Intraduodenal infusion of α-ketoglutarate decreases whole body energy expenditure in growing pigs

Clinical Nutrition

Volumn 25, Issue 3, 2006, Pages 489-496

  Junghans, Peter ^a   Derno, Michael ^a   Pierzynowski, Stefan ^b,c   Hennig, Ulf ^a   Eberhard Rudolph, Paul ^d   Souffrant, Wolfgang B ^a  

^a LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^b LUND UNIVERSITY   (Sweden)

^c NATIONAL MARINE FISHERIES RESEARCH INSTITUTE   (Poland)

^d Research Unit Genetics and Biometry   (Germany)

Author keywords

Ketoglutarate; Administration route; Energy expenditure; Pig model

Indexed keywords

2 OXOGLUTARIC ACID; ALANINE; ARGININE; ASCORBIC ACID; ASPARTIC ACID; CALCIUM ION; CARBOHYDRATE; CARBON 13; CARBON DIOXIDE; CYANOCOBALAMIN; FAT; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HISTIDINE; ISOLEUCINE; KABIVEN; LEUCINE; LYSINE; MAGNESIUM ION; METHIONINE; PANTOTHENIC ACID; PHENYLALANINE; POTASSIUM ION; PROLINE; PYRIDOXINE; RIBOFLAVIN; SODIUM ION; SOLUVIT; THIAMINE; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CARBON DIOXIDE BREATHING; CATHETER; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG INFUSION; ENERGY EXPENDITURE; EXPERIMENTAL MODEL; GROWTH; LIPID OXIDATION; MALE; METABOLIC ACTIVATION; NONHUMAN; NUTRIENT SOLUTION; STATISTICAL ANALYSIS; SWINE;

ANIMALS; BREATH TESTS; CARBON ISOTOPES; CATHETERIZATION; DUODENUM; ENERGY METABOLISM; INFUSIONS, INTRAVENOUS; KETOGLUTARIC ACIDS; MALE; MODELS, ANIMAL; NUTRITIONAL SUPPORT; ORCHIECTOMY; SOLUTIONS; STOMACH; SWINE;

EID: 33744935791     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2005.11.003     Document Type: Article

References (21)

1. Clark E.C., Patel S.D., Chadwick P.R., et al. Glutamine deprivation facilitates tumour necrosis factor induced bacterial translocation in Caco-2 cells by depletion of enterocyte fuel substrate. Gut 52 (2003) 224-230
2. Wiren M., Permert J., and Larsson J. Alpha-ketoglutarate-supplemented enteral nutrition: effects on postoperative nitrogen balance and muscle catabolism. Nutrition 18 (2002) 725-728
3. Blomqvist B.I., Hammarqvist F., von der Decken A., et al. Glutamine and alpha-ketoglutarate prevent the decrease in muscle free glutamine concentration and influence protein synthesis after total hip replacement. Metabolism 44 (1995) 1215-1222
4. Jeevanandam M., Begay C.K., Holaday N.J., et al. Nutritional and metabolic effects and significance of mild orotic aciduria during dietary supplementation with arginine or its organic salts after trauma injury in rats. Metabolism 46 (1997) 785-792
5. Harrison A.P., Tygesen M.P., Sawa-Wojtanowicz B., et al. Alpha-ketoglutarate treatment early in postnatal life improves bone density in lambs at slaughter. Bone 35 (2004) 204-209
6. Velvizhi S., Dakshayani K.B., and Subramanian P. Effects of alpha-ketoglutarate on antioxidants and lipid peroxidation products in rats treated with ammonium acetate. Nutrition 18 (2002) 747-750
7. Pierzynowski S.G., and Sjodin A. A perspective of glutamine and its derivates. J Anim Feed Sci 7 (1998) 79-91
8. Lambert B.D., Stoll B., Niinikoski H., et al. Net portal absorption of enterally fed alpha-ketoglutarate is limited in young pigs. J Nutr 132 (2002) 3383-3386
9. Gesellschaft für Ernährungsphysiologie der Haustiere (GEH). Energie- und Nährstoffbedarf landwirtschaftlicher Nutztiere. Nr. 4: Versorgungsempfehlungen für Mastschweine. DLG-Verlag, Frankfurt, Main, 1987.
10. Junghans P., Derno M., Gehre M., et al. Calorimetric validation of 13C bicarbonate and doubly labelled water method for determining the energy expenditure in goats. Z Ernährungswiss 36 (1997) 268-272
11. Wessel D., and Flugge U.I. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal Biochem 138 (1984) 141-143
12. 2 in human bicarbonate studies: a critical review with original data. Clin Sci 91 (1996) 665-677
13. Hoffmann L., and Schiemann R. From calorie to joule. New proportions in measuring energy metabolism and calculating the parameters of energetic feed evaluation. Arch Tierernahr 30 (1980) 733-742 [in German]
14. Kaboth W. In: Begemann H. (Ed). Klinische Hämatologie (1975), Georg Thieme, Stuttgart
15. Brouwer E. Report of sub-committee on constants and factors. In: Blaxter KL, editor. Proceedings of the third symposium on energy metabolism. London, New York; 1965. p. 441-3.
16. Simonson D.C., and DeFronzo R.A. Indirect calorimetry: methodological and interpretative problems. Am J Physiol 258 (1990) E399-E412
17. ® user's guide, version 8 (1999), SAS Institute Inc., Cary, NC
18. 15N-amino acid approach. In: McCracken K.J., Unsworth E.F., and Wylie A.R.G. (Eds). Energy metabolism in animals. Proceedings of the 14th symposium on energy metabolism in farm animals (1998), CAB International, Wallingford, UK 181-184
19. Buddington R.K., Pajor A., Buddington K.K., et al. Absorption of alpha-ketoglutarate by the gastrointestinal tract of pigs. Comp Biochem Physiol A: Mol Integr Physiol 138 (2004) 215-220
20. Reeds P.J., Burrin D.G., Jahoor F., et al. Enteral glutamate is almost completely metabolized in first pass by the gastrointestinal tract of infant pigs. Am J Physiol 270 (1996) E413-E418
21. Feinle C., O'Donovan D., and Horowitz M. Carbohydrate and satiety. Nutr Rev 60 (2002) 155-169