Drug development targeting the glycogen synthase kinase-3β (GSK-β)-mediated signal transduction pathway: The role of GSK-β in the maintenance of steady-state levels of insulin receptor signaling molecules and nav1.7 sodium channel in adrenal chromaffin cells

Journal of Pharmacological Sciences

Volumn 109, Issue 2, 2009, Pages 157-161

  Nemoto, Takayuki ^a   Yanagita, Toshihiko ^a   Kanai, Tasuku ^a   Wada, Akihiko ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

Adrenal chromaffin cell; Glycogen synthase kinase 3 (GSK 3 ); Insulin receptor substrates 1 and 2; LiCl; Nav1.7 sodium channel

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINIC RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; SOMATOMEDIN C; TACROLIMUS; VOLTAGE GATED SODIUM CHANNEL; GLYCOGEN SYNTHASE KINASE 3; SODIUM CHANNEL;

CARCINOGENESIS; CELL CULTURE; CELL SURFACE; CHROMAFFIN CELL; DOWN REGULATION; DRUG TARGETING; ENZYME ACTIVITY; HUMAN; INFLAMMATION; INSULIN RESISTANCE; NERVE DEGENERATION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SHORT SURVEY; SIGNAL TRANSDUCTION; STEADY STATE; UPREGULATION; ADRENAL GLAND; ANIMAL; CATTLE; DRUG DELIVERY SYSTEM; METABOLISM; REVIEW;

ADRENAL GLANDS; ANIMALS; CATTLE; CHROMAFFIN CELLS; DOWN-REGULATION; DRUG DELIVERY SYSTEMS; GLYCOGEN SYNTHASE KINASE 3; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; SODIUM CHANNELS; UP-REGULATION;

EID: 65449152616     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08R20FM     Document Type: Short Survey

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