Effect of dietary alpha-ketoglutarate on blood lipid profile during hypercholesterolaemia in rats

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 69, Issue 2, 2009, Pages 175-180

  Radzki, Radoslaw P ^a   Bieńko, Marek ^a   Pierzynowski, Stefan G ^b  

^a UNIVERSITY OF LIFE SCIENCES IN LUBLIN   (Poland)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Alpha ketoglutarate; Blood lipids; Hypercholesterolaemia; Nutrition; Rats

Indexed keywords

2 OXOGLUTARIC ACID; CHOLESTEROL; DRINKING WATER; HIGH DENSITY LIPOPROTEIN; HYDROCHLORIC ACID; LARD; LIPID; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; ALPHA-KETOGLUTARIC ACID;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROL GROUP; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL STUDY; FEMALE; FLUID INTAKE; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RISK REDUCTION; SPECTROPHOTOMETRY; TRIACYLGLYCEROL BLOOD LEVEL; WISTAR RAT; ANIMAL; BLOOD; BODY WEIGHT; DIET;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

ANIMALS; BODY WEIGHT; DIET; FEMALE; HYPERCHOLESTEROLEMIA; KETOGLUTARIC ACIDS; LIPIDS; MALE; RATS; RATS, WISTAR;

EID: 65649107718     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510802464633     Document Type: Article

References (21)

1. Barter P. HDL: a recipe for longevity. Atheroscler Suppl 2004;5:25-31.
2. Giampaoli S, Palmieri L, Chiodini P, Cesana G, Ferrario M, Panico S, et al. The global cardiovascular risk chart. Ital Heart J Suppl 2004;5:177-85.
3. Wernerman J, Hammarqvist F. Glutamine: a necessary nutrient for the intensive care patient. Int J Colorectal Dis 1999;14:137-42.
4. Den HE, Hiele M, Peeters M, Ghoos Y, Rutgeerts P. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease. JPEN J Parenter Enteral Nutr 1999;23:7-11.
5. Plauth M, Raible A, Vieillard-Baron D, Bauder-Gross D, Hartmann F. Is glutamine essential for the maintenance of intestinal function? A study in the isolated perfused rat small intestine. Int J Colorectal Dis 1999;14:86-94.
6. Pierzynowski SG, Sjodin A. Perspectives of glutamine and its derivatives as feed additives for farm animals. J Anim Feed Sci 1998;7 Suppl 1:79-93.
7. Junghans P, Derno M, Pierzynowski S, Rudolph PE, Souffrant WB. Intraduodenal infusion of a-ketoglutarate decreases whole body energy expenditure in growing pigs. Clin Nutr 2006;25:489-96.
8. Pierzynowski SG, Burrin D. Use of alpha-ketoglutaric acid for treatment of malnutrition or high plama glucose condition. 2004; EP20040749100 20040701.
9. Kristensen NB, Jungvid H, Fernandez JA, Pierzynowski SG. Absorption and metabolism of alpha-ketoglutarate in growing pigs. J Anim Physiol Anim Nutr (Berl) 2002;86:239-45.
10. Lambert BD, Stoll B, Niinikoski H, Pierzynowski S, Burrin DG. Net portal absorption of enterally fed alpha-ketoglutarate is limited in young pigs. J Nutr 2002;132:3383-6.
11. Wu G, Morris SM Jr. Arginine metabolism: nitric oxide and beyond. Biochem J 1998;336 Pt 1:1-17.
12. Bazzano G, Bazzano GS. Hypocholesterolemic effect of a-ketoglutarate in the Mongolian gerbil. Proc Soc Exp Biol Med 1972;140:36-9.
13. Horiguchi N, Horiguchi H, Suzuki Y. Out-hospital patients with hyperlipidemia and hepatitis with various backgrounds improved by wheat protein hydrolysate (glutamine peptide) administration. Jpn Pharmacol Ther 2004;32:415-20.
14. Cooke JP, Andon NA, Girerd XJ, Hirsch AT, Creager MA. Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta. Circulation 1991;83:1057-62.
15. Tsao PS, Cooke JP. Endothelial alterations in hypercholesterolemia: more than simply vasodilator dysfunction. J Cardiovasc Pharmacol 1998;32 Suppl 3:S48-53.
16. Kurowska EM, Carroll KK. Hypocholesterolemic properties of nitric oxide. In vivo and in vitro studies using nitric oxide donors. Biochim Biophys Acta 1998;1392:41-50.
17. Wells BJ, Mainous AG III, Everett CJ. Association between dietary arginine and C-reactive protein. Nutrition 2005;21:125-30.
18. Velvizhi S, Dakshayani KB, Subramanian P. Effects of alpha-ketoglutarate on antioxidants and lipid peroxidation products in rats treated with ammonium acetate. Nutrition 2002;18:747-50.
19. Khedara A, Kawai Y, Kayashita J, Kato N. Feeding rats the nitric oxide synthase inhibitor, L-N(omega)nitroarginine, elevates serum triglyceride and cholesterol and lowers hepatic fatty acid oxidation. J Nutr 1996;126:2563-7.
20. Fu WJ, Haynes TE, Kohli R, Hu J, Shi W, Spencer TE, et al. Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats. J Nutr 2005;135:714-21.
21. Fruhbeck G, Gomez-Ambrosi J. Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide. Cell Signal 2001;13:827-33.