Amphotericin B-induced renal tubular cell injury is mediated by Na+ influx through ion-permeable pores and subsequent activation of mitogen-activated protein kinases and elevation of intracellular Ca2+ concentration

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 4, 2009, Pages 1420-1426

  Takahisatyano, Yano ^a   Yoshinori, Itoh ^b   Eiko, Kawamura ^a   Asuka, Maeda ^a   Nobuaki, Egashira ^a   Motohiro, Nishida ^c   Hitoshi, Kurose ^c   Ryozo, Oishi ^a  

^a KYUSHU UNIVERSITY HOSPITAL   (Japan)

^b GIFU UNIVERSITY HOSPITAL   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; ADENOSINE TRIPHOSPHATE; AMPHOTERICIN B; CALCIUM; CHOLESTEROL; DANTROLENE; DNA NUCLEOTIDYLEXOTRANSFERASE; LACTATE DEHYDROGENASE; METHYL BETA CYCLODEXTRIN; MITOGEN ACTIVATED PROTEIN KINASE; PROPIDIUM IODIDE; RYANODINE RECEPTOR; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL DAMAGE; CELL LINE; CELL MEMBRANE; CHELATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; EXTRACELLULAR FLUID; ION PERMEABILITY; KIDNEY TUBULE CELL; MITOCHONDRION; NEPHROTOXICITY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SODIUM TRANSPORT; SWINE;

ADENOSINE TRIPHOSPHATE; AMPHOTERICIN B; ANIMALS; ANTIFUNGAL AGENTS; CALCIUM; CHOLESTEROL; ENDOPLASMIC RETICULUM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; KIDNEY TUBULES; LLC-PK1 CELLS; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; SODIUM; SWINE;

EID: 65649140517     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01137-08     Document Type: Article

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