The catalytic flexibility of tRNAIle-lysidine synthetase can generate alternative tRNA substrates for isoleucyl-tRNA synthetase

Journal of Biological Chemistry

Volumn 284, Issue 15, 2009, Pages 9656-9662

  Salowe, Scott P ^a   Wiltsie, Judyann ^a   Hawkins, Julio C ^a   Sonatore, Lisa M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL AMINES; ALTERNATIVE SUBSTRATES; AMINOACYLATION; ANTICODON; BACILLUS SUBTILIS; CYTIDINE; E. COLI; GEL ELECTROPHORESIS; IN-VITRO; POTENTIAL INHIBITORS; RECOMBINANT ENZYMES; STRUCTURAL REQUIREMENTS; SYNTHETASE;

AMINATION; AMINES; AMINO ACIDS; BACTERIOLOGY; ELECTROPHORESIS; ENZYMES; ESCHERICHIA COLI; GELATION; MASS SPECTROMETRY;

SUBSTRATES;

ADENOSINE TRIPHOSPHATE; ALIPHATIC AMINE; CYTIDINE DERIVATIVE; ISOLEUCINE; ISOLEUCINE TRANSFER RNA LIGASE; LYSINE; METHIONINE TRANSFER RNA LIGASE; TRANSFER RNA; ISOLEUCINE TRANSFER RNA; RECOMBINANT PROTEIN;

AMINOACYLATION; ANTICODON; ARTICLE; CODON; CONTROLLED STUDY; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; GEL ELECTROPHORESIS; GENETIC TRANSCRIPTION; IN VITRO STUDY; MASS SPECTROMETRY; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MODIFICATION; RIBOSOME; BACILLUS SUBTILIS; CATALYSIS; CHEMICAL MODEL; CHEMISTRY; ENZYME SPECIFICITY; KINETICS; METABOLISM; MUTAGENESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS;

BACILLUS SUBTILIS; ESCHERICHIA COLI;

ADENOSINE TRIPHOSPHATE; BACILLUS SUBTILIS; CATALYSIS; CODON; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; ISOLEUCINE-TRNA LIGASE; KINETICS; METHIONINE-TRNA LIGASE; MODELS, CHEMICAL; MUTAGENESIS; RECOMBINANT PROTEINS; RNA, TRANSFER; RNA, TRANSFER, ILE; SUBSTRATE SPECIFICITY;

EID: 65649116177     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809013200     Document Type: Article

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