Effects of Bezafibrate and Simvastatin on Endothelial Activation and Lipid Peroxidation in Hypercholesterolemia: Evidence of Different Vascular Protection by Different Lipid-Lowering Treatments

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 11, 2003, Pages 5341-5347

  Desideri, Giovambattista ^a   Croce, Giuseppe ^a   Tucci, Marzia ^a   Passacquale, Gabriella ^a   Broccoletti, Simona ^a   Valeri, Letizia ^a   Santucci, Anna ^a   Ferri, Claudio ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

8 ISOPROSTAGLANDIN E2; ALPHA TOCOPHEROL; ANTILIPEMIC AGENT; BEZAFIBRATE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; LIPID; SIMVASTATIN; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; CARDIOVASCULAR SYSTEM; CELL ACTIVATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG EFFICACY; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTECTION; TREATMENT OUTCOME; VITAMIN SUPPLEMENTATION;

ADULT; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; BENZIMIDAZOLES; DINOPROST; E-SELECTIN; ENDOTHELIUM, VASCULAR; F2-ISOPROSTANES; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; INTERCELLULAR ADHESION MOLECULE-1; LIPID PEROXIDATION; MALE; MIDDLE AGED; SIMVASTATIN; SOLUBILITY; VASCULAR CELL ADHESION MOLECULE-1; VITAMIN E;

EID: 0345305421     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030724     Document Type: Article

References (36)

1. Springer TA 1994 Traffic signals for lymphocyte recirculation and leucocyte emigration: the multistep paradigm. Cell 76:301-304
2. Ross R 1999 Atherosclerosis: an inflammatory disease. N Engl J Med 340: 115-126
3. De Caterina R 1997 The regulation of expression of endothelial leucocyte adhesion molecules as a regulatory step in atherosclerosis and inflammation. Int Med 5:71-82
4. Resnick N, Gimbrone Jr MA 1995 Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J 9:874-882
5. Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T 1997 Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB J 9:899-909
6. Kume N, Cybulsky MI, Gimbrone Jr MA 1992 Lysophosphatidylcholine, a component of atherogenic lipoproteins induces mononuclear leucocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest 90:1138-1144
7. Cominacini L, Garbin U, Pasini AF, Davoli A, Campagnola M, Contessi GB, Pastorino AM, Lo Cascio V 1997 Antioxidants inhibit the expression of intercellular adhesion molecule-1 and vascular adhesion molecule-1 induced by oxidized LDL on human umbilical endothelial cells. Free Radical Biol Med 22:118-127
8. Richardson M, Hadcock SJ, DeReske M, Cybulsky MI 1994 Increased expression of VCAM-1 and E-selectin by the aortic endothelium of normolipemic and hyperlipidemic diabetic rabbits. Arterioscler Thromb 14:760-769
9. Li H, Cybulsky MI, Gimbrone Jr MA, Libby P 1993 An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leucocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb 13:197-204
10. Scalia R, Appel III JZ, Lefer AM 1998 Leucocyte-endothelium interaction during the early stages of hypercholesterolemia in the rabbit: role of P-selectin, ICAM-1, and VCAM-1. Arterioscler Thromb Vasc Biol 18:1093-1100
11. Sampietro T, Tuoni M, Federghini M, Ciardi A, Marracini P, Prontera C, Sassi G, Taddei M, Bionda A 1997 Plasma cholesterol regulates soluble cell adhesion molecule expression in familial hypercholesterolemia. Circulation 96:1381-1385
12. Hackman A, Abe Y, Insull Jr W, Pownall H, Smith L, Dunn K, Gotto Jr AM, Ballantyne CM 1996 Levels of soluble cell adhesion molecules in patients with dyslipidemia. Circulation 93:1334-1338
13. Sardo MA, Castaldo M, Cinquegrani M, Bonaiuto M, Maesano A, Schepis F, Zema MC, Campo GM, Squadrito F, Saitta A 2001 Effects of simvastatin treatment on sICAM-1 and sE-selectin levels in hypercholesterolemic subjects. Atherosclerosis 155:143-147
14. Paiker JE, Raal FJ, Veller M, von Arb M, Chetty N, Naran NH 2000 Cell adhesion molecules - can they be used to predict coronary artery disease in patients with familial hypercholesterolemia? Clin Chim Acta 293:105-113
15. Blann AD, Seigneur M, Steiner M, Miller JP, McCollum CN 1998 Circulating ICAM-1 and VCAM-1 in peripheral artery disease and hypercholesterolemia: relationship to the location of atherosclerotic disease, smoking, and in the prediction of adverse events. Thromb Haemostasis 79:1080-1085
16. Desideri G, Marinucci MC, Tomassoni G, Masci PG, Santucci A, Ferri C 2002 Vitamin E supplementation reduces plasma VCAM-1 and von Willebrand factor levels and increases nitric oxide concentrations in hypercholesterolemic patients. J Clin Endocrinol Metab 87:2940-2945
17. 2α is increased in hypercholesterolemia. Arterioscler Thromb Vasc Biol 17:3230-3235
18. Patrono C, Fitzgerald GA 1997 Isoprostanes: potential markers of oxidant stress in atherothrombotic disease. Arterioscler Thromb Vasc Biol 17:2309-2315
19. De Caterina R, Cipollone F, Filardo FP, Zimarino M, Bernini W, Lazzerini G, Bucciarelli T, Falco A, Marchesani P, Muraro R, Mezzetti A, Ciabattoni G 2002 Low-density lipoprotein level reduction by the 3-hydroxy-3-methyl-glutaryl coenzyme-A inhibitor simvastatin is accompanied by a related reduction of F2-isoprostane formation in hypercholesterolemic subjects: no further effect of vitamin E. Circulation 106:2543-2549
20. Giroux LM, Davignon J, Naruszewicz M 1993 Simvastatin inhibits the oxidation of low-density lipoproteins by activated human monocyte-derived macrophages. Biochem Biophys Acta 1165:335-338
21. Koenig A, Norgard-Sumnicht K, Linhardt R, Varki A 1998 Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents. J Clin Invest 101:877-889
22. Friedewald WT, Levy RI, Fredrickson DS 1972 Estimation of concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499-502
23. Lee BL, Chua SC, Ong HY, Ong CN 1992 High-performance liquid chromatography method for routine determination of vitamins A and E and β-carotene in plasma. J Chromatogr 581:41-47
24. Jordan P, Brubacher D, Moser U, Stahelin HB, Gey KF 1995 Vitamin E and vitamin A concentrations in plasma adjusted for cholesterol and triglycerides by multiple regression. Clin Chem 41:924-927
25. Thurnham DI, Davies JA, Crump BJ, Situnayake RD, Davis M 1986 The use of different lipids to express serum tocopherol: lipid ratios for the measurements of vitamin E status. Ann Clin Biochem 23:514-520
26. Ferri C, Desideri G, Baldoncini R, Bellini C, De Angelis C, Mazzocchi C, Santucci A 1998 Early activation of the vascular endothelium in nonobese, nondiabetic essential hypertensive patients with multiple metabolic abnormalities. Diabetes 47:660-667
27. Desideri G, Croce G, Marinucci MC, Masci G, Stati M, Valeri L, Santucci A, Ferri C 2002 Prolonged, low dose α-tocopherol therapy counteracts intercellular cell adhesion molecule-1 activation. Clin Chim Acta 320:5-9
28. Wierzbicki AS, Poston R, Ferro A 2003 The lipid and non-lipid effects of statins. Pharmacol Ther 99:95-112
29. März W, Köenig W 2003 HMG-CoA reductase inhibition: anti-inflammatory effects beyond lipid lowering? J Cardiovasc Risk 10:169-179
30. Li D, Chen H, Romeo F, Sawamura T, Saldeen T, Mehta JL 2002 Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1. J Pharmacol Exp Ther 302:601-605
31. Jones P, Kafonek S, Laurora I, Hunninghake D 1998 Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study). Am J Cardiol 81:582-587
32. Patrignani P, Panara MR, Tacconelli S, Seta F, Bucciarelli T, Ciabattoni G, Alessandrini P, Mezzetti A, Santini G, Sciulli MG, Cipollone F, Davi G, Gallina P, Bon GB, Patrono C 2000 Effects of vitamin E supplementation on F2-isoprostane and thromboxane biosynthesis in healthy cigarette smokers. Circulation 102:539-545
33. Romero JC, Reckelhoff JF 1999 Role of angiotensin and oxidative stress in essential hypertension. Hypertension 34:943-949
34. 2α and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Circulation 99:224-229
35. Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, Strauss WE, Oates JA, Roberts II LJ 1995 Increase in circulating products of lipid peroxidation (F2 isoprostanes) in smokers: smoking as a cause of oxidative damage. N Engl J Med 332:1198-1203
36. Heart Protection Study Collaborative Group 2002 MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomised placebo-controlled trial. Lancet 35:89-95