Chronic β-AR activation-induced calpain activation and impaired eNOS-Akt signaling mediates cardiac injury in ovariectomized female rats

Expert Opinion on Therapeutic Targets

Volumn 13, Issue 3, 2009, Pages 275-286

  Bhuiyan, Md Shenuarin ^a   Shioda, Norifumi ^a   Fukunaga, Kohji ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Akt; Calpain; eNOS; Isoproterenol; Ovariectomy

Indexed keywords

BETA ADRENERGIC RECEPTOR; CALCIUM; CALPAIN; CALPASTATIN; CAVEOLIN 3; DYSTROPHIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK PROTEIN 90; ISOPRENALINE; PROTEIN KINASE B; SEX HORMONE; SPECTRIN; UTROPHIN; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; DEREGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HEART LEFT VENTRICLE; HEART MUSCLE INJURY; NONHUMAN; OVARIECTOMY; PATHOPHYSIOLOGY; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; HEART VENTRICLE; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; WISTAR RAT;

ADRENERGIC BETA-AGONISTS; ANIMALS; CALCIUM; CALCIUM-BINDING PROTEINS; CALPAIN; FEMALE; HEART VENTRICLES; ISOPROTERENOL; NITRIC OXIDE SYNTHASE TYPE III; OVARIECTOMY; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION;

EID: 65549097680     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728220902721312     Document Type: Article

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