Presence of t(14;18) positive cells in blood and bone marrow does not predict outcome in follicular lymphoma

Medical Oncology

Volumn 26, Issue 1, 2009, Pages 16-21

  Paszkiewicz Kozik, E ^a   Kulik, J ^a   Fabisiewicz, A ^a   Tysarowski, A ^a   Kraszewska, E ^a   Siedlecki, J A ^a   Walewski, J ^a  

^a INSTITUTE OF ONCOLOGY   (Poland)

Author keywords

BCL 2 rearrangement; Follicular Lymphoma; PCR; Prognosis

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; PREDNISONE; PROTEIN BCL 2; VINCRISTINE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; COP PROTOCOL 2; PROTEIN BAK;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BLOOD SAMPLING; BONE MARROW EXAMINATION; CANCER DIAGNOSIS; CANCER RADIOTHERAPY; CANCER SURVIVAL; CHROMOSOME TRANSLOCATION 14; CHROMOSOME TRANSLOCATION 18; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FOLLICULAR LYMPHOMA; GENE REARRANGEMENT; HUMAN; LYMPH NODE BIOPSY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; RISK ASSESSMENT; SURVIVAL RATE; SURVIVAL TIME; TREATMENT OUTCOME; BLOOD CELL; BONE MARROW CELL; CHROMOSOME 14; CHROMOSOME 18; GENE TRANSLOCATION; GENETICS; IMMUNOTHERAPY; MIDDLE AGED; PATHOPHYSIOLOGY; RADIOTHERAPY;

ADULT; AGED; AGED, 80 AND OVER; ALKYLATING AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BLOOD CELLS; BONE MARROW CELLS; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 18; CYCLOPHOSPHAMIDE; FEMALE; GENE REARRANGEMENT; HUMANS; IMMUNOTHERAPY; LYMPHATIC IRRADIATION; LYMPHOMA, FOLLICULAR; MALE; MIDDLE AGED; PREDNISONE; PROGNOSIS; TRANSLOCATION, GENETIC; VINCRISTINE;

EID: 65549085401     PISSN: 13570560     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12032-008-9071-1     Document Type: Article

References (37)

1. Jaffe ES, Harris NL, Stein H, Vardiman JW. Pathology and genetics of tumors of hematopoietic and lymphoid tissues. In: Kleihues P, Sobin L, editors. World Health Organization classification of tumors. vol. 3. Lyon: IARC Press; 2001.
2. JO Armitage DD Weisenburger 1998 New approach to classifying non-Hodgkin's lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin's Lymphoma Classification Project J Clin Oncol 16 8 2780 95
3. G Buchonnet 2000 Characterization of Bcl2-JH rearrangement in follicular lymphoma: PCR detection of 3' Bcl2 breakpoints and evidence of new cluster Leukemia 14 1563 9
4. U Jaeger 1994 Molecular mechanism of the t(14,18)-a model for lymphoid-specific chromosomal translocations Leuk Lymphoma 14 197 202
5. K Mrózek CD Bloomfield 1993 Cytogenetics of Indolent Lymphomas Semin Oncol 20 Suppl 5 47 57
6. J Aster J Longtine 2002 Detection of Bcl2 rearrangements in follicular lymphoma Am J Pathol 160 759 63
7. IA Voutsadakis 2000 Apoptosis and pathogenesis of lymphoma Acta Oncol 39 151 6
8. A predictive model for aggressive non-Hodgkin's lymphoma 1993 The International Non-Hodgkin's Lymphoma Prognostic Factors Project N Engl J Med 329 987 94
9. P Solal-Celigny 2004 Follicular lymphoma international index Blood 104 1258 65
10. Maniatis T, et al. Molecular cloning: a laboratory manual. CSH Laboratory Press; 1982.
11. JG Gribben 1991 All advanced stage non-Hodgkin's lymphomas with a polymerase chain reaction amplifiable breakpoint of bcl-2 have residual cells containing the bcl-2 rearrangement at evaluation and after treatment Blood 78 3275 80
12. B Cheson 1999 Report of an International Workshop to Standardize Response Criteria for Non-Hodgkin's lymphomas J Clin Oncol 17 1244 53
13. AM Muller G Ihorst R Mertelsmann M Engelhardt 2005 Epidemiology of non-Hodgkin's lymphoma (NHL): trends, geographic distribution, and etiology Ann Hematol 84 1 12
14. JJ Biagi JF Seymour 2002 Insights into the molecular pathogenesis of follicular lymphoma arising from analysis from geographic variation Blood 99 4265 75
15. Wojciechowska U, Didkowska J, Tarkowski W, Zatonski W. Cancer in Poland in 2005. http://epid.coi.waw.pl/krn.
16. K Galazka J Szpor R Maryniak 2007 Incidence of lymphomas in Poland. The National Register Data for 2006 Pol J Pathol 58 199 206
17. JC Aster JA Longtine 2002 Detection of Bcl2 rearrangements in follicular lymphoma Am J Pathol 160 759 63
18. JJM van Dongen 2003 Design of standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of BIOMED-2 concerted action BMH4-CT98-3936 Leukemia 17 2257 317
19. PWM Johnson 1999 Variability of polymerase chain reaction detection of bcl-2-Igh translocation in an international multicentre study Ann Oncol 10 1349 54
20. A Bagg RM Braziel DA Arber KE Bijwaard AY Chu 2002 Immunoglobulin heavy chain gene analisis in lymphomas. A multi-center study demonstrating the heterogenity of performance of polymerase chain reaction assays J Mol Diagn 4 81 9
21. J Liu RM Johson ST Traweek 1993 Rearrangement of BCL-2 gene in follicular lymphoma. Detection by PCR in both fresh and fixed tissue samples Diagn Mol Pathol 2 241 7
22. A Albinger-Hegyi 2002 High frequency of t(14;18)-translocation breakpoints outside of major breakpoint and minor cluster regions in follicular lymphomas. Improved polymerase chain reaction protocols for their detection Am J Pathol 160 823 32
23. A James 2002 Follicular lymphoma with novel t(14;18) breakpoint involving the immunoglobulin heavy chain switch mu region indicates an origin from germinal center B cells Blood 15 716 8
24. J Lubinski 1995 Environmental factors may regulate BCL2 associated lymphomagenesis: a very low incidence of BCL2-MBR translocation in Poland Pol J Pathol 46 219 24
25. G Dölken G Illerhaus C Hirt R Mertelsmann 1996 BCL-2/JH rearrangement in circulating B cells of healthy blood donors and patients with non-malignant diseases J Clin Oncol 14 1333 44
26. K Summers 2001 Frequency of the BCL-2/JH rearrangement in normal individuals: implication for the monitoring of disease in patients with follicular lymphoma J Clin Oncol 19 420 4
27. D McGregor 2005 The implication of follicular lymphoma patients receiving allogeneic stem cell transplantation from donors carrying t(14;18)-positive cells Bone Marrow Transplant 35 1049 54
28. LH Sehn RD Gascoyne JM Connors RJ Klasa DE Horsman 2000 Comparison of t(14;18) positive and t(14;18) negative follicular lymphoma (FL): clinical characteristics, outcomes and cytogenetics Blood 96 574
29. A Lopez-Guillermo 1999 Correlation of BCL-2 rearrangement with clinical characteristics and outcome in indolent follicular lymphomas Blood 91 2955 60
30. S Iqubal 2004 Reliable detection of clonal IgH/BCL2 MBR rearrangements in follicular lymphoma: methodology and clinical significance Br J Haematol 124 325 8
31. S Montoto 2003 Incidence and clinical significance of BCL-2/IgH rearrangements in follicular lymphoma Leuk Lymphoma 44 71 6
32. RD Gascoyne 1997 Prognostic significance of BCL 2 protein expression and BCL 2 gene rearrangements in diffuse aggressive non-Hodgkin's lymphoma Blood 90 244 51
33. SL Barrans 2003 The t(14;18) is associated with germinal center-derived diffuse large B-cell lymphoma and is a strong predictor of outcome Clin Cancer Res 9 2133 39
34. JR Goodlad 2006 BCL2 gene abnormalities define distinct clinical subsets of follicular lymphoma Histopathology 49 229 41
35. R Franco 2001 Cutaneous follicular B-cell lymphoma: description of a series of 18 cases Am J Surg Pathol 25 875 83
36. A Lopez-Guillermo 1998 The significance of molecular response in indolent follicular lymphomas Blood 91 2955 60
37. J Finke J Slanina W Lange G Dölken 1993 Persistence of circulating t(14;18)-positive cells in long term remission after radiation therapy for localized-stage follicular lymphoma. J Clin Oncol 11 1668 73