Discriminative stimulus properties of ethanol in the rat: Effects of neurosteroids and picrotoxin

Brain Research

Volumn 753, Issue 2, 1997, Pages 348-352

  Bienkowski, Przemyslaw ^a,b   Kostowski, Wojciech ^a,b  

^a INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Poland)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

drug discrimination; ethanol; GABA(A) receptor complex; neurosteroid; picrotoxin; rat

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ALCOHOL; PICROTOXIN; TETRAHYDRODEOXYCORTICOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG DISCRIMINATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; DEHYDROEPIANDROSTERONE SULFATE; DISCRIMINATION (PSYCHOLOGY); ETHANOL; GABA ANTAGONISTS; MALE; PICROTOXIN; RATS; RATS, WISTAR; SODIUM CHLORIDE; STIMULATION, CHEMICAL;

EID: 0031564607     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00165-0     Document Type: Article

References (28)

1. Ator, N.A., Grant, K.A., Purdy, R.H., Paul, S.M. and Griffiths, R.R., Drug discrimination analysis of endogenous neuroactive steroids in rats, Eur. J. Pharmacol., 241 (1993) 237-243.
2. A ligands in male and female monkeys discriminating a low dose of ethanol, Alcohol. Clin. Exp. Res., 20 (1996) 63A (abstract).
3. Bienkowski, P., Stefanski, R. and Kostowski, W., Competitive NMDA receptor antagonist, CGP 40116 substitutes for the discriminative stimulus effects of ethanol, Eur. J. Pharmacol., 314 (1996) 277-280.
4. Colombo, G., Agabio, R., Balaklievskaia, N., Fadda, F., Gatto G., Gessa, G.L., Lobina, C., Reali, R. and Grant, K.A., Drug discrimination procedures to investigate the neurochemical basis of the subjective effects of ethanol, Alcohol Alcohol., 30 (1995), 493 (abstract).
5. Colpaert, F., Drug discrimination: behavioural, pharmacological and molecular mechanisms of discriminative drug effects. In S.R. Goldberg and I.P. Stolerman (Eds.), Behavioural Analysis of Drug Dependence, Academic Press, New York, 1986, pp. 161-193.
6. Grant, K.A., Emerging neurochemical concepts in the actions of ethanol at ligand-gated ion channels, Behav. Pharmacol., 5 (1994) 383-404.
7. Grant, K.A., Azarov, A., Bowen, C.A., Mirkis, S. and Purdy, R.H., Ethanol-like discriminative stimulus effects of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in female Macaca fascicularis monkeys, Psychopharmacology, 124 (1996) 340-346.
8. Grant, K.A. and Colombo, G., Discriminative stimulus effects of ethanol: Effect of training dose on the substitution of N-methyl-D-aspartate antagonists, J. Pharmacol. Exp. Ther., 264 (1993) 1241-1247.
9. Hiltunen, A.J. and Jarbe, T.U., Discrimination of Ro 11-6896, chlordiazepoxide and ethanol in gerbils: generalization and antagonism tests, Psychopharmacology, 89 (1986) 284-290.
10. Hiltunen, A.J. and Jarbe, T.U., Ro 15-4513 does not antagonize the discriminative stimulus- or rate-depressant effects of ethanol in rats, Alcohol, 5 (1988) 203-207.
11. Kokate, T.G., Svensson, B.E. and Rogawski, M., Anticonvulsant activity of neurosteroids: correlation with γ-aminobutyric acid-evoked chloride current potentiation, J. Pharmacol. Exp. Ther., 270 (1994) 1223-1229.
12. A receptor function, TIPS, 16 (1995) 295-303.
13. Liljequist, S. and Engel, J., Effects of GABAergic agonists and antagonists on various ethanol-induced behavioural changes, Psychopharmacology, 78 (1982) 71-75.
14. A receptor. Mechanism of action and physiological significance, Prog. Neurobiol., 38 (1992) 379-395.
15. Melchior, C.L. and Ritzmann, R.F., Dehydroepiandrosterone is an anxiolytic in mice on the plus maze, Pharmacol. Biochem. Behav., 47 (1994) 437-441.
16. Melchior, C.L. and Ritzmann, R.F., Dehydroepiandrosterone enhances the hypnotic and hypothermic effects of ethanol and pentobarbital, Pharmacol. Biochem. Behav., 43 (1992) 223-227.
17. Melchior, C.L. and Ritzmann, R.F., Neurosteroids block the memory-impairing effects of ethanol in mice, Pharmacol. Biochem. Behav., 53 (1996) 51-56.
18. Mereu, G. and Gessa, G.L., Low doses of ethanol inhibit the firing of neurons in the substantia nigra pars reticulata: a GABAergic effect?, Brain Res., 360 (1985) 325-330.
19. Morrow, A.l., Pace, J.R., Purdy, R.H. and Paul, S.M., Characterisation of steroid interactions with γ-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites, Mol. Pharmacol., 37 (1990) 263-270.
20. Paul, S.M. and Purdy, R.H., Neuroactive steroids, FASEB J., 6 (1992) 2311-2322.
21. Randall, R.D., Lee, S.Y., Meyer, J.H., Wittenberg, G.F. and Gruol, D.L., Acute alcohol blocks neurosteroid modulation of synaptic transmission and long-term potentiation in the rat hippocampal slice, Brain Res., 701 (1995) 238-248.
22. Rees, D.C. and Balster, R.L., Attenuation of the discriminative stimulus properties of ethanol and oxazepam, but not of pentobarbital, by Ro 15-4513 in mice, J. Pharmacol. Exp. Ther., 244 (1988) 592-598.
23. Schumacher, M. and Baulieu, E.-E., Neurosteroids: synthesis and functions in the central and peripheral nervous systems. In Non-reproductive Actions of Sex Steroids, Wiley, Chichester (Ciba Foundation Symposium 191), 1995, pp. 90-112.
24. Shelton, K.L. and Balster, R.L., Ethanol drug discrimination in rats. Substitution with GABA agonists and NMDA antagonists, Behav. Pharmacol., 5 (1994) 441-450.
25. Smith, B.R., Segal, R.B. and Amit, Z., Administration of a GABA antagonist selectively attenuates an ethanol-induced conditioned taste aversion, Pharmacol. Biochem. Behav., 33 (1989) 269-271.
26. 3 receptors in the mediation of the ethanol interoceptive cue, Eur. J. Pharmacol., 309 (1996) 141-147.
27. Suzdak, P.D., Schwartz, R.D., Skolnik, P. and Paul, S.M., Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes, Proc. Natl. Acad. Sci. USA, 83 (1986) 4071-4075.
28. Tallarida, R.J. and Murray, R.B., Manual of Pharmacological Calculations, Springer, New York, 1987.