Contribution of Calcium-activated Neutral Protease to the Degradation Process of Ischemic Heart

Japanese Circulation Journal

Volumn 55, Issue 11, 1991, Pages 1124-1126

  Toyo Oka, Teruhiko ^a   Morita, Minoru ^a   Shin, Woo See ^a   Okai Matsuo, Yoko ^a   Sugimoto, Tsuneaki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Calcium; Calpain; Potease

Indexed keywords

NEUTRAL PROTEINASE;

CALCIUM TRANSPORT; CELL DEATH; CONFERENCE PAPER; HEART MUSCLE ISCHEMIA; NONHUMAN;

EID: 0025933294     PISSN: 00471828     EISSN: None     Source Type: Journal    
DOI: 10.1253/jcj.55.1124     Document Type: Article

References (10)

1. Toyo-Oka T., Shimizu T., Masaki T.: Inhibition of proteolytic activity of calcium activated neutral protease by leupeptin and antipain. Biochem Biophys Res Commun 1978; 82: 484—491
2. Toyo-Oka T., Masaki T.: Calcium-activated neutral protease from bovine ventricular muscle: Isolation and some of its properties. J Mol Cell Cardiol 1979; 11: 769–786
3. Toyo-Oka T., Ross J. Jr.: Ca2+ sensitivity change and troponin loss in cardiac natural actomyosin after coronary occlusion. Am J Physiol 1981; 240: H704-8
4. Toyo-Oka T.: Phosphorylation with cyclic adenosine 3’ 5’ monophosphate-dependent protein kinase renders bovine cardiac troponin sensitive to the degradation by calcium-activated neutral protease. Biochem Biophys Res Commun 1982; 107: 44–50
5. Toyo-Oka T., Kamishiro T., Masaki M., Masaki T.: Reduction of experimentally produced acute myocardial infarction size by a new synthetic inhibitor, NCO-700, against calcium-activated neutral protease. Jpn Heart J 1982; 23: 829–834
6. Toyo-Oka T., Kamishiro T., Hara K., Nakamura N., Kitahara M., Masaki T.: Suppression of myocardial protein degradation by the protease inhibitor bis [ethyl (2R, 3R)-3-[(S)-methyl-1-[4-(2, 3, 4-tri-methoxy-phenyl-methyl) piperazine-l-ylcarbonyl] butyl-carbonyl] oxiran-2-carboxylat e] sulfate under hypoxia. Arzneimitte/forschung/Drug Res 1986; 36: 190—193
7. Toyo-Oka T., Kamishiro T., Gotoh Y., Fumino H., Masaki T., Hosoda S.: Temporary salvage of ischemic myocardium by the protease inhibitor bis [ethyl (2R, 3R)-3-[(S)-methyl-l-[4-(2, 3, 4-trimethoxyphenyl-methyl) piperazin-1-ylcarbonyl] butyl-carbonyl] oxiran-2-carboxylate] sulfate. Arzneimittelforschung 1986; 36: 671—675
8. Toyo-Oka T., Shin W.S., Okai Y., Dan Y., Morita M., Iizuka M., Sugimoto T.: Collagen-stimulated human platelet aggregation is mediated by endogenous calcium-activated neutral protease. Circ Res 1989; 64: 407—410
9. Ikeda U., Toyo-Oka T., Hosoda S.: Identification of two new calcium dependent hydrolases in the human heart. Biochem Biophys Res Commun 1986; 136: 773–777
10. Toyo-Oka., Hara K., Nakamura N., Kitahara M., Masaki T.: Ca overload and the action of calcium sensitive proteases, phospho-lipases and prostaglandin E2in myocardial cell degradation. Basic Res Cardiol 1985; 80: 303—315