메뉴 건너뛰기




Volumn 24, Issue 4, 2009, Pages 606-620

Phenotypic integration among trabecular and cortical bone traits establishes mechanical functionality of inbred mouse vertebrae

Author keywords

Biomechanics; Inbred mice; Path analysis; Phenotypic integration; Vertebral body

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGY; BIOMECHANICS; BODY SIZE; BONE MINERALIZATION; BONE STRENGTH; BONE STRESS; BONE STRUCTURE; CORTICAL BONE; ENVIRONMENTAL FACTOR; FEMALE; GENETIC ANALYSIS; GENETIC TRAIT; GENETIC VARIABILITY; GENOMICS; HEREDITY; LUMBAR VERTEBRA; MORPHOLOGY; MOUSE; MOUSE STRAIN; MULTIVARIATE ANALYSIS; NONHUMAN; PHENOTYPE; RECOMBINANT INBRED STRAIN; TRABECULAR BONE; VERTEBRA; VERTEBRA BODY;

EID: 65549148071     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.081224     Document Type: Article
Times cited : (25)

References (65)
  • 1
    • 84942948140 scopus 로고
    • Post-mcnopausal osteoporosis. Its clinical features
    • Albright F, Smith PH, Richardson AM 1941 Post-mcnopausal osteoporosis. Its clinical features. JAMA 116:2465-2474.
    • (1941) JAMA , vol.116 , pp. 2465-2474
    • Albright, F.1    Smith, P.H.2    Richardson, A.M.3
  • 3
    • 0032848694 scopus 로고    scopus 로고
    • Vertebral bone mass, size, and volumetric density in women with spinal fractures
    • Duan Y, Parfitt A, Seeman E 1999 Vertebral bone mass, size, and volumetric density in women with spinal fractures. J Bone Miner Res 14:1796-1802.
    • (1999) J Bone Miner Res , vol.14 , pp. 1796-1802
    • Duan, Y.1    Parfitt, A.2    Seeman, E.3
  • 4
    • 0035192279 scopus 로고    scopus 로고
    • The biomechanical basis of vertebral body fragility in men and women
    • Duan Y, Seeman E, Turner CH 2001 The biomechanical basis of vertebral body fragility in men and women. J Bone Miner Res 16:2276-2283.
    • (2001) J Bone Miner Res , vol.16 , pp. 2276-2283
    • Duan, Y.1    Seeman, E.2    Turner, C.H.3
  • 5
    • 0035196028 scopus 로고    scopus 로고
    • Sexual dimorphism in vertebral fragility is more the result of gender differences in age-related bone gain than bone loss
    • Duan Y, Turner CH, Kim BT, Seeman E 2001 Sexual dimorphism in vertebral fragility is more the result of gender differences in age-related bone gain than bone loss. J Bone Miner Res 16:2267-2275.
    • (2001) J Bone Miner Res , vol.16 , pp. 2267-2275
    • Duan, Y.1    Turner, C.H.2    Kim, B.T.3    Seeman, E.4
  • 7
    • 0028946274 scopus 로고
    • Vertebral size in elderly women with osteoporosis. Mechanical implications and relationship to fractures
    • Gilsanz V, Loro ML, Roe TF, Sayre J, Gilsanz R, Schulz EE 1995 Vertebral size in elderly women with osteoporosis. Mechanical implications and relationship to fractures. J Clin Invest 95:2332-2337.
    • (1995) J Clin Invest , vol.95 , pp. 2332-2337
    • Gilsanz, V.1    Loro, M.L.2    Roe, T.F.3    Sayre, J.4    Gilsanz, R.5    Schulz, E.E.6
  • 10
    • 34548430612 scopus 로고    scopus 로고
    • Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility
    • Jepsen KJ. Hu B, Tommasini SM, Courtland HW, Price C, Terranova CJ, Nadeau JH 2007 Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility. Mamm Genome 18:492-507.
    • (2007) Mamm Genome , vol.18 , pp. 492-507
    • Jepsen, K.J.1    Hu, B.2    Tommasini, S.M.3    Courtland, H.W.4    Price, C.5    Terranova, C.J.6    Nadeau, J.H.7
  • 11
    • 38549178032 scopus 로고    scopus 로고
    • Biological co-adaptation of morphological and composition traits contributes to mechanical functionality and skeletal fragility
    • Tommasini SM, Nasser P. Hu B, Jepsen KJ 2008 Biological co-adaptation of morphological and composition traits contributes to mechanical functionality and skeletal fragility. J Bone Miner Res 23:236-246.
    • (2008) J Bone Miner Res , vol.23 , pp. 236-246
    • Tommasini, S.M.1    Nasser, P.2    Hu, B.3    Jepsen, K.J.4
  • 12
    • 84871926462 scopus 로고    scopus 로고
    • Available online at, Accessed May 20, 2008
    • National Osteoporosis Foundation. National Osteoporosis Foundation Fast Facts on Osteoporosis. Available online at http://www.nof.org/osteoporosis/ diseasefacts.htm. Accessed May 20, 2008.
    • National Osteoporosis Foundation Fast Facts on Osteoporosis
  • 13
    • 34548538229 scopus 로고    scopus 로고
    • Automated compartmental analysis for high-throughput skeletal pheno-typing in femora of genetic mouse models
    • Kohler T, Stauber M, Donahue LR, Muller R 2007 Automated compartmental analysis for high-throughput skeletal pheno-typing in femora of genetic mouse models. Bone 41:659-667.
    • (2007) Bone , vol.41 , pp. 659-667
    • Kohler, T.1    Stauber, M.2    Donahue, L.R.3    Muller, R.4
  • 15
    • 0022743241 scopus 로고
    • Mechanical properties of the tibiotarsus of broilers and poults loaded with artificial weight and fed various dietary protein levels
    • Patterson PH, Cook ME, Crenshaw TD, Sunde ML 1986 Mechanical properties of the tibiotarsus of broilers and poults loaded with artificial weight and fed various dietary protein levels. Poult Sci 65:1357-1364.
    • (1986) Poult Sci , vol.65 , pp. 1357-1364
    • Patterson, P.H.1    Cook, M.E.2    Crenshaw, T.D.3    Sunde, M.L.4
  • 16
    • 34547678685 scopus 로고    scopus 로고
    • Osteoporosis: A pediatric concern?
    • Faulkner RA, Bailey DA 2007 Osteoporosis: A pediatric concern? Med Sport Sci 51:1-12.
    • (2007) Med Sport Sci , vol.51 , pp. 1-12
    • Faulkner, R.A.1    Bailey, D.A.2
  • 17
    • 17644390924 scopus 로고    scopus 로고
    • Genetic variation in structure-function relationships for the inbred mouse lumbar vertebral body
    • Tommasini SM, Morgan TG, van der Meulen M, Jepsen KJ 2005 Genetic variation in structure-function relationships for the inbred mouse lumbar vertebral body. J Bone Miner Res 20:817-827.
    • (2005) J Bone Miner Res , vol.20 , pp. 817-827
    • Tommasini, S.M.1    Morgan, T.G.2    van der Meulen, M.3    Jepsen, K.J.4
  • 18
    • 34548080918 scopus 로고    scopus 로고
    • Age-related changes in trabecular architecture differ in female and male C57BL/6J mice
    • Glatt V, Canalis E, Stadmeyer L, Bouxsein ML 2007 Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res 22:1197-1207.
    • (2007) J Bone Miner Res , vol.22 , pp. 1197-1207
    • Glatt, V.1    Canalis, E.2    Stadmeyer, L.3    Bouxsein, M.L.4
  • 19
    • 33744479690 scopus 로고    scopus 로고
    • Bone loss dynamics result in trabecular alignment in aging and ovariectomized rats
    • Waarsing JH, Day JS, Verhaar JA, Ederveen AG, Weinans H 2006 Bone loss dynamics result in trabecular alignment in aging and ovariectomized rats. J Orthop Res 24:926-935.
    • (2006) J Orthop Res , vol.24 , pp. 926-935
    • Waarsing, J.H.1    Day, J.S.2    Verhaar, J.A.3    Ederveen, A.G.4    Weinans, H.5
  • 20
    • 33746158977 scopus 로고    scopus 로고
    • Developmental integration and the evolution of pleiotropy
    • Cheverud JM 1996 Developmental integration and the evolution of pleiotropy. Am Zool 36:44-50.
    • (1996) Am Zool , vol.36 , pp. 44-50
    • Cheverud, J.M.1
  • 21
    • 84985407437 scopus 로고
    • The thickness of the walls of tubular bones
    • Currey JD, Alexander RMcN 1985 The thickness of the walls of tubular bones. J Zool 206:453-468.
    • (1985) J Zool , vol.206 , pp. 453-468
    • Currey, J.D.1    Alexander, R.M.N.2
  • 22
    • 0023492075 scopus 로고
    • Bone "mass" and the "mechanostat": A proposal
    • Frost HM 1987 Bone "mass" and the "mechanostat": A proposal. Anat Rec 219:1-9.
    • (1987) Anat Rec , vol.219 , pp. 1-9
    • Frost, H.M.1
  • 23
    • 33144465965 scopus 로고    scopus 로고
    • Cortical and trabecular load sharing in the human vertebral body
    • Eswaran SK, Gupta A, Adams MF, Keaveny TM 2006 Cortical and trabecular load sharing in the human vertebral body. J Bone Miner Res 21:307-314.
    • (2006) J Bone Miner Res , vol.21 , pp. 307-314
    • Eswaran, S.K.1    Gupta, A.2    Adams, M.F.3    Keaveny, T.M.4
  • 24
    • 0031043730 scopus 로고    scopus 로고
    • Load sharing between the shell and centrum in the lumbar vertebral body
    • Silva MJ, Keaveny TM, Hayes WC 1997 Load sharing between the shell and centrum in the lumbar vertebral body. Spine 22:140-150.
    • (1997) Spine , vol.22 , pp. 140-150
    • Silva, M.J.1    Keaveny, T.M.2    Hayes, W.C.3
  • 25
    • 0141742300 scopus 로고    scopus 로고
    • Pleiotropy, homeostasis, and functional networks based on assays of cardiovascular traits in genetically randomized populations
    • Nadeau JH, Burrage LC, Restivo J, Pao YH, Churchill G, Hoit BD 2003 Pleiotropy, homeostasis, and functional networks based on assays of cardiovascular traits in genetically randomized populations. Genome Res 13:2082-2091.
    • (2003) Genome Res , vol.13 , pp. 2082-2091
    • Nadeau, J.H.1    Burrage, L.C.2    Restivo, J.3    Pao, Y.H.4    Churchill, G.5    Hoit, B.D.6
  • 27
    • 27444443677 scopus 로고    scopus 로고
    • Genetic variation in bone growth patterns defines adult mouse bone fragility
    • Price C, Herman BC, Lufkin T, Goldman HM, Jepsen KJ 2005 Genetic variation in bone growth patterns defines adult mouse bone fragility. J Bone Miner Res 20:1983-1991.
    • (2005) J Bone Miner Res , vol.20 , pp. 1983-1991
    • Price, C.1    Herman, B.C.2    Lufkin, T.3    Goldman, H.M.4    Jepsen, K.J.5
  • 29
    • 0018306059 scopus 로고
    • A threshold selection method from gray-level histograms
    • Otsu N 1979 A threshold selection method from gray-level histograms. IEEE Trans Syst Man Cybern 9:62-66.
    • (1979) IEEE Trans Syst Man Cybern , vol.9 , pp. 62-66
    • Otsu, N.1
  • 30
    • 40849120471 scopus 로고    scopus 로고
    • Percolation theory relates corticocancellous architecture to mechanical function in vertebrae of inbred mouse strains
    • Tommasini SM, Wearne SL, Hof PR, Jepsen KJ 2008 Percolation theory relates corticocancellous architecture to mechanical function in vertebrae of inbred mouse strains. Bone 42:743-750.
    • (2008) Bone , vol.42 , pp. 743-750
    • Tommasini, S.M.1    Wearne, S.L.2    Hof, P.R.3    Jepsen, K.J.4
  • 31
    • 0028151261 scopus 로고
    • Empirical threshold values for quantitative trait mapping
    • Churchill GA, Doerge RW 1994 Empirical threshold values for quantitative trait mapping. Genetics 138:963-971.
    • (1994) Genetics , vol.138 , pp. 963-971
    • Churchill, G.A.1    Doerge, R.W.2
  • 32
    • 0031914691 scopus 로고    scopus 로고
    • Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains
    • Belknap JK 1998 Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains. Behav Genet 28:29-38.
    • (1998) Behav Genet , vol.28 , pp. 29-38
    • Belknap, J.K.1
  • 35
    • 34447326675 scopus 로고    scopus 로고
    • Genes in context: Probing the genetics of fracture resistance
    • Sharkey NA, Lang DH 2007 Genes in context: Probing the genetics of fracture resistance. Exerc Sport Sci Rev 35:86-96.
    • (2007) Exerc Sport Sci Rev , vol.35 , pp. 86-96
    • Sharkey, N.A.1    Lang, D.H.2
  • 36
    • 0031510495 scopus 로고    scopus 로고
    • Power analysis in covariance structural modeling using GFI and AGFI
    • MacCallum RC, Hong S 1997 Power analysis in covariance structural modeling using GFI and AGFI. Multivariate Behav Res 32:193-210.
    • (1997) Multivariate Behav Res , vol.32 , pp. 193-210
    • MacCallum, R.C.1    Hong, S.2
  • 37
    • 34548396763 scopus 로고
    • Statistically based tests for the number of common factors
    • May 28-30, Iowa City, I A, USA
    • Stieger JH, Lind JM 1980 Statistically based tests for the number of common factors. Annual Meeting of the Psychometric Society, May 28-30, 1980, Iowa City, I A, USA.
    • (1980) Annual Meeting of the Psychometric Society
    • Stieger, J.H.1    Lind, J.M.2
  • 38
    • 0000501656 scopus 로고
    • Information theory as an extension of the maximum likelihood principle
    • Petrov B, Csaki F eds, Akademiai Kiado, Budapest, Hungary
    • Akaike H 1973 Information theory as an extension of the maximum likelihood principle. In: Petrov B, Csaki F (eds.). Second International Symposium on Information Theory. Akademiai Kiado, Budapest, Hungary, 297-281.
    • (1973) Second International Symposium on Information Theory , pp. 297-281
    • Akaike, H.1
  • 40
    • 0001233581 scopus 로고
    • Alternative ways of assessing model fit
    • 40, Bollen K, Long S eds, Sage Press, Thousand Oaks, CA, USA, pp
    • 40.Browne M, Cudeck R 1993 Alternative ways of assessing model fit. In: Bollen K, Long S (eds.). Testing Structural Equation Models. Sage Press, Thousand Oaks, CA, USA, pp. 136-162.
    • (1993) Testing Structural Equation Models , pp. 136-162
    • Browne, M.1    Cudeck, R.2
  • 41
    • 0029880186 scopus 로고    scopus 로고
    • Genetic variability in adult bone density among inbred strains of mice
    • Beamer WG, Donahue LR, Rosen CJ, Baylink DJ 1996 Genetic variability in adult bone density among inbred strains of mice. Bone 18:397-403.
    • (1996) Bone , vol.18 , pp. 397-403
    • Beamer, W.G.1    Donahue, L.R.2    Rosen, C.J.3    Baylink, D.J.4
  • 46
    • 17644406476 scopus 로고    scopus 로고
    • Lang DH, Sharkey NA, Mack HA, Vogler GP, Vandenbergh DJ, Blizard DA, Stout JT, McClearn GE 2005 Quantitative trait loci analysis of structural and material skeletal pheno-types in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res 20:88-99.47.
    • Lang DH, Sharkey NA, Mack HA, Vogler GP, Vandenbergh DJ, Blizard DA, Stout JT, McClearn GE 2005 Quantitative trait loci analysis of structural and material skeletal pheno-types in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res 20:88-99.47.
  • 48
    • 0035188787 scopus 로고    scopus 로고
    • Defining the genetics of osteoporosis: Using the mouse to understand man
    • Rosen CJ, Beamer WG. Donahue LR 2001 Defining the genetics of osteoporosis: Using the mouse to understand man. Osteoporos Int 12:803-810.
    • (2001) Osteoporos Int , vol.12 , pp. 803-810
    • Rosen, C.J.1    Beamer, W.G.2    Donahue, L.R.3
  • 51
    • 33645975172 scopus 로고    scopus 로고
    • Cortical bone development under the growth plate is regulated by mechanical load transfer
    • Tanck E, Hannink G, Ruimerman R, Buma P, Burger EH, Huiskes R 2006 Cortical bone development under the growth plate is regulated by mechanical load transfer. J Anat 208:73-79.
    • (2006) J Anat , vol.208 , pp. 73-79
    • Tanck, E.1    Hannink, G.2    Ruimerman, R.3    Buma, P.4    Burger, E.H.5    Huiskes, R.6
  • 53
    • 0037326383 scopus 로고    scopus 로고
    • Hierarchical relationship between bone traits and mechanical properties in inbred mice
    • Jepsen KJ, Akkus OJ, Majeska RJ, Nadeau JH 2003 Hierarchical relationship between bone traits and mechanical properties in inbred mice. Mamm Genome 14:97-104.
    • (2003) Mamm Genome , vol.14 , pp. 97-104
    • Jepsen, K.J.1    Akkus, O.J.2    Majeska, R.J.3    Nadeau, J.H.4
  • 54
    • 0034807638 scopus 로고    scopus 로고
    • Bone brittleness varies with genetic background in A/J and C57BL/6J inbred mice
    • Jepsen KJ, Pennington DE, Lee YL, Warman M, Nadeau J 2001 Bone brittleness varies with genetic background in A/J and C57BL/6J inbred mice. J Bone Miner Res 16:1854-1862.
    • (2001) J Bone Miner Res , vol.16 , pp. 1854-1862
    • Jepsen, K.J.1    Pennington, D.E.2    Lee, Y.L.3    Warman, M.4    Nadeau, J.5
  • 56
    • 20444428007 scopus 로고    scopus 로고
    • Structural and biomechanical basis of racial and sex differences in vertebral fragility in Chinese and Caucasians
    • Duan Y, Wang XF, Evans A, Seeman E 2005 Structural and biomechanical basis of racial and sex differences in vertebral fragility in Chinese and Caucasians. Bone 36:987-998.
    • (2005) Bone , vol.36 , pp. 987-998
    • Duan, Y.1    Wang, X.F.2    Evans, A.3    Seeman, E.4
  • 60
    • 0030938012 scopus 로고    scopus 로고
    • Quantitative analysis of trabecular morphogenesis in the human costochondral junction during the postnatal period in normal subjects
    • Fazzalari NL, Moore AJ, Byers S, Byard RW 1997 Quantitative analysis of trabecular morphogenesis in the human costochondral junction during the postnatal period in normal subjects. Anat Rec 248:1-12.
    • (1997) Anat Rec , vol.248 , pp. 1-12
    • Fazzalari, N.L.1    Moore, A.J.2    Byers, S.3    Byard, R.W.4
  • 61
    • 0034978270 scopus 로고    scopus 로고
    • Increase in bone volume fraction precedes architectural adaptation in growing bone
    • Tanck E, Homminga J, van Lenthe GH, Huiskes R 2001 Increase in bone volume fraction precedes architectural adaptation in growing bone. Bone 28:650-654.
    • (2001) Bone , vol.28 , pp. 650-654
    • Tanck, E.1    Homminga, J.2    van Lenthe, G.H.3    Huiskes, R.4
  • 63
    • 33846004778 scopus 로고    scopus 로고
    • Sexual dimorphism affects tibia size and shape but not tissue-level mechanical properties
    • Tommasini SM, Nasser P, Jepsen KJ 2007 Sexual dimorphism affects tibia size and shape but not tissue-level mechanical properties. Bone 40:498-505.
    • (2007) Bone , vol.40 , pp. 498-505
    • Tommasini, S.M.1    Nasser, P.2    Jepsen, K.J.3
  • 64
    • 22744453198 scopus 로고    scopus 로고
    • The relationship between bone morphology and bone quality in male tibiae: Implications for stress fracture risk
    • Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ 2005 The relationship between bone morphology and bone quality in male tibiae: Implications for stress fracture risk. J Bone Miner Res 20:1372-1380.
    • (2005) J Bone Miner Res , vol.20 , pp. 1372-1380
    • Tommasini, S.M.1    Nasser, P.2    Schaffler, M.B.3    Jepsen, K.J.4
  • 65
    • 0036214369 scopus 로고    scopus 로고
    • The use of a quadruped as an in vivo model for the study of the spine-biomechanical considerations
    • Smit TH 2002 The use of a quadruped as an in vivo model for the study of the spine-biomechanical considerations. Eur Spine J 11:137-144.
    • (2002) Eur Spine J , vol.11 , pp. 137-144
    • Smit, T.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.