Expedited SAR study of an mGluR5 antagonists: Generation of a focused library using a solution-phase Suzuki coupling methodology

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 22, 2004, Pages 5485-5488

  Eastman, Brian ^a   Chen, Chixu ^a   Smith, Nicholas D ^a   Poon, Steven ^a   Chung, Janice ^a   Reyes Manalo, Grace ^a   Cosford, Nicholas D P ^a   Munoz, Benito ^a  

^a GENERAL ATOMICS   (United States)

Author keywords

Antagonist; Library; Metabotropic glutamate; Suzuki coupling; Tetrazole

Indexed keywords

2 (2 BIPHENYL 3 YL 2H TETRAZOL 5 YL)PYRIDINE; 2 [2 (5 FLUOROBIPHENYL 3 YL) 2H TETRAZOL 5 YL]PYRIDINE; BENZENE DERIVATIVE; DIMETHYLISOXAZOLE; HETEROCYCLIC COMPOUND; ISOXAZOLE DERIVATIVE; METABOTROPIC RECEPTOR ANTAGONIST; RESIN; UNCLASSIFIED DRUG;

ARTICLE; CATION EXCHANGE; DRUG POTENCY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SUZUKI REACTION;

COMBINATORIAL CHEMISTRY TECHNIQUES; ISOXAZOLES; MOLECULAR STRUCTURE; RECEPTORS, METABOTROPIC GLUTAMATE; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

LATEOLABRAX JAPONICUS;

EID: 5144232199     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.09.016     Document Type: Article

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