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Volumn 22, Issue 3, 2009, Pages 256-263

Management of paediatric HIV-1 resistance

Author keywords

Aantiretroviral; Children; HIV; Resistance

Indexed keywords

ABACAVIR; AMPRENAVIR; AMPRENAVIR PHOSPHATE; ATAZANAVIR; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; DARUNAVIR; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; ENFURVITIDE; INTEGRASE INHIBITOR; LAMIVUDINE; LAMIVUDINE PLUS NEVIRAPINE PLUS STAVUDINE; LAMIVUDINE PLUS ZIDOVUDINE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; NELFINAVIR; NEVIRAPINE; PEDIMUNE BABY; PEDIMUNE JUNIOR; PROTEINASE INHIBITOR; RIFAMPICIN; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; TENOFOVIR; TIPRANAVIR; UNCLASSIFIED DRUG; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

EID: 65549118631     PISSN: 09517375     EISSN: 14736527     Source Type: Journal    
DOI: 10.1097/QCO.0b013e3283298f1f     Document Type: Review
Times cited : (24)

References (65)
  • 1
    • 33646773540 scopus 로고    scopus 로고
    • Collaborative HIV Paediatric Study. Outcomes for human immunodeficiency virus-1-infected infants in the United Kingdom and Republic of Ireland in the era of effective antiretroviral therapy
    • Doerholt K, Duong T, Tookey P, et al., Collaborative HIV Paediatric Study. Outcomes for human immunodeficiency virus-1-infected infants in the United Kingdom and Republic of Ireland in the era of effective antiretroviral therapy. Pediatr Infect Dis J 2006; 25:420-426.
    • (2006) Pediatr Infect Dis J , vol.25 , pp. 420-426
    • Doerholt, K.1    Duong, T.2    Tookey, P.3
  • 2
    • 0242288797 scopus 로고    scopus 로고
    • Gibb DM, Duong T, Tookey PA, et al., National Study of HIV in Pregnancy and Childhood Collaborative HIV Paediatric Study. Decline in mortality, AIDS, and hospital admissions in perinatally HIV-1 infected children in the United Kingdom and Ireland. BMJ 2003; 327:1019; Erratum in BMJ 2004; 328:686.
    • Gibb DM, Duong T, Tookey PA, et al., National Study of HIV in Pregnancy and Childhood Collaborative HIV Paediatric Study. Decline in mortality, AIDS, and hospital admissions in perinatally HIV-1 infected children in the United Kingdom and Ireland. BMJ 2003; 327:1019; Erratum in BMJ 2004; 328:686.
  • 3
    • 0035936007 scopus 로고    scopus 로고
    • Impact of introduction of protease inhibitor therapy on reductions in mortality among children and youth infected with HIV-1
    • Gortmaker S, Hughes M, Oyomopito R, et al. Impact of introduction of protease inhibitor therapy on reductions in mortality among children and youth infected with HIV-1. N Engl J Med 2001; 345:1522-1528.
    • (2001) N Engl J Med , vol.345 , pp. 1522-1528
    • Gortmaker, S.1    Hughes, M.2    Oyomopito, R.3
  • 4
    • 0034641328 scopus 로고    scopus 로고
    • Reduction in mortality with availability of antiretroviral therapy for children with perinatal HIV-1 infection
    • De Martino MM, Tovo PA, Balducci M, et al. Reduction in mortality with availability of antiretroviral therapy for children with perinatal HIV-1 infection. JAMA 2000; 284:190-197.
    • (2000) JAMA , vol.284 , pp. 190-197
    • De Martino, M.M.1    Tovo, P.A.2    Balducci, M.3
  • 5
    • 0142089125 scopus 로고    scopus 로고
    • Impact of HAART on the survival and disease progression in HIV-1-infected children
    • Sanchez-Granados J, Ramos JT, Rojo P, et al. Impact of HAART on the survival and disease progression in HIV-1-infected children. Pediatr Infect Dis J 2003; 22:863-867.
    • (2003) Pediatr Infect Dis J , vol.22 , pp. 863-867
    • Sanchez-Granados, J.1    Ramos, J.T.2    Rojo, P.3
  • 7
    • 4043162723 scopus 로고    scopus 로고
    • PENTA Steering Committee. PENTA guidelines for the use of antiretroviral therapy, 2004
    • Sharland M, Blanche S, Castelli G, et al., PENTA Steering Committee. PENTA guidelines for the use of antiretroviral therapy, 2004. HIV Med 2004; 5 (Suppl 2):61-86.
    • (2004) HIV Med , vol.5 , Issue.SUPPL. 2 , pp. 61-86
    • Sharland, M.1    Blanche, S.2    Castelli, G.3
  • 8
    • 0003487632 scopus 로고    scopus 로고
    • Working Group on Antiretroviral Therapy and Medical Management of HIV-Infected Children, Available at, Accessed 12 January 2008
    • Working Group on Antiretroviral Therapy and Medical Management of HIV-Infected Children. Guidelines for the use of antiretroviral agents in pediatric HIV infection. Available at http://aidsinfo.nih.gov/OrderPublication/ OrderPubsBrowseSearchResultsTable.aspx?MenuItem=AIDSinfoTools&ID=115. [Accessed 12 January 2008]
    • Guidelines for the use of antiretroviral agents in pediatric HIV infection
  • 9
    • 2442670578 scopus 로고    scopus 로고
    • Viral load and disease progression in infants infected with human immunodeficiency virus type 1. Women and Infants Transmission Study Group
    • Shearer WT, Quinn TC, LaRussa P, et al. Viral load and disease progression in infants infected with human immunodeficiency virus type 1. Women and Infants Transmission Study Group. N Engl J Med 1997; 336:1337-1342.
    • (1997) N Engl J Med , vol.336 , pp. 1337-1342
    • Shearer, W.T.1    Quinn, T.C.2    LaRussa, P.3
  • 10
    • 17344372636 scopus 로고    scopus 로고
    • Abrams EJ, Weedon J, Steketee RW, et al. Association of human immunodeficiency virus (HIV) load early in life with disease progression among HIV-infected infants. New York City Perinatal HIV Transmission Collaborative Study Group. J Infect Dis 1998; 178:101-810; 11.
    • Abrams EJ, Weedon J, Steketee RW, et al. Association of human immunodeficiency virus (HIV) load early in life with disease progression among HIV-infected infants. New York City Perinatal HIV Transmission Collaborative Study Group. J Infect Dis 1998; 178:101-810; 11.
  • 11
    • 33646927843 scopus 로고    scopus 로고
    • Collaborative HIV Paediatric Study Steering Committee. Underdosing of antiretrovirals in UK and Irish children with HIV as an example of problems in prescribing medicines to children, 1997-2005: Cohort study
    • Menson EN, Walker AS, Sharland M, et al., Collaborative HIV Paediatric Study Steering Committee. Underdosing of antiretrovirals in UK and Irish children with HIV as an example of problems in prescribing medicines to children, 1997-2005: cohort study. BMJ 2006; 332:1183-1187.
    • (2006) BMJ , vol.332 , pp. 1183-1187
    • Menson, E.N.1    Walker, A.S.2    Sharland, M.3
  • 12
    • 0036488217 scopus 로고    scopus 로고
    • Efficacy of highly active antiretroviral therapy in HIV-1 infected children
    • van Rossum AM, Fraaij PL, de Groot R. Efficacy of highly active antiretroviral therapy in HIV-1 infected children. Lancet Infect Dis 2002; 2:93-102.
    • (2002) Lancet Infect Dis , vol.2 , pp. 93-102
    • van Rossum, A.M.1    Fraaij, P.L.2    de Groot, R.3
  • 13
    • 49849095857 scopus 로고    scopus 로고
    • Collaboration of Observational HIV Epidemiological Research Europe (COHERE) Study Group. Response to combination antiretroviral therapy: variation by age. AIDS 2008; 22:1463-1473. This paper importantly showed that children do not respond as well as adults to first-line HAART.
    • Collaboration of Observational HIV Epidemiological Research Europe (COHERE) Study Group. Response to combination antiretroviral therapy: variation by age. AIDS 2008; 22:1463-1473. This paper importantly showed that children do not respond as well as adults to first-line HAART.
  • 14
    • 20844446474 scopus 로고    scopus 로고
    • Efficacy of highly active antiretroviral therapy in HIV-infected children participating in Thailand's National Access to Antiretroviral Program
    • Puthanakit T, Oberdorfer A, Akarathum N, et al. Efficacy of highly active antiretroviral therapy in HIV-infected children participating in Thailand's National Access to Antiretroviral Program. Clin Infect Dis 2005; 41:100-107.
    • (2005) Clin Infect Dis , vol.41 , pp. 100-107
    • Puthanakit, T.1    Oberdorfer, A.2    Akarathum, N.3
  • 15
    • 48749107884 scopus 로고    scopus 로고
    • Adjé-Touré C, Hanson DL, Talla-Nzussouo N, et al. Virologic and immunologic response to antiretroviral therapy and predictors of HIV type 1 drug resistance in children receiving treatment in Abidjan, Côte d'Ivoire. AIDS Res Hum Retroviruses 2008; 24:911-917. This work provided data on resistance following first-line failure in a setting without regular viral load monitoring.
    • Adjé-Touré C, Hanson DL, Talla-Nzussouo N, et al. Virologic and immunologic response to antiretroviral therapy and predictors of HIV type 1 drug resistance in children receiving treatment in Abidjan, Côte d'Ivoire. AIDS Res Hum Retroviruses 2008; 24:911-917. This work provided data on resistance following first-line failure in a setting without regular viral load monitoring.
  • 16
    • 29444451897 scopus 로고    scopus 로고
    • Genotypic human immunodeficiency virus type 1 drug resistance in highly active antiretroviral therapy-treated children in Abidjan, Côte d'Ivoire
    • Chaix ML, Rouet F, Kouakoussui KA, et al. Genotypic human immunodeficiency virus type 1 drug resistance in highly active antiretroviral therapy-treated children in Abidjan, Côte d'Ivoire. Pediatr Infect Dis J 2005; 24:1072-1076.
    • (2005) Pediatr Infect Dis J , vol.24 , pp. 1072-1076
    • Chaix, M.L.1    Rouet, F.2    Kouakoussui, K.A.3
  • 17
    • 57049168210 scopus 로고    scopus 로고
    • HIV type 1 subtype C drug resistance among pediatric and adult South African patients failing antiretroviral therapy
    • Pillay V, Pillay C, Kantor R, et al. HIV type 1 subtype C drug resistance among pediatric and adult South African patients failing antiretroviral therapy. AIDS Res Hum Retroviruses 2008; 24:1449-1454.
    • (2008) AIDS Res Hum Retroviruses , vol.24 , pp. 1449-1454
    • Pillay, V.1    Pillay, C.2    Kantor, R.3
  • 18
    • 36048946593 scopus 로고    scopus 로고
    • Effectiveness of highly active antiretroviral therapy in HIV-positive children: Evaluation at 12 months in a routine program in Cambodia
    • This study provided valuable resistance data on children aged more than 13 years using generic adult stavudine/lamivudine and nevirapine
    • Janssens B, Raleigh B, Soeung S, et al. Effectiveness of highly active antiretroviral therapy in HIV-positive children: evaluation at 12 months in a routine program in Cambodia. Pediatrics 2007; 120:e1134-e1140. This study provided valuable resistance data on children aged more than 13 years using generic adult stavudine/lamivudine and nevirapine.
    • (2007) Pediatrics , vol.120
    • Janssens, B.1    Raleigh, B.2    Soeung, S.3
  • 19
    • 62749141273 scopus 로고    scopus 로고
    • High prevalence of antiretroviral drug resistance mutations and HIV-1 non-B subtype strains from children receiving antiretroviral therapy regimen according to the 2006 revised WHO recommendations
    • This study demonstrated low virological response rates and high rates of resistance at only 6 months following initiation of HAART
    • Gody J-C, Charpentier C, Mbitikon O, Si-Mohamed A. High prevalence of antiretroviral drug resistance mutations and HIV-1 non-B subtype strains from children receiving antiretroviral therapy regimen according to the 2006 revised WHO recommendations. J Acquir Immune Defic Syndr 2008; 49:566-569. This study demonstrated low virological response rates and high rates of resistance at only 6 months following initiation of HAART.
    • (2008) J Acquir Immune Defic Syndr , vol.49 , pp. 566-569
    • Gody, J.-C.1    Charpentier, C.2    Mbitikon, O.3    Si-Mohamed, A.4
  • 20
    • 33846442836 scopus 로고    scopus 로고
    • Options for a second-line antiretroviral regimen for HIV type 1-infected patients whose initial regimen of a fixed-dose combination of stavudine, lamivudine, and nevirapine fails
    • Sungkanuparph S, Manosuthi W, Kiertiburanakul S, et al. Options for a second-line antiretroviral regimen for HIV type 1-infected patients whose initial regimen of a fixed-dose combination of stavudine, lamivudine, and nevirapine fails. Clin Infect Dis 2007; 44:447-452.
    • (2007) Clin Infect Dis , vol.44 , pp. 447-452
    • Sungkanuparph, S.1    Manosuthi, W.2    Kiertiburanakul, S.3
  • 21
    • 43249086528 scopus 로고    scopus 로고
    • South Africa Resistance Cohort Study Team. Prevalence of HIV-1 drug resistance after failure of a first highly active antiretroviral therapy regimen in KwaZulu Natal, South Africa
    • This paper, although looking at adults, reported resistance data on a large number of patients in a resource-poor setting
    • Marconi VC, Sunpath H, Lu Z, et al., South Africa Resistance Cohort Study Team. Prevalence of HIV-1 drug resistance after failure of a first highly active antiretroviral therapy regimen in KwaZulu Natal, South Africa. Clin Infect Dis 2008; 46:1589-1597. This paper, although looking at adults, reported resistance data on a large number of patients in a resource-poor setting.
    • (2008) Clin Infect Dis , vol.46 , pp. 1589-1597
    • Marconi, V.C.1    Sunpath, H.2    Lu, Z.3
  • 22
    • 33646440592 scopus 로고    scopus 로고
    • The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations
    • Parikh UM, Bacheler L, Koontz D, Mellors JW. The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations. J Virol 2006; 80:4971-4977.
    • (2006) J Virol , vol.80 , pp. 4971-4977
    • Parikh, U.M.1    Bacheler, L.2    Koontz, D.3    Mellors, J.W.4
  • 23
    • 33748297583 scopus 로고    scopus 로고
    • Change to a once-daily combination including boosted atazanavir in HIV-1-infected children
    • Macassa E, Delaugerre C, Teglas JP, et al. Change to a once-daily combination including boosted atazanavir in HIV-1-infected children. Pediatr Infect Dis J 2006; 25:809-814.
    • (2006) Pediatr Infect Dis J , vol.25 , pp. 809-814
    • Macassa, E.1    Delaugerre, C.2    Teglas, J.P.3
  • 24
    • 0036836634 scopus 로고    scopus 로고
    • Antiretroviral drug resistance among HIV-1 infected children failing treatment
    • Mullen J, Leech S, O'Shea S, et al. Antiretroviral drug resistance among HIV-1 infected children failing treatment. J Med Virol 2002; 68:299-304.
    • (2002) J Med Virol , vol.68 , pp. 299-304
    • Mullen, J.1    Leech, S.2    O'Shea, S.3
  • 25
    • 47849105010 scopus 로고    scopus 로고
    • Pediatric AIDS Clinical Trials Group 381 Study Team. Analyses of HIV-1 drug-resistance profiles among infected adolescents experiencing delayed antiretroviral treatment switch after initial nonsuppressive highly active antiretroviral therapy
    • This study highlights the resistance implications associated with delayed switch after viral failure in adolescents
    • Agwu A, Lindsey JC, Ferguson K, et al., Pediatric AIDS Clinical Trials Group 381 Study Team. Analyses of HIV-1 drug-resistance profiles among infected adolescents experiencing delayed antiretroviral treatment switch after initial nonsuppressive highly active antiretroviral therapy. AIDS Patient Care STDS 2008; 22:545-552. This study highlights the resistance implications associated with delayed switch after viral failure in adolescents.
    • (2008) AIDS Patient Care STDS , vol.22 , pp. 545-552
    • Agwu, A.1    Lindsey, J.C.2    Ferguson, K.3
  • 26
    • 33645100953 scopus 로고    scopus 로고
    • Minimizing resistance consequences after virologic failure on initial combination therapy: A systematic overview
    • Bartlett JA, Buda JJ, von Scheele B, et al. Minimizing resistance consequences after virologic failure on initial combination therapy: a systematic overview. J Acquir Immune Defic Syndr 2006; 41:323-331.
    • (2006) J Acquir Immune Defic Syndr , vol.41 , pp. 323-331
    • Bartlett, J.A.1    Buda, J.J.2    von Scheele, B.3
  • 27
    • 49449099010 scopus 로고    scopus 로고
    • Gupta R, Hill A, Sawyer AW, Pillay D. Emergence of drug resistance in HIV type 1-infected patients after receipt of first-line highly active antiretroviral therapy: a systematic review of clinical trials. Clin Infect Dis 2008; 47:712-722. This meta-analysis using data from 8000 patients compares resistance outcomes following boosted protease inhibitor vs NNRTI-based HAART, showing that resistance to both the third agent and NRTI is lower when boosted protease inhibitor are used.
    • Gupta R, Hill A, Sawyer AW, Pillay D. Emergence of drug resistance in HIV type 1-infected patients after receipt of first-line highly active antiretroviral therapy: a systematic review of clinical trials. Clin Infect Dis 2008; 47:712-722. This meta-analysis using data from 8000 patients compares resistance outcomes following boosted protease inhibitor vs NNRTI-based HAART, showing that resistance to both the third agent and NRTI is lower when boosted protease inhibitor are used.
  • 28
    • 0037344230 scopus 로고    scopus 로고
    • Forty-eight-week evaluation of lopinavir/ritonavir, a new protease inhibitor, in human immunodeficiency virusinfected children
    • Sáez-Llorens X, Violari A, Deetz CO, et al. Forty-eight-week evaluation of lopinavir/ritonavir, a new protease inhibitor, in human immunodeficiency virusinfected children. Pediatr Infect Dis J 2003; 22:216-224.
    • (2003) Pediatr Infect Dis J , vol.22 , pp. 216-224
    • Sáez-Llorens, X.1    Violari, A.2    Deetz, C.O.3
  • 29
    • 4644333096 scopus 로고    scopus 로고
    • Predictive factors of virologic success in HIV-1-infected children treated with lopinavir/ritonavir
    • Delaugerre C, Teglas JP, Treluyer JM, et al. Predictive factors of virologic success in HIV-1-infected children treated with lopinavir/ritonavir. J Acquir Immune Defic Syndr 2004; 37:1269-1275.
    • (2004) J Acquir Immune Defic Syndr , vol.37 , pp. 1269-1275
    • Delaugerre, C.1    Teglas, J.P.2    Treluyer, J.M.3
  • 30
    • 34248165997 scopus 로고    scopus 로고
    • Pediatric AIDS Clinical Trials Group P1030 Team. Early archiving and predominance of nonnucleoside reverse transcriptase inhibitor-resistant HIV-1 among recently infected infants born in the United States
    • Persaud D, Palumbo P, Ziemniak C, et al., Pediatric AIDS Clinical Trials Group P1030 Team. Early archiving and predominance of nonnucleoside reverse transcriptase inhibitor-resistant HIV-1 among recently infected infants born in the United States. J Infect Dis 2007; 195:1402-1410.
    • (2007) J Infect Dis , vol.195 , pp. 1402-1410
    • Persaud, D.1    Palumbo, P.2    Ziemniak, C.3
  • 31
    • 43549094732 scopus 로고    scopus 로고
    • AIDS Clinical Trials Group Study A5142 Team. Class-sparing regimens for initial treatment of HIV-1 infection
    • This randomized trial showed that NNRTI-based and protease inhibitor based regimens were highly efficacious; although viral failure was more common in patients using boosted protease inhibitor, prevalence of resistance was lower in this group
    • Riddler SA, Haubrich R, DiRienzo AG, et al., AIDS Clinical Trials Group Study A5142 Team. Class-sparing regimens for initial treatment of HIV-1 infection. N Engl J Med 2008; 358:2095-2106. This randomized trial showed that NNRTI-based and protease inhibitor based regimens were highly efficacious; although viral failure was more common in patients using boosted protease inhibitor, prevalence of resistance was lower in this group.
    • (2008) N Engl J Med , vol.358 , pp. 2095-2106
    • Riddler, S.A.1    Haubrich, R.2    DiRienzo, A.G.3
  • 32
    • 16544384038 scopus 로고    scopus 로고
    • Salvage lopinavir-ritonavir therapy in human immunodeficiency virus-infected children
    • Resino S, Bellon JM, Ramos JT, et al. Salvage lopinavir-ritonavir therapy in human immunodeficiency virus-infected children. Pediatr Infect Dis J 2004; 23:923-930.
    • (2004) Pediatr Infect Dis J , vol.23 , pp. 923-930
    • Resino, S.1    Bellon, J.M.2    Ramos, J.T.3
  • 33
    • 26944478140 scopus 로고    scopus 로고
    • Safety and antiviral response at 12 months of lopinavir/ritonavir therapy in human immunodeficiency virus-1-infected children experienced with three classes of antiretrovirals
    • Ramos JT, De Jose MI, Duenas J, et al. Safety and antiviral response at 12 months of lopinavir/ritonavir therapy in human immunodeficiency virus-1-infected children experienced with three classes of antiretrovirals. Pediatr Infect Dis J 2005; 24:867-873.
    • (2005) Pediatr Infect Dis J , vol.24 , pp. 867-873
    • Ramos, J.T.1    De Jose, M.I.2    Duenas, J.3
  • 34
    • 0036972280 scopus 로고    scopus 로고
    • Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial)
    • Gibb DM, Walker AS, Kaye S, et al. Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial). Antivir Ther 2002; 7:293-303.
    • (2002) Antivir Ther , vol.7 , pp. 293-303
    • Gibb, D.M.1    Walker, A.S.2    Kaye, S.3
  • 35
    • 0036721511 scopus 로고    scopus 로고
    • Impact of human immunodeficiency virus type 1 subtypes on virologic response and emergence of drug resistance among children in the Paediatric European Network for Treatment of AIDS (PENTA) 5 trial
    • Pillay D, Walker AS, Gibb DM, et al. Impact of human immunodeficiency virus type 1 subtypes on virologic response and emergence of drug resistance among children in the Paediatric European Network for Treatment of AIDS (PENTA) 5 trial. J Infect Dis 2002; 186:617-625.
    • (2002) J Infect Dis , vol.186 , pp. 617-625
    • Pillay, D.1    Walker, A.S.2    Gibb, D.M.3
  • 36
    • 59949103751 scopus 로고    scopus 로고
    • PACTG 1051/BI Study Team. Efficacy, safety and tolerability of tipranavir coadministered with ritonavir in HIV-1-infected children and adolescents
    • An important study using the second-generation protease inhibitor tipranavir in children
    • Salazar JC, Cahn P, Yogev R, et al., PACTG 1051/BI Study Team. Efficacy, safety and tolerability of tipranavir coadministered with ritonavir in HIV-1-infected children and adolescents. AIDS 2008; 22:1789-1798. An important study using the second-generation protease inhibitor tipranavir in children.
    • (2008) AIDS , vol.22 , pp. 1789-1798
    • Salazar, J.C.1    Cahn, P.2    Yogev, R.3
  • 37
    • 33750338185 scopus 로고    scopus 로고
    • Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir
    • Baxter JD, Schapiro JM, Boucher CA, et al. Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol 2006; 80:10794-10801.
    • (2006) J Virol , vol.80 , pp. 10794-10801
    • Baxter, J.D.1    Schapiro, J.M.2    Boucher, C.A.3
  • 38
    • 67651104795 scopus 로고    scopus 로고
    • Blanche S, Bologna R, Cahn P, et al. 48-week safety and efficacy of darunavir/ritonavir in treatment-experienced children and adolescents in DELPHI. Proceedings of the 48th Interscience Conference on Antimicrobial Agents and Chemotherapy; 25-28 October 2008; Washington: American Society of Microbiology; abstract H-894. An important salvage study using the second-generation protease inhibitor darunavir in children.
    • Blanche S, Bologna R, Cahn P, et al. 48-week safety and efficacy of darunavir/ritonavir in treatment-experienced children and adolescents in DELPHI. Proceedings of the 48th Interscience Conference on Antimicrobial Agents and Chemotherapy; 25-28 October 2008; Washington: American Society of Microbiology; abstract H-894. An important salvage study using the second-generation protease inhibitor darunavir in children.
  • 39
    • 50949083015 scopus 로고    scopus 로고
    • HIV-NAT017 Study Team. Double boosted protease inhibitors, saquinavir, and lopinavir/ritonavir, in nucleoside pretreated children at 48 weeks
    • An interesting study into double boosted protease inhibitor in children
    • Kosalaraksa P, Bunupuradah T, Engchanil C, et al., HIV-NAT017 Study Team. Double boosted protease inhibitors, saquinavir, and lopinavir/ritonavir, in nucleoside pretreated children at 48 weeks. Pediatr Infect Dis J 2008; 27:623-628. An interesting study into double boosted protease inhibitor in children.
    • (2008) Pediatr Infect Dis J , vol.27 , pp. 623-628
    • Kosalaraksa, P.1    Bunupuradah, T.2    Engchanil, C.3
  • 40
    • 50949107933 scopus 로고    scopus 로고
    • PACTG 1038 Team. Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitors
    • Important pharmacokinetic data for LPV as part of a single or dual boosted protease inhibitor strategy
    • Robbins BL, Capparelli EV, Chadwick EG, et al., PACTG 1038 Team. Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitors. Antimicrob Agents Chemother 2008; 52:3276-3283. Important pharmacokinetic data for LPV as part of a single or dual boosted protease inhibitor strategy.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3276-3283
    • Robbins, B.L.1    Capparelli, E.V.2    Chadwick, E.G.3
  • 41
    • 0033606540 scopus 로고    scopus 로고
    • Drug-resistance genotyping in HIV-1 therapy: The VIRADAPT randomised controlled trial
    • Durant J, Clevenbergh P, Halfon P, et al. Drug-resistance genotyping in HIV-1 therapy: the VIRADAPT randomised controlled trial. Lancet 1999; 353:2195-2199.
    • (1999) Lancet , vol.353 , pp. 2195-2199
    • Durant, J.1    Clevenbergh, P.2    Halfon, P.3
  • 42
    • 0034065841 scopus 로고    scopus 로고
    • Persisting long-term benefit of genotype-guided treatment for HIV-infected patients failing HAART. Viradapt study: Week 48 follow-up
    • Clevenbergh P, Durant J, Halfon P, et al. Persisting long-term benefit of genotype-guided treatment for HIV-infected patients failing HAART. Viradapt study: week 48 follow-up. Antivir Ther 2000; 5:65-70.
    • (2000) Antivir Ther , vol.5 , pp. 65-70
    • Clevenbergh, P.1    Durant, J.2    Halfon, P.3
  • 43
    • 33750942273 scopus 로고    scopus 로고
    • Paediatric European Network for the Treatment of AIDS. A randomized controlled trial of genotypic HIV drug resistance testing in HIV-1-infected children: The PERA (PENTA 8) trial
    • Green H, Gibb DM, Compagnucci A, et al., Paediatric European Network for the Treatment of AIDS. A randomized controlled trial of genotypic HIV drug resistance testing in HIV-1-infected children: the PERA (PENTA 8) trial. Antivir Ther 2006; 11:857-867.
    • (2006) Antivir Ther , vol.11 , pp. 857-867
    • Green, H.1    Gibb, D.M.2    Compagnucci, A.3
  • 44
    • 10744223424 scopus 로고    scopus 로고
    • The Swiss HIV Cohort Study. Emergence of minor populations of human immunodeficiency virus type 1 carrying the M184V and L90M mutations in subjects undergoing structured treatment interruptions
    • Metzner KJ, Bonhoeffer S, Fischer M, et al., The Swiss HIV Cohort Study. Emergence of minor populations of human immunodeficiency virus type 1 carrying the M184V and L90M mutations in subjects undergoing structured treatment interruptions. J Infect Dis 2003; 188:1433-1443.
    • (2003) J Infect Dis , vol.188 , pp. 1433-1443
    • Metzner, K.J.1    Bonhoeffer, S.2    Fischer, M.3
  • 45
    • 27544452984 scopus 로고    scopus 로고
    • Detection of minor populations of drugresistant HIV-1 in acute seroconverters
    • Metzner KJ, Rauch P, Walter H, et al. Detection of minor populations of drugresistant HIV-1 in acute seroconverters. AIDS 2005; 19:1819-1825.
    • (2005) AIDS , vol.19 , pp. 1819-1825
    • Metzner, K.J.1    Rauch, P.2    Walter, H.3
  • 46
    • 1842484005 scopus 로고    scopus 로고
    • Role of minority populations of human immunodeficiency virus type 1 in the evolution of viral resistance to protease inhibitors
    • Charpentier C, Dwyer DE, Mammano F, et al. Role of minority populations of human immunodeficiency virus type 1 in the evolution of viral resistance to protease inhibitors. J Virol 2004; 78:4234-4247.
    • (2004) J Virol , vol.78 , pp. 4234-4247
    • Charpentier, C.1    Dwyer, D.E.2    Mammano, F.3
  • 47
    • 0942290560 scopus 로고    scopus 로고
    • Gag noncleavage site mutations contribute to full recovery of viral fitness in protease inhibitor-resistant human immunodeficiency virus type 1
    • Myint LM, Matsuda Z, Matsuda Y, et al. Gag noncleavage site mutations contribute to full recovery of viral fitness in protease inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother 2004; 48: 444-452.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 444-452
    • Myint, L.M.1    Matsuda, Z.2    Matsuda, Y.3
  • 48
    • 0037155193 scopus 로고    scopus 로고
    • Amino acid substitutions in Gag protein at noncleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors
    • Gatanaga H, Suzuki Y, Tsang H, et al. Amino acid substitutions in Gag protein at noncleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors. J Biol Chem 2002; 277:5952-5961.
    • (2002) J Biol Chem , vol.277 , pp. 5952-5961
    • Gatanaga, H.1    Suzuki, Y.2    Tsang, H.3
  • 49
    • 33846702679 scopus 로고    scopus 로고
    • A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism
    • Nijhuis M, van Maarseveen NM, Lastere S, et al. A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism. PLoS Med 2007; 4:e36.
    • (2007) PLoS Med , vol.4
    • Nijhuis, M.1    van Maarseveen, N.M.2    Lastere, S.3
  • 50
    • 34347390840 scopus 로고    scopus 로고
    • Predictive factors of virological success to salvage regimens containing protease inhibitors in HIV-1 infected children
    • Larru B, de Mendoza C, Bellón JM, et al. Predictive factors of virological success to salvage regimens containing protease inhibitors in HIV-1 infected children. BMC Infect Dis 2007; 7:55.
    • (2007) BMC Infect Dis , vol.7 , pp. 55
    • Larru, B.1    de Mendoza, C.2    Bellón, J.M.3
  • 51
    • 35348878749 scopus 로고    scopus 로고
    • Characterization of HIV-1 isolates from antiretroviral drug-naive children in southern India
    • Important data on transmitted resistance in the Indian subcontinent
    • Soundararajan L, Karunaianandham R, Jauvin V, et al. Characterization of HIV-1 isolates from antiretroviral drug-naive children in southern India. AIDS Res Hum Retroviruses 2007; 23:1119-1126. Important data on transmitted resistance in the Indian subcontinent.
    • (2007) AIDS Res Hum Retroviruses , vol.23 , pp. 1119-1126
    • Soundararajan, L.1    Karunaianandham, R.2    Jauvin, V.3
  • 52
    • 34748846895 scopus 로고    scopus 로고
    • Predictors of long-term viral failure among Ugandan children and adults treated with antiretroviral therapy
    • Kamya MR, Mayanja-Kizza H, Kambugu A, et al. Predictors of long-term viral failure among Ugandan children and adults treated with antiretroviral therapy. J Acquir Immune Defic Syndr 2007; 46:187-193.
    • (2007) J Acquir Immune Defic Syndr , vol.46 , pp. 187-193
    • Kamya, M.R.1    Mayanja-Kizza, H.2    Kambugu, A.3
  • 53
    • 34249905472 scopus 로고    scopus 로고
    • High prevalence of primary antiretroviral resistance among HIV-1-infected adults and children in Bahia, a northeast state of Brazil
    • Pedroso C, Queiroz AT, Alcântara LC, et al. High prevalence of primary antiretroviral resistance among HIV-1-infected adults and children in Bahia, a northeast state of Brazil. J Acquir Immune Defic Syndr 2007; 45:251-253.
    • (2007) J Acquir Immune Defic Syndr , vol.45 , pp. 251-253
    • Pedroso, C.1    Queiroz, A.T.2    Alcântara, L.C.3
  • 54
    • 36148989153 scopus 로고    scopus 로고
    • High frequency of primary mutations associated with antiretroviral drug resistance in recently diagnosed HIV-infected children
    • This study shows that baseline resistance is a concern among children in middleincome areas
    • Vignoles M, Barboni G, Agosti MR, et al. High frequency of primary mutations associated with antiretroviral drug resistance in recently diagnosed HIV-infected children. Antivir Ther 2007; 12:1133-1137. This study shows that baseline resistance is a concern among children in middleincome areas.
    • (2007) Antivir Ther , vol.12 , pp. 1133-1137
    • Vignoles, M.1    Barboni, G.2    Agosti, M.R.3
  • 55
    • 33845213744 scopus 로고    scopus 로고
    • Adolescent Medicine Trials Network for HIV/AIDS Interventions. Prevalence of primary HIV-1 drug resistance among recently infected adolescents: A multicenter adolescent medicine trials network for HIV/AIDS interventions study
    • Viani RM, Peralta L, Aldrovandi G, et al., Adolescent Medicine Trials Network for HIV/AIDS Interventions. Prevalence of primary HIV-1 drug resistance among recently infected adolescents: a multicenter adolescent medicine trials network for HIV/AIDS interventions study. J Infect Dis 2006; 194:1505-1509.
    • (2006) J Infect Dis , vol.194 , pp. 1505-1509
    • Viani, R.M.1    Peralta, L.2    Aldrovandi, G.3
  • 56
    • 2542561168 scopus 로고    scopus 로고
    • Prevention of mother-to-child transmission of HIV infection
    • Thorne C, Newell ML. Prevention of mother-to-child transmission of HIV infection. Curr Opin Infect Dis 2004; 17:247-252.
    • (2004) Curr Opin Infect Dis , vol.17 , pp. 247-252
    • Thorne, C.1    Newell, M.L.2
  • 57
    • 59849097134 scopus 로고    scopus 로고
    • Antiretroviral therapy in pregnant women with advanced HIV disease and pregnancy outcomes in Abidjan, Côte d'Ivoire
    • Ekouevi DK, Coffie PA, Becquet R, et al. Antiretroviral therapy in pregnant women with advanced HIV disease and pregnancy outcomes in Abidjan, Côte d'Ivoire. AIDS 2008; 22:1815-1820.
    • (2008) AIDS , vol.22 , pp. 1815-1820
    • Ekouevi, D.K.1    Coffie, P.A.2    Becquet, R.3
  • 58
    • 67651137642 scopus 로고    scopus 로고
    • World Health Organization. Report of the WHO Technical Reference Group, Paediatric HIV/ART Care Guideline Group Meeting; 10-11 April 2008; Geneva, Switzerland: WHO Headquarters. Available at http://www.who.int/hiv/topics/ paediatric/en/index.html. [Accessed 10 November 2008]
    • World Health Organization. Report of the WHO Technical Reference Group, Paediatric HIV/ART Care Guideline Group Meeting; 10-11 April 2008; Geneva, Switzerland: WHO Headquarters. Available at http://www.who.int/hiv/topics/ paediatric/en/index.html. [Accessed 10 November 2008]
  • 59
    • 35548942272 scopus 로고    scopus 로고
    • Ghent Group on HIV in Women and Children. Prevalence of resistance to nevirapine in mothers and children after single-dose exposure to prevent vertical transmission of HIV-1: A metaanalysis
    • A very important meta-analysis of studies into PMTCT with single-dose NVP vs NVP combined with one or more NRTI
    • Arrivé E, Newell ML, Ekouevi DK, et al., Ghent Group on HIV in Women and Children. Prevalence of resistance to nevirapine in mothers and children after single-dose exposure to prevent vertical transmission of HIV-1: a metaanalysis. Int J Epidemiol 2007; 36:1009-1021. A very important meta-analysis of studies into PMTCT with single-dose NVP vs NVP combined with one or more NRTI.
    • (2007) Int J Epidemiol , vol.36 , pp. 1009-1021
    • Arrivé, E.1    Newell, M.L.2    Ekouevi, D.K.3
  • 60
    • 0034161409 scopus 로고    scopus 로고
    • Effect of breastfeeding and formula feeding on transmission of HIV-1: A randomized clinical trial
    • Nduati R, John G, Mbori-Ngacha D. Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trial. JAMA 2000; 283:1167-1174.
    • (2000) JAMA , vol.283 , pp. 1167-1174
    • Nduati, R.1    John, G.2    Mbori-Ngacha, D.3
  • 61
    • 46949108668 scopus 로고    scopus 로고
    • Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission
    • This study showed that extended prophylaxis substantially reduced transmission associated with breast-feeding in African patients
    • Kumwenda NI, Hoover DR, Mofenson LM, et al. Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission. N Engl J Med 2008; 359:119-129. This study showed that extended prophylaxis substantially reduced transmission associated with breast-feeding in African patients.
    • (2008) N Engl J Med , vol.359 , pp. 119-129
    • Kumwenda, N.I.1    Hoover, D.R.2    Mofenson, L.M.3
  • 62
    • 77649211938 scopus 로고    scopus 로고
    • Six Week Extended-Dose Nevirapine (SWEN) Study Team, Bedri A, Gudetta B, et al. Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding in Ethiopia, India, and Uganda: an analysis of three randomised controlled trials. Lancet 2008; 372:300-313. This study showed that extended prophylaxis substantially reduced transmission associated with breast-feeding in subtype A, C and D infected patients.
    • Six Week Extended-Dose Nevirapine (SWEN) Study Team, Bedri A, Gudetta B, et al. Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding in Ethiopia, India, and Uganda: an analysis of three randomised controlled trials. Lancet 2008; 372:300-313. This study showed that extended prophylaxis substantially reduced transmission associated with breast-feeding in subtype A, C and D infected patients.
  • 63
    • 58149464331 scopus 로고    scopus 로고
    • Nevirapine resistance and breast-milk HIV transmission: Effects of single and extended-dose nevirapine prophylaxis in subtype C HIV-infected infants
    • Moorthy A, Gupta A, Bhosale R, et al. Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine prophylaxis in subtype C HIV-infected infants. PLoS ONE 2009; 4:e4096.
    • (2009) PLoS ONE , vol.4
    • Moorthy, A.1    Gupta, A.2    Bhosale, R.3
  • 64
    • 51849085325 scopus 로고    scopus 로고
    • Analysis of nevirapine (NVP) resistance in Ugandan infants who were HIV infected despite receiving single-dose (SD) NVP versus SD NVP plus daily NVP up to 6 weeks of age to prevent HIV vertical transmission
    • This study demonstrates that extended NVP prophylaxis in infants is associated with increased NVP resistance in those who become infected
    • Church JD, Omer SB, Guay LA, et al. Analysis of nevirapine (NVP) resistance in Ugandan infants who were HIV infected despite receiving single-dose (SD) NVP versus SD NVP plus daily NVP up to 6 weeks of age to prevent HIV vertical transmission. J Infect Dis 2008; 198:1075-1082. This study demonstrates that extended NVP prophylaxis in infants is associated with increased NVP resistance in those who become infected.
    • (2008) J Infect Dis , vol.198 , pp. 1075-1082
    • Church, J.D.1    Omer, S.B.2    Guay, L.A.3
  • 65
    • 56749097184 scopus 로고    scopus 로고
    • Early antiretroviral therapy and mortality among HIV-infected infants
    • This very important trial of early vs deferred HAART in infants showed a mortality benefit for the former group. WHO guidelines were changed as a result of this study
    • Violari A, Cotton MF, Gibb DM, et al. Early antiretroviral therapy and mortality among HIV-infected infants. N Engl J Med 2008; 359:2233-2244. This very important trial of early vs deferred HAART in infants showed a mortality benefit for the former group. WHO guidelines were changed as a result of this study.
    • (2008) N Engl J Med , vol.359 , pp. 2233-2244
    • Violari, A.1    Cotton, M.F.2    Gibb, D.M.3


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