Modelling the interdependence between the stoichiometry of receptor oligomerization and ligand binding for a coexisting dimer/tetramer receptor system

British Journal of Pharmacology

Volumn 156, Issue 1, 2009, Pages 28-35

  Rovira, X ^b   Vivo M ^c   Serra, J ^b   Roche, D ^b   Strange, P G ^c   Giraldo, J ^a,b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b INSTITUT DE NEUROCIÈNCIES   (Spain)

^c UNIVERSITY OF READING   (United Kingdom)

Author keywords

Binding capacity; Cell surface receptor expression; G protein coupled receptors; Ligand binding; Oligomerization; Receptor dimerization

Indexed keywords

DIMER; G PROTEIN COUPLED RECEPTOR; METABOTROPIC RECEPTOR; TETRAMER; LIGAND;

BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; DIMERIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIGAND BINDING; MATHEMATICAL MODEL; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DENSITY; RECEPTOR OCCUPANCY; REVIEW; STOICHIOMETRY; ANIMAL; BIOLOGICAL MODEL; DRUG ANTAGONISM; GENETICS; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; LIGANDS; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 65549121608     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2008.00031.x     Document Type: Review

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