Silver-catalyzed cross-coupling reactions of alkyl bromides with alkyl or aryl Grignard reagents

Tetrahedron Letters

Volumn 50, Issue 26, 2009, Pages 3270-3272

  Someya, Hidenori ^a   Yorimitsu, Hideki ^a   Oshima, Koichiro ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; BROMINE DERIVATIVE; GRIGNARD REAGENT; POTASSIUM FLUORIDE; SILVER;

ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; CROSS COUPLING REACTION; STEREOCHEMISTRY;

EID: 65549088076     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.02.040     Document Type: Article

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22. We also detected alkenes and alkanes in these reactions. The alkanes were the main byproducts.
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24. 2O, and THF resulted in lower yields. The reaction in pentane resulted in a similar yield with a prolonged reaction time of 11 h.
25. 3, and KF were used as additives in refluxing hexane, 3c was obtained in 44%, 16%, 54%, and 56% yields, respectively. When no additive was used, 3c was obtained in 41% yield.