메뉴 건너뛰기




Volumn 9, Issue 3, 2009, Pages 336-340

Autoimmune disorders of the neuromuscular junction

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AZATHIOPRINE; CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR ANTIBODY; ECULIZUMAB; GANGLIOSIDE GD 1A; GANGLIOSIDE GD 1B; GANGLIOSIDE GM1; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; RITUXIMAB; TACROLIMUS; TRANSCRIPTION FACTOR SOX1; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

EID: 65749120107     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2009.04.005     Document Type: Review
Times cited : (48)

References (38)
  • 1
    • 56049125725 scopus 로고    scopus 로고
    • Autoimmune disorders of the neuromuscular junction
    • Vincent A. Autoimmune disorders of the neuromuscular junction. Neurol India 56 (2008) 305-313
    • (2008) Neurol India , vol.56 , pp. 305-313
    • Vincent, A.1
  • 2
    • 34548151158 scopus 로고    scopus 로고
    • An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
    • Demonstration of a variant in the promoter region of CHRNA1 gene that has been associated with early onset of MG. Authors show that this variant, through IRF8 binding, significantly reduces the AIRE-regulated AChR expression in the thymus, which may alter self-tolerance thresholds.
    • Giraud M., Taubert R., Vandiedonck C., Ke X., Lévi-Strauss M., Pagani F., Baralle F.E., Eymard B., Tranchant C., Gajdos P., et al. An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature 448 (2007) 934-937. Demonstration of a variant in the promoter region of CHRNA1 gene that has been associated with early onset of MG. Authors show that this variant, through IRF8 binding, significantly reduces the AIRE-regulated AChR expression in the thymus, which may alter self-tolerance thresholds.
    • (2007) Nature , vol.448 , pp. 934-937
    • Giraud, M.1    Taubert, R.2    Vandiedonck, C.3    Ke, X.4    Lévi-Strauss, M.5    Pagani, F.6    Baralle, F.E.7    Eymard, B.8    Tranchant, C.9    Gajdos, P.10
  • 3
    • 0036231364 scopus 로고    scopus 로고
    • True epithelial hyperplasia in the thymus of early-onset myasthenia gravis patients: implications for immunopathogenesis
    • Roxanis I., Micklem K., McConville J., Newsom-Davis J., and Willcox N. True epithelial hyperplasia in the thymus of early-onset myasthenia gravis patients: implications for immunopathogenesis. J Neuroimmunol 125 (2002) 185-197
    • (2002) J Neuroimmunol , vol.125 , pp. 185-197
    • Roxanis, I.1    Micklem, K.2    McConville, J.3    Newsom-Davis, J.4    Willcox, N.5
  • 4
    • 34548863119 scopus 로고    scopus 로고
    • Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells complement attack on them, and correlations with autoantibody status
    • Demonstration of upregulation of complement components in the hyperplastic thymic epithelial cells and especially in the myoid cells in early onset MG patients. Additionally, myoid cells show a downregulation of complement regulators making myoid cells particularly susceptible to autoantibody attack.
    • Leite M.I., Jones M., Ströbel P., Marx A., Gold R., Niks E., Verschuuren J.J., Berrih-Aknin S., Scaravilli F., Canelhas A., et al. Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells complement attack on them, and correlations with autoantibody status. Am J Pathol 171 (2007) 893-905. Demonstration of upregulation of complement components in the hyperplastic thymic epithelial cells and especially in the myoid cells in early onset MG patients. Additionally, myoid cells show a downregulation of complement regulators making myoid cells particularly susceptible to autoantibody attack.
    • (2007) Am J Pathol , vol.171 , pp. 893-905
    • Leite, M.I.1    Jones, M.2    Ströbel, P.3    Marx, A.4    Gold, R.5    Niks, E.6    Verschuuren, J.J.7    Berrih-Aknin, S.8    Scaravilli, F.9    Canelhas, A.10
  • 7
    • 46849112624 scopus 로고    scopus 로고
    • IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis
    • Demonstration of anti-AChR antibodies in the sera of MG patients, previously described as 'sero-negative', using a cell-based assay in which HEK cell subunits have been co-transfected with AChR and rapsyn, a protein that clusters the AChR at the NMJ.
    • Leite M.I., Jacob S., Viegas S., Cossins J., Clover L., Morgan B.P., Beeson D., Willcox N., and Vincent A. IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis. Brain 131 (2008) 1940-1952. Demonstration of anti-AChR antibodies in the sera of MG patients, previously described as 'sero-negative', using a cell-based assay in which HEK cell subunits have been co-transfected with AChR and rapsyn, a protein that clusters the AChR at the NMJ.
    • (2008) Brain , vol.131 , pp. 1940-1952
    • Leite, M.I.1    Jacob, S.2    Viegas, S.3    Cossins, J.4    Clover, L.5    Morgan, B.P.6    Beeson, D.7    Willcox, N.8    Vincent, A.9
  • 8
    • 0035105784 scopus 로고    scopus 로고
    • Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies
    • Hoch W., McConville J., Helms S., Newsom-Davis J., Melms A., and Vincent A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 7 (2001) 365-368
    • (2001) Nat Med , vol.7 , pp. 365-368
    • Hoch, W.1    McConville, J.2    Helms, S.3    Newsom-Davis, J.4    Melms, A.5    Vincent, A.6
  • 10
    • 2942532978 scopus 로고    scopus 로고
    • Is 'seronegative' MG explained by autoantibodies to MuSK?
    • Lindstrom J. Is 'seronegative' MG explained by autoantibodies to MuSK?. Neurology 62 (2004) 1920-1921
    • (2004) Neurology , vol.62 , pp. 1920-1921
    • Lindstrom, J.1
  • 11
    • 1642487117 scopus 로고    scopus 로고
    • Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference
    • Kong X.C., Barzaghi P., and Ruegg M.A. Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference. EMBO Rep 5 (2004) 183-188
    • (2004) EMBO Rep , vol.5 , pp. 183-188
    • Kong, X.C.1    Barzaghi, P.2    Ruegg, M.A.3
  • 12
    • 33646780233 scopus 로고    scopus 로고
    • Myasthenia gravis induced in mice by immunization with the recombinant extracellular domain of rat muscle-specific kinase (MuSK)
    • Active immunisation against MuSK induces muscle weakness and reduces miniature endplate potential amplitudes in mice with evidence of morphological changes at the neuromuscular junction.
    • Jha S., Xu K., Maruta T., Oshima M., Mosier D.R., Atassi M.Z., and Hoch W. Myasthenia gravis induced in mice by immunization with the recombinant extracellular domain of rat muscle-specific kinase (MuSK). J Neuroimmunol 175 (2006) 107-117. Active immunisation against MuSK induces muscle weakness and reduces miniature endplate potential amplitudes in mice with evidence of morphological changes at the neuromuscular junction.
    • (2006) J Neuroimmunol , vol.175 , pp. 107-117
    • Jha, S.1    Xu, K.2    Maruta, T.3    Oshima, M.4    Mosier, D.R.5    Atassi, M.Z.6    Hoch, W.7
  • 13
    • 33645521800 scopus 로고    scopus 로고
    • Induction of myasthenia by immunization against muscle-specific kinase
    • Active immunisation against MuSK induces muscle weakness and demonstrates electromyographical evidence of a neuromuscular transmission defect. The antibodies act in a similar fashion to those in the human patients in various in vitro models.
    • Shigemoto K., Kubo S., Maruyama N., Hato N., Yamada H., Jie C., Kobayashi N., Mominoki K., Abe Y., Ueda N., and Matsuda S. Induction of myasthenia by immunization against muscle-specific kinase. J Clin Invest 116 (2006) 1016-1024. Active immunisation against MuSK induces muscle weakness and demonstrates electromyographical evidence of a neuromuscular transmission defect. The antibodies act in a similar fashion to those in the human patients in various in vitro models.
    • (2006) J Clin Invest , vol.116 , pp. 1016-1024
    • Shigemoto, K.1    Kubo, S.2    Maruyama, N.3    Hato, N.4    Yamada, H.5    Jie, C.6    Kobayashi, N.7    Mominoki, K.8    Abe, Y.9    Ueda, N.10    Matsuda, S.11
  • 14
    • 46749148845 scopus 로고    scopus 로고
    • Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction
    • IgG from anti-MuSK patients causes weakness and neuromuscular junction morphological abnormalities after injection into mice. A nice study but with limited evidence of the electrophysiological consequences of the antibodies.
    • Cole R.N., Reddel S.W., Gervásio O.L., and Phillips W.D. Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction. Ann Neurol 63 (2008) 782-789. IgG from anti-MuSK patients causes weakness and neuromuscular junction morphological abnormalities after injection into mice. A nice study but with limited evidence of the electrophysiological consequences of the antibodies.
    • (2008) Ann Neurol , vol.63 , pp. 782-789
    • Cole, R.N.1    Reddel, S.W.2    Gervásio, O.L.3    Phillips, W.D.4
  • 15
    • 0033537356 scopus 로고    scopus 로고
    • Favourable prognosis in Lambert-Eaton myasthenic syndrome and small-cell lung carcinoma
    • Maddison P., Newsom-Davis J., Mills K.R., and Souhami R.L. Favourable prognosis in Lambert-Eaton myasthenic syndrome and small-cell lung carcinoma. Lancet 353 (1999) 117-118
    • (1999) Lancet , vol.353 , pp. 117-118
    • Maddison, P.1    Newsom-Davis, J.2    Mills, K.R.3    Souhami, R.L.4
  • 18
    • 23044503286 scopus 로고    scopus 로고
    • Lambert-Eaton myasthenic syndrome has a more progressive course in patients with lung cancer
    • Wirtz P.W., Wintzen A.R., and Verschuuren J.J. Lambert-Eaton myasthenic syndrome has a more progressive course in patients with lung cancer. Muscle Nerve 32 (2005) 226-229
    • (2005) Muscle Nerve , vol.32 , pp. 226-229
    • Wirtz, P.W.1    Wintzen, A.R.2    Verschuuren, J.J.3
  • 19
    • 52049103838 scopus 로고    scopus 로고
    • Screening for small-cell lung cancer: a follow-up study of patients with Lambert-Eaton myasthenic syndrome
    • Titulaer M.J., Wirtz P.W., Willems L.N., van Kralingen K.W., Smitt P.A., and Verschuuren J.J. Screening for small-cell lung cancer: a follow-up study of patients with Lambert-Eaton myasthenic syndrome. J Clin Oncol 26 (2008) 4276-4281
    • (2008) J Clin Oncol , vol.26 , pp. 4276-4281
    • Titulaer, M.J.1    Wirtz, P.W.2    Willems, L.N.3    van Kralingen, K.W.4    Smitt, P.A.5    Verschuuren, J.J.6
  • 20
    • 22144447808 scopus 로고    scopus 로고
    • Anti-glial nuclear antibody: marker of lung cancer-related paraneoplastic neurological syndromes
    • Graus F., Vincent A., Pozo-Rosich P., Sabater L., Saiz A., Lang B., and Dalmau J. Anti-glial nuclear antibody: marker of lung cancer-related paraneoplastic neurological syndromes. J Neuroimmunol 165 (2005) 166-171
    • (2005) J Neuroimmunol , vol.165 , pp. 166-171
    • Graus, F.1    Vincent, A.2    Pozo-Rosich, P.3    Sabater, L.4    Saiz, A.5    Lang, B.6    Dalmau, J.7
  • 21
    • 41149101950 scopus 로고    scopus 로고
    • SOX1 antibodies are markers of paraneoplastic Lambert-Eaton myasthenic syndrome
    • The presence of antibodies to SOX-1 in the sera of patients with LEMS may aid the search for an underlying carcinoma.
    • Sabater L., Titulaer M., Saiz A., Verschuuren J., Gure A.O., and Graus F. SOX1 antibodies are markers of paraneoplastic Lambert-Eaton myasthenic syndrome. Neurology 70 (2008) 924-928. The presence of antibodies to SOX-1 in the sera of patients with LEMS may aid the search for an underlying carcinoma.
    • (2008) Neurology , vol.70 , pp. 924-928
    • Sabater, L.1    Titulaer, M.2    Saiz, A.3    Verschuuren, J.4    Gure, A.O.5    Graus, F.6
  • 22
    • 54349088442 scopus 로고    scopus 로고
    • Lambert-Eaton myasthenic syndrome differential reactivity of tumor versus non-tumor patients to subunits of the voltage-gated calcium channel
    • Pellkofer H.L., Armbruster L., Krumbholz M., Titulaer M.J., Verschuuren J.J., Schumm F., and Voltz R. Lambert-Eaton myasthenic syndrome differential reactivity of tumor versus non-tumor patients to subunits of the voltage-gated calcium channel. J Neuroimmunol 204 (2008) 136-139
    • (2008) J Neuroimmunol , vol.204 , pp. 136-139
    • Pellkofer, H.L.1    Armbruster, L.2    Krumbholz, M.3    Titulaer, M.J.4    Verschuuren, J.J.5    Schumm, F.6    Voltz, R.7
  • 23
    • 0036348608 scopus 로고    scopus 로고
    • Phenotypic variants of autoimmune peripheral nerve hyperexcitability
    • Hart I.K., Maddison P., Newsom-Davis J., Vincent A., and Mills K.R. Phenotypic variants of autoimmune peripheral nerve hyperexcitability. Brain 125 (2002) 887-895
    • (2002) Brain , vol.125 , pp. 887-895
    • Hart, I.K.1    Maddison, P.2    Newsom-Davis, J.3    Vincent, A.4    Mills, K.R.5
  • 24
    • 10744229052 scopus 로고    scopus 로고
    • Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis
    • Vincent A., Buckley C., Schott J.M., Baker I., Dewar B.K., Detert N., Clover L., Parkinson A., Bien C.G., Omer S., et al. Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain 127 (2004) 701-712
    • (2004) Brain , vol.127 , pp. 701-712
    • Vincent, A.1    Buckley, C.2    Schott, J.M.3    Baker, I.4    Dewar, B.K.5    Detert, N.6    Clover, L.7    Parkinson, A.8    Bien, C.G.9    Omer, S.10
  • 25
    • 33745105091 scopus 로고    scopus 로고
    • Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations
    • Antibodies to various subtypes of the Shaker-type (Kv1) channels may be associated with different clinical phenotypes in patients with NMT, LE and Morvan's syndrome.
    • Kleopa K.A., Elman L.B., Lang B., Vincent A., and Scherer S.S. Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations. Brain 129 (2006) 1570-1584. Antibodies to various subtypes of the Shaker-type (Kv1) channels may be associated with different clinical phenotypes in patients with NMT, LE and Morvan's syndrome.
    • (2006) Brain , vol.129 , pp. 1570-1584
    • Kleopa, K.A.1    Elman, L.B.2    Lang, B.3    Vincent, A.4    Scherer, S.S.5
  • 27
    • 22144499664 scopus 로고    scopus 로고
    • The immunobiology of Guillain-Barré syndromes
    • Willison H.J. The immunobiology of Guillain-Barré syndromes. J Peripher Nerv Syst 10 (2005) 94-112
    • (2005) J Peripher Nerv Syst , vol.10 , pp. 94-112
    • Willison, H.J.1
  • 28
    • 40749124758 scopus 로고    scopus 로고
    • Antibodies against gangliosides and ganglioside complexes in Guillain-Barré syndrome: new aspects of research
    • The presence of antibodies to conformational epitopes formed by two gangliosides (ganglioside complexes) is predictive of the clinical phenotype in patients with GBS.
    • Kusunoki S., Kaida K., and Ueda M. Antibodies against gangliosides and ganglioside complexes in Guillain-Barré syndrome: new aspects of research. BBA 1780 (2008) 41-44. The presence of antibodies to conformational epitopes formed by two gangliosides (ganglioside complexes) is predictive of the clinical phenotype in patients with GBS.
    • (2008) BBA , vol.1780 , pp. 41-44
    • Kusunoki, S.1    Kaida, K.2    Ueda, M.3
  • 31
    • 53149147772 scopus 로고    scopus 로고
    • Ganglioside complexes containing GQ1b as targets in Miller Fisher and Guillain-Barré syndromes
    • Kanzaki M., Kaida K., Ueda M., Morita D., Hirakawa M., Motoyoshi K., Kamakura K., and Kusunoki S. Ganglioside complexes containing GQ1b as targets in Miller Fisher and Guillain-Barré syndromes. JNNP 79 (2008) 1148-1152
    • (2008) JNNP , vol.79 , pp. 1148-1152
    • Kanzaki, M.1    Kaida, K.2    Ueda, M.3    Morita, D.4    Hirakawa, M.5    Motoyoshi, K.6    Kamakura, K.7    Kusunoki, S.8
  • 32
    • 39849096550 scopus 로고    scopus 로고
    • Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barré syndrome
    • Jacobs B.C., Koga M., van Rijs W., Geleijns K., van Doorn P.A., Willison H.J., and Yuki N. Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barré syndrome. J Neuroimmunol 194 (2008) 181-190
    • (2008) J Neuroimmunol , vol.194 , pp. 181-190
    • Jacobs, B.C.1    Koga, M.2    van Rijs, W.3    Geleijns, K.4    van Doorn, P.A.5    Willison, H.J.6    Yuki, N.7
  • 33
    • 33746534220 scopus 로고    scopus 로고
    • Guidelines for the treatment of autoimmune neuromuscular transmission disorders
    • Consensus guidelines for the treatment of autoimmune disorders of the peripheral nervous system.
    • Skeie G.O., Apostolski S., Evoli A., Gilhus N.E., Hart I.K., Harms L., Hilton-Jones D., Melms A., Verschuuren J., and Horge H.W. Guidelines for the treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol 13 (2006) 691-699. Consensus guidelines for the treatment of autoimmune disorders of the peripheral nervous system.
    • (2006) Eur J Neurol , vol.13 , pp. 691-699
    • Skeie, G.O.1    Apostolski, S.2    Evoli, A.3    Gilhus, N.E.4    Hart, I.K.5    Harms, L.6    Hilton-Jones, D.7    Melms, A.8    Verschuuren, J.9    Horge, H.W.10
  • 34
    • 54049122104 scopus 로고    scopus 로고
    • B cells as therapeutic targets in autoimmune neurological disorders
    • Dalakas M.C. B cells as therapeutic targets in autoimmune neurological disorders. Nat Clin Pract Neurol 4 (2008) 557-567
    • (2008) Nat Clin Pract Neurol , vol.4 , pp. 557-567
    • Dalakas, M.C.1
  • 37
    • 40049103666 scopus 로고    scopus 로고
    • Anti-C5 antibody treatment ameliorates weakness in experimentally acquired myasthenia gravis
    • Clinical weakness can be alleviated in a rat model of experimental autoimmune MG by pre-treatment with antibodies to complement component C5. The experiment raises the possibility of targeting complement activation in the treatment of MG.
    • Zhou Y., Gong B., Lin F., Rother R.P., Medof M.E., and Kaminski H.J. Anti-C5 antibody treatment ameliorates weakness in experimentally acquired myasthenia gravis. J Immunol 179 (2007) 8562-8567. Clinical weakness can be alleviated in a rat model of experimental autoimmune MG by pre-treatment with antibodies to complement component C5. The experiment raises the possibility of targeting complement activation in the treatment of MG.
    • (2007) J Immunol , vol.179 , pp. 8562-8567
    • Zhou, Y.1    Gong, B.2    Lin, F.3    Rother, R.P.4    Medof, M.E.5    Kaminski, H.J.6
  • 38
    • 34548694517 scopus 로고    scopus 로고
    • Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange
    • IgG4 is an anti-inflammatory subclass of IgG that has the ability to exchange Fab arms; after such an exchange it can become functionally monovalent. Using a passive transfer monkey model of MG, the authors demonstrated that IgG4 protects the animal from experimental autoimmune MG and hence IgG4 may be useful in immunomodulatory therapy.
    • van der Neut Kolfschoten M., Schuurman J., Losen M., Bleeker W.K., Martínez-Martínez P., Vermeulen E., den Bleker T.H., Wiegman L., Vink T., Aarden L.A., et al. Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science 317 (2007) 1554-1557. IgG4 is an anti-inflammatory subclass of IgG that has the ability to exchange Fab arms; after such an exchange it can become functionally monovalent. Using a passive transfer monkey model of MG, the authors demonstrated that IgG4 protects the animal from experimental autoimmune MG and hence IgG4 may be useful in immunomodulatory therapy.
    • (2007) Science , vol.317 , pp. 1554-1557
    • van der Neut Kolfschoten, M.1    Schuurman, J.2    Losen, M.3    Bleeker, W.K.4    Martínez-Martínez, P.5    Vermeulen, E.6    den Bleker, T.H.7    Wiegman, L.8    Vink, T.9    Aarden, L.A.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.