Phenotypic analysis of EcR-A mutants suggests that EcR isoforms have unique functions during Drosophila development

Developmental Biology

Volumn 282, Issue 2, 2005, Pages 385-396

  Davis, Melissa B ^a,c   Carney, Ginger E ^a,b   Robertson, Anne E ^a   Bender, Michael ^a  

^a University of Georgia ^*  (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Drosophila; Ecdysone receptor; EcR A; Metamorphosis

Indexed keywords

ECR A PROTEIN; ECR B1 PROTEIN; ECR B2 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DROSOPHILA; EXON; FEMALE; GENE DELETION; GENE EXPRESSION; LARVA; MALE; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TRANSPOSON; WESTERN BLOTTING;

ANIMALIA;

EID: 20444372635     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2005.03.019     Document Type: Article

References (43)

1. A.J. Andres, and C.S. Thummel Methods for quantitative analysis of transcription in larvae and prepupae Methods Cell Biol. 44 1994 565 573
2. E.H. Baehrecke Steroid regulation of programmed cell death during Drosophila development Cell Death Differ. 7 2000 1057 1062
3. E.H. Baehrecke How death shapes life during development Nat. Rev., Mol. Cell Biol. 3 2002 779 787
4. S.P. Bainbridge, and M. Bownes Staging the metamorphosis of Drosophila melanogaster J. Embryol. Exp. Morphol. 66 1981 57 80
5. C.A. Bayer, S.R. Halsell, J.W. Fristrom, D.P. Kiehart, and L. von Kalm Genetic interactions between the RhoA and Stubble-stubbleoid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis Genetics 165 2003 1417 1432
6. M. Bender, F.B. Imam, W.S. Talbot, B. Ganetzky, and D.S. Hogness Drosophila ecdysone receptor mutations reveal functional differences among receptor isoforms Cell 91 1997 777 788
7. P. Berreu, P. Porcheron, M. Moriniere, J. Berreur-Bonnenfant, S. Belinski-Deutsch, D. Busson, and C. Lamour-Audit Ecdysteroids during the third larval instar in 1(3)ecd-1ts, a temperature-sensitive mutant of Drosophila melanogaster Gen. Comp. Endocrinol. 54 1984 76 84
8. M. Bialecki, A. Shilton, C. Fichtenberg, W.A. Segraves, and C.S. Thummel Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila Dev. Cell 3 2002 209 220
9. D.W. Borst, W.E. Bollenbacher, J.D. O'Connor, D.S. King, and J.W. Fristrom Ecdysone levels during metamorphosis of Drosophila melanogaster Dev. Biol. 39 1974 308 316
10. G.E. Carney, and M. Bender The Drosophila ecdysone receptor (EcR) gene is required maternally for normal oogenesis Genetics 154 2000 1203 1211
11. G.E. Carney, A. Robertson, M.B. Davis, and M. Bender Creation of EcR isoform-specific mutations in Drosophila melanogaster via local P element transposition, imprecise P element excision, and male recombination Mol. Genet. Genomics 271 2004 282 290
12. G.-C. Chen, P. Gajowniczek, and J. Settleman Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis Curr. Biol. 14 2004 309 313
13. L. Cherbas, X. Hu, I. Zhimulev, E. Belyaeva, and P. Cherbas EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue Development 130 2003 271 284
14. P.P. D'Avino, and C.S. Thummel The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosis Dev. Biol. 220 2000 211 224
15. F.E. Dela Cruz, D.R. Kirsch, and J.N. Henrich Transcriptional activity of Drosophila melanogaster ecdysone receptor isoforms and ultraspiracle in Saccharomyces cerevisiae J. Mol. Endocrinol. 24 2000 183 191
16. J.S. Fletcher, K.C. Burtis, D.S. Hogness, and C.S. Thummel The Drosophila E74 gene is required for metamorphosis and plays a role in the polytene chromosome puffing response to ecdysone Development 121 1995 1455 1465
17. V.C. Henrich, L. Livingston, and L.I. Gilbert Developmental requirements for the ecdysoneless (ecd) locus in Drosophila melanogaster Dev. Genet. 14 1993 369 377
18. X. Hu, L. Cherbas, and P. Cherbas Transcription activation by the ecdysone receptor (EcR/USP): identification of activation functions Mol. Endocrinol. 17 2003 716 731
19. C. Jiang, E. Baehrecke, and C.S. Thummel Steroid regulated programmed cell death during Drosophila metamorphosis Development 124 1997 4673 4683
20. S.J. Kim, J.G. Park, and C.C. Lee Transcript titers of ecdysteroid receptor components vary between tissues and stages during Drosophila development Mol. Cells 9 1999 61 66
21. I. Kiss, A.H. Beaton, J. Tardiff, D. Fristrom, and J.W. Fristrom Interactions and developmental effects of mutations in the Broad-complex of Drosophila melanogaster Genetics 118 1988 247 259
22. Koelle, M.R., 1992. Molecular analysis of the Drosophila ecdysone receptor complex. Ph.D. thesis, Stanford University, Stanford, CA.
23. T. Lee, S. Marticke, C. Sung, S. Robinow, and L. Luo Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila Neuron 28 2000 807 818
24. C. Lee, B. Cooksey, and E. Baehrecke Steroid regulation of midgut cell death during Drosophila development Dev. Biol. 250 2002 101
25. T.-R. Li, and M. Bender A conditional rescue system reveals essential functions for the ecdysone receptor (EcR) gene during molting and metamorphosis in Drosophila Development 127 2000 2897 2905
26. J.F. Mouillet, V.C. Henrich, M. Lezzi, and M. Vogtli Differential control of gene activity by isoforms A, B1 and B2 of the Drosophila ecdysone receptor Eur. J. Biochem. 268 2001 1811 1819
27. G. Richards The radioimmune assay of ecdysteroid titres in Drosophila melanogaster Mol. Cell. Endocrinol. 21 1981 181 197
28. L.M. Riddiford Hormones and Drosophila development M. Bate A. Martinez-Arias The Development of Drosophila melanogaster vol. 2 1993 Cold Spring Harbor Laboratory Press Cold Spring Harbor 899 940
29. C.W. Robertson The metamorphosis of Drosophila melanogaster, including an accurately timed account of the principal morphological changes J. Morphol. 59 1936 351 399
30. S. Robinow, W.S. Talbot, D.S. Hogness, and J.W. Truman Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform Development 119 1993 1251 1259
31. J.-Y. Roignant, C. Carre, B. Mugat, D. Szymczak, J.A. Lepesant, and C. Antoniewski Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila RNA 9 2003 299 308
32. C.R. Roseland, and H.A. Schneiderman Regulation and metamorphosis of the abdominal histoblasts of Drosophila melanogaster Roux's Arch. Dev. Biol. 186 1979 235 265
33. M. Schubiger, A.A. Wade, G.E. Carney, J.W. Truman, and M. Bender Drosophila EcR-B ecdysone receptor isoforms are required for larval molting and for neuron remodeling during metamorphosis Development 125 1998 2053 2062
34. M. Schubiger, S. Tomita, C. Sung, S. Robinow, and J.W. Truman Isoform specific control of gene activity in vivo by the Drosophila ecdysone receptor Mech. Dev. 120 2003 909 918
35. T.J. Sliter, and L.I. Gilbert Developmental arrest and ecdysteroid deficiency resulting from mutations at the dre4 locus of Drosophila Genetics 130 1992 555 568
36. C. Sung, and S. Robinow Characterization of the regulatory elements controlling neuronal expression of the A-isoform of the ecdysone receptor gene of Drosophila melanogaster Mech. Dev. 91 2000 237 248
37. W.S. Talbot, E.A. Swyryd, and D.S. Hogness Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms Cell 73 1993 1323 1337
38. H.E. Thomas, H.G. Stunnenberg, and A.F. Stewart Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle Nature 362 1993 471 475
39. C.S. Thummel Steroid-triggered death by autophagy Bioessays 23 2001 677 682
40. J.W. Truman, W.S. Talbot, S.E. Fahrbach, and D.S. Hogness Ecdysone receptor expression in the CNS correlates with stage-specific responses to ecdysteroids during Drosophila and Manduca development Development 120 1994 219 234
41. R.E. Ward, J. Evans, and C.S. Thummel Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis Genetics 165 2003 1397 1415
42. T.P. Yao, W.A. Segraves, A.E. Oro, M. McKeown, and R.M. Evans Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation Cell 71 1992 63 72
43. T.-P. Yao, B.M. Forman, Z. Jlang, L. Cherbas, J.-D. Chen, M. McKeown, P. Cherbas, and R.M. Evans Functional ecdysone receptor is the product of EcR and Ultraspiracle genes Nature 366 1993 476 479