Particles induce apical plasma membrane enlargement in epithelial lung cell line depending on particle surface area dose

Respiratory Research

Volumn 10, Issue , 2009, Pages

  Brandenberger, Christina ^a   Rothen Rutishauser, Barbara ^a   Blank, Fabian ^a,b   Gehr, Peter ^a   Mühlfeld, Christian ^a,c  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

POLYSTYRENE; IL8 PROTEIN, HUMAN; INTERLEUKIN 8; LACTATE DEHYDROGENASE; POLYSTYRENE DERIVATIVE;

ARTICLE; CELL COUNT; CELL INTERACTION; CELL LINE; CELL MEMBRANE; CELL SURFACE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; EPITHELIUM CELL; FLUORESCENCE; HUMAN; HUMAN CELL; INCUBATION TEMPERATURE; LUNG ALVEOLUS EPITHELIUM; PARTICLE SIZE; QUANTITATIVE ANALYSIS; STEREOLOGY; TRANSMISSION ELECTRON MICROSCOPY; ALGORITHM; APOPTOSIS; CHEMISTRY; CONFOCAL MICROSCOPY; DOSE RESPONSE; DRUG EFFECT; ENDOCYTOSIS; GENETIC TRANSCRIPTION; GENETICS; LIPOGENESIS; LUNG; METABOLISM; NECROSIS; PARTICULATE MATTER; SIGNAL PROCESSING; TIME; TUMOR CELL LINE; ULTRASTRUCTURE;

ALGORITHMS; APOPTOSIS; CELL LINE, TUMOR; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCYTOSIS; EPITHELIAL CELLS; HUMANS; INTERLEUKIN-8; L-LACTATE DEHYDROGENASE; LIPOGENESIS; LUNG; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; NECROSIS; PARTICLE SIZE; PARTICULATE MATTER; POLYSTYRENES; SIGNAL PROCESSING, COMPUTER-ASSISTED; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 65649132770     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-10-22     Document Type: Article

References (50)

1. Mühlfeld C, Rothen-Rutishauser B, Blank F, Vanhecke D, Ochs M, Gehr P. Interactions of nanoparticles with pulmonary structures and cellular responses. Am J Physiol Lung Cell Mol Physiol 2008, 294:L817-L829. 10.1152/ajplung.00442.2007, 18263666.
2. Kreyling WG, Semmler-Behnke M, Moller W. Ultrafine particle-lung interactions: does size matter?. J Aerosol Med 2006, 19:74-83. 10.1089/jam.2006.19.74, 16551218.
3. Gehr P, Blank F, Rothen-Rutishauser BM. Fate of inhaled particles after interaction with the lung surface. Paediatr Respir Rev 2006, 7(Suppl 1):S73-S75. 10.1016/j.prrv.2006.04.169, 16798602.
4. Donaldson K, Tran L, Jimenez LA, Duffin R, Newby DE, Mills N, MacNee W, Stone V. Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure. Part Fibre Toxicol 2005, 2:10. 1280930, 16242040, 10.1186/1743-8977-2-10.
5. Pope CA. Air pollution and health - good news and bad. N Engl J Med 2004, 351:1132-1134. 10.1056/NEJMe048182, 15356311.
6. Schulz H, Harder V, Ibald-Mulli A, Khandoga A, Koenig W, Krombach F, Radykewicz R, Stampfl A, Thorand B, Peters A. Cardiovascular effects of fine and ultrafine particles. J Aerosol Med 2005, 18:1-22. 10.1089/jam.2005.18.1, 15741770.
7. Peters A, Pope CA. Cardiopulmonary mortality and air pollution. Lancet 2002, 360:1184-1185. 10.1016/S0140-6736(02)11289-X, 12401239.
8. Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 2003, 111:455-460. 1241427, 12676598.
9. Rhoden CR, Wellenius GA, Ghelfi E, Lawrence J, Gonzalez-Flecha B. PM-induced cardiac oxidative stress and dysfunction are mediated by autonomic stimulation. Biochim Biophys Acta 2005, 1725:305-313.
10. Murphy G, Rouse RL, Polk WW, Henk WG, Barker SA, Boudreaux MJ, Floyd ZE, Penn AL. Combustion-derived hydrocarbons localize to lipid droplets in respiratory cells. Am J Respir Cell Mol Biol 2008, 38:532-540. 10.1165/rcmb.2007-0204OC, 18079490.
11. Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 2005, 113:823-839. 1257642, 16002369.
12. Schuerch S, Gehr P, Im HV, Geiser M, Green F. Surfactant displaces particles toward the epithelium in airways and alveoli. Respir Physiol 1990, 80:17-32. 10.1016/0034-5687(90)90003-H, 2367749.
13. Gehr P, Schuerch S, Berthiaume Y, Im Hof V, Geiser M. Particle retention in airways by surfactant. J Aerosol Med 1990, 3:27-43.
14. Erpenbeck VJ, Malherbe DC, Sommer S, Schmiedl A, Steinhilber W, Ghio AJ, Krug N, Wright JR, Hohlfeld JM. Surfactant protein D increases phagocytosis and aggregation of pollen-allergen starch granules. Am J Physiol Lung Cell Mol Physiol 2005, 288:L692-L698. 10.1152/ajplung.00362.2004, 15591410.
15. Kendall M, Guntern J, Lockyer NP, Jones FH, Hutton BM, Lippmann M, Tetley TA. Urban PM2.5 surface chemistry and interactions with bronchoalveolar lavage fluid. Inhal Toxicol 2004, 16:115-129. 10.1080/08958370490443204, 15204800.
16. Geiser M, Casaulta M, Kupferschmid B, Schulz H, Semmler-Behnke M, Kreyling W. The role of macrophages in the clearance of inhaled ultrafine titanium dioxide particles. Am J Respir Cell Mol Biol 2008, 38:371-376. 10.1165/rcmb.2007-0138OC, 17947511.
17. Geiser M. Morphological aspects of particle uptake by lung phagocytes. Microsc Res Tech 2002, 57:512-522. 10.1002/jemt.10105, 12112434.
18. Yacobi NR, Demaio L, Xie J, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Polystyrene nanoparticle trafficking across alveolar epithelium. Nanomedicine 2008, 4:139-145.
19. Mühlfeld C, Gehr P, Rothen-Rutishauser B. Translocation and cellular entering mechanisms of nanoparticles in the respiratory tract. Swiss Med Wkly 2008, 138:387-391.
20. Rothen-Rutishauser B, Mühlfeld C, Blank F, Musso C, Gehr P. Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model. Part Fibre Toxicol 2007, 4:9. 2039730, 17894871, 10.1186/1743-8977-4-9.
21. Unfried K, Albrecht C, Klotz L-O, Von Mikecz A, Grether-Beck S, Schins RPF. Cellular response to nanoparticles: Target structures and mechanisms. Nanotoxicology 2007, 1:57-71.
22. Kim JS, Yoon TJ, Yu KN, Noh MS, Woo M, Kim BG, Lee KH, Sohn BH, Park SB, Lee JK, et al. Cellular uptake of magnetic nanoparticle is mediated through energy-dependent endocytosis in A549 cells. J Vet Sci 2006, 7:321-326.
23. Stearns RC, Paulauskis JD, Godleski JJ. Endocytosis of ultrafine particles by A549 cells. Am J Respir Cell Mol Biol 2001, 24:108-115.
24. Vlahakis NE, Schroeder MA, Pagano RE, Hubmayr RD. Deformation-induced lipid trafficking in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2001, 280:L938-L946.
25. Vlahakis NE, Schroeder MA, Pagano RE, Hubmayr RD. Role of deformation-induced lipid trafficking in the prevention of plasma membrane stress failure. Am J Respir Crit Care Med 2002, 166:1282-1289. 10.1164/rccm.200203-207OC, 12403699.
26. van Niel G, Porto-Carreiro I, Simoes S, Raposo G. Exosomes: a common pathway for a specialized function. J Biochem 2006, 140:13-21. 10.1093/jb/mvj128, 16877764.
27. Schorey JS, Bhatnagar S. Exosome function: From tumor immunology to pathogen biology. Traffic 2008, 9:871-881. 10.1111/j.1600-0854.2008.00734.x, 18331451.
28. Borgonovo B, Cocucci E, Racchetti G, Podini P, Bachi A, Meldolesi J. Regulated exocytosis: a novel, widely expressed system. Nat Cell Biol 2002, 4:955-962. 10.1038/ncb888, 12447386.
29. Blank F, Rothen-Rutishauser BM, Schuerch S, Gehr P. An optimized in vitro model of the respiratory tract wall to study particle cell interactions. J Aerosol Med 2006, 19:392-405. 10.1089/jam.2006.19.392, 17034314.
30. Geiser M, Rothen-Rutishauser B, Kapp N, Schuerch S, Kreyling W, Schulz H, Semmler M, Im HV, Heyder J, Gehr P. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 2005, 113:1555-1560. 1310918, 16263511.
31. Chithrani BD, Chan WCW. Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Letters 2007, 7:1542-1550. 10.1021/nl070363y, 17465586.
32. Lieber M, Smith B, Szakal A, Nelsonrees W, Todaro G. Continuous tumor-cell line from a human lung carcinoma with properties of type-II alveolar epithelial cells. Int J Cancer 1976, 17:62-70. 10.1002/ijc.2910170110, 175022.
33. Mühlfeld C, Rothen-Rutishauser B, Vanhecke D, Blank F, Gehr P, Ochs M. Visualization and quantitative analysis of nanoparticles in the respiratory tract by transmission electron microscopy. Part Fibre Toxicol 2007, 4:11. 2211502, 17996124, 10.1186/1743-8977-4-11.
34. Baddeley AJ, Gundersen HJG, Cruz-Orive LM. Estimation of surface-area from vertical sections. J Microsc 1986, 142:259-276.
35. Mühlfeld C, Liakopoulos OJ, Schaefer IM, Schondube FA, Richter J, Dorge H. Methylprednisolone fails to preserve pulmonary surfactant and blood-air barrier integrity in a porcine cardiopulmonary bypass model. J Surg Res 2008, 146:57-65. 10.1016/j.jss.2007.03.026, 17583746.
36. Sterio DC. The unbiased estimation of number and sizes of arbitrary particles using the dissector. J Microsc 1984, 134:127-136.
37. Jensen EBV, Gundersen HJG. The rotator. J Microsc 1993, 170:282.
38. Mayhew TM. Taking tissue samples from the placenta: An illustration of principles and strategies. Placenta 2008, 29:1-14. 10.1016/j.placenta.2007.05.010, 17658596.
39. Weibel ER, Hsia CC, Ochs M. How much is there really? Why stereology is essential in lung morphometry. J Appl Physiol 2007, 102:459-467. 10.1152/japplphysiol.00808.2006, 16973815.
40. Rothen-Rutishauser BM, Schurch S, Haenni B, Kapp N, Gehr P. Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques. Environ Sci Technol 2006, 40:4353-4359. 10.1021/es0522635, 16903270.
41. Castoreno AB, Wang Y, Stockinger W, Jarzylo LA, Du H, Pagano JC, Shieh EC, Nothturfft A. Transcriptional regulation of phagocytosis-induced membrane biogenesis by sterol regulatory element binding protein. PNAS 2005, 102:13129-13134. 1201629, 16141315, 10.1073/pnas.0506716102.
42. Rothen-Rutishauser B, Blank F, Mühlfeld C, Gehr P. In vitro models of the human epithelial airway barrier to study the toxic potential of particulate matter. Expert Opin Drug Metab Toxicol 2008, 4:1075-1089. 10.1517/17425255.4.8.1075, 18680442.
43. Barar J, Campbell L, Hollins AJ, Thomas NPB, Smith MW, Morris CJ, Gumbleton M. Cell selective glucocorticoid induction of caveolin-1 and caveolae in differentiating pulmonary alveolar epithelial cell cultures. Biochem Biophys Res Commun 2007, 359:360-366. 10.1016/j.bbrc.2007.05.106, 17537407.
44. Rao DS, Chang JC, Kumar PD, Mizukami I, Smithson GM, Bradley SV, Parlow BAF, Ross TS. Huntingtin interacting protein 1 is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors. Mol Cell Biol 2001, 21:7796-7806. 99949, 11604514, 10.1128/MCB.21.22.7796-7806.2001.
45. Limbach LK, Li Y, Grass RN, Brunner TJ, Hintermann MA, Muller M, Gunther D, Stark WJ. Oxide nanoparticle uptake in human lung fibroblasts: effects of particle size, agglomeration, and diffusion at low concentrations. Environ Sci Technol 2005, 39:9370-9376. 10.1021/es051043o, 16382966.
46. Morris CE, Homann U. Cell surface area regulation and membrane tension. J Membr Biol 2001, 179:79-102.
47. Holevinsky KO, Nelson DJ. Membrane capacitance changes associated with particle uptake during phagocytosis in macrophages. Biophys J 1998, 75:2577-2586. 1299933, 9788954, 10.1016/S0006-3495(98)77703-3.
48. Aderem A. How to eat something bigger than your head. Cell 2002, 110:5-8. 10.1016/S0092-8674(02)00819-X, 12150991.
49. Stoeger T, Schmid O, Takenaka S, Schulz H. Inflammatory response to TiO2 and Carbonaceous particles scales best with BET surface area. Environ Health Perspect 2007, 115:A290-A291. 1892122, 17589572.
50. Stoeger T, Reinhard C, Takenaka S, Schroeppel A, Karg E, Ritter B, Heyder J, Schulz H. Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice. Environ Health Perspect 2006, 114:328-333. 1392224, 16507453.