Two different homing pathways involving integrin β7 and E-selectin significantly influence trafficking of CD4 cells to the genital tract following chlamydia muridarum infection

American Journal of Reproductive Immunology

Volumn 61, Issue 6, 2009, Pages 438-445

  Kelly, Kathleen A ^a   Chan, Ann M ^b   Butch, Anthony ^a   Darville, Toni ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Cell migration; Chemokines; Chlamydia; Lymphocytes; Murine

Indexed keywords

BETA7 INTEGRIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CD4+ T LYMPHOCYTE; CHLAMYDIA; CHLAMYDIASIS; CONFERENCE PAPER; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GENITAL SYSTEM; GENITAL TRACT INFECTION; IN VIVO STUDY; KNOCKOUT MOUSE; LYMPHOCYTE HOMING; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CHLAMYDIA INFECTIONS; CHLAMYDIA MURIDARUM; CHLAMYDIA TRACHOMATIS; E-SELECTIN; FEMALE; GENITALIA, FEMALE; INTEGRIN BETA CHAINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT;

EID: 65549092076     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2009.00704.x     Document Type: Conference Paper

References (31)

1. Morrison RP, Caldwell HD: Immunity to murine chlamydial genital infection. Infect Immun 2002; 70:2741-2751.
2. Rank RG: Models of Immunity. Washington, DC, ASM Press, 1999.
3. Kelly KA, Robinson EA, Rank RG: Initial route of antigen administration alters the T-cell cytokine profile produced in response to the mouse pneumonitis biovar of Chlamydia trachomatis following genital infection. Infect Immun 1996; 64:4976-4983.
4. Campbell DJ, Butcher EC: Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues. J Exp Med 2002; 195:135-141.
5. Hawkins RA, Rank RG, Kelly KA: Expression of mucosal homing receptor alpha4beta7 is associated with enhanced migration to the Chlamydia - infected murine genital mucosa in vivo. Infect Immun 2000; 68:5587-5594.
6. Kelly KA, Rank RG: Identification of homing receptors that mediate the recruitment of CD4 T cells to the genital tract following intravaginal infection with Chlamydia trachomatis. Infect Immun 1997; 65:5198-5208.
7. Kelly KA, Natarajan S, Ruther P, Wisse A, Chang MH, Ault KA: Chlamydia trachomatis infection induces mucosal addressin cell adhesion molecule-1 and vascular cell adhesion molecule-1, providing an immunologic link between the fallopian tube and other mucosal tissues. J Infect Dis 2001; 184: 885-891.
8. Wagner N, Luhler J, Kunkel EJ, Ley K, Leung E, Krissansen G, Rajewsky K, Muller W: Critical role for á7 integrins in formation of the gut-associated lymphoid tissue. Nature 1996; 382:366-370.
9. Lefrancois L, Parker CM, Olson S, Muller W, Wagner N, Schon MP, Puddington L: The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response. J Exp Med 1999; 189:1631-1638.
10. Bullard DC, Kunkel EJ, Kubo H, Hicks MJ, Lorenzo I, Doyle NA, Doerschuk CM, Ley K, Beaudet AL: Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med 1996; 183:2329-2336.
11. Caldwell HD, Kromhout J, Schachter J: Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis. Infect Immun 1981; 31:1161-1176.
12. Maxion HKM, Liu W, Chang MH, Kelly KA: The infecting dose of Chlamydia muridarum modulates the innate immune response and ascending infection. Infect Immun 2004; 72:6330-6340.
13. Igietseme JU, Ramsey KH, Magee DM, Williams DM, Kincy TJ, Rank RG: Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific TH1 lymphocyte clone. Regional Immunol 1993; 5:317-324.
14. Hawkins RA, Rank RG, Kelly KA: A Chlamydia trachomatis - bspecific Th2 clone does not provide protection against a genital infection and displays reduced trafficking to the infected genital mucosa. Infect Immun 2002; 70:5132-5139.
15. Hamann A, Andrew DP, Jablonski-Westrich D, Holzmann B, Butcher EC: Role of a4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol 1994; 152:3282-3293.
16. Maxion HK, Kelly KA: Differential chemokine expression in distinct regions of the murine genital tract during Chlamydia trachomatis infection. Infect Immun 2002; 70:1538-1546.
17. Arenberg DA, Kunkel SL, Polverini PJ, Morris SB, Burdick MD, Glass MC, Taub DT, Iannettoni MD, Whyte RI, Strieter RM: Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases. J Exp Med 1996; 184:981-992.
18. Berlin C, Berg EL, Briskin MJ, Andrew DP, Kilshaw PJ, Holzmann B, Weissman IL, Hamann A, Butcher EC: A4b7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1993; 74:185-195.
19. Ni Z, Walcheck B: Varied levels of reactivity by different E-selectin/Fc constructs with cutaneous lymphocyte-associated antigen (CLA)+ CD4+ T cells. Immunol Lett 2007; 108:179-182.
20. Min W, Pober JS: TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC/ CDC42-JNK-c-Jun/ATF2 pathways. J Immunol 1997; 159:3508-3518.
21. Darville T, Andrews CW Jr, Rank RG: Does inhibition of tumor necrosis factor alpha affect chlamydial genital tract infection in mice and guinea pigs? Infect Immun 2000; 68:5299-5305.
22. Lukacs NW, John A, Berlin A, Bullard DC, Knibbs R, Stoolman LM: E- and P-Selectins Are Essential for the Development of Cockroach Allergen-Induced Airway Responses. J Immunol 2002; 169:2120-2125.
23. Brunham RC, Rey-Ladino J: Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine. Nat Rev Immunol 2005; 5:149-161.
24. Rank RG, Bavoil PM: Prospects for a vaccine against Chlamydia genital disease. 2. Immunity and vaccine development. Bull Inst Pasteur 1996; 94:55-82.
25. Rappuoli R: Bridging the knowledge gaps in vaccine design. Nat Biotech 2007; 25:1361-1366.
26. Neutra MR, KTzlowski PA: Mucosal vaccines: the promise and the challenge. Nat Rev Immunol 2006; 6:148-158.
27. Mora JR, Cheng G, Picarella D, Briskin M, Buchanan N, von Andrian UH: Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues. J Exp Med 2005; 201:303-316.
28. Mora JR, Bono MR, Manjunath N, Weninger W, Cavanagh LL, Rosemblatt M, Von Andrian UH: Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature 2003; 424:88-93.
29. Austrup F, Vestweber D, Borges E, Lohning M, Brauer R, Herz U, Renz H, Hallmann R, Scheffold A, Radbruch A, Hamann A: P- and E-selectin mediate recruitment of T helper 1 but not T helper 2 cells into inflammed tissues. Nature 1997; 385:81-83.
30. Haddad W, Cooper CJ, Zhang Z, Brown JB, Zhu Y, Issekutz A, Fuss I, Lee HO, Kansas GS, Barrett TA: P-selectin and P-selectin glycoprotein ligand 1 are major determinants for Th1 cell recruitment to nonlymphoid effector sites in the intestinal lamina propria. J Exp Med 2003; 198:369-377.
31. Perry LL, Feilzer K, Portis JL, Caldwell HD: Distinct homing pathways direct T lymphocytes to the genital and intestinal mucosae in Chlamydia - infected mice. J Immunol 1998; 160:2905-2914.