Alternate splicing of interleukin-1 receptor type II (IL1R2) in vitro correlates with clinical glucocorticoid responsiveness in patients with AIED

PLoS ONE

Volumn 4, Issue 4, 2009, Pages

  Vambutas, Andrea ^a,b   DeVoti, James ^b   Goldofsky, Elliot ^a   Gordon, Michael ^a   Lesser, Martin ^b   Bonagura, Vincent ^b  

^a North Shore LIJ Health System ^*  (United States)

^b FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DEXAMETHASONE; GLUCOCORTICOID; INTERLEUKIN 1 RECEPTOR TYPE II; PREDNISONE; RNA; IL1R2 PROTEIN, HUMAN;

ADULT; ALTERNATIVE RNA SPLICING; ARTICLE; AUTOIMMUNE DISEASE; CELL MEMBRANE; CELL STIMULATION; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE MARKER; DISEASE SEVERITY; DRUG MECHANISM; DRUG RESPONSE; EAR SURGERY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INNER EAR DISEASE; PERILYMPH; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; AGED; BIOSYNTHESIS; CASE CONTROL STUDY; DRUG EFFECT; FEMALE; GENETICS; IMMUNOLOGY; INFANT; MALE; MIDDLE AGED; MONONUCLEAR CELL; PERCEPTION DEAFNESS; PRESCHOOL CHILD;

ADULT; AGED; ALTERNATIVE SPLICING; AUTOIMMUNE DISEASES; CASE-CONTROL STUDIES; CHILD, PRESCHOOL; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; HEARING LOSS, SENSORINEURAL; HUMANS; INFANT; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PERILYMPH; RECEPTORS, INTERLEUKIN-1 TYPE II;

EID: 65549129527     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005293     Document Type: Article

References (46)

1. Ruckenstein MJ (2004) Autoimmune inner ear disease. Curr Opin Otolaryngol Head Neck Surg 12: 426-430.
2. Ryan AF, Harris JP, Keithley EM (2002) Immune-mediated hearing loss: basic mechanisms and options for therapy. Acta Otolaryngol Supp 548: 38-43.
3. Niparko JK, Wang NY, Rauch SD, Russell GB, Espeland MA, et al. (2005) Serial audiometry in a clinical trial of AIED treatment. Otol Neurotol 26: 908-917.
4. McCabe BF (1979) Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol 88: 585-589.
5. Harris JP, Weissman MH, Derebery JM, Espeland MA, Gantz BJ, et al. (2003) Treatment of corticosteroid-responsive autoimmune inner ear disease with methotrexate: a randomized controlled trial. JAMA 290: 1875-1883.
6. Broughton SS, Meyerhoff WE, Cohen SB (2004) Immune mediated inner ear disease: 10-year experience. Semin Arthritis Rheum 34: 544-548.
7. Cohen S, Shoup A, Weisman MH, Harris J (2005) Etanercept treatment for autoimmune inner ear disease: results of a pilot placebo-controlled study. Otol Neurotol 26: 903-907.
8. Berrocal JR, Ramirez-Camacho R (2002) Sudden sensorineural hearing loss: supporting the immunologic theory. Ann Otol Rhinol Laryngol 11: 989-997.
9. Park SN, Yeo SW, Park KH (2006) Serum heat shock protein 70 and its correlation with clinical characteristics in patients with sudden sensorineural hearing loss. Laryngoscope 116: 121-125.
10. Amor-Dorado JC, Paco L, Martin J, Lopez-Nevot MA, Gonzalez-Gay MA (2005) Human leukocyte antigen-DQB1 and -DRB1 associations in patients with idiopathic sudden sensorineural hearing loss from a defined population of Northwest Spain2005. Acta Otolaryngol 125: 1277-1282.
11. Zantut-Wittmann DE, Persoli L, Tambascia MA, Fischer E, Franco Maldonado D, et al. (2004) HLA-DRB1*04 and HLA-DQB1*03 association with the atrophic but not with the goitrous form of chronic autoimmune thyroiditis in a Brazilian population. Horm Metab Res 36: 492-500.
12. Alsaeid K, Alawadhi A, Al-Saeed O, Haider MZ (2006) Human leukocyte antigen DRB1*04 is associated with rheumatoid arthritis in Kuwaiti patients. Joint Bone Spine 73: 62-65.
13. Agrup C, Luxon LM (2006) Immune mediated inner-ear disorders in neuro-otology. Cur Opin Neurol 19: 26-32.
14. Moscicki RA, San Martin JE, Quintero CH, Rausch SD, Nadol JB, et al. (1994) Serum antibody to inner ear proteins in patients with progressive hearing loss. Correlation with disease activity and response to corticosteroid treatment. JAMA 272: 611-616.
15. Zeitoun H, Beckman JG, Arts HA, Lansford CD, Lee DS, et al. (2005) Corticosteroid response and supporting cell antibody in autoimmune hearing loss. Arch Otolaryngol Head Neck Surg 131: 665-672.
16. Yeom K, Gray J, Nair TS, Arts HA, Telian SA, et al. (2003) Antibodies to HSP-70 in normal donors and autoimmune hearing loss patients. Laryngoscope 113: 1770-1776.
17. Trune DR, Kempton JB, Mitchell CR, Hefeneider SH (1998) Failure of elevated heat shock protein 70 antibodies to alter cochlear function in mice. Hear Res 116: 65-70.
18. Gloddek B, Arnold W (2002) Clinical and experimental studies of autoimmune inner ear disease. Acta Otolaryngol Suppl 548: 10-14.
19. Iwai HTK, Tomoda K, Sugiura K, Inaba M, Ikehara S, et al. (1999) T cells infiltrating from the systemic circulation proliferate in the endolymphatic sac. Ann Otol Rhinol Laryngol 108: 1146-1150.
20. Hashimoto S, Billings P, Harris JP, Firestein GS, Keithley EM (2005) Innate Immunity Contributes to Cochlear Adaptive Immune Responses. Audiology & Neurotology 10: 35-43.
21. Solares CA, Edling AE, Johnson JM, Baek MJ, Hirose K, et al. (2004) Murine autoimmune hearing loss mediated by CD4+ T cells specific for inner ear peptides. J Clin Invest 113: 1210-1217.
22. Lorenz RR, Solares CA, Williams P, Sikora J, Pelfrey CM, et al. (2002) Interferon-gamma production to inner ear antigens by T cells from patients with autoimmune sensorineural hearing loss. J Neuroimmunol 130: 173-178.
23. Matsuki T, Nakae S, Sudo K, Horai R, Iwakura Y (2006) Abnormal T cell activation caused by the imbalance of IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis. Int Immunol 18: 399-407.
24. Reefhuis J, Honein MA, Whitney CG, Chamany S, Mann EA, et al. (2003) Risk of bacterial meningitis in children with cochlear implants. NEJM 349: 435-445.
25. Liu C, Hart RP, Liu XJ, Clevenger W, Maki RA, et al. (1996) Cloning and characterization of an alternativly processed human type II interleukin-1 receptor mRNA. J Biol Chem 271: 20965-20972.
26. Orlando S, Sironi M, Bianchi G, Drummond AH, Boraschi D, et al. (1997) Role of metalloproteases in the release of the IL-1 type 2 decoy receptor. J Biol Chem 272: 31764-31769.
27. Cui X, Rouhani FN, Hawani F, Levine SJ (2003) Shedding of the type II IL-1 decoy receptor requires a functional aminopeptidase, aminopeptidase regulator of TNF receptor type 1 shedding. J Immunol 171: 6814-6819.
28. Penton-Rol G, Orlando S, Polentarutti N, Bernasconi S, Muzio M, et al. (1999) Bacterial lipopolysaccharide causes rapid shedding, followed by inhibition of mRNA expression, of the IL-1 type II receptor, with concommitant upregulation of the type I receptor and induction of incompletely spliced transcripts. J Immunol 162: 2931-2938.
29. Neumann D, Kollewe C, Martin MU, Boraschi D (2000) The membrane bound form of the type II IL-1 receptor accounts for inhibitiory function. J Immunol 165: 3350-3357.
30. Mantovani A, Muzio M, Ghezzi P, Colotta C, Introna M (1998) Regulation of Inhibitory Pathways of the Interleukin-1 System. Ann NY Acad Sci 840: 338-351.
31. Mantovani A, Bonecchi R, Martinez FO, Galliera E, Perrier P, et al. (2003) Tuning of innate immunity and polarized responses by decoy receptors. Int Arch Allergy Immunol 132: 109-115.
32. Coletta F, Re F, Muzio M, Bertini R, Polentarutti N, et al. (1993) Interleukin-1 type 2 receptor: a decoy target for IL-1 that is regulated by IL-4. Science 261: 472-475.
33. Dickensheets HL, Donnelly RP (1997) IFN-gamma and IL-10 inhibit induction of the IL-1 receptor type I and II gene expression by IL-4 and IL-13 in human monocytes. J Immunol 159: 6226-6233.
34. Docagne F, Campbell SJ, Bristow AF, Poole S, Vigues S, et al. (2005) Differential regulation of type I and type 2 interleukin-1 receptors in focal brain inflammation. Eur J Neurosci 21: 1205-1214.
35. Bessis N, Guery L, Mantovani A, Vecchi A, Sims JE, et al. (2000) The type 2 decoy receptor of IL-1 inhibits murine collagen-induced arthritis. Eur J Immunol 30: 867-875.
36. Attur MG, Dave MN, Leung MY, Cipolletta C, Meseck M, et al. (2002) Functional genomic analysis of type 2 IL-1beta decoy receptor: potential for gene therapy in human arthritis and inflammation. J Immunol 168: 2001-2010.
37. Colotta F, Saccani S, Giri JG, Dower SK, Sims JE, et al. (1996) Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes. J Immunol 156: 2534-2541.
38. Re F, Muzio M, De Rossi M, Polentarutti N, Giri JG, et al. (1994) They type II "Receptor" as a decoy target for interleukin 1 in polymorphnuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor. J Exp Med 179: 739-743.
39. Brown EA, Dare HA, Marsh CB, Wewers MD (1996) The combination of endotoxin and dexamethasone induces type 2 interleukin I receptor (IL-1R2) in monocytes: a comparison to interleukin 1 beta (IL-1 beta) and interleukin 1 receptor antagonsist (IL-1ra). Cytokine 8: 828-836.
40. Auboeuf D, Honig A, Berget SM, O'Malley BW (2002) Coordinate regulation of transcription and splicing by steroid receptor coregulators. Science 298: 416-419.
41. Kozyrev SV, Abelson AK, Wojcik J, Zaghlool A, Linga Reddy MV, et al. (2008) Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus. Nature Genetics 40: 211-216.
42. Mirault T, Launay D, Cuisset L, Hachulla E, Lambert M, et al. (2006) Recopvery from deafness in a patient with Muckle-Wells syndrome treated with anakinra. Arthritis Rheum 54: 1697-1700.
43. Yamazaki T, Masumoto J, Agematsu K, Sawai N, Kobayashi S, et al. (2008) Anakinra improves sensory deafness in a japanese patient with Muckle-Wells syndrome, possibly inhibiting the cryopyrin inflammasome. Arthritis Rheum 58: 864-868.
44. Hirose K, Discolo CM, Keasler JR, Ransohoff R (2005) Mononuclear phagocytes migrate into the murine cochlea after acoustic trauma. J Comp Neurol 489: 180-194.
45. Fujioka M, Kanzaki S, Okano HJ, Masuda M, Ogawa K, et al. (2006) Proinflammatory cytokines expression in noise-induced damaged cochlea. J Neurosci Res 83: 575-583.
46. Wuorimaa T, Kayhty H, Eskola J, Bloigu A, Leroy O, Surcel HM (2001) Activation of cell mediated immunity following immunization with pneumococcal conjugate or polysaccharide vaccine. Scand J Immunol 53: 422-428.