Tissue depletion of amoxicillin and its major metabolites in pigs: Influence of the administration route and the simultaneous dosage of clavulanic acid

Journal of Agricultural and Food Chemistry

Volumn 56, Issue 2, 2008, Pages 448-454

  Reyns, Tim ^a   De Boever, Sandra ^a   De Baere, Siegrid ^a   De Backer, Patrick ^a   Croubels, Siska ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Amoxicillin; Amoxicilloic acid metabolite; Residue depletion; Risk assessment

Indexed keywords

AMOXICILLIN; CLAVULANIC ACID; DRUG DERIVATIVE;

ANIMAL; ARTICLE; CHEMISTRY; COMPARATIVE STUDY; HALF LIFE TIME; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; LIVER; MEAT; METABOLISM; ORAL DRUG ADMINISTRATION; SWINE;

ADMINISTRATION, ORAL; AMOXICILLIN; ANIMALS; CLAVULANIC ACID; HALF-LIFE; INJECTIONS, INTRAVENOUS; KIDNEY; LIVER; MEAT; SWINE;

ANIMALIA; SUIDAE;

EID: 38949186068     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf072398p     Document Type: Article

References (36)

1. Hernandez, E.; Rey, R.; Puig, M.; Garcia, M. A.; Solans, C.; Bregante, M. A. Pharmacokinetics and residues of a new oral amoxicillin formation in piglet: A preliminary study. Vet. J. 2005, 170, 237-242.
2. Pijpers, A.; van Klingelen, B.; Schoevers, E. J.; Verheijen, J. H. M.; van Miert, A. S. J. P. A. M. In vitro activity of five tetracyclines and some other antimicrobial agents against four porcine respiratory tract pathogens. J. Vet. Pharmacol. Therap. 1989, 12, 267-276.
3. Commission Regulation (EU) No 2377/90 of 26 June 1990 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in food stuffs of animal origin (Off J. Eur. Commun. 1990 No L224), as amended by Concil Regulation No 2593/99 (Off. J. Eur. Commun. 1999 N0 L315).
4. Doyle, M. E. Veterinary residues in processed meats - potential health risk. FRI Briefings - Dept. Food Microbiology & Toxicology. 2006, 1-8.
5. Lindemayr, H.; Knobler, R.; Kraft, D.; Baumgartner, W. Challenge of pencillin-allergic volunteers with penicillin-contaminated meat. Allergy 1981, 36, 471-478.
6. Dupont, H. L.; Steele, J. H. Use of antimicrobial agents in animal feeds: implications for human health. Rev. Infect. Dis. 1987, 3, 447-460.
7. Woodward, K. N. Hypersensitivity in humans and exposure to veterinary drugs. Vet. Hum. Toxicol. 1991, 33, 168-172.
8. Kanny, G.; Puygrenier, J.; Beaudoin, E.; Moneret-Vautrin, D. A. Alimentary anaphylactic shock: implication of penicillin residues. Allerg. Immunol. 1994, 26, 181-183.
9. Sundlof, S. F.; Cooper, J. Human health risks associated with drug residues in animal-derived foods. ACS Symp Ser. 1996, 636, 5-17.
10. Peyron-Raison, N.; Messaad, D.; Bousquet, J.; Demoly, P. Anaphylaxis to beef in penicillin-allergic patient. Allergy 2001, 56, 796-797.
11. Dewdney, J. M.; Maes, L.; Raynaud, J. P.; Blanc, F.; Scheid, J. P.; Jackson, T.; Lens, S.; Verschueren, C. Risk assessment of antibiotic residues of β-lactams and macrolides in food products with regard to their immuno-allergic potential. Food. Chem. Toxic. 1991, 29, 477-483.
12. Chowdhury B. A.; Lieberman, P. L. Drug allergens, haptens and anaphylatoxins. In Allergens and Allergen Immunotherapy 2nd ed.; Lockey, R. F., Bukantz, S. C., Eds.; Dekker: New York, 1999; pp 273-296.
13. Nägele, E.; Moritz, R. Structure elucidation of degradation products of the antibiotic amoxicillin with ion trap MSn and accurate mass determination by ESI TOF. J. Am. Soc. Mass Spectrom. 2005, 16, 1670-1670.
14. Sandanayaka, V. P.; Prashad, A. S. Resistance to β-lactam antibiotiocs: structure and mechanism based design of β-lactamase inhibitors. Curr. Med. Chem. 2002, 9, 1145-1165.
15. Sorum, H.; Sunde, M. Resistance to antibiotics in the normal flora of animals. Vet. Res. 2001, 32, 227-241.
16. Chesa-Jiménez, J.; Peris, J. E.; Torres-Molina, F.; Grandero, L. Low bioavailability of amoxicillin in rats as a consequence of presystemic degradation in the intestine. Antimicrob. Agents Chemother. 1994, 38, 842-847.
17. Janosi, A.; Maghuin-Rogister, G.; Degelaen, J. A sensitive screening method for the multi-analyte determination of β-lactam antibiotic residues in swine tissue. In Euroresidue IV. Conference on Residues of Veterinary Drugs in Food, van Ginkel, L. A.; Ruiter, A., Eds.; National Insitute of Public Health and the Environment (RIVM), Laboratorium for residue analysis: Bilthoven, The Netherlands, 2000; Vol. 2, 639-644.
18. Huber, W. G. Allergenicity of antibacterial drug residues. In Drug Residues in Animals; Rico A. G., Ed.; Academic Press: Toulouse, France, 1986; 33-49.
19. Boison, J. O.; Keng, L. J.-Y. Multiresidue liquid chromatographic method for determining residues of mono-and dibasic penicillins in bovine muscle tissues. J. AOAC Int. 1998, 81, 1113-1120.
20. Sørensen, L. K.; Snor, L. K.; Elkær, T.; Hansen, H. Simultaneous determination of seven penicillins in muscle, liver and kidney tissues from cattle and pigs by a multiresidue high-performance liquid chromatographic method. J. Chromatogr., B 1999, 734, 307-318.
21. Luo, W.; Ang, C. Y. W. Determination of amoxicillin residues in tissues by solid-phase extraction and liquid chromatography with fluorescence detection. J. AOAC Int. 2000, 83, 20-25.
22. Becker, M.; Zittlau, E.; Petz, M. Residue analysis of 15 penicillins and cephalosporins in bovine muscle, kidney and milk by liquid chromatography-tandem mass spectrometry. Anal. Chim. Acta 2004, 520, 19-32.
23. Bogialli, S.; Capitolino, V.; Curini, R.; Di Corcia, A.; Nazzari, M.; Sergi, M. Simple and rapid liquid chromatography-tandem mass spectrometry confirmatory assay for determining amoxicillin and ampicillin in bovine tissues and milk. J. Agric. Food Chem. 2004, 52, 3286-3291.
24. De Baere, S.; Wassink, P.; Croubels, S.; De Boever, S.; Baert, K.; De Backer, P. Quantitative liquid chromatographic-mass spectrometric analysis of amoxycillin in broiler edible tissues. Anal. Chim. Acta 2005, 529, 221-227.
25. Fagerquist, C. K.; Lightfield, A. R.; Lehotay, S. J. Confiramtory and quantitative analysis of β-lactam antibiotics in bovine kidney tissue by dispersive solid-phase extraction and liquid chromatography-tandem mass spectrometry. Anal. Chem. 2005, 77, 1473-1482.
26. De Baere, S.; Cherlet, M.; Baert, K.; De Backer, P. Quantitative analysis of amoxycillin and its major metabolites in animal tissues by liquid chromatography combined with electrospray ionization tandem mass spectrometry. Anal. Chem. 2002, 74, 1393-1401.
27. Connor, S. C.; Everett, J. R.; Jennings, K. R.; Nicholson, J. K.; Woodnutt, G. High resolution 1H NMR spectroscopic studies of the metabolism and excretion of ampiciflin in rats and amoxicillin in rats and humans. J. Pharm. Pharmacol. 1994, 46, 128-134.
28. Notice to applicants, Veterinary medicinal products: Establishment of maximum residue limits (MRLs) for residues of veterinary products in foodstuff of animal origin: Development and validation of a proposed regulatory method. EMEA/CVMP/573/00-FINAL The European Agency for the Evaluation of Medicinal Products, Veterinary Medicines and Information Technology: London, February, 2001; Vol. 2.
29. Reyns, T.; Cherlet, M.; De Baere, S.; De Backer, P.; Croubels, S. Rapid method for the quantification of amoxicillin and its major metabolites in pig tissues by liquid chromatography-tandem mass spectrometry with emphasis on stability issues. J. Chromatogr., B 2007, in press.
30. Note for guidance: approach towards harmonization of withdrawal periods. EMEA/CVMP/036/95; The European Agency for the Evaluation of Medicinal Products: London, 1996.
31. Martinez-Larrañaga, M. R.; Anadon, A.; Martinez, M. A.; Diaz, M. J.; Frejo, M. T.; Castellano, V. J.; Isea, G.; De La Crez, C. O. Pharmacokinetics of amoxycillin and the rate of depletion of its residues in pigs. Vet. Rec. 2004, 154, 627-632.
32. Dayan, A. D. Allergy to antimicrobial residues in food: assessment of the risk to man. Vet. Microbiol. 1993, 35, 213-226.
33. Reyns, T.; De Boever, S.; De Baere, S.; Croubels, S.; De Backer, P. Influence of the administration route and simultaneous administration dosage of clavulanic acid on the biotransformation of amoxicillin in pigs. Poster Presented at the 3rd International Conference on Antimicrobial Agents in Veterinary Medicine, 2006, Florida, USA, May 16-20.
34. Reyns, T.; De Boever, S.; Baert, K.; Croubels, S.; Schauvliege, S.; Gasthuys, F.; De Backer, P. Disposition and oral bioavailability of amoxicillin and clavulanic acid in pigs. J. Vet. Pharmacol. Therap. 2007, 30, 550-555.
35. Agersø, H.; Friis, C. Bioavailability of amoxicillin in pigs. J. Vet. Pharmacol. Therap. 1998, 21, 41-46.
36. Anadon, A.; Martinez-Larrañaga, M. R.; Diaz, M. J.; Martinez, M. A. M.; Martinez, M.; Frejo, M. T.; Tafur, M.; Bringas, P. Pharmacokinetics and oral bioavailability of amoxicillin in pigs. In Abstract Presented at the 8th EAVPT Congress. 2000, Jerusalem, Israel, July 30-August 3.