Discriminative stimulus effects of ethanol, pregnanolone, and dehydroepiandrosterone (DHEA) in rats administered ethanol or saline as adolescents

Pharmacology Biochemistry and Behavior

Volumn 93, Issue 1, 2009, Pages 82-90

  Gurkovskaya, Olga V ^a,b   Winsauer, Peter J ^a,b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Adolescence; Dehydroepiandrosterone; Drug discrimination; Ethanol; Pregnanolone; Rats

Indexed keywords

ALCOHOL; ELTANOLONE; NEUROSTEROID; PRASTERONE; SODIUM CHLORIDE;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; TRAINING;

ADOLESCENT; ADOLESCENT PSYCHOLOGY; ADULT; AGE FACTORS; ALCOHOLISM; ANIMALS; DEHYDROEPIANDROSTERONE; DISCRIMINATION (PSYCHOLOGY); ETHANOL; HUMANS; MALE; MODELS, ANIMAL; PREGNANOLONE; RATS; RATS, LONG-EVANS;

RATTUS;

EID: 65549159949     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2009.04.012     Document Type: Article

References (57)

1. Ator N.A., Grant K.A., Purdy R.H., Paul S.M., and Griffiths R.R. Drug discrimination analysis of endogenous neuroactive steroids in rats. Eur J Pharmacol 241 (1993) 237-243
2. Barbaccia M.L., Affricano D., Trabucchi M., Purdy R.H., Colombo G., Agabio R., et al. Ethanol markedly increases "GABAergic" neurosteroids in alcohol-preferring rats. Eur J Pharmacol 384 (1999) R1-R2
3. Bienkowski P., and Kostowski W. Discriminative stimulus properties of ethanol in the rat: effects of neurosteroids and picrotoxin. Brain Res 753 (1997) 348-352
4. Bowen C.A., Purdy R.H., and Grant K.A. An investigation of endogenous neuroactive steroid-induced modulation of ethanol's discriminative stimulus effects. Behav Pharmacol 10 (1999) 297-311
5. Bowen C.A., Purdy R.H., and Grant K.A. Ethanol-like discriminative stimulus effects of endogenous neuroactive steroids: effect of ethanol training dose and dosing procedure. J Pharmacol Exp Ther 289 (1999) 405-411
6. Cagetti E., Liang J., Spigelman I., and Olsen R.W. Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors. Mol Pharmacol 63 (2003) 53-64
7. Colpaert F.C., Niemegeers C.J., and Janssen P.A. Theoretical and methodological considerations on drug discrimination learning. Psychopharmacologia 46 (1976) 169-177
8. Corpechot C., Robel P., Axelson M., Sjovall J., and Baulieu E.E. Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc Natl Acad Sci U S A 78 (1981) 4704-4707
9. Crews F.T., Morrow A.L., Criswell H., and Breese G. Effects of ethanol on ion channels. Int Rev Neurobiol 39 (1996) 283-367
10. Demirgoren S., Majewska M.D., Spivak C.E., and London E.D. Receptor binding and electrophysiological effects of dehydroepiandrosterone sulfate, an antagonist of the GABAA receptor. Neuroscience 45 (1991) 127-135
11. Devaud L.L., Purdy R.H., Finn D.A., and Morrow A.L. Sensitization of gamma-aminobutyric acidA receptors to neuroactive steroids in rats during ethanol withdrawal. J Pharmacol Exp Ther 278 (1996) 510-517
12. File S.E., and Mabbutt P.S. Long-lasting effects on habituation and passive avoidance performance of a period of chronic ethanol administration in the rat. Behav Brain Res 36 (1990) 171-178
13. Ford M.M., Mark G.P., Nickel J.D., Phillips T.J., and Finn D.A. Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice. Behav Brain Res 179 (2007) 265-272
14. Gerak L.R., Moerschbaecher J.M., and Winsauer P.J. Overlapping, but not identical, discriminative stimulus effects of the neuroactive steroid pregnanolone and ethanol. Pharmacol Biochem Behav 89 (2008) 473-479
15. Ginsburg B.C., and Lamb R.J. Alphaxalone and epiallopregnanolone in rats trained to discriminate ethanol. Alcohol Clin Exp Res 29 (2005) 1621-1629
16. Grant K.A., and Colombo G. Discriminative stimulus effects of ethanol: effect of training dose on the substitution of N-methyl-D-aspartate antagonists. J Pharmacol Exp Ther 264 (1993) 1241-1247
17. Grant B.F., and Dawson D.A. Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. J Subst Abuse 9 (1997) 103-110
18. Green K.L., and Grant K.A. Evidence for overshadowing by components of the heterogeneous discriminative stimulus effects of ethanol. Drug Alcohol Depend 52 (1998) 149-159
19. Grobin A.C., Matthews D.B., Devaud L.L., and Morrow A.L. The role of GABA(A) receptors in the acute and chronic effects of ethanol. Psychopharmacology (Berl) 139 (1998) 2-19
20. Hawkins J.D., Graham J.W., Maguin E., Abbott R., Hill K.G., and Catalano R.F. Exploring the effects of age of alcohol use initiation and psychosocial risk factors on subsequent alcohol misuse. J Stud Alcohol 58 (1997) 280-290
21. Hiltunen A.J., and Jarbe T.U. Ro 15-4513 does not antagonize the discriminative stimulus- or rate-depressant effects of ethanol in rats. Alcohol 5 (1988) 203-207
22. Hiltunen A.J., and Jarbe T.U. Discriminative stimulus properties of ethanol: effects of cumulative dosing and Ro 15-4513. Behav Pharmacol 1 (1989) 133-140
23. Hodge C.W., Nannini M.A., Olive M.F., Kelley S.P., and Mehmert K.K. Allopregnanolone and pentobarbital infused into the nucleus accumbens substitute for the discriminative stimulus effects of ethanol. Alcohol Clin Exp Res 25 (2001) 1441-1447
24. Holtzman S.G. Discriminative stimulus effects of drugs: relationship to potential for abuse. In: Adler M.W., and Cowan A. (Eds). Testing and evaluation of drugs of abuse (1990), John Wiley & Sons, New York 193-210
25. Kang M.H., Spigelman I., and Olsen R.W. Alteration in the sensitivity of GABA(A) receptors to allosteric modulatory drugs in rat hippocampus after chronic intermittent ethanol treatment. Alcohol Clin Exp Res 22 (1998) 2165-2173
26. Kostowski W., and Bienkowski P. Discriminative stimulus effects of ethanol: neuropharmacological characterization. Alcohol 17 (1999) 63-80
27. Losel R.M., Falkenstein E., Feuring M., Schultz A., Tillmann H.C., Rossol-Haseroth K., et al. Nongenomic steroid action: controversies, questions, and answers. Physiol Rev 83 (2003) 965-1016
28. Majewska M.D. Interaction of ethanol with the GABAA receptor in the rat brain: possible involvement of endogenous steroids. Alcohol 5 (1988) 269-273
29. Mehta A.K., and Ticku M.K. Chronic ethanol administration alters the modulatory effect of 5alpha-pregnan-3alpha-ol-20-one on the binding characteristics of various radioligands of GABAA receptors. Brain Res 805 (1998) 88-94
30. Mehta A.K., and Ticku M.K. Unsulfated and sulfated neurosteroids differentially modulate the binding characteristics of various radioligands of GABA(A) receptors following chronic ethanol administration. Neuropharmacology 40 (2001) 668-675
31. Melchior C.L., and Allen P.M. Interaction of pregnanolone and pregnenolone sulfate with ethanol and pentobarbital. Pharmacol Biochem Behav 42 (1992) 605-611
32. Morrow A.L., Janis G.C., VanDoren M.J., Matthews D.B., Samson H.H., Janak P.H., et al. Neurosteroids mediate pharmacological effects of ethanol: a new mechanism of ethanol action?. Alcohol Clin Exp Res 23 (1999) 1933-1940
33. Morrow A.L., VanDoren M.J., Penland S.N., and Matthews D.B. The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. Brain Res Brain Res Rev 37 (2001) 98-109
34. National Research Council. Guide for the care and use of laboratory animals (1996), National Academy Press, Washington, DC
35. Negro M., Casanova E., Chinchetru M.A., Fernandez-Lopez A., and Calvo P. Differential effect of chronic ethanol treatment on barbiturate and steroid modulation of muscimol-binding to rat brain cortex. Neurosci Lett 158 (1993) 83-86
36. O'Dell L.E., Alomary A.A., Vallée M., Koob G.F., Fitzgerald R.L., and Purdy R.H. Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats. Eur J Pharmacol 484 (2004) 241-247
37. O'Dell L.E., Roberts A.J., Smith R.T., and Koob G.F. Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure. Alcohol Clin Exp Res 28 (2004) 1676-1682
38. O'Dell L.E., Purdy R.H., Covey D.F., Richardson H.N., Roberto M., and Koob G.F. Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats. Pharmacol Biochem Behav 81 (2005) 543-550
39. Olsen R.W., Liang J., Cagetti E., and Spigelman I. Plasticity of GABAA receptors in brains of rats treated with chronic intermittent ethanol. Neurochem Res 30 (2005) 1579-1588
40. Park-Chung M., Malayev A., Purdy R.H., Gibbs T.T., and Farb D.H. Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites. Brain Res 830 (1999) 72-87
41. Rassnick S., D'Amico E., Riley E., and Koob G.F. GABA antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol. Alcohol Clin Exp Res 17 (1993) 124-130
42. Rupprecht R., and Holsboer F. Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci 22 (1999) 410-416
43. Samson H.H., Tolliver G.A., Pfeffer A.O., Sadeghi K.G., and Mills F.G. Oral ethanol reinforcement in the rat: effect of the partial inverse benzodiazepine agonist RO15-4513. Pharmacol Biochem Behav 27 (1987) 517-519
44. Sanna E., Talani G., Busonero F., Pisu M.G., Purdy R.H., Serra M., et al. Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus. J Neurosci 24 (2004) 6521-6530
45. Santucci A.C., Mercado M., Bettica A., Cortes C., York D., and Moody E. Residual behavioral and neuroanatomical effects of short-term chronic ethanol consumption in rats. Brain Res Cogn Brain Res 20 (2004) 449-461
46. Silvers J.M., Tokunaga S., Mittleman G., and Matthews D.B. Chronic intermittent injections of high-dose ethanol during adolescence produce metabolic, hypnotic, and cognitive tolerance in rats. Alcohol Clin Exp Res 27 (2003) 1606-1612
47. Silvers J.M., Tokunaga S., Mittleman G., O'Buckley T., Morrow A.L., and Matthews D.B. Chronic intermittent ethanol exposure during adolescence reduces the effect of ethanol challenge on hippocampal allopregnanolone levels and Morris water maze task performance. Alcohol 39 (2006) 151-158
48. Stolerman I.P., and Olufsen K. Generalisation of ethanol with drug mixtures containing a positive modulator of the GABA(A) receptor and an NMDA antagonist. Neuropharmacology 40 (2001) 123-130
49. Suzdak P.D., Glowa J.R., Crawley J.N., Schwartz R.D., Skolnick P., and Paul S.M. A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 234 (1986) 1243-1247
50. Tokunaga S., Silvers J.M., and Matthews D.B. Chronic intermittent ethanol exposure during adolescence blocks ethanol-induced inhibition of spontaneously active hippocampal pyramidal neurons. Alcohol Clin Exp Res 30 (2006) 1-6
51. VanDoren M.J., Matthews D.B., Janis G.C., Grobin A.C., Devaud L.L., and Morrow A.L. Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol. J Neurosci 20 (2000) 1982-1989
52. A receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol. Psychopharmacology (Berl) 141 (1999) 77-82
53. Volkow N.D., and Fowler J.S. Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb Cortex 10 (2000) 318-325
54. Walker D.W., Hunter B.E., and Abraham W.C. Neuroanatomical and functional deficits subsequent to chronic ethanol administration in animals. Alcohol Clin Exp Res 5 (1981) 267-282
55. White A.M., Bae J.G., Truesdale M.C., Ahmad S., Wilson W.A., and Swartzwelder H.S. Chronic-intermittent ethanol exposure during adolescence prevents normal developmental changes in sensitivity to ethanol-induced motor impairments. Alcohol Clin Exp Res 26 (2002) 960-968
56. White A.M., Ghia A.J., Levin E.D., and Swartzwelder H.S. Binge pattern ethanol exposure in adolescent and adult rats: differential impact on subsequent responsiveness to ethanol. Alcohol Clin Exp Res 24 (2000) 1251-1256
57. Wilder J. Stimulus and response: the law of initial value (1967), John Wright, Bristol, England