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For exhaustive reviews on iron-mediated coupling reactions see: (a) Fürstner, A.; Martin, R. Chem. Lett. 2005, 34, 624.
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62149106743
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Palladium- or nickel-catalyzed alkylation reactions generally suffer from β-elimination processes from the intermediate alkyl-metal species formed during the reaction, thus limiting the scope of the possible halogenoalkanes used as a substrate
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Palladium- or nickel-catalyzed alkylation reactions generally suffer from β-elimination processes from the intermediate alkyl-metal species formed during the reaction, thus limiting the scope of the possible halogenoalkanes used as a substrate.
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18
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62149105601
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Several interesting exemples of reaction between ArMgX and primary functionalized alkyl halides in the presence of [Fe(C2H 4)4][Li(tmeda)]2 as a catalyst were recently described by Fürstner.4a However, the yields are significantly lower when secondary functionalized unactivated alkyl bromides are used
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4a However, the yields are significantly lower when secondary functionalized unactivated alkyl bromides are used.
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Manganese salts are also very attractive from both economical and environmental points of view. For Mn-catalyzed cross-coupling reactions, see: a, in press
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Manganese salts are also very attractive from both economical and environmental points of view. For Mn-catalyzed cross-coupling reactions, see: (a) Cahiez, G.; Duplais, C.; Buendia, J. Chem. Rev. 2008, in press.
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