The importance of transmethylation reactions to methionine metabolism in sheep: Effects of supplementation with creatine and choline

British Journal of Nutrition

Volumn 75, Issue 1, 1996, Pages 47-56

  Lobley, G E ^a   Connell, A ^a   Revell, D ^a,b  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Methionine; Methylation; Stable isotopes; Wool growth

Indexed keywords

CHOLINE; CREATINE; HOMOCYSTEINE; METHIONINE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ISOTOPE LABELING; JEJUNUM; KIDNEY; LIVER; METHYLATION; NONHUMAN; RECYCLING; RUMINANT STOMACH; SHEEP; VENOUS BLOOD; VISCERA; WOOL;

ANIMALS; CHOLINE; CREATINE; HOMOCYSTEINE; METHIONINE; METHYLATION; SHEEP; WOOL;

ALGAE; ANIMALIA; OVIS ARIES;

EID: 0030046153     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN19960109     Document Type: Article

References (22)

1. Aurousseau, B., Connell, A., Revell, D. K., Rocha, H. J. G. & Lobley, G E. (1993). Hind-limb protein metabolism in growing sheep: effects of acute and chronic infusion of clenbuterol by close arterial and systemic routes. Comparative Biochemistry and Physiology 106C, 529-535.
2. Bardocz, S., Grant, G., Brown, D. S. & Pusztai, A. (1989). Stimulation of polyamine synthesis and growth of the small intestine by dietary kidney bean lectin. In Recent Advances of Research in Antinutritional Factors in Legume Seeds, pp. 39-42 [J. Huisman, T. F. B. van der Poet and J. E. Liener, editors]. Wageningen: Pudoc.
3. Benevenga, N. J., Radcliffe, B. C. & Egan, A. R. (1983). Tissue metabolism of methionine in sheep. Australian Journal of Biological Sciences 36, 475-485.
4. Boss, G. R. (1985). Cobalamin inactivation decreases purine and methionine synthesis in cultured lymphoblasts. Journal of Clinical Investigation 76, 213-218.
5. Calder, A. G. & Smith, A. (1988). Stable isotope ratio analysis of leucine and ketoisocaproic acid in blood plasma by gas chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry 2, 14-16.
6. Campbell, I. M. (1974). Incorporation and dilution values-their calculation in mass spectrally assayed stable isotope labelling experiments. Bioorganic Chemistry 3, 386-397.
7. Dawson, R. M. C., Grime, D. W. & Lindsay, D. B. (1981). On the insensitivity of sheep to the almost complete microbial destruction of dietary choline before alimentary tract absorption. Biochemical Journal 196, 499-504.
8. Emmanuel, B. & Kennelly, J. J. (1984). Kinetics of methionine and choline and their incorporation into plasma lipids and milk components in lactating goats. Journal of Dairy Science 67, 1912-1918.
9. Ferger, M. F. & Vigneaud, V. (1950). Oxidation in vivo of the methyl groups of choline, betaine, dimethylthetm and dimethyl-β-propiothetin. Journal of Biological Chemistry 185, 53-57.
10. Finkelstein, J D & Martin, J. J. (1984). Methionine metabolism in mammals. Distribution of homocysteine between competing pathways. Journal of Biological Chemistry 259, 9508-9513.
11. Genstat 5 (1987). Genstat 5 Reference Manual. Rothamsted Experimental Station. Oxford: Clarendon Press.
12. Gill, M. & Ulyatt, M. J. (1979). The metabolism of methionine in silage-fed sheep. British Journal of Nutrition 41, 605-609.
13. Henderson, G. D., Xue, G.-P. & Snoswell, A. M. (1983). Carnitine and creatine content of tissues of normal and alloxan-diabetic sheep and rats. Comparative Biochemistry and Physiology 76B, 295-298.
14. 13C] amino acid mixture in response to choline plus creatine supplementation. British Journal of Nutrition (In the Press).
15. Mudd, S. H. & Pool, J. R. (1975). Labile methyl balances for normal humans on various dietary regimens. Metabolism 24, 721-735.
16. Neill, A. R., Grime, D. W., Snoswell, A. M., Northrop, A. J., Lindsay, D. B. & Dawson, R. M. C. (1979). The low availability of dietary choline for the nutrition of the sheep. Biochemical Journal 180, 559-565.
17. Pisulewski, P. M. & Buttery, P. J. (1985). The effect of increasing methionine supply on the methionine conversion to cyst(e)ine in sheep. British Journal of Nutrition 54, 121-129.
18. Sharma, B. K & Erdman, R. A. (1988). Abomasal infusion of choline and methionine with or without 2-amino-2-methyl-L-propanol for lactating dairy cows. Journal of Dairy Science 71, 2406-2411.
19. 13C]methionine. American Journal of Physiology 255, E322-331.
20. Walker, J. B. (1960). Metabolic control of creatine biosynthesis. 1. Effect of dietary creatine. Journal of Biological Chemistry 235, 2357-2361.
21. Xue, G.-P. & Snoswell, A. M. (1985). Comparative studies on the methionine synthesis in sheep and rat tissues. Comparative Biochemistry and Physiology 80B, 489-494.
22. Xue, G.-P. & Snoswell, A. M. (1986). Developmental changes in the activities of enzymes related to methyl group metabolism in sheep tissues. Comparative Biochemistry and Physiology 83B, 115-120.