-
1
-
-
56049125725
-
Autoimmune disorders of the neuromuscular junction
-
Vincent A. Autoimmune disorders of the neuromuscular junction. Neurol India 56 (2008) 305-313
-
(2008)
Neurol India
, vol.56
, pp. 305-313
-
-
Vincent, A.1
-
2
-
-
34548151158
-
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
-
Demonstration of a variant in the promoter region of CHRNA1 gene that has been associated with early onset of MG. Authors show that this variant, through IRF8 binding, significantly reduces the AIRE-regulated AChR expression in the thymus, which may alter self-tolerance thresholds.
-
Giraud M., Taubert R., Vandiedonck C., Ke X., Lévi-Strauss M., Pagani F., Baralle F.E., Eymard B., Tranchant C., Gajdos P., et al. An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature 448 (2007) 934-937. Demonstration of a variant in the promoter region of CHRNA1 gene that has been associated with early onset of MG. Authors show that this variant, through IRF8 binding, significantly reduces the AIRE-regulated AChR expression in the thymus, which may alter self-tolerance thresholds.
-
(2007)
Nature
, vol.448
, pp. 934-937
-
-
Giraud, M.1
Taubert, R.2
Vandiedonck, C.3
Ke, X.4
Lévi-Strauss, M.5
Pagani, F.6
Baralle, F.E.7
Eymard, B.8
Tranchant, C.9
Gajdos, P.10
-
3
-
-
0036231364
-
True epithelial hyperplasia in the thymus of early-onset myasthenia gravis patients: implications for immunopathogenesis
-
Roxanis I., Micklem K., McConville J., Newsom-Davis J., and Willcox N. True epithelial hyperplasia in the thymus of early-onset myasthenia gravis patients: implications for immunopathogenesis. J Neuroimmunol 125 (2002) 185-197
-
(2002)
J Neuroimmunol
, vol.125
, pp. 185-197
-
-
Roxanis, I.1
Micklem, K.2
McConville, J.3
Newsom-Davis, J.4
Willcox, N.5
-
4
-
-
34548863119
-
Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells complement attack on them, and correlations with autoantibody status
-
Demonstration of upregulation of complement components in the hyperplastic thymic epithelial cells and especially in the myoid cells in early onset MG patients. Additionally, myoid cells show a downregulation of complement regulators making myoid cells particularly susceptible to autoantibody attack.
-
Leite M.I., Jones M., Ströbel P., Marx A., Gold R., Niks E., Verschuuren J.J., Berrih-Aknin S., Scaravilli F., Canelhas A., et al. Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells complement attack on them, and correlations with autoantibody status. Am J Pathol 171 (2007) 893-905. Demonstration of upregulation of complement components in the hyperplastic thymic epithelial cells and especially in the myoid cells in early onset MG patients. Additionally, myoid cells show a downregulation of complement regulators making myoid cells particularly susceptible to autoantibody attack.
-
(2007)
Am J Pathol
, vol.171
, pp. 893-905
-
-
Leite, M.I.1
Jones, M.2
Ströbel, P.3
Marx, A.4
Gold, R.5
Niks, E.6
Verschuuren, J.J.7
Berrih-Aknin, S.8
Scaravilli, F.9
Canelhas, A.10
-
5
-
-
20044374002
-
Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG
-
Leite M.I., Ströbel P., Jones M., Micklem K., Moritz R., Gold R., Niks E.H., Berrih-Aknin S., Scaravilli F., Canelhas A., et al. Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG. Ann Neurol 57 (2005) 444-448
-
(2005)
Ann Neurol
, vol.57
, pp. 444-448
-
-
Leite, M.I.1
Ströbel, P.2
Jones, M.3
Micklem, K.4
Moritz, R.5
Gold, R.6
Niks, E.H.7
Berrih-Aknin, S.8
Scaravilli, F.9
Canelhas, A.10
-
6
-
-
13244295348
-
Thymus changes in anti-MuSK-positive and -negative myasthenia gravis
-
Lauriola L., Ranelletti F., Maggiano N., Guerriero M., Punzi C., Marsili F., Bartoccioni E., and Evoli A. Thymus changes in anti-MuSK-positive and -negative myasthenia gravis. Neurology 64 (2005) 536-538
-
(2005)
Neurology
, vol.64
, pp. 536-538
-
-
Lauriola, L.1
Ranelletti, F.2
Maggiano, N.3
Guerriero, M.4
Punzi, C.5
Marsili, F.6
Bartoccioni, E.7
Evoli, A.8
-
7
-
-
46849112624
-
IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis
-
Demonstration of anti-AChR antibodies in the sera of MG patients, previously described as 'sero-negative', using a cell-based assay in which HEK cell subunits have been co-transfected with AChR and rapsyn, a protein that clusters the AChR at the NMJ.
-
Leite M.I., Jacob S., Viegas S., Cossins J., Clover L., Morgan B.P., Beeson D., Willcox N., and Vincent A. IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis. Brain 131 (2008) 1940-1952. Demonstration of anti-AChR antibodies in the sera of MG patients, previously described as 'sero-negative', using a cell-based assay in which HEK cell subunits have been co-transfected with AChR and rapsyn, a protein that clusters the AChR at the NMJ.
-
(2008)
Brain
, vol.131
, pp. 1940-1952
-
-
Leite, M.I.1
Jacob, S.2
Viegas, S.3
Cossins, J.4
Clover, L.5
Morgan, B.P.6
Beeson, D.7
Willcox, N.8
Vincent, A.9
-
8
-
-
0035105784
-
Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies
-
Hoch W., McConville J., Helms S., Newsom-Davis J., Melms A., and Vincent A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 7 (2001) 365-368
-
(2001)
Nat Med
, vol.7
, pp. 365-368
-
-
Hoch, W.1
McConville, J.2
Helms, S.3
Newsom-Davis, J.4
Melms, A.5
Vincent, A.6
-
9
-
-
1642348179
-
Detection and characterization of MuSK antibodies in seronegative myasthenia gravis
-
McConville J., Farrugia M.E., Beeson D., Kishore U., Metcalfe R., Newsom-Davis J., and Vincent A. Detection and characterization of MuSK antibodies in seronegative myasthenia gravis. Ann Neurol 55 (2004) 580-584
-
(2004)
Ann Neurol
, vol.55
, pp. 580-584
-
-
McConville, J.1
Farrugia, M.E.2
Beeson, D.3
Kishore, U.4
Metcalfe, R.5
Newsom-Davis, J.6
Vincent, A.7
-
10
-
-
2942532978
-
Is 'seronegative' MG explained by autoantibodies to MuSK?
-
Lindstrom J. Is 'seronegative' MG explained by autoantibodies to MuSK?. Neurology 62 (2004) 1920-1921
-
(2004)
Neurology
, vol.62
, pp. 1920-1921
-
-
Lindstrom, J.1
-
11
-
-
1642487117
-
Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference
-
Kong X.C., Barzaghi P., and Ruegg M.A. Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference. EMBO Rep 5 (2004) 183-188
-
(2004)
EMBO Rep
, vol.5
, pp. 183-188
-
-
Kong, X.C.1
Barzaghi, P.2
Ruegg, M.A.3
-
12
-
-
33646780233
-
Myasthenia gravis induced in mice by immunization with the recombinant extracellular domain of rat muscle-specific kinase (MuSK)
-
Active immunisation against MuSK induces muscle weakness and reduces miniature endplate potential amplitudes in mice with evidence of morphological changes at the neuromuscular junction.
-
Jha S., Xu K., Maruta T., Oshima M., Mosier D.R., Atassi M.Z., and Hoch W. Myasthenia gravis induced in mice by immunization with the recombinant extracellular domain of rat muscle-specific kinase (MuSK). J Neuroimmunol 175 (2006) 107-117. Active immunisation against MuSK induces muscle weakness and reduces miniature endplate potential amplitudes in mice with evidence of morphological changes at the neuromuscular junction.
-
(2006)
J Neuroimmunol
, vol.175
, pp. 107-117
-
-
Jha, S.1
Xu, K.2
Maruta, T.3
Oshima, M.4
Mosier, D.R.5
Atassi, M.Z.6
Hoch, W.7
-
13
-
-
33645521800
-
Induction of myasthenia by immunization against muscle-specific kinase
-
Active immunisation against MuSK induces muscle weakness and demonstrates electromyographical evidence of a neuromuscular transmission defect. The antibodies act in a similar fashion to those in the human patients in various in vitro models.
-
Shigemoto K., Kubo S., Maruyama N., Hato N., Yamada H., Jie C., Kobayashi N., Mominoki K., Abe Y., Ueda N., and Matsuda S. Induction of myasthenia by immunization against muscle-specific kinase. J Clin Invest 116 (2006) 1016-1024. Active immunisation against MuSK induces muscle weakness and demonstrates electromyographical evidence of a neuromuscular transmission defect. The antibodies act in a similar fashion to those in the human patients in various in vitro models.
-
(2006)
J Clin Invest
, vol.116
, pp. 1016-1024
-
-
Shigemoto, K.1
Kubo, S.2
Maruyama, N.3
Hato, N.4
Yamada, H.5
Jie, C.6
Kobayashi, N.7
Mominoki, K.8
Abe, Y.9
Ueda, N.10
Matsuda, S.11
-
14
-
-
46749148845
-
Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction
-
IgG from anti-MuSK patients causes weakness and neuromuscular junction morphological abnormalities after injection into mice. A nice study but with limited evidence of the electrophysiological consequences of the antibodies.
-
Cole R.N., Reddel S.W., Gervásio O.L., and Phillips W.D. Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction. Ann Neurol 63 (2008) 782-789. IgG from anti-MuSK patients causes weakness and neuromuscular junction morphological abnormalities after injection into mice. A nice study but with limited evidence of the electrophysiological consequences of the antibodies.
-
(2008)
Ann Neurol
, vol.63
, pp. 782-789
-
-
Cole, R.N.1
Reddel, S.W.2
Gervásio, O.L.3
Phillips, W.D.4
-
15
-
-
0033537356
-
Favourable prognosis in Lambert-Eaton myasthenic syndrome and small-cell lung carcinoma
-
Maddison P., Newsom-Davis J., Mills K.R., and Souhami R.L. Favourable prognosis in Lambert-Eaton myasthenic syndrome and small-cell lung carcinoma. Lancet 353 (1999) 117-118
-
(1999)
Lancet
, vol.353
, pp. 117-118
-
-
Maddison, P.1
Newsom-Davis, J.2
Mills, K.R.3
Souhami, R.L.4
-
16
-
-
20444480101
-
P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome and survival in small cell lung cancer
-
Wirtz P.W., Lang B., Graus F., van den Maagdenberg A.M., Saiz A., de Koning Gans P.A., Twijnstra A., and Verschuuren J.J. P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome and survival in small cell lung cancer. J Neuroimmunol 164 (2005) 161-165
-
(2005)
J Neuroimmunol
, vol.164
, pp. 161-165
-
-
Wirtz, P.W.1
Lang, B.2
Graus, F.3
van den Maagdenberg, A.M.4
Saiz, A.5
de Koning Gans, P.A.6
Twijnstra, A.7
Verschuuren, J.J.8
-
17
-
-
19944432088
-
HLA and smoking in prediction and prognosis of small cell lung carcinoma in autoimmune Lambert-Eaton myasthenic syndrome
-
Wirtz P.W., van Dijk J.G., van Doorn P.A., van Engelen B.G., van der Kooi A.J., Kuks J.B., Twijnstra A., de Visser M., de Visser L.H., Wokke J.H., et al. HLA and smoking in prediction and prognosis of small cell lung carcinoma in autoimmune Lambert-Eaton myasthenic syndrome. J Neuroimmunol 159 (2005) 230-237
-
(2005)
J Neuroimmunol
, vol.159
, pp. 230-237
-
-
Wirtz, P.W.1
van Dijk, J.G.2
van Doorn, P.A.3
van Engelen, B.G.4
van der Kooi, A.J.5
Kuks, J.B.6
Twijnstra, A.7
de Visser, M.8
de Visser, L.H.9
Wokke, J.H.10
-
18
-
-
23044503286
-
Lambert-Eaton myasthenic syndrome has a more progressive course in patients with lung cancer
-
Wirtz P.W., Wintzen A.R., and Verschuuren J.J. Lambert-Eaton myasthenic syndrome has a more progressive course in patients with lung cancer. Muscle Nerve 32 (2005) 226-229
-
(2005)
Muscle Nerve
, vol.32
, pp. 226-229
-
-
Wirtz, P.W.1
Wintzen, A.R.2
Verschuuren, J.J.3
-
19
-
-
52049103838
-
Screening for small-cell lung cancer: a follow-up study of patients with Lambert-Eaton myasthenic syndrome
-
Titulaer M.J., Wirtz P.W., Willems L.N., van Kralingen K.W., Smitt P.A., and Verschuuren J.J. Screening for small-cell lung cancer: a follow-up study of patients with Lambert-Eaton myasthenic syndrome. J Clin Oncol 26 (2008) 4276-4281
-
(2008)
J Clin Oncol
, vol.26
, pp. 4276-4281
-
-
Titulaer, M.J.1
Wirtz, P.W.2
Willems, L.N.3
van Kralingen, K.W.4
Smitt, P.A.5
Verschuuren, J.J.6
-
20
-
-
22144447808
-
Anti-glial nuclear antibody: marker of lung cancer-related paraneoplastic neurological syndromes
-
Graus F., Vincent A., Pozo-Rosich P., Sabater L., Saiz A., Lang B., and Dalmau J. Anti-glial nuclear antibody: marker of lung cancer-related paraneoplastic neurological syndromes. J Neuroimmunol 165 (2005) 166-171
-
(2005)
J Neuroimmunol
, vol.165
, pp. 166-171
-
-
Graus, F.1
Vincent, A.2
Pozo-Rosich, P.3
Sabater, L.4
Saiz, A.5
Lang, B.6
Dalmau, J.7
-
21
-
-
41149101950
-
SOX1 antibodies are markers of paraneoplastic Lambert-Eaton myasthenic syndrome
-
The presence of antibodies to SOX-1 in the sera of patients with LEMS may aid the search for an underlying carcinoma.
-
Sabater L., Titulaer M., Saiz A., Verschuuren J., Gure A.O., and Graus F. SOX1 antibodies are markers of paraneoplastic Lambert-Eaton myasthenic syndrome. Neurology 70 (2008) 924-928. The presence of antibodies to SOX-1 in the sera of patients with LEMS may aid the search for an underlying carcinoma.
-
(2008)
Neurology
, vol.70
, pp. 924-928
-
-
Sabater, L.1
Titulaer, M.2
Saiz, A.3
Verschuuren, J.4
Gure, A.O.5
Graus, F.6
-
22
-
-
54349088442
-
Lambert-Eaton myasthenic syndrome differential reactivity of tumor versus non-tumor patients to subunits of the voltage-gated calcium channel
-
Pellkofer H.L., Armbruster L., Krumbholz M., Titulaer M.J., Verschuuren J.J., Schumm F., and Voltz R. Lambert-Eaton myasthenic syndrome differential reactivity of tumor versus non-tumor patients to subunits of the voltage-gated calcium channel. J Neuroimmunol 204 (2008) 136-139
-
(2008)
J Neuroimmunol
, vol.204
, pp. 136-139
-
-
Pellkofer, H.L.1
Armbruster, L.2
Krumbholz, M.3
Titulaer, M.J.4
Verschuuren, J.J.5
Schumm, F.6
Voltz, R.7
-
23
-
-
0036348608
-
Phenotypic variants of autoimmune peripheral nerve hyperexcitability
-
Hart I.K., Maddison P., Newsom-Davis J., Vincent A., and Mills K.R. Phenotypic variants of autoimmune peripheral nerve hyperexcitability. Brain 125 (2002) 887-895
-
(2002)
Brain
, vol.125
, pp. 887-895
-
-
Hart, I.K.1
Maddison, P.2
Newsom-Davis, J.3
Vincent, A.4
Mills, K.R.5
-
24
-
-
10744229052
-
Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis
-
Vincent A., Buckley C., Schott J.M., Baker I., Dewar B.K., Detert N., Clover L., Parkinson A., Bien C.G., Omer S., et al. Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain 127 (2004) 701-712
-
(2004)
Brain
, vol.127
, pp. 701-712
-
-
Vincent, A.1
Buckley, C.2
Schott, J.M.3
Baker, I.4
Dewar, B.K.5
Detert, N.6
Clover, L.7
Parkinson, A.8
Bien, C.G.9
Omer, S.10
-
25
-
-
33745105091
-
Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations
-
Antibodies to various subtypes of the Shaker-type (Kv1) channels may be associated with different clinical phenotypes in patients with NMT, LE and Morvan's syndrome.
-
Kleopa K.A., Elman L.B., Lang B., Vincent A., and Scherer S.S. Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations. Brain 129 (2006) 1570-1584. Antibodies to various subtypes of the Shaker-type (Kv1) channels may be associated with different clinical phenotypes in patients with NMT, LE and Morvan's syndrome.
-
(2006)
Brain
, vol.129
, pp. 1570-1584
-
-
Kleopa, K.A.1
Elman, L.B.2
Lang, B.3
Vincent, A.4
Scherer, S.S.5
-
26
-
-
33646950789
-
Wasp sting induced autoimmune neuromyotonia
-
Turner M.R., Madkhana A., Ebers G.C., Clover L., Vincent A., McGavin G., Sarrigiannis P., Kennett R., and Warrell D.A. Wasp sting induced autoimmune neuromyotonia. JNNP 77 (2006) 704-705
-
(2006)
JNNP
, vol.77
, pp. 704-705
-
-
Turner, M.R.1
Madkhana, A.2
Ebers, G.C.3
Clover, L.4
Vincent, A.5
McGavin, G.6
Sarrigiannis, P.7
Kennett, R.8
Warrell, D.A.9
-
27
-
-
22144499664
-
The immunobiology of Guillain-Barré syndromes
-
Willison H.J. The immunobiology of Guillain-Barré syndromes. J Peripher Nerv Syst 10 (2005) 94-112
-
(2005)
J Peripher Nerv Syst
, vol.10
, pp. 94-112
-
-
Willison, H.J.1
-
28
-
-
40749124758
-
Antibodies against gangliosides and ganglioside complexes in Guillain-Barré syndrome: new aspects of research
-
The presence of antibodies to conformational epitopes formed by two gangliosides (ganglioside complexes) is predictive of the clinical phenotype in patients with GBS.
-
Kusunoki S., Kaida K., and Ueda M. Antibodies against gangliosides and ganglioside complexes in Guillain-Barré syndrome: new aspects of research. BBA 1780 (2008) 41-44. The presence of antibodies to conformational epitopes formed by two gangliosides (ganglioside complexes) is predictive of the clinical phenotype in patients with GBS.
-
(2008)
BBA
, vol.1780
, pp. 41-44
-
-
Kusunoki, S.1
Kaida, K.2
Ueda, M.3
-
29
-
-
58149240680
-
GM1/GalNAc-GD1a complex: a target for pure motor Guillain-Barré syndrome
-
Kaida K., Sonoo M., Ogawa G., Kamakura K., Ueda-Sada M., Arita M., Motoyoshi K., and Kusunoki S. GM1/GalNAc-GD1a complex: a target for pure motor Guillain-Barré syndrome. Neurology 71 (2008) 1683-1690
-
(2008)
Neurology
, vol.71
, pp. 1683-1690
-
-
Kaida, K.1
Sonoo, M.2
Ogawa, G.3
Kamakura, K.4
Ueda-Sada, M.5
Arita, M.6
Motoyoshi, K.7
Kusunoki, S.8
-
30
-
-
48449086818
-
GD1b-specific antibody induces ataxia in Guillain-Barré syndrome
-
Kaida K., Kamakura K., Ogawa G., Ueda M., Arita M., Motoyoshi K., Arita M., and Kusunoki S. GD1b-specific antibody induces ataxia in Guillain-Barré syndrome. Neurology 71 (2008) 196-201
-
(2008)
Neurology
, vol.71
, pp. 196-201
-
-
Kaida, K.1
Kamakura, K.2
Ogawa, G.3
Ueda, M.4
Arita, M.5
Motoyoshi, K.6
Arita, M.7
Kusunoki, S.8
-
31
-
-
53149147772
-
Ganglioside complexes containing GQ1b as targets in Miller Fisher and Guillain-Barré syndromes
-
Kanzaki M., Kaida K., Ueda M., Morita D., Hirakawa M., Motoyoshi K., Kamakura K., and Kusunoki S. Ganglioside complexes containing GQ1b as targets in Miller Fisher and Guillain-Barré syndromes. JNNP 79 (2008) 1148-1152
-
(2008)
JNNP
, vol.79
, pp. 1148-1152
-
-
Kanzaki, M.1
Kaida, K.2
Ueda, M.3
Morita, D.4
Hirakawa, M.5
Motoyoshi, K.6
Kamakura, K.7
Kusunoki, S.8
-
32
-
-
39849096550
-
Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barré syndrome
-
Jacobs B.C., Koga M., van Rijs W., Geleijns K., van Doorn P.A., Willison H.J., and Yuki N. Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barré syndrome. J Neuroimmunol 194 (2008) 181-190
-
(2008)
J Neuroimmunol
, vol.194
, pp. 181-190
-
-
Jacobs, B.C.1
Koga, M.2
van Rijs, W.3
Geleijns, K.4
van Doorn, P.A.5
Willison, H.J.6
Yuki, N.7
-
33
-
-
33746534220
-
Guidelines for the treatment of autoimmune neuromuscular transmission disorders
-
Consensus guidelines for the treatment of autoimmune disorders of the peripheral nervous system.
-
Skeie G.O., Apostolski S., Evoli A., Gilhus N.E., Hart I.K., Harms L., Hilton-Jones D., Melms A., Verschuuren J., and Horge H.W. Guidelines for the treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol 13 (2006) 691-699. Consensus guidelines for the treatment of autoimmune disorders of the peripheral nervous system.
-
(2006)
Eur J Neurol
, vol.13
, pp. 691-699
-
-
Skeie, G.O.1
Apostolski, S.2
Evoli, A.3
Gilhus, N.E.4
Hart, I.K.5
Harms, L.6
Hilton-Jones, D.7
Melms, A.8
Verschuuren, J.9
Horge, H.W.10
-
34
-
-
54049122104
-
B cells as therapeutic targets in autoimmune neurological disorders
-
Dalakas M.C. B cells as therapeutic targets in autoimmune neurological disorders. Nat Clin Pract Neurol 4 (2008) 557-567
-
(2008)
Nat Clin Pract Neurol
, vol.4
, pp. 557-567
-
-
Dalakas, M.C.1
-
35
-
-
51849141688
-
Sustained response to Rituximab in anti-AChR and anti-MuSK positive Myasthenia Gravis patients
-
Illa I., Diaz-Manera J., Rojas-Garcia R., Pradas J., Rey A., Blesa R., Juarez C., and Gallardo E. Sustained response to Rituximab in anti-AChR and anti-MuSK positive Myasthenia Gravis patients. J Neuroimmunol 201-202 (2008) 90-94
-
(2008)
J Neuroimmunol
, vol.201-202
, pp. 90-94
-
-
Illa, I.1
Diaz-Manera, J.2
Rojas-Garcia, R.3
Pradas, J.4
Rey, A.5
Blesa, R.6
Juarez, C.7
Gallardo, E.8
-
36
-
-
44949251941
-
Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in a murine model
-
Halstead S.K., Zitman F.M., Humphreys P.D., Greenshields K., Verschuuren J.J., Jacobs B.C., Rother R.P., Plomp J.J., and Willison H.J. Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in a murine model. Brain 131 (2008) 1197-1208
-
(2008)
Brain
, vol.131
, pp. 1197-1208
-
-
Halstead, S.K.1
Zitman, F.M.2
Humphreys, P.D.3
Greenshields, K.4
Verschuuren, J.J.5
Jacobs, B.C.6
Rother, R.P.7
Plomp, J.J.8
Willison, H.J.9
-
37
-
-
40049103666
-
Anti-C5 antibody treatment ameliorates weakness in experimentally acquired myasthenia gravis
-
Clinical weakness can be alleviated in a rat model of experimental autoimmune MG by pre-treatment with antibodies to complement component C5. The experiment raises the possibility of targeting complement activation in the treatment of MG.
-
Zhou Y., Gong B., Lin F., Rother R.P., Medof M.E., and Kaminski H.J. Anti-C5 antibody treatment ameliorates weakness in experimentally acquired myasthenia gravis. J Immunol 179 (2007) 8562-8567. Clinical weakness can be alleviated in a rat model of experimental autoimmune MG by pre-treatment with antibodies to complement component C5. The experiment raises the possibility of targeting complement activation in the treatment of MG.
-
(2007)
J Immunol
, vol.179
, pp. 8562-8567
-
-
Zhou, Y.1
Gong, B.2
Lin, F.3
Rother, R.P.4
Medof, M.E.5
Kaminski, H.J.6
-
38
-
-
34548694517
-
Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange
-
IgG4 is an anti-inflammatory subclass of IgG that has the ability to exchange Fab arms; after such an exchange it can become functionally monovalent. Using a passive transfer monkey model of MG, the authors demonstrated that IgG4 protects the animal from experimental autoimmune MG and hence IgG4 may be useful in immunomodulatory therapy.
-
van der Neut Kolfschoten M., Schuurman J., Losen M., Bleeker W.K., Martínez-Martínez P., Vermeulen E., den Bleker T.H., Wiegman L., Vink T., Aarden L.A., et al. Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science 317 (2007) 1554-1557. IgG4 is an anti-inflammatory subclass of IgG that has the ability to exchange Fab arms; after such an exchange it can become functionally monovalent. Using a passive transfer monkey model of MG, the authors demonstrated that IgG4 protects the animal from experimental autoimmune MG and hence IgG4 may be useful in immunomodulatory therapy.
-
(2007)
Science
, vol.317
, pp. 1554-1557
-
-
van der Neut Kolfschoten, M.1
Schuurman, J.2
Losen, M.3
Bleeker, W.K.4
Martínez-Martínez, P.5
Vermeulen, E.6
den Bleker, T.H.7
Wiegman, L.8
Vink, T.9
Aarden, L.A.10
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