JNJ-10181457, a selective non-imidazole histamine H3 receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition

Neuropharmacology

Volumn 56, Issue 8, 2009, Pages 1131-1137

  Galici, Ruggero ^a   Boggs, Jamin D ^a   Aluisio, Leah ^a   Fraser, Ian C ^a   Bonaventure, Pascal ^a   Lord, Brian ^a   Lovenberg, Timothy W ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Acetylcholine; H3; Histamine; JNJ 10181457; Reversal learning; Working memory

Indexed keywords

4 [3 (4 PIPERIDIN 1 YLBUT 1 YNYL)BENZYL]MORPHOLINE; CHOLINESTERASE INHIBITOR; DONEPEZIL; HISTAMINE H3 RECEPTOR ANTAGONIST; IMETIT; JNJ 10181457; SCOPOLAMINE; THIOPERAMIDE; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG EFFICACY; LEARNING DISORDER; MICRODIALYSIS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR OCCUPANCY; REPEATED DRUG DOSE; TASK PERFORMANCE; WATER LICKING MODEL; WORKING MEMORY;

ACETYLCHOLINE; ANIMALS; ANTICONVULSANTS; BRAIN; CHOLINESTERASE INHIBITORS; COGNITION; CONDITIONING, OPERANT; DRINKING BEHAVIOR; DRUG EVALUATION, PRECLINICAL; HISTAMINE AGONISTS; HISTAMINE ANTAGONISTS; IMIDAZOLES; INDANS; LEARNING; MICRODIALYSIS; MORPHOLINES; MUSCARINIC ANTAGONISTS; NOOTROPIC AGENTS; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, HISTAMINE H3; SCOPOLAMINE; SYNAPTIC TRANSMISSION; THIOUREA;

EID: 65649092990     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2009.03.011     Document Type: Article

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