DNA-binding properties of Drosophila ecdysone receptor isoforms and their modification by the heterodimerization partner ultraspiracle

Archives of Insect Biochemistry and Physiology

Volumn 72, Issue 3, 2009, Pages 172-191

  Braun, Simone ^a   Azoitei, Anca ^a   Spindler Barth, Margarethe ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Dimerization; Hormone response element; Insect; Moulting hormone; Nuclear receptor; Retinoic acid receptor; Ultraspiracle

Indexed keywords

CF1 PROTEIN, INSECT; DNA; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; ECDYSONE RECEPTOR; HEAT SHOCK PROTEIN 27; ISOPROTEIN; STEROID RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; CHO CELL; CRICETULUS; DROSOPHILA MELANOGASTER; GENE DELETION; GENETICS; HAMSTER; METABOLISM; PROTEIN BINDING;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DNA; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HSP27 HEAT-SHOCK PROTEINS; PROTEIN BINDING; PROTEIN ISOFORMS; RECEPTORS, STEROID; SEQUENCE DELETION; TRANSCRIPTION FACTORS;

HEXAPODA; VERTEBRATA;

EID: 65549099001     PISSN: 07394462     EISSN: 15206327     Source Type: Journal    
DOI: 10.1002/arch.20328     Document Type: Article

References (59)

1. Azoitei A, Ruff H, Tremmel Ch, Braun S, Spindler-Barth M. 2009. Functional analysis of ecdysteroid receptor from Drosophila melangoaster ''in vitro.'' In: Smagghe G, editor. Ecdysone, structures and functions. Berlin: Springer. p 377-388.
2. Azoitei A, Spindler-Barth M. 2009. DNA affects ligand binding of the ecdysone receptor of Drosophila melanogaster. Mol Cell Endocrinol 303:91-99.
3. Beatty J, Fauth Th, Callendar JL, Spindler-Barth M, Henrich VC. 2006. Functional analysis of ecdysteroid receptor isoforms in Drosophila melanogaster in a cell culture system. Insect Mol Biol 15:785-795.
4. Beckstead RB, Lam G, Thummel CS. 2005. The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Genome Biol 6:R99.
5. Bender M, Imam FB, Talbot WS, Ganetzky B, Hogness DS. 1997. Drosophila ecdysone receptor mutations reveal functional differences among receptor isoforms. Cell 91:777-788.
6. Billas IM, Moras D. 2005. Ligand-binding pocket of the ecdysone receptor. Vitam Horm 73:101-129.
7. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
8. Burnette WN. 1981. Western blotting: electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem 112:195-203.
9. Chandra V, Huang P, Hamuro Y, Raghuram S, Wang Y, Burris TP, Rastinejad F. 2008. Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature 456:350-356.
10. Cherbas L, Hu X, Zhimulev I, Belyaeva E, Cherbas P. 2003. EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue. Development 130:271-284.
11. Cronauer MV, Ince Y, Engers R, Rinnab L, Weidemann W, Suschek CV, Burchardt M, Kleinert H, Wiedenmann J, Sies H, Ackermann R, Kröncke KD. 2007. Nitric oxide mediated inhibition of androgen receptor activity: possible implications for prostate cancer progression. Oncogene 26:1875-1884.
12. Davis MB, Carney GE, Robertson AE, Bender M. 2005. Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms. Dev Biol 282:385-396.
13. Dela Cruz FE, Kirsch DR, Heinrich JN. 2000. Transcriptional activity of Drosophila melanogaster ecdysone receptor isoforms and ultraspiracle in Saccharomyces cerevisiae. J Mol Endocrinol 24:183-191.
14. Elke C, Rauch P, Spindler-Barth M, Spindler K-D. 1999. DNA-binding properties of the ecdysteroid receptor-complex (EcR/USP) of the epithelial cell line from Chironomus tentans. Arch Insect Biochem Physiol 41:124-133.
15. Ghbeish N, Tsai CC, Schubiger M, Zhou JY, Evans RM, McKeown M. 2001. EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue. Proc Natl Acad Sci USA 98:3867-3872.
16. Grad I, Niedziela-Majka A, Kochman M, Ozyhar A. 2001. Analysis of Usp DNA binding domain targeting reveals critical determinants of the ecdysone receptor complex interaction with the response element. Eur J Biochem 268:3751-3758.
17. Grad I, Kochman M, Ozyhar A. 2002. Functionality versus strength: has functional selection taken place in the case of the ecdysteroid receptor response element? Acta Biochim Pol 49:747-756.
18. Greb-Markiewicz B, Fauth T, Spindler-Barth M. 2005. Ligand binding is without effect on complex formation of the ligand binding domain of the ecdysone receptor (EcR). Arch Insect Biochem Physiol 59:1-11.
19. Grebe M, Fauth T, Spindler-Barth M. 2004. Dynamic of ligand binding to Drosophila melanogaster ecdysteroid receptor. Insect Biochem Mol Biol 34:981-989.
20. Haelens A, Tanner T, Denayer S, Callwaert L, Claessens F. 2007. The hinge region regulates DNA binding, nuclear translocation, and transactivation of the androgen receptor. Cancer Res 67:4514-4523.
21. Haluska GJ, Wells TR, Hirst JJ, Brenner RM, Sadowsky DW, Novy MJ. 2002. Progesterone receptor localization and isoforms in myometrium, decidua, and fetal membranes from rhesus macaques: evidence for functional progesterone withdrawal at parturition. J Soc Gynecol Invest 9:125-136.
22. Harvey CB, Williams GR. 2002. Mechanism of thyroid hormone action. Thyroid 12:441-446
23. Henrich VC. 2005. The ecdysteroid receptor. In: Gilbert LJ, Iatrou K, Gill SS, editors. Comprehensive molecular insect science, vol. 3. Oxford: Elsevier/Pergamon. p 243-282.
24. Henrich VC, Burns E, Yelverton DP, Christensen E, Weinberger C. 2003. Juvenile hormone potentiates ecdysone receptor-dependent transcription in a mammalian cell culture system. Insect Biochem Mol Biol 33:1239-1247.
25. Henrich VC, Beatty J, Ruff H, Callender J, Grebe M, Spindler-Barth M. 2009. The multiple partnership of EcR and Usp. In: Smagghe G, editor. Ecdysone, structures and functions. New York: Springer. p 361-376.
26. Hu X, Cherbas L, Cherbas P. 2003. Transcription activation by the ecdysone receptor (EcR/USP): identification of activation functions. Mol Endocrinol 17:716-731.
27. Kim HW, Lee SG, Mykles DL. 2005. Ecdysteroid-responsive genes, RXR and E75, in the tropical land crab, Gecarcinus lateralis: differential tissue expression of multiple RXR isoforms generated at three alternative splicing sites in the hinge and ligand-binding domains. Mol Cell Endocrinol 242:80-95.
28. Lämmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 27:680-685.
29. Lan Q, Hiruma K, Hu X, Jindra M, Riddiford LM. 1999. Activation of a delayed-early gene encoding MHR3 by the ecdysone receptor heterodimer EcR-B1-USP-1 but not by EcR-B1- USP-2. Mol Cell Biol 19:4897-4906.
30. Maestro O, Cruz, Pascual N, Martín D, Bellés X. 2005. Differential expression of two RXR/ ultraspiracle isoforms during the life cycle of the hemimetabolous insect Blattella germanica (Dictyoptera, Blattellidae). Mol Cell Endocrinol 238:27-37.
31. Maki A, Sawatsubashi S, Ito S, Shirode Y, Suzuki E, Zhao Y, Yamagata K, Kouzmenko A, Takeyama K, Kato S. 2004. Juvenile hormones antagonize ecdysone actions through co-repressor recruitment to EcR/USP heterodimers. Biochem Biophys Res Commun 320:262-267.
32. Matthews J, Gustafsson JA. 2003. Estrogen signaling: a subtle balance between ER alpha and ER beta. Mol Interv 3:281-292.
33. Mouillet JF, Henrich VC, Lezzi M, Vögtli M. 2001. Differential control of gene activity by isoforms A, B1 and B2 of the Drosophila ecdysone receptor. Eur J Biochem 268:1811-1819.
34. Niedziela-Majka A, Kochman MA, Ozyhar A. 2000. Polarity of the ecdysone receptor complex interaction with the palindromic response element from the hsp27 gene promoter. Eur J Biochem 267:507-519.
35. Nieva C, Gwóźdź T, Dutko-Gwóźdź J, Wiedenmann J, Spindler-Barth M, Wieczorek E, Dobrucki J, Duś D, Henrich VC, Ozyhar A, Spindler K-D. 2005. Ultraspiracle promotes the nuclear localization of ecdysteroid receptor in mammalian cells. Biol Chem 386:463-470.
36. Nieva C, Spindler-Barth M, Spindler K-D. 2008. Impact of heterodimerization on intracellular localization of the ecdysteroid receptor (EcR). Arch Insect Biochem Physiol 68:40-48.
37. Palanker L, Necakov AS, Sampson HM, Ni R, Hu C. 2006. Dynamic regulation of Drosophila nuclear receptor activity in vivo. Development 133:3549-3562.
38. Palli SR, Kapitskaya MZ, Potter DW. 2005. The influence of heterodimer partner ultraspiracle/ retinoid X receptor on the function of ecdysone receptor. FEBS J 272:5979-5990.
39. Perera SC, Zheng S, Feng QL, Krell PJ, Retnakaran A, Palli SR. 2005. Heterodimerization of ecdysone receptor and ultraspiracle on symmetric and asymmetric response elements. Arch Insect Biochem Physiol 60:55-70.
40. Picard N, Charbonneau C, Sanchez M, Licznar A, Busson M, Lazennec G, Tremblay A. 2008. Phosphorylation of activation function-1 regulates proteasome-dependent nuclear mobility and E6-associated protein ubiquitin ligase recruitment to the estrogen receptor beta. Mol Endocrinol 22:317-330.
41. Rauch P, Grebe M, Elke C, Spindler K-D, Spindler-Barth M. 1998. Ecdysteroid receptor and ultraspiracle from Chironomus tentans (Insecta) are phosphoproteins and are regulated differently by molting hormone. Insect Biochem Mol Biol 28:265-275.
42. Riddiford LM, Cherbas P, Truman JW. 2000. Ecdysone receptors and their biological actions. Vitam Horm 60:1-73.
43. Robinow S, Talbot WS, Hogness DS, Truman JW. 1993. Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform. Development 119:1251-1259.
44. Scatchard G. 1949. The attraction of proteins for small molecules and ion. Ann NY Acad Sci 51:660-672.
45. Schubiger M, Tomita S, Sung C, Robinow S, Truman JW. 2003. Isoform specific control of gene activity in vivo by the Drosophila ecdysone receptor. Mech Dev 120:909-918.
46. Serra J. 1984. Image analysis and mathematical morphology series: image analysis and mathematical morphology, vol. 1. New York: Academic Press. p 601.
47. Sun X, Song Q. 2006. PKC-mediated USP phosphorylation is required for 20E-induced gene expression in the salivary glands of Drosophila melanogaster. Arch Insect Biochem Physiol 62:116-127.
48. Talbot WS, Swyryd EA, Hogness DS. 1993. Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms. Cell 73:1323-1337.
49. Temple KA, Cohen RN, Wondisford SR, Yu C, Deplewski D, Wondisford FE. 2005. An intact DNA-binding domain is not required for peroxisome proliferator-activated receptor gamma (PPARgamma) binding and activation on some PPAR response elements. J Biol Chem 280:3529-3540.
50. Tetel MJ, Giangrande PH, Leonhardt SA, McDonnell DP, Edwards DP. 1999. Hormone- dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. Mol Endocrinol 13:910-924.
51. Tirard M, Almeida OF, Hutzler P, Melchior F, Michaelidis TM. 2007. Sumoylation and proteasomal activity determine the transactivation properties of the mineralocorticoid receptor. Mol Cell Endocrinol 268:20-29.
52. Tran HT, Shaaban S, Askari HB, Walfish PG, Raikhel AS, Butt TR. 2001. Requirement of co-factors for the ligand-mediated activity of the insect ecdysteroid receptor in yeast. J Mol Endocrinol 27:191-209.
53. Truman JW. 1996. Steroid receptors and nervous system metamorphosis in insects. Dev Neurosci 18:87-101.
54. Tsai CC, Kao HY, Yao TP. 1999. SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. Mol Cell 4:175-186.
55. Tung L, Abdel-Hafiz H, Shen T, Harvell DM, Nitao LK, Richter KJ, Sartorius CA, Takimoto GS, Horwitz KB. 2006. Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B. Mol Endocrinol 20:2656-2670.
56. Turberg A, Spindler K-D. 1992. Properties of nuclear and cytosolic ecdysteroid receptors from an epithelial cell line from Chironomus tentans. J Insect Physiol 38:82-91.
57. Wu TJ, Monokian G, Mark DF, Wobbe CR. 1994. Transcriptional activation by herpes simplex virus type 1 VP16 in vitro and its inhibition by oligopeptides. Mol Cell Biol 14:3484-3493.
58. Zhou J, Cidlowski JA. 2005. The human glucocorticoid receptor: one gene, multiple proteins and diverse responses. Steroids 70:407-417.
59. Zhou ZX, Lane MV, Kemppainen JA, French FS, Wilson EM. 1995. Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability. Mol Endocrinol 9:208-218.