Sexual dimorphism affects tibia size and shape but not tissue-level mechanical properties

Bone

Volumn 40, Issue 2, 2007, Pages 498-505

  Tommasini, Steven M ^a   Nasser, Philip ^b   Jepsen, Karl J ^b  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Biomechanics; Bone quality; Dimorphism; Gender sex; Morphology; Strength; Stress fracture

Indexed keywords

ADULT; ARTICLE; BIOMECHANICS; BODY SIZE; BONE GROWTH; BONE STRENGTH; BONE STRUCTURE; CRUSHING STRENGTH; DIAPHYSIS; FEMALE; GENDER; HUMAN; HUMAN TISSUE; MALE; NORMAL HUMAN; RIGIDITY; RISK FACTOR; SEX DIFFERENCE; SOLDIER; STRESS FRACTURE; TIBIA;

ADOLESCENT; ADULT; AGING; BIOMECHANICS; FEMALE; HUMANS; MALE; MIDDLE AGED; SEX CHARACTERISTICS; TIBIA;

EID: 33846004778     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2006.08.012     Document Type: Article

References (67)

1. Jones B.H., Bovee M.W., Harris III J.M., and Cowan D.N. Intrinsic risk factors for exercise-related injuries among male and female army trainees. Am. J. Sports Med. 21 (1993) 705-710
2. Beck T.J., Ruff C.B., Shaffer R.A., Betsinger K., Trone D.W., and Brodine S.K. Stress fracture in military recruits: gender differences in muscle and bone susceptibility factors. Bone 27 (2000) 437-444
3. Gallagher J.C., Melton L.J., Riggs B.L., and Bergstrath E. Epidemiology of fractures of the proximal femur in Rochester, Minnesota. Clin. Orthop. Relat. Res. (1980) 163-171
4. Cooper C., Campion G., and Melton III L.J. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 2 (1992) 285-289
5. Cummings S.R., and Melton L.J. Epidemiology and outcomes of osteoporotic fractures. Lancet 359 (2002) 1761-1767
6. Duan Y., Beck T.J., Wang X.F., and Seeman E. Structural and biomechanical basis of sexual dimorphism in femoral neck fragility has its origins in growth and aging. J. Bone Miner. Res. 18 (2003) 1766-1774
7. Winner S.J., Morgan C.A., and Evans J.G. Perimenopausal risk of falling and incidence of distal forearm fracture. BMJ 298 (1989) 1486-1488
8. Seeman E. The structural basis of bone fragility in men. Bone 25 (1999) 143-147
9. van der Meulen M.C., Jepsen K.J., and Mikic B. Understanding bone strength: size isn't everything. Bone 29 (2001) 101-104
10. Currey J.D., and Butler G. The mechanical properties of bone tissue in children. J. Bone Joint Surg. Am. 57 (1975) 810-814
11. Currey J.D. Changes in the impact energy absorption of bone with age. J. Biomech. 12 (1979) 459-469
12. Tommasini S.M., Nasser P., Schaffler M.B., and Jepsen K.J. Relationship between bone morphology and bone quality in male tibias: implications for stress fracture risk. J. Bone Miner. Res. 20 (2005) 1372-1380
13. Ruff C.B. Body size, body shape, and long bone strength in modern humans. J. Hum. Evol. 38 (2000) 269-290
14. Miller G.J., and Purkey Jr. W.W. The geometric properties of paired human tibiae. J. Biomech. 13 (1980) 1-8
15. Selker F., and Carter D.R. Scaling of long bone fracture strength with animal mass. J. Biomech. 22 (1989) 1175-1183
16. Gustafson M.B., Martin R.B., Gibson V., Storms D.H., Stover S.M., Gibeling J., et al. Calcium buffering is required to maintain bone stiffness in saline solution. J. Biomech. 29 (1996) 1191-1194
17. Nadai A. Theory of flow and fracture of solids. Engineering Societies Monographs (1950), McGraw-Hill, New York, NY
18. Burstein A.H., Currey J.D., Frankel V.H., and Reilly D.T. The ultimate properties of bone tissue: the effects of yielding. J. Biomech. 5 (1972) 35-44
19. Jepsen K.J., and Davy D.T. Comparison of damage accumulation measures in human cortical bone. J. Biomech. 30 (1997) 891-894
20. Jepsen K.J., Davy D.T., and Krzypow D.J. The role of the lamellar interface during torsional yielding of human cortical bone. J. Biomech. 32 (1999) 303-310
21. Yeni Y.N., Christopherson G.T., Turner A.S., Les C.M., and Fyhrie D.P. Apparent viscoelastic anisotropy as measured from nondestructive oscillatory tests can reflect the presence of a flaw in cortical bone. J. Biomed. Mater. Res., A 69 (2004) 124-130
22. Morgan E.F., Lee J.J., and Keaveny T.M. Sensitivity of multiple damage parameters to compressive overload in cortical bone. J. Biomech. Eng. 127 (2005) 557-562
23. Di Masso R.J., Font M.T., Capozza R.F., Detarsio G., Sosa F., and Ferretti J.L. Long-bone biomechanics in mice selected for body conformation. Bone 20 (1997) 539-545
24. Iscan M.Y., and Miller-Shaivitz P. Discriminant function sexing of the tibia. J. Forensic Sci. 29 (1984) 1087-1093
25. Turner R.T., Wakley G.K., and Hannon K.S. Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats. J. Orthop. Res. 8 (1990) 612-617
26. Wiren K.M., Zhang X.W., Toombs A.R., Kasparcova V., Gentile M.A., Harada S., et al. Targeted overexpression of androgen receptor in osteoblasts: unexpected complex bone phenotype in growing animals. Endocrinology 145 (2004) 3507-3522
27. Gordon K.R., Levy C., Perl M., and Weeks O.I. Experimental perturbation of the development of sexual size dimorphism in the mouse skeleton. Growth Dev. Aging 58 (1994) 95-104
28. Reilly D.T., and Burstein A.H. The elastic and ultimate properties of compact bone tissue. J. Biomech. 8 (1975) 393-405
29. Burstein A.H., Reilly D.T., and Martens M. Aging of bone tissue: mechanical properties. J. Bone Joint Surg. Am. 58 (1976) 82-86
30. McCalden R.W., McGeough J.A., Barker M.B., and Court-Brown C.M. Age-related changes in the tensile properties of cortical bone. The relative importance of changes in porosity, mineralization, and microstructure. J Bone Joint Surg Am 75 (1993) 1193-1205
31. Enlow, D.H. Principles of Bone Remodeling; An Account of Post-natal Growth and Remodeling Processes in Long Bones and the Mandible: Thomas; 1963.
32. Parfitt A.M. Age-related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences. Calcif. Tissue Int. 36 (1984) S123-S128
33. Melick R.A., and Miller D.R. Variations of tensile strength of human cortical bone with age. Clin. Sci. 30 (1966) 243-248
34. Evans F.G., and Riolo M.L. Relations between the fatigue life and histology of adult human cortical bone. J. Bone Joint Surg. Am. 52 (1970) 1579-1586
35. Wang X., Shen X., Li X., and Agrawal C.M. Age-related changes in the collagen network and toughness of bone. Bone 31 (2002) 1-7
36. Wang X., Li X., Shen X., and Agrawal C.M. Age-related changes of noncalcified collagen in human cortical bone. Ann. Biomed. Eng. 31 (2003) 1365-1371
37. Reid S.A., and Boyde A. Changes in the mineral density distribution in human bone with age: image analysis using backscattered electrons in the SEM. J. Bone Miner. Res. 2 (1987) 13-22
38. Garn S. The Earlier Gain and the Later Loss of Cortical Bone (1970), Charles C Thomas, Springfield, IL
39. Sumner D.R., and Andriacchi T.P. Adaptation to differential loading: comparison of growth-related changes in cross-sectional properties of the human femur and humerus. Bone 19 (1996) 121-126
40. Moro M., van der Meulen M.C., Kiratli B.J., Marcus R., Bachrach L.K., and Carter D.R. Body mass is the primary determinant of midfemoral bone acquisition during adolescent growth. Bone 19 (1996) 519-526
41. Ruff C. Growth in bone strength, body size, and muscle size in a juvenile longitudinal sample. Bone 33 (2003) 317-329
42. Forwood M.R., Bailey D.A., Beck T.J., Mirwald R.L., Baxter-Jones A.D., and Uusi-Rasi K. Sexual dimorphism of the femoral neck during the adolescent growth spurt: a structural analysis. Bone 35 (2004) 973-981
43. Frost H.M. Bone "mass" and the "mechanostat": a proposal. Anat. Rec. 219 (1987) 1-9
44. Ferretti J.L., Capozza R.F., Mondelo N., and Zanchetta J.R. Interrelationships between densitometric, geometric, and mechanical properties of rat femora: inferences concerning mechanical regulation of bone modeling. J. Bone Miner. Res. 8 (1993) 1389-1396
45. Currey J.D. Mechanical properties of bone tissues with greatly differing functions. J. Biomech. 12 (1979) 313-319
46. Jepsen K.J., Pennington D.E., Lee Y.L., Warman M., and Nadeau J. Bone brittleness varies with genetic background in A/J and C57BL/6J inbred mice. J. Bone Miner. Res. 16 (2001) 1854-1862
47. Tommasini S.M., Morgan T.G., van der Meulen M., and Jepsen K. Genetic variation in structure-function relationships for the inbred mouse lumbar vertebral body. J. Bone Miner. Res. 20 (2005) 817-827
48. Price C.P., Herman B.C., Lufkin T., Goldman H.M., and Jepsen K.J. Genetic variation in bone growth patterns defines adult mouse bone fragility. J. Bone Miner. Res. 20 (2005) 1983-1991
49. Swartz S.M., Bennett M.B., and Carrier D.R. Wing bone stresses in free flying bats and the evolution of skeletal design for flight. Nature 359 (1992) 726-729
50. Carrier D., and Leon L.R. Skeletal growth and function in the California gull (Larus californicus). J. Zool. (London) 222 (1990) 375-389
51. Brear K., Currey J.D., and Pond C.M. Ontogenetic changes in the mechanical properties of the femur of the polar bear Ursus maritimus. J. Zool. (London) 222 (1990) 49-58
52. Currey J.D. Effects of differences in mineralization on the mechanical properties of bone. Philos. Trans. R. Soc. Lond., B Biol. Sci. 304 (1984) 509-518
53. Turner C.H. Biomechanics of bone: determinants of skeletal fragility and bone quality. Osteoporos Int. 13 (2002) 97-104
54. Geusens P., Cantatore F., Nijs J., Proesmans W., Emma F., and Dequeker J. Heterogeneity of growth of bone in children at the spine, radius and total skeleton. Growth Dev. Aging 55 (1991) 249-256
55. Looker A.C., Beck T.J., and Orwoll E.S. Does body size account for gender differences in femur bone density and geometry?. J. Bone Miner. Res. 16 (2001) 1291-1299
56. Nieves J.W., Formica C., Ruffing J., Zion M., Garrett P., Lindsay R., et al. Males have larger skeletal size and bone mass than females, despite comparable body size. J. Bone Miner. Res. 20 (2005) 529-535
57. Friedl K.E., Nuovo J.A., Patience T.H., and Dettori J.R. Factors associated with stress fracture in young army women: indications for further research. Mil. Med. 157 (1992) 334-338
58. Beck T.J., Ruff C.B., Mourtada F.A., Shaffer R.A., Maxwell-Williams K., Kao G.L., et al. Dual-energy X-ray absorptiometry derived structural geometry for stress fracture prediction in male U.S. Marine Corps recruits. J. Bone Miner. Res. 11 (1996) 645-653
59. Taaffe D.R., Snow-Harter C., Connolly D.A., Robinson T.L., Brown M.D., and Marcus R. Differential effects of swimming versus weight-bearing activity on bone mineral status of eumenorrheic athletes. J. Bone Miner. Res. 10 (1995) 586-593
60. Petit M.A., Beck T.J., Shults J., Zemel B.S., Foster B.J., and Leonard M.B. Proximal femur bone geometry is appropriately adapted to lean mass in overweight children and adolescents. Bone 36 (2005) 568-576
61. Horber F.F., Gruber B., Thomi F., Jensen E.X., and Jaeger P. Effect of sex and age on bone mass, body composition, and fuel metabolism in humans. Nutrition 13 (1997) 524-534
62. Johnson L., Stradford H.T., Geis R.W., and Dineen J.R. Histogenesis of stress fractures. J. Bone Joint Surg. Am. 45 (1963) 1542
63. Burr D.B., Milgrom C., Boyd R.D., Higgins W.L., Robin G., and Radin E.L. Experimental stress fractures of the tibia. Biological and mechanical aetiology in rabbits. J. Bone Joint Surg. Br. 72 (1990) 370-375
64. Martin R. Mathematical model for repair of fatigue damage and stress fracture in osteonal bone. J. Orthop. Res. 13 (1995) 309-316
65. Lanyon L., and Skerry T. Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: a hypothesis. J. Bone Miner. Res. 16 (2001) 1937-1947
66. Milgrom C., Simkin A., Eldad A., Nyska M., and Finestone A. Using bone's adaptation ability to lower the incidence of stress fractures. Am. J. Sports Med. 28 (2000) 245-251
67. Warden S.J., Hurst J.A., Sanders M.S., Turner C.H., Burr D.B., and Li J. Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance. J. Bone Miner. Res. 20 (2005) 809-816