Immune-mediated inner-ear disorders in neuro-otology

Current Opinion in Neurology

Volumn 19, Issue 1, 2006, Pages 26-32

  Ågrup, Charlotte ^a,b   Luxon, Linda M ^a  

^a NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Antibodies; Autoimmune; Hearing loss; Immune mediated; Vestibular dysfunction

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; BETA ACTIN; C REACTIVE PROTEIN; CARDIOLIPIN ANTIBODY; CELL DENSITY ENHANCHED PROTEIN TYROSINE PHOSPHATASE 1; CHOLINE TRANSPORTER LIKE PROTEIN 2; COCHLIN; COLLAGEN TYPE 2; COLLAGEN TYPE 9; CONNEXIN 26; CORTICOSTEROID; DOUBLE STRANDED DNA ANTIBODY; ENDOTHELIAL CELL ANTIBODY; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOSUPPRESSIVE AGENT; MYELIN PROTEIN; NEUTROPHIL CYTOPLASMIC ANTIBODY; PHOSPHOLIPID ANTIBODY; PROTEIN; RAF PROTEIN; RHEUMATOID FACTOR; THYROID ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY PRODUCTION; ANTIPHOSPHOLIPID SYNDROME; AUTOIMMUNE DISEASE; BEHCET DISEASE; CHICK; CHRONIC OTITIS MEDIA; CLINICAL FEATURE; COGAN SYNDROME; CORTICOSTEROID THERAPY; DIAGNOSTIC PROCEDURE; DIAGNOSTIC TEST; DISEASE ASSOCIATION; ERYTHROCYTE SEDIMENTATION RATE; GUINEA PIG; HASHIMOTO DISEASE; HEMATURIA; HUMAN; IMMUNOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INNER EAR; INNER EAR DISEASE; MENIERE DISEASE; NONHUMAN; OTORHINOLARYNGOLOGY; PATHOGENESIS; PERCEPTION DEAFNESS; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; PROTEINURIA; REVIEW; RHEUMATOID ARTHRITIS; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; THROMBOCYTE COUNT; THYROID DISEASE; THYROIDITIS; TUBERCULIN TEST; VESTIBULAR DISORDER; WEGENER GRANULOMATOSIS;

EID: 31644449684     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wco.0000194143.02171.46     Document Type: Review

References (66)

1. Lehnhardt E. Sudden hearing disorders occurring simultaneously or successively on both sides [in German]. Z Laryngol Rhinol Otol 1958; 37:1-16.
2. McCabe BF. Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol 1979; 88:585-590.
3. Mogi G, Lim D, Watanabe N. Immunologic study on the inner ear. Immunoglobulins in perilymph. Arch Otol 1982; 108:270-275.
4. Stearns GS, Keithley EM, Harris JP. Development of high endothelial venule-like characteristics in the spiral modiolar vein induced by viral labyrinthitis. Laryngoscope 1993; 103:890-898.
5. Hashimoto S, Billings P, Harris JP, et al. Innate immunity contributes to cochlear adaptive immune responses. Audiol Neurootol 2005; 10:35-43. This article suggests involvement of the innate immune system in the establishment of an inner ear immune response. An interesting experimental study.
6. Veldman JE, Roord JJ, O'Connor AF, Shea JJ. Autoimmunity and inner ear disorders; an immune-complex mediated sensorineural hearing loss. Laryngoscope 1984; 94:501-507.
7. Harris JP, Sharp PA. Inner ear autoantibodies in patients with rapidly progressive SNHL. Laryngoscope 1990; 100:516-524.
8. Solares CA, Hughes GB, Tuohy VK. Autoimmune sensorineural hearing loss: an immunologic perspective. J Neuroimm 2003; 138:1-7.
9. Solares CA, Edling AE, Johnson JM, et al. Murine autoimmune hearing loss mediated by CD4+ T cells specific for inner ear peptides. J Clin Invest 2004; 113:1210-1217. An excellent experimental study showing evidence that T cells specific for the inner-ear proteins cochlin and β-tectorin mediate experimental autoimmune hearing loss. Results support that autoimmune sensorineural hearing loss may be a T cell-dependent autoimmune disorder of the inner ear.
10. Helfgott SM, Mosciscki RA, San Martin J, et al. Correlation between antibodies to type II collagen and treatment outcome in bilateral progressive sensorineural hearing loss. Lancet 1991; 337:387-389.
11. Suzuki M, Krug M, Cheng K-C, et al. Antibodies against inner-ear proteins in the sera of patients with inner-ear diseases. ORL J Otorhindaryngol Relat Spec 1997; 59:10-17.
12. Boulassel MR, Tomasi JP, Deggouj N, Gersdorff M. Identification of β-actin as a candidate autoantigen in autoimmune inner ear disease. Clin Otolaryngol 2000; 25:535-541.
13. Cheng KC, Matsuoka H, Lee KM, et al. Proto-oncogene Raf-1 as an autoantigen in Meniere's disease. Ann Otol Rhinol Laryngol 2000; 109:1093-1098.
14. Boulassel MR, Deggouj N, Tomasi JP, Gersdorff M. Inner ear autoantibodies and their targets in patients with autoimmune inner ear disease. Acta Otolaryngol 2001; 121:28-34.
15. Gong S-S, Yu D-Z, Wang J-B. Relationship between three inner ear antigens with different molecular weights and autoimmune inner ear disease. Acta Otolaryngol 2002; 122:5-9.
16. Yoo TJ, Du X, Kwon SS. Molecular mechanism of autoimmune hearing loss. Acta Otolaryngol Suppl 2002; 548:3-9.
17. Garcia-Berrocal JR, Ramirez-Camacho R, Trinidad A, et al. Controversies and criticisms on designs for experimental autoimmune labyrinthitis. Ann Otol Rhinol Laryngol 2004; 113:404-410. This article compares experimental animal models previously employed to study autoimmune labyrinthitis. Possible anatomical targets of autoantibodies in autoimmune hearing loss are discussed and an immune-complex-/IgG-mediated pathogenesis is suggested.
18. Gloddek B, Gloddek J, Arnold W. A rat T-cell line that mediates autoimmune disease of the inner ear in the Lewis rat. ORL J Otorhinolaryngol Relat Spec 1999; 61:181-187.
19. Ikezono T, Tomiyama S, Pawankar R, et al. Passive transfer of experimental labyrinthitis. Audiol Neurootol 2000; 5:292-299.
20. Lunardi C, Bason C, Leandri M, et al. Autoantibodies to inner ear and endothelial antigens in Cogan's syndrome. Lancet 2002; 360:915-921.
21. Nair TS, Kozma KE, Hoefling NL, et al. Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss. J Neurosci 2004; 18:1772-1779. Excellent experimental study suggesting that choline transporter-like protein 2 is a target of antibody-mediated hearing loss. Results indicate that antibody binding disturbs the function of this molecule and that proper function of choline transporter-like protein 2 is required for hair-cell survival.
22. Zeitoun H, Beckham JG, Arts HA, et al. Corticosteroid response and supporting cell antibody in auroimmune hearing loss. Arch Otolaryngol Head Neck Surg 2005; 131:665-672.
23. Arbusow V, Strupp M, Dieterich M, et al. Serum antibodies against membranous labyrinth in patients with "idiopathic" bilateral vestibulopathy. Neurology 1998; 245:132-136.
24. Schüler O, Strupp M, Arbusow V, Brandt T. A case of possible autoimmune bilateral vestibolupathy treated with steroids. J Neurol Neurosurg Psychiatry 2003; 74:825.
25. Ten Cate WJ, Bachor E. Autoimmune-mediated sympathetic hearing loss: a case report. Otol Neurotol 2005; 26:161-165. An interesting case report on immune-mediated sympathetic hearing loss suggesting that preexisting hearing loss may predispose to sympathetic hearing loss.
26. Schindler JS, Niparko JK. Imaging quiz case 1: transverse temporal bone fractures (left) with subsequent progressive SNHL, consistent with sympathetic cochleolabyrinthitis. Arch Otolaryngol Head Neck Surg 1998; 124:814-818.
27. Richards ML, Moorehead JE, Antonelli PJ. Sympathetic cochleolabyrinthitis in revision stapedectomy surgery. Otolaryngol Head Neck Surg 2002; 126:273-280.
28. Hughes GB, Barna BP, Kinney SE, et al. Clinical diagnosis of immune inner-ear disease. Laryngoscope 1988; 98:251-253.
29. Kanzaki J. Diagnostic criteria for acute profound deafness. Acta Otolaryngol (Stockh) Suppl 1994; 514:7-8.
30. Kastanioudakis I, Ziavra N, Politi EN, et al. Hearing loss in progressive systemic sclerosis patients a comparative study. Otolaryngol Head Neck Surg 2001; 124:522-525.
31. Erdinç AK, Harputluoglu U, Oghan F, Baykal B. Behcet's disease and hearing loss. Auris Nasus Larynx 2004; 31:29-33.
32. Baumann A, Helbling A, Oertle S, et al. Cogan's syndrome: clinical evolution of deafness and vertigo in three patients. Eur Arch Otorhinolaryngol 2005; 262:45-49. Article based on three patients with Cogan's syndrome. Auditory and ophthalmological pathologies are described beautifully.
33. Schulz P, Arbusow V, Strupp M, et al. Sympathetic contralateral vestibulopathy after unilateral zoster oticus. J Neurol Neurosurg Psychiatry 1999; 66:672-676.
34. Rinne T, Bronstein AM, Rudge P, et al. Bilateral loss of vestibular function: clinical findings in 53 patients. J Neurol 1998; 245:314-321.
35. Mathews J, Kumar BN. Autoimmune sensorineural hearing loss. Clin Otolaryngol 2003; 28:479-488.
36. Nuti D, Biagini C, Salerni L, et al. Use of mammalian inner ear antigens for the diagnosis of autoimmune sudden loss of vestibular function. Acta Otolaryngol Suppl 2002; 548:34-37.
37. Passali D, Damiani V, Mora P, et al. P0 antigen detection in sudden hearing loss and Meniere's disease: a new diagnostic marker? Acta Otolaryngol 2004; 124:1145-1148.
38. Yoo TJ, Shea J Jr, Ge X, et al. Presence of autoantibodies in the sera of Meniere's disease. Ann Otol Rhinol Laryngol 2001; 110:425-429.
39. Riente L, Bongiorni F, Nacci A, et al. Antibodies to inner ear antigens in Meniere's disease. Clin Exp Immunol 2004; 135:159-163.
40. Mouadeb DB, Ruckenstein MJ. Antiphospholipid inner ear syndrome. Laryngoscope 2005; 115:879-883.
41. Sobin A, Anniko M, Flock A. Rods of actin filaments in type I hair cells of the shaker-2 mouse. Arch Otorhinolaryngol 1982; 236:1-6.
42. Boulassel MR, Tomasi JP, Deggouj N, Gersdorff M. COCH5B2 is a target antigen of anti-inner ear antibodies in autoimmune inner ear diseases. Otol Neurotol 2001; 22:614-618.
43. Nair TS, Prieskorn DM, Miller JM, et al. In vivo binding and hearing loss after intracochlear infusion of KHRI-3 antibody. Hear Res 1997; 107:93-101.
44. Nair TS, Prieskorn DM, Miller JM, et al. KHRI-3 monoclonal antibody-induced damage to the inner ear: antibody staining of nascent scars. Hear Res 1999; 129:50-60.
45. Agrup C, Keir G, Thompson EJ, Bronstein AM. Systemic autoantibodies against discrete inner ear compartments in bilateral vestibular loss. Neurology 2005; 65:167. Study using discrete inner-ear tissues as antigens to investigate the presence of systemic autoantibodies in two patients with BIVF.
46. Moscicki RA, San Martin JE, Quintero C, et al. Serum antibody to inner ear proteins in patients with progressive hearing loss. Correlation with disease activity and response to corticosteroid treatment. J Am Med Assoc 1994; 272:611-616.
47. Billings PB, Keithley EM, Harris JP. Evidence linking the 68 kilodalton antigen identified in progressive sensorineural hearing loss patient sera with heat shock protein 70. Ann Otol Rhinol Laryngol 1995; 104:181-188.
48. Bloch DB, San Martin JE, Rauch SD, et al. Serum antibodies to heat shock protein 70 in sensorineural hearing loss. Arch Otolaryngol Head Neck Surg 1995; 121:1167-1171.
49. Trune DR, Kempton JB, Mitchell CR, Hefeneider SH. Failure of elevated heat shock protein 70 antibodies to alter cochlear function in mice. Hear Res 1998; 116:65-70.
50. Yeom K, Gray J, Nair TS, et al. Antibodies to HSP-70 in normal donors and autoimmune hearing loss patients. Laryngoscope 2003; 113:1770-1776.
51. Samuelsson A-K, Hyden D, Roberg M, Skogh T. Evaluation of Anti-hsp70 antibody screening in sudden deafness. Ear Hearing 2003; 24:233-235.
52. Ottaviani F, Cadoni G, Marinelli L, et al. Anti-endothelial autoantibodies in patients with sudden hearing loss. Laryngoscope 1999; 109:1084-1087.
53. Loveman DM, de Comarmond C, Cepero R, Baldwin DM. Autoimmune sensorineural hearing loss: clinical course and treatment outcome. Semin Arthritis Rheum 2004; 34:538-543.
54. Toubi E, Ben-David J, Kessel A, et al. Immune-mediated disorders associated with idiopathic sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol 2004; 113:445-449. Study investigating the presence of tissue-non-specific antibodies in sera from 51 patients presenting with idiopathic sudden sensorineural hearing loss.
55. Maguchi S, Fukuda S, Chida E, Terayama Y. Myeloperoxidase-antineutrophil cytoplasmic antibody-associated sensorineural hearing loss. Auris Nasus Larynx 2001; 28:3103-8106.
56. Cadoni G, Fetoni AR, Agostino S, et al. Autoimmunity in sudden sensorineural hearing loss: possible role of anti-endothelial cell autoantibodies. Acta Otolaryngol Suppl 2002; 548:30-33.
57. Hughes GB, Barna BP, Kinney SE, et al. Predictive value of laboratory tests in "autoimmune" inner ear disease: preliminary report. Laryngoscope 1986; 96:502-505.
58. Soliman AM. Immune-mediated inner ear disease. Am J Otol 1992; 13:575-579.
59. Hirose K, Wener MH, Duckert LG. Utility of laboratory testing in autoimmune inner ear disease. Laryngoscope 1999; 109:1749-1754.
60. Arnold W, Pfaltz CR. Critical evaluation of the immunofluorescence microscopic test for identification of serum antibodies against human inner ear tissue. Acta Otolaryngol (Stockh) 1987; 103:373-378.
61. Berger P, Koja S, Rogowski M, et al. The lymphocyte transformation test for detecting immunologic inner ear deafness. HNO 1989; 37:153-157.
62. Soliman AM. Autoantibodies in inner ear disease. Acta Otolaryngol 1997; 117:501-505.
63. Garcia Berrocal JR, Ramirez-Camacho R, Arellano B, Vargas JA. Validity of the Western blot immunoassay for heat shock protein-70 in associated and isolated immunorelated inner ear disease. Laryngoscope 2002; 112:304-309.
64. Munari L, Charchat S, Rodrigues L, et al. An ELISA serum assay for autoantibodies to HSP70 in immune-mediated hearing loss. J Immunol Methods 2003; 283:155-161.
65. Solares CA, Tuohy VK. ELISPOT determination of interferon-gamma T-cell frequencies in patients with autoimmune sensorineural hearing loss. Methods Mol Biol 2005; 302:253-260. This article describes a method for measuring frequencies of interferon-γ-producing cells, which may be useful in supporting the diagnosis of autoimmune inner-ear disorders.
66. Mazlumzadeh M, Lowe VJ, Mullan BP, et al. The utility of positron emission tomography in the evaluation of autoimmune hearing loss. Otol Neurotol 2003; 24:201-204.