Ganglioside complexes containing GQ1b as targets in Miller Fisher and Guillain-Barré syndromes

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 79, Issue 10, 2008, Pages 1148-1152

  Kanzaki, M ^a   Kaida, K ^a   Ueda, M ^b   Morita, D ^b   Hirakawa, M ^b   Motoyoshi, K ^a   Kamakura, K ^a   Kusunoki, S ^b  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIGEN; EPITOPE; GANGLIOSIDE; GANGLIOSIDE GM1 ANTIBODY; GD1A ANTIBODY; GQ1B ANTIBODY; GT1A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; SIALIC ACID; UNCLASSIFIED DRUG;

ADULT; ANTIBODY BLOOD LEVEL; ANTIGEN ANTIBODY REACTION; ARTICLE; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GUILLAIN BARRE SYNDROME; HUMAN; MAJOR CLINICAL STUDY; MALE; OPHTHALMOPLEGIA; PRIORITY JOURNAL; SENSORY DYSFUNCTION;

ADULT; ANTIBODIES; ANTIBODY SPECIFICITY; FEMALE; GANGLIOSIDES; GUILLAIN-BARRE SYNDROME; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; MILLER FISHER SYNDROME; OPHTHALMOPLEGIA;

EID: 53149147772     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2007.142950     Document Type: Article

References (22)

1. Fisher M. An unusual variant of acute idiopathic polyneuntis (syndrome of ophthalmoplegia, ataxia and areflexia). N Engl J Med 1956;255:57-65.
2. Chiba A, Kusunoki S, Shimizu T, et al. Serum IgG antibody to ganglioside GQ1b is a possible marker of Miller Fisher syndrome. Ann Neurol 1992;31:677-9.
3. Chiba A, Kusunoki S, Obata H, et al. Serum anti-GQ1b IgG antibody is associated with ophthalmoplegia in Miller Fisher syndrome and Guillain-Barré syndrome: clinical and immunohistochemical studies. Neurology 1993;43:1911-7.
4. Odaka M, Yuki N. Yamada M, et al. Bickerstaff's brainstem encephalitis: clinical features of 62 cases and a subgroup associated with Guillain-Barré syndrome. Brain 2003;126:2279-90.
5. Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000;1:31-9.
6. Hakomori S. The glycosynapse. Proc NatS Acad Sci USA 2002;99:225-32.
7. Simons K, Ehehalt R. Cholesterol, lipid rafts, and disease. J Clin Invest 2002;110:597-603.
8. Simons K. Ikonen E. Functional rafts in cell membranes. Nature 1997;317:569-72.
9. Kaida K, Morita D, Kanzaki M, et al. Ganglioside complexes: as new target antigens in Guillain-Barré syndrome. Ann Neurol 2004;56:567-71.
10. Kaida K, Kanzaki M, Morita D, et al. Anti-ganglioside complex antibodies in Miller Fisher syndrome. J Neurol Neurosurg Psychiatry 2006;77:1043-6.
11. Asbury AK, Cornblath DR. Assessment of current diagnostic criteria for Guillain-Barré syndrome. Ann Neurol 1990;27(Suppl): S21-S24.
12. Kusunoki S, Chiba A, Kon K. et al. N-acetylgalactosaminyl G01a is a target molecule for serum antibody in Guillain-Barré syndrome. Ann Neurol 1994;35:570-6
13. Hughes RA, Newsom-Davis JM. et al. Controlled trial of prednisolone in acute polyneuropathy. Lancet 1978;2:750-3.
14. Kusunoki S, Chiba A, Kanazawa I. Anti-GQIb IgG antibody is associated with ataxia as well as ophthalmoplegia. Muscle Nerve 1999;22:1071-4.
15. Mori M, Kuwabara S, Fukutake T, et al. Clinical features and prognosis of Miller Fisher syndrome. Neurology 2001;56:1104-6.
16. Kuwabara S, Asahina M, Nakajima M, et al. Special sensory ataxia in Miller Fisher syndrome detected by postural body sway analysis. Ann Neurol 1999;45:533-6.
17. Ropper AH, Shahani B. Proposed mechanism of ataxia in Fisher's syndrome. Arch Neurol 1983;40:537-8.
18. Matsuo M, Odaka M, Koga M, et al. Bickerstaff's brainstem encephalitis associated with IgM antibodies to GM1b and GalNAc-GD1a. J Neurol Sci 2004;217:225-8.
19. Kaida K. Morita D, Kanzaki M, et al. Anti-ganglioside complex antibodies associated with severe disability in GBS. J Neuroimmunol 2007;112:212-8.
20. Franch Cooporative Group on Plasma Exchange in Guillain-Barré syndrome. Efficiency of plasma exchange in Guillain-Barré syndrome: role of replacement fluids. Ann Neurol 1987;22:753-61.
21. The Guillain-Barré syndrome Study Group. Plasmapheresis and acute Guillain-Barre syndrome. Neurology 1985;35:1096-104.
22. Willson HJ, Townson K, Veitch J, et al. Synthetic disialvlgalactose immunoadsorbents deplete anti-GQ1b antibodies from autoimmune neuropathy sera. Brain 2004;127:680-91.