Pharmacophore-based 3D-QSAR of HIF-1 inhibitors

Archives of Pharmacal Research

Volumn 32, Issue 3, 2009, Pages 317-323

  Chung, Jae Yoon ^a   Pasha, F A ^a   Cho, Seung Joo ^b   Won, Misun ^c   Lee, Jung Joon ^c   Lee, Kyeong ^c  

^a Korea Institute of Science and Technology   (South Korea)

^b Chosun University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

3D QSAR; CoMFA; CoMSIA; Drug design; HIF 1 Inhibitor; Pharmacophore

Indexed keywords

ANTINEOPLASTIC AGENT; BENZOIC ACID DERIVATIVE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; HYDROGEN BOND; PHARMACOPHORE; PROTEIN STRUCTURE; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BENZOIC ACIDS; COMPUTER-AIDED DESIGN; DRUG DESIGN; HYDROGEN BONDING; HYPOXIA-INDUCIBLE FACTOR 1; IMAGING, THREE-DIMENSIONAL; ISONICOTINIC ACIDS; LEAST-SQUARES ANALYSIS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NICOTINIC ACIDS; PROTEIN CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRODUCIBILITY OF RESULTS;

EID: 65449166088     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-009-1301-3     Document Type: Article

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