Platelet activation impairs placental function

Thrombosis Research

Volumn 123, Issue SUPPL. 2, 2009, Pages

  Isermann, Berend ^a   Kashif, Muhammed ^a   Nawroth, Peter P ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ANIMAL MODEL; ARTICLE; BLOOD; FEMALE; FETUS DEATH; HUMAN; PHYSIOLOGY; PLACENTA; PLACENTA INSUFFICIENCY; PREGNANCY; THROMBOCYTE ACTIVATION;

ANIMALS; FEMALE; FETAL DEATH; HUMANS; MODELS, ANIMAL; PLACENTA; PLACENTAL INSUFFICIENCY; PLATELET ACTIVATION; PREGNANCY;

EID: 65549094894     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/S0049-3848(09)70018-0     Document Type: Article

References (15)

1. Vincelot A, et al. Platelet function during pregnancy: An evaluation using the PFA-100 analyser. Br J Anaesth 2001; 87:890 3.
2. Kam PC, Thompson SA, Liew AC. Thrombocytopenia in the parturient. Anaesthesia 2004;59:255 64.
3. Palumbo JS, et al. Role of fibrinogen- and plateletmediated hemostasis in mouse embryogenesis and reproduction. J Thromb Haemost 2004;2:1368 79.
4. Isermann B, et al. Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis. J Clin Invest 2001;108:537 46.
5. Isermann B, Hendrickson SB, Hutley K, Wing M, Weiler H. Tissue-restricted expression of thrombomodulin in the placenta rescues thrombomodulin-deficient mice from early lethality and reveals a secondary developmental block. Development 2001;128:827-38.
6. Isermann B, et al. The thrombomodulin protein C system is essential for the maintenance of pregnancy. Nat Med 2003;9:331-7.
7. Gu JM, et al. Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality. J Biol Chem 2002;277: 43335-43.
8. Li W, et al. Extraembryonic expression of EPCR is essential for embryonic viability. Blood 2005;106:2716-22.
9. Sood R, et al. Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin. Blood 2008;112:585-91.
10. Sood R, et al. Fetal gene defects precipitate plateletmediated pregnancy failure in factor V Leiden mothers. J Exp Med 2007;204:1049 56.
11. Sood R, Kalloway S, Mast AE, Weiler H. Thrombophilia and pregnancy failure: Feto maternal interactions in the vascular bed of the placenta. Thromb Res 2005; 115(Suppl 1):92-4.
12. Ohlsson R et al. PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta. Dev Biol 1999;212:124 36.
13. Smith S, Francis R, Guilbert L, Baker PN. Growth factor rescue of cytokine mediated trophoblast apoptosis. Placenta 2002;23:322-30.
14. Sato Y, et al. Platelet-derived soluble factors induce human extravillous trophoblast migration and differentiation: Platelets are a possible regulator of trophoblast infiltration into maternal spiral arteries. Blood 2005;106: 428 35.
15. Zhou Y, Damsky CH, Fisher SJ. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? J Clin Invest 1997;99:2152 64.