Structural basis of glyphosate resistance resulting from the double mutation Thr97 → Ile and Pro101 → Ser in 5-enolpyruvylshikimate-3-phosphate synthase from Escherichia coli

Journal of Biological Chemistry

Volumn 284, Issue 15, 2009, Pages 9854-9860

  Funke, Todd ^a   Yang, Yan ^b   Han, Huijong ^b   Healy Fried, Martha ^a   Olesen, Sanne ^b   Becker, Andreas ^b   Schönbrunn, Ernst ^a,b  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROAD-SPECTRUM HERBICIDE GLYPHOSATE; CLASS I; CLASS II; CONFORMATIONAL CHANGE; DOUBLE MUTATION; E. COLI; GLYPHOSATE; GLYPHOSATE-RESISTANT; GRAM-POSITIVE BACTERIUM; HIGH AFFINITY; MOLECULAR BASIS; PHOSPHOENOLPYRUVATE; POINT MUTATIONS; SHIKIMATE PATHWAY; SIDE CHAINS; SINGLE SITES; STRUCTURAL BASIS; STRUCTURAL EFFECT; SUBSTRATE-BINDING SITES; SYNTHASE; TRANSGENIC SOYBEAN; ZEA MAYS;

BACTERIA; BINDING ENERGY; BINDING SITES; CATALYSTS; CRYSTAL STRUCTURE; ENZYMES; ESCHERICHIA COLI; GENETIC ENGINEERING; PLANTS (BOTANY);

HERBICIDES;

3 PHOSPHOSHIKIMATE 1 CARBOXYVINYLTRANSFERASE; GLYCINE; GLYPHOSATE; HERBICIDE; ISOLEUCINE; PROLINE; SERINE; SHIKIMIC ACID; THREONINE; DRUG DERIVATIVE; ENZYME INHIBITOR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CORN; COTTON; CROP PRODUCTION; CRYSTAL STRUCTURE; ENZYME ISOLATION; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; GENE MUTATION; GENETIC ENGINEERING; GRAM POSITIVE BACTERIUM; HERBICIDE RESISTANCE; MAIZE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAPESEED; SOYBEAN; TRANSGENIC PLANT; ANTIBIOTIC RESISTANCE; CHEMICAL MODEL; CHEMISTRY; CONFORMATION; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; METHODOLOGY; MUTATION; X RAY CRYSTALLOGRAPHY;

BRASSICA NAPUS VAR. NAPUS; ESCHERICHIA COLI; GLYCINE MAX; GOSSYPIUM HIRSUTUM; POSIBACTERIA; ZEA MAYS;

3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; ESCHERICHIA COLI; GLYCINE; ISOLEUCINE; KINETICS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MUTATION; PROLINE; SERINE; THREONINE;

EID: 65649140477     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809771200     Document Type: Article

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