Microtubule proteins and their post-translational forms in the cerebrospinal fluid of patients with paraparesis associated with HTLV-I infection and in SH-SY5Y cells: An in vitro model of HTLV-I-induced disease

Biological Research

Volumn 41, Issue 3, 2008, Pages 239-252

  Maldonado, Horacio ^a   Ortiz Riaño, Emilio ^a   Krause, Bernardo ^a   Barriga, Andrés ^a   Medina, Fernando ^a   Pando, M Elsa ^a   Alberti, Carolina ^a   Kettlun, Ana M ^a   Collados, Lucía ^a   García, Lorena ^a   Cartier, Luis ^b   Valenzuela, M Antonieta ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

Acetyl tubulin; Cerebrospinal fluid; Phosphorylatedtau forms; Retraction; SH SY5Y cells; Tau; Tropical spastic paraparesis; Tubulin

Indexed keywords

MICROTUBULE PROTEIN; POLYCLONAL ANTIBODY; TAX PROTEIN; TUBULIN;

ACETYLATION; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS INFECTION; MASS SPECTROMETRY; NERVE FIBER DEGENERATION; NEUROBLASTOMA CELL; PARAPLEGIA; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SPASTIC PARAPLEGIA; SPINAL CORD DISEASE; SUPERNATANT; WESTERN BLOTTING;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 65949093722     PISSN: 07169760     EISSN: 07176287     Source Type: Journal    
DOI: 10.4067/S0716-97602008000300001     Document Type: Article

References (54)

1. ALEFANTIS T, MOSTOLLER K, JAIN P, HARHAJ E, GRANT C, WIGDAHL B (2005). Secretion of the human T cell leukemia virus type I transactivator protein tax. J Biol Chem 280: 17353-17362
2. ALONSO A DEL C, LI B, GRUNDKE-IQBAL I, IQBAL K (2006) Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. Proc Natl Acad Sci U S A 103: 8864-8869
3. AVILA J, LUCAS JJ, PÉREZ M, HERNÁNDEZ F (2004) Role of tau protein in both physiological and pathological conditions. Physiol Rev 84: 361-384
4. BARTOSIK-PSUJEK H, STELMASIAK Z (2006) The CSF levels of total and phosphotau in patients with relapsing-remitting multiple sclerosis. J Neural Transm 113: 339-345
5. BLENNOW K, ZETTERBERG H, MINTHON L, LANNFELT L, STRID S, ANNAS P, BASUN H, ANDREASEN N (2007) Longitudinal stability of CSF biomarkers in Alzheimer's disease. Neurosci Lett 419: 18-22
6. BORRONI B, GARDONI F, PARNETTI L, MAGNO L, MALINVERNO M, SAGGESE E, CALABRESI P, SPILLANTINI MG, PADOVANI A, DI LUCA M (2007). Pattern of Tau forms in CSF is altered in progressive supranuclear palsy. Neurobiol Aging. Aug 18. [Epub ahead of print]
7. BRETTSCHNEIDER J, PETZOLD A, JUNKER A, TUMANI H (2006a) Axonal damage markers in the cerebrospinal fluid of patients with clinically isolated syndrome improve predicting conversion to definite multiple sclerosis. Mult Scler 12: 143-148
8. BRETTSCHNEIDER J, PETZOLD A, SÜSSMUTH SD, LUDOLPH AC, TUNAMI H (2006b) Axonal damage markers in cerebrospinal fluid are increased in ALS. Neurology 66: 852-856
9. BUÉE L, BUSSIERE T, BUÉE-SCHERRER V, DELACOURTE A, HOF PR (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 33: 95-130
10. BUERGER K, EWERS M, PIRTTILÄ T, ZINKOWSKI R, ALAFUZOFF I, TEIPEL SJ, DEBERNARDIS J, KERKMAN D, MCCULLOCH C, SOININEN H, HAMPEL H (2006) CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain 129: 3035-3041
11. CARTIER L, RAMÍREZ E (2005) Presence of HTLV-I Tax protein in cerebrospinal fluid from HAM/TSP patients. Arch Virol 150: 743-753
12. CARTIER L, VERGARA C, VALENZUELA MA (2007) Immunohistochemistry of degenerative changes in the central nervous system in spastic paraparesis associated to human T lymphotropic virus type I (HTLV-I). Rev Med Chil 135: 1139-1146
13. CARTIER LM, CEA J, VERGARA C, ARAYA F, BORN P (1997) Clinical and neuropathological study of six patients with spastic paraparesis associated with HTLV-I: an axomyelinic degeneration of the central nervous system. J Neuropathol Exp Neurol 56: 403-413
14. COWAN EP, ALEXANDER RK, DANIEL S, KASHANCHI F, BRADY JN (1997) Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax. J Virol 71: 6982-6989
15. DELUCA GC, EBERS G, ESIRI MM (2004) The extent of axonal loss in the long tracts in hereditary spastic paraplegia. Neuropathol Appl Neurobiol 30: 576-584
16. FERREIRINHA F, QUATTRINI A, PIROZZI M, VALSECCHI V, DINA G, BROCCOLI V, AURICCHIO A, PIEMONTE F, TOZZI G, GAETA L, CASARI G, BALLABIO A, RUGARLI EI (2004) Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport. J Clin Invest 113: 231-242
17. FU DX, KUO YL, LIU BY, JEANG KT, GIAM CZ (2003) Human T-lymphotropic virus type I tax activates Ikappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A. J Biol Chem 278: 1487-1493
18. GALENO H, RAMÍREZ E, MORA J, OJEDA M, CARTIER L (1994) Anti HTLV-I antibody titers in seropositive infected individuals. Rev Med Chil 122: 1004-1007
19. GOODALL CA, HEAD MW, EVERINGTON D, IRONSIDE JW, KNIGHT RS, GREEN AJ (2006) Raised CSF phospho-tau concentrations in variant Creutzfeldt-Jakob disease: diagnostic and pathological implications. J Neurol Neurosurg Psychiatry 77: 89-91
20. GRANT C, BARMAK K, ALEFANTIS T, YAO J, JACOBSON S, WIGDAHL B (2002) Human T cell leukemia virus type I and neurologic disease: events in bone marrow, peripheral blood, and central nervous system during normal immune surveillance and neuroinflammation. J Cell Physiol 190: 133-159
21. GUSTKE N, TRINCZEK B, BIERNAT J, MANDELKOW EM, MANDELKOW E (1994) Domains of tau protein and interactions with microtubules. Biochemistry 33: 9511-9522
22. HAMPEL H, BURGER K, PRUESSNER JC, ZINKOWSKI R, DEBERNARDIS J, KERKMAN D, LEINSINGER G, EVANS AC, DAVIES P, MÖLLER HJ, TEIPEL SJ (2005) Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease. Arch Neurol 62: 770-773
23. HESSE C, ROSENGREN L, ANDREASEN N, DAVIDSSON P, VANDERSTICHELE H, VANMECHELEN E, BLENNOW K (2001). Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke. Neurosci Lett 297: 187-190
24. IQBAL K, ALONSO A DEL C, CHEN S, CHOHAN MO, EL-AKKAD E, GONG CX, KHATOON S, LI B, LIU F, RAHMAN A, TANIMUKAI H, GRUNDKE-IQBAL I (2005) Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta 1739: 198-210
25. JÄMSÄ, HASSLUND K, COWBURN RF, BÄCKSTRÖM A, VASÄNGE M (2004). The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation. Biochem Biophys Res Commun 319: 993-1000
26. JAIN P, MOSTOLLER K, FLAIG KE, AHUJA J, LEPOUTRE V, ALEFANTIS T, KHAN ZK, WIGDAHL B (2007) Identification of human T cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoprotein. J Biol Chem 282: 34581-34593
27. JOHNSON GV, STOOTHOFF WH (2004) Tau phosphorylation in neuronal cell function and dysfunction. J Cell Sci 117: 5721-5729
28. KREITZER G, LIAO G, GUNDERSEN GG (1999) Detyrosination of tubulin regulates the interaction of intermediate filaments with microtubules in vivo via a kinesin-dependent mechanism. Mol Biol Cell 10: 1105-1118
29. LI T, HAWKES C, QURESHI HY, KAR S, PAUDEL HK (2006) Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta. F Biochemistry 45: 3134-3145
30. MACCIONI RB, LAVADOS M, GUILLON, MUJICA C, BOSCH R, FARÍAS G, FUENTES P (2006) Anomalously phosphorylated tau and Abeta fragments in the CSF correlates with cognitive impairment in MCI subjects. Neurobiol Aging 27: 237-244
31. MONDRAGÓN-RODRÍGUEZ S, BASURTO-ISLAS G, SANTA-MARÍA I, MENA R, BINDER LI, ÁVILA J, SMITH MA, PERRY G, GARCÍA-SIERRA F (2008) Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease. Int J Exp Pathol 89: 81-90
32. NOGALES E (2000) Structural insights into microtubule function. Annu Rev Biochem 69: 277-302
33. OLSSON A, VANDERSTICHELE H, ANDREASEN N, DE MEYER G, WALLIN A, HOLMBERG B, ROSENGREN L, VANMECHELEN E, BLENNOW K (2005) Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology. Clin Chem 51: 336-345
34. OSAME M (2002) Pathological mechanisms of human Tcell lymphotropic virus type I-associated myelopathy (HAM/TSP). J Neurovirol 8: 359-364
35. OTTO M, LEWCZUK P, WILTFANG J (2008) Neurochemical approaches of cerebrospinal fluid diagnostics in neurodegenerative diseases. Methods 44: 289-298
36. PLATTNER F, ANGELO M, GIESE KP (2006) The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation. J Biol Chem 281: 25457-25465
37. RAMÍREZ E, FERNÁNDEZ J, CARTIER L, VILLOTA C, RÍOS M (2003) Defective human T-cell lymphotropic virus type I (HTLV-I) provirus in seronegative tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM) patients. Virus Res 91: 231-239
38. RAMÍREZ E, CARTIER L, FLORES R (2004) In vitro cytoskeleton changes of mouse neurons induced by purified HTLV-1, and PBMC from HAM/ TSP patients and HTLV-1 carriers. Arch Virol 149: 2307-2317
39. SAYAS CL, AVILA J, WANDOSELL F (2002) Regulation of neuronal cytoskeleton by lysophosphatidic acid: role of GSK-3. Biochim Biophys Acta 1582: 144-153
40. SEMRA YK, SEIDI OA, SHARIEF MK (2002) Heightened intrathecal release of axonal cytoskeletal proteins in multiple sclerosis is associated with progressive disease and clinical disability. J Neuroimmunol 122: 132-139
41. SENGUPTA A, GRUNDKE-IQBAL I, IQBAL K (2006a) Regulation of phosphorylation of tau by protein kinases in rat brain. Neurochem Res 31: 1473-1480
42. SENGUPTA A, NOVAK M, GRUNDKE-IQBAL I, IQBAL K (2006b) Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level. FEBS Lett 580: 5925-5933
43. SERGEANT N, DELACOURTE A, BUÉE L (2005) Tau protein as a differential biomarker of tauopathies. Biochim Biophys Acta 1739: 179-197
44. SHAHANI N, BRANDT R (2002) Functions and malfunctions of the tau proteins. Cell Mol Life Sci 59: 1668-1680
45. SJÖGREN M, DAVIDSSON P, TULLBERG M, MINTHON L, WALLIN A, WIKKELSO C, GRANÉRUS AK, VANDERSTICHELE H, VANMECHELEN E, BLENNOW K (2001) Both total and phosphorylated tau are increased in Alzheimer's disease. J Neurol Neurosurg Psychiatry 70: 624-630
46. SKINNINGSRUD A, STENSET V, GUNDERSEN AS, FLADBY T (2008) Cerebrospinal fluid markers in Creutzfeldt-Jakob disease. Cerebrospinal Fluid Res. 27; 5: 14 (Doi: 10.1186/1743-8454-5-14)
47. SZYMOCHA R, AKAOKA H, DUTUIT M, MALCUS C, DIDIER-BAZES M, BELIN MF, GIRAUDON P (2000). Human T-cell lymphotropic virus type 1-infected T lymphocytes impair catabolism and uptake of glutamate by astrocytes via Tax-1 and tumor necrosis factor alpha. J Virol 74: 6433-6441
48. TERZI M, BIRINCI A, CETINKAYA E, ONAR MK (2007) Cerebrospinal fluid total tau protein levels in patients with multiple sclerosis. Acta Neurol Scand 115: 325-330
49. TEUNISSEN CE, DIJKSTRA C, POLMAN C (2005): Biological markers in CSF and blood for axonal degeneration in multiple sclerosis. Lancet Neurol 4: 32-41
50. TRINCZEK B, EBNETH A, MANDELKOW EM, MANDELKOW E (1999) Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles. J Cell Sci 112: 2355-2367
51. UMEHARA F, ABE M, KOREEDA Y, IZUMO S, OSAME M: (2000) Axonal damage revealed by accumulation of beta-amyloid precursor protein in HTLV-I-associated myelopathy. J Neurol Sci 176: 95-101
52. VAN EVERBROECK B, GREEN AJ, VANMECHELEN E, VANDERSTICHELE H, PALS P, SÁNCHEZ-VALLE R, CORRALES NC, MARTIN JJ, CRAS P (2002) Phosphorylated tau in cerebrospinal fluid as a marker for Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry 73: 79-81
53. WANG JZ, GRUNDKE-IQBAL I, IQBAL K (2007) Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. Eur J Neurosci 25: 59-68
54. WU K, BOTTAZZI ME, DE LA FUENTE C, DENG L, GITLIN SD, MADDUKURI A, DADGAR S, LI H, VERTES A, PUMFERY A, KASHANCHI F (2004) Protein profile of tax-associated complexes. J Biol Chem 279: 495-508