Keratin 18 provides resistance to Fas-mediated liver failure in mice

European Journal of Clinical Investigation

Volumn 39, Issue 6, 2009, Pages 481-488

  Leifeld, L ^a,b   Kothe, S ^c   Sohl G ^c   Hesse, M ^c   Sauerbruch, T ^c   Magin, T M ^c   Spengler, U ^c  

^a Evangelisches Krankenhaus Kalk   (Germany)

^b Evangelisches Krankenhaus Kalk   (Germany)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

Apoptosis; Fas; Fulminant hepatic failure; Keratin 18; Liver

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOKERATIN 18; FAS ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; LIVER FAILURE; LIVER INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SURVIVAL;

ANIMALS; ANTIBODIES; APOPTOSIS REGULATORY PROTEINS; CASPASES; CELLS, CULTURED; KERATIN-18; KERATIN-8; LIVER FAILURE; MICE; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 65549107433     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2009.02133.x     Document Type: Article

References (32)

1. Zhong B, Zhou Q, Toivola DM, Tao GZ, Resurreccion EZ, Omary MB. Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation. J Cell Sci 2004 117 : 1709 19. (Pubitemid 38559303)
2. Loranger A, Duclos S, Grenier A, Price J, Wilson-Heiner M, Baribault H et al. Simple epithelium keratins are required for maintenance of hepatocyte integrity. Am J Pathol 1997 151 : 1673 83. (Pubitemid 27527930)
3. Ku NO, Michie S, Oshima RG, Omary MB. Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant. J Cell Biol 1995 131 : 1303 14.
4. Toivola DM, Omary MB, Ku NO, Peltola O, Baribault H, Eriksson JE. Protein phosphatase inhibition in normal and keratin 8/18 assembly-incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity. Hepatology 1998 28 : 116 28. (Pubitemid 28299993)
5. Galarneau L, Loranger A, Gilbert S, Marceau N. Keratins modulate hepatic cell adhesion, size and G1/S transition. Exp Cell Res 2007 313 : 179 94.
6. Gilbert S, Loranger A, Daigle N, Marceau N. Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation. J Cell Biol 2001 154 : 763 73. (Pubitemid 34292958)
7. Ku NO, Soetikno RM, Omary MB. Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury. Hepatology 2003 37 : 1006 14. (Pubitemid 36538677)
8. Toivola DM, Nieminen MI, Hesse M, He T, Baribault H, Magin TM et al. Disturbances in hepatic cell-cycle regulation in mice with assembly-deficient keratins 8/18. Hepatology 2001 34 : 1174 83. (Pubitemid 33096590)
9. Magin TM, Schroder R, Leitgeb S, Wanninger F, Zatloukal K, Grund C et al. Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates. J Cell Biol 1998 140 : 1441 51. (Pubitemid 28152992)
10. Omary MB, Ku NO. Intermediate filament proteins of the liver: emerging disease association and functions. Hepatology 1997 25 : 1043 8. (Pubitemid 27199925)
11. Marceau N, Loranger A, Gilbert S, Daigle N, Champetier S. Keratin-mediated resistance to stress and apoptosis in simple epithelial cells in relation to health and disease. Biochem Cell Biol 2001 79 : 543 55. (Pubitemid 33702324)
12. Toivola DM, Ku NO, Resurreccion EZ, Nelson DR, Wright TL, Omary MB. Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease. Hepatology 2004 40 : 459 66. (Pubitemid 39062864)
13. Strnad P, Stumptner C, Zatloukal K, Denk H. Intermediate filament cytoskeleton of the liver in health and disease. Histochem Cell Biol 2008 129 : 735 49.
14. Yagmur E, Trautwein C, Leers MP, Gressner AM, Tacke F. Elevated apoptosis-associated cytokeratin 18 fragments (CK18Asp386) in serum of patients with chronic liver diseases indicate hepatic and biliary inflammation. Clin Biochem 2007 40 : 651 5. (Pubitemid 46829060)
15. Luft T, Conzelmann M, Benner A, Rieger M, Hess M, Strohhaecker U et al. Serum cytokeratin-18 fragments as quantitative markers of epithelial apoptosis in liver and intestinal graft-versus-host disease. Blood 2007 110 : 4535 42.
16. Hetz H, Hoetzenecker K, Hacker S, Faybik P, Pollreisz A, Moser B et al. Caspase-cleaved cytokeratin 18 and 20 S proteasome in liver degeneration. J Clin Lab Anal 2007 21 : 277 81. (Pubitemid 47556805)
17. Ku NO, Wright TL, Terrault NA, Gish R, Omary MB. Mutation of human keratin 18 in association with cryptogenic cirrhosis. J Clin Invest 1997 99 : 19 23. (Pubitemid 27058289)
18. Ku NO, Gish R, Wright TL, Omary MB. Keratin 8 mutations in patients with cryptogenic liver disease. N Engl J Med 2001 344 : 1580 7. (Pubitemid 32479910)
19. Ku NO, Lim JK, Krams SM, Esquivel CO, Keeffe EB, Wright TL et al. Keratins as susceptibility genes for end-stage liver disease. Gastroenterology 2005 129 : 885 93. (Pubitemid 41242681)
20. Strnad P, Lienau TC, Tao GZ, Lazzeroni LC, Stickel F, Schuppan D et al. Keratin variants associate with progression of fibrosis during chronic hepatitis C infection. Hepatology 2006 43 : 1354 63. (Pubitemid 43980115)
21. Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y et al. Lethal effect of the anti-Fas antibody in mice. Nature 1993 364 : 806 9. (Pubitemid 23261761)
22. Woo M, Hakem A, Elia AJ, Hakem R, Duncan GS, Patterson BJ et al. In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes. J Immunol 1999 163 : 4909 16. (Pubitemid 29501256)
23. Fink K, Zhu J, Namura S, Shimizu-Sasamata M, Endres M, Ma J et al. Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation. J Cereb Blood Flow Metab 1998 18 : 1071 6. (Pubitemid 28465354)
24. Leifeld L, Fink K, Debska G, Fielenbach M, Schmitz V, Sauerbruch T et al. Anti-apoptotic function of gelsolin in fas antibody-induced liver failure in vivo. Am J Pathol 2006 168 : 778 85. (Pubitemid 43327730)
25. Sivaramakrishnan S, DeGiulio JV, Lorand L, Goldman RD, Ridge KM. Micromechanical properties of keratin intermediate filament networks. Proc Natl Acad Sci U S A 2008 105 : 889 94. (Pubitemid 350213270)
26. Magin TM, Vijayaraj P, Leube RE. Structural and regulatory functions of keratins. Exp Cell Res 2007 313 : 2021 32. (Pubitemid 46842973)
27. Ku NO, Liao J, Omary MB. Apoptosis generates stable fragments of human type I keratins. J Biol Chem 1997 272 : 33197 203. (Pubitemid 28023666)
28. Caulin C, Ware CF, Magin TM, Oshima RG. Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. J Cell Biol 2000 149 : 17 22. (Pubitemid 30196695)
29. Schutte B, Henfling M, Kolgen W, Bouman M, Meex S, Leers MP et al. Keratin 8/18 breakdown and reorganization during apoptosis. Exp Cell Res 2004 297 : 11 26. (Pubitemid 38759558)
30. Caulin C, Salvesen GS, Oshima RG. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J Cell Biol 1997 138 : 1379 94. (Pubitemid 27415063)
31. Leers MP, Kolgen W, Bjorklund V, Bergman T, Tribbick G, Persson B et al. Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis. J Pathol 1999 187 : 567 72. (Pubitemid 29151999)
32. Ku NO, Strnad P, Zhong BH, Tao GZ, Omary MB. Keratins let liver live: mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies. Hepatology 2007 46 : 1639 49. (Pubitemid 350155545)