A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 11, 2009, Pages 3916-3922

  Heng, Sabrina ^a   Gryncel, Kimberly R ^a   Kantrowitz, Evan R ^a  

^a BOSTON COLLEGE   (United States)

Author keywords

Enzyme inhibition; Fructose 1,6 bisphosphatase; Thiazole derivatives; Type 2 diabetes; Virtual high throughput screening; ZINC database

Indexed keywords

4 [2 (3 HYDROXYPHENYLAMINO)THIAZOL 4 YL]BENZENE 1,3 DIOL; 4 [4 (4 HYDROXYPHENYL)THIAZOL 2 YLAMINO]BENZENESULFONAMIDE; ALPHA BROMOKETONE; ANTIDIABETIC AGENT; ENZYME INHIBITOR; FRUCTOSE BISPHOSPHATASE; REAGENT; THIAZOLE DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DATA BASE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; IC 50; KIDNEY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; POLYMERIZATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SWINE;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; FRUCTOSE-BISPHOSPHATASE; INHIBITORY CONCENTRATION 50; MODELS, BIOLOGICAL; SWINE;

SUIDAE;

EID: 65549112536     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.030     Document Type: Article

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