass determination by ESI TOF. Journal of the American Society for Mass Spectrometry, 16, 1670 1676. (Pubitemid 41345159)
33. Nauta, E.H., Mattie, H. Goslings, W.R.O. (1974) Effect of probenecid on the apparent volume of distribution and elimination of cloxacillin. Antimicrobial Agents and Chemotherapy, 6, 300 303.
34. Oh, D.M., Sinko, P.J. Amidon, G.L. (1992) Characterization of the oral absorption of several aminopenicillins: determination of intrinsic membrane absorption parameters in the rat intestine in situ. International Journal of Pharmaceutics, 85, 181 187.
35. +-gradient- dependent transport of aminocephalosporins in rat intetsinal brush-border membrane vesicles. Biochemical Pharmacology, 35, 1781 1786.
36. Painthaud, G., Alván, G., Dahl, M.L., Grahnén, A., Sjövall, J. Svensson, J.O. (1992) Nonlinearity of amoxicillin absorption kinetics in human. European Journal of Clinical Pharmacology, 42, 283 288.
37. Passàli, D., Mazzei, T., Novelli, A., Fallani, S., Dentico, P., Mezzedimi, C., Passàli, C. Bellussi, L. (2001) Amoxicillin/clavulanate in chronic rhinosinusitis: tissue and serum distribution. Ancta Oto-Rhino-Laryngologica Belgica, 55, 259 264. (Pubitemid 32938777)
38. Plumb, C.D. (1999) Penicillins. In Veterinary Drug Handbook, 3rd edn, pp. 487 494. Iowa State University Press, Ames.
39. Plumb, C.D. (2002) Amoxicillin. In Veterinary Drug Handbook, 4th edn, pp. 42 45. Iowa State Press, Ames.
40. Reyns, T., De Baere, S., Croubels, S. De Backer, P. (2006) Determination of clavulanic acid in calf plasma by liquid chromatography tandem mass spectrometry. Journal of Mass Spectrometry, 41, 1414 1420.
41. Reyns, T., De Boever, S., Baert, K., Croubels, S., Schauvliege, S., Gasthuys, F. De Backer, P. (2007) Disposition and oral bioavailability of amoxicillin and clavulanic acid in pigs. Journal of Veterinary Pharmacology and Therapeutics, 30, 550 555. (Pubitemid 350060565)
42. Reyns, T., De Boever, S., De Baere, S., De Backer, P. Croubels, S. (2008a) Tissue depletion of amoxicillin and its major metabolites in pigs: influence of the administration route and simultaneous dosage of clavulanic acid. Journal of Agricultural and Food Chemistry, 56, 448 454.
43. Reyns, T., Cherlet, M., De Baere, S., De Backer, P. Croubels, S. (2008b) Rapid method for the quantification of amoxicillin and its major metabolites in pig tissues by liquid chromatography-tandem mass spectrometry with emphasis on stability issues. Journal of Chromatography B, 861, 108 116. (Pubitemid 350298063)
44. Riviere, J.E., Craigmill, A.L. Sundlof, S.F. (1991) Beta-lactam antibiotics. In Handbook of Comparative Pharmacokinetics and Residues of Veterinary Antimicrobials, pp. 37 110. CRC Press, Florida, USA.
45. Sader, H.S. Gales, A.C. (2001) Emerging strategies in infectious diseases - new carbapenem and trinem antibacterial agents. Drugs, 61, 553 564. (Pubitemid 32453367)
46. Saitoh, H., Gerard, C. Aungst, B.J. (1996) The secretory intestinal transport of some beta-lactam antibiotics and anionic compounds: a mechanism contributing to poor oral absorption. The Journal of Pharmacology and Experimental Therapeutics, 278, 205 211. (Pubitemid 27167097)
47. Saitoh, H., Aungst, B.J., Tohyama, M., Hatakeyama, Y., Ohwada, K., Kobayashi, M., Fujisaki, H. Miyazaki, K. (2002) In vitro permeation of β-lactam antibiotics across rat jejunum and its correlation with oral bioavailability in humans. British Journal of Clinical Pharmacology, 54, 445 448. (Pubitemid 35334960)
48. Sjövall, J., Alvàn, G., Akerlund, J.E., Svensson, J.O., Paintaud, G., Nord, C.E. Angelin, B. (1992) Dose-dependent absorption of amoxicillin in patients with ileostomy. European Journal of Clinical Pharmacology, 43, 277 281.
49. Sørum, H. Sunde, M. (2001) Resistance to antibiotics in the normal flora of animals. Veterinary Research, 32, 227 241. (Pubitemid 32595207)
50. Spyker, D.A., Rugloski, R.J., Vann, R.L. O'Brien, W.M. (1977) Pharmacokinetics of amoxicillin: dose dependent absorption after intravenous, oral and intramuscular administration. Antimicrobials Agents and Chemotherapy, 11, 132 141. (Pubitemid 8022387)
51. Staniford, D.H., Jackson, D., Clarke, H.L. Horton, R. (1983) Amoxycillin/clavulanic acid: the effect of probenecid. Journal of Antimicrobial Chemotherapy, 12, 273 275.
52. Stark, C.A., Edlund, C., Sjöstedt, S., Kirstenten, G. Nord, C.E. (1993) Antimicrobial resistance in humal oral and intestinal anaerobic micofloras. Antimicrobial Agents and Chemotherapy, 37, 1665 1669. (Pubitemid 23226380)
53. Sutton, S.C. (2004) Companion animal physiology and dosage performance. Advanced Drug Delivery Reviews, 56, 1383 1398. (Pubitemid 38748822)
54. Torres-Molina, F., Peris-Ribera, J.E., García-Carbonell, M.C., Aristorena, J.C. Plá-Delfina, J.M. (1992) Nonlinearities in amoxicillin pharmacokinetics II. Absorption studies in the rat. Biopharmaceutics & Drug Disposition, 13, 39 53.
55. Watson, A.D.J., Emslie, D.R., Martin, I.C.A. Egerton, J.R. (1986) Effect of ingesta on systemic availability of penicillins administered orally in dogs. Journal of Veterinary Pharmacology and Therapeutics, 9, 140 149.
56. Westphal, J.F., Deslandes, A., Brogard, J.M. Carbon, C. (1991) Reappraisal of amoxycillin absorption kinetics. Journal of Antimicrobial Chemotherapy, 27, 647 654.
57. Yamaoka, K., Nakagawa, T. Uno, T. (1978) Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. Journal of Pharmacokinetics and Pharmacodynamics, 6, 165 175. (Pubitemid 8384279)