β cell protecting and immunomodulatory activities of Paecilomyces Hepiali Chen mycelium in STZ induced T1DM mice

American Journal of Chinese Medicine

Volumn 37, Issue 2, 2009, Pages 361-372

  Xiang, Ming ^a   Tang, Jing ^b   Zou, Xiao Lei ^a   Zhao, Zeng Yu ^a   Wang, Yun Yang ^a   Xie, Sheng Nan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

cell protection; CD4+ T cells; Diabetes; Immunomodulatory effect; Paecilomyces Hepiali Chen

Indexed keywords

ANTIDIABETIC AGENT; METFORMIN; PAECILOMYCES HEPIALI EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; IMMUNOMODULATION; INFLAMMATORY INFILTRATE; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PAECILOMYCES; PAECILOMYCES HEPIALI; PANCREAS ISLET BETA CELL; STREPTOZOCIN DIABETES;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; IMMUNOLOGIC FACTORS; INSULIN; ISLETS OF LANGERHANS; MALE; METFORMIN; MICE; MICE, INBRED BALB C; PAECILOMYCES; STREPTOZOCIN;

EID: 65449147839     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X09006825     Document Type: Article

References (23)

1. Elliott, J.I., H. Dewchand and D.M. Altmann. Streptozotocin-induced diabetes in mice lacking α β T cells. Clin. Exp. Immunol. 109: 116-120, 1997.
2. Jong-Yuh, C. and S. Mei-Fen. Potential hypoglycemic effects of Chlorella in streptozotocin- induced diabetic mice. Life Sci. 77: 980-990, 2005.
3. Kiho, T., Y. Shiose, K. Nagai and S. Ukai. Polysaccharides in fungi. XXX. Antitumor and immunomodulating activities of two polysaccharides from the fruiting bodies of Armillariella tabescens. Chem. Pharm. Bull. 40: 2110-2114, 1992.
4. Kiho, T., A. Yamane, J. Hui, S. Usui and S. Ukai. Polysaccharide in fungi. XXXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultural mycelium of Cordyceps sinensis and its effects on glucose metabolism in mouse liver. Biol. Pharm. Bull. 19: 294-296, 1996.
5. Kim, K.M., Y.G. Kwon, H.T. Chung, Y.G. Yun, H.O. Pae, J.A. Han, K.S. Ha, T.W. Kim and Y.M. Kim. Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppressing NF-kappaB activation. Toxicol. Appl. Pharmacol. 190: 1-8, 2003.
6. Koarada, S., Y. Wu and W.M. Ridgway. Increased entry into the IFN-gamma effector pathway by CD4+ T cells selected by I-Ag7 on a nonobese diabetic versus C57BL/6 genetic background. J. Immunol. 167: 1693-1702, 2001.
7. Kolb, H., M. Oschilewski, U. Oschilewski, E. Schwab, C.M. Moumé, B. Greulich, V. Burkart, J. Zielasek and U. Kiesel. Analysis of 22 immunomodulatory substances for efficacy in low-dose streptozotocin-induced diabetes. Diabetes Res. 6: 21-27, 1987.
8. Kolb-Bachofen, V., S. Epstein, U. Kiesel and H. Kolb. Low dose streptozotocin induced diabetes in mice. Electron microscopy reveals single-cell insulitis before diabetes onset. Diabetes 37: 21-27, 1988.
9. Lucienne, C. Protection from autoimmunity: Immunological indifference versus T-cell mediated suppression? Eur. J. Immunol., 36, 2296-2298, 2006.
10. Lukic, M.L., S. Stosic-Grujicic and A. Shahin. Effector mechanisms in low dose streptozotocin induced diabetes. Dev. Immunol. 6: 119-128, 1998.
11. Maksimovic-Ivanic, D., V. Trajkovic, D.J. Miljkovic, M. Mostarica Stojkovic and S. Stosic- Grujicic. Down-regulation of multiple low dose streptozotocin-induced diabetes by mycophenolate mofetil. Clin. Exp. Immunol. 129: 214-223, 2002.
12. Ng, T.B. and H.X. Wang. Pharmacological actions of Cordyceps, a prized folk medicine. J. Pharm. Pharmacol. 57: 1509-1519, 2005.
13. Pearl-Yafe, M., A. Kaminitz, E.S. Yolcu, I. Yaniv, J. Stein and N. Askenasy. Pancreatic islets under attack: Cellular and molecular effectors. Curr. Pharm. Des. 13: 749-760, 2007.
14. Pechhold, K., N.B. Patterson, C. Blum, C.L. Fleischacker, B.O. Boehm and D.M. Harlan. Low dose streptozotocin-induced diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent. J. Immunol. 166: 2531-2539, 2001.
15. Sai, P., D. Maugendre, O. Loreal, C. Maurel and S. Pogu. Effects of cyclosporin on autoimmune diabetes induced in mice by streptozotocin. Diabete Metab. 14: 455-462, 1988.
16. Stosic-Grujicic, S., I. Cvetkovic, K. Mangano, M. Fresta, D. Maksimovic-Ivanic, L. Harhaji, D. Popadic, M. Momcilovic, D. Miljkovic, J. Kim, Y. Al-Abed and F. Nicoletti. A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immuno-inflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice. J. Pharmacol. Exp. Ther. 320: 1038-1049, 2007.
17. Suarez-Pinzon, W., O. Sorensen, R.C. Bleackley, J.F. Elliott, R.V. Rajotte and A. Rabinovitch. Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets. Diabetes 48: 21-28, 1999.
18. Sun, M., Y.R. Yang, Y.P. Lu, R. Gao, L. Wang, J. Wang and K. Tang. Clinical study on application of Bailing capsule after renal transplantation. Zhongguo Zhong Xi Yi Jie He Za Zhi 24: 808-810, 2004.
19. Tsunoo, A.,N. Taketomo, M. Kamijo, N. Kinjo, A.Yamashita and N.L. Huan. Pharmacological effects of themycelial extract of cultured Cordyceps sinensis on airways and aortal of the rat. In: Elliott, T.J. (ed.), Science and Cultivation of Edible Fungi, pp. 425-431, 1995.
20. Xiang, M., J. Tang, T. Chu, C.L. Zhang and X.L. Zou. Hypoglycemic effect and mechanism study on streptozocin induced diabetes in mice by Paecilomyces hepiali Chen Mycelium. Chin. Hosp. Pharm. J. 26: 556-559, 2006.
21. + T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice. Eur. J. Immunol. 22: 2387-2393, 1992.
22. Yang, Z.,M. Chen, L.B. Fialkow, J.D. Ellet, R.Wu and J.L. Nadler. The novel anti- inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice. Pancreas 26: e99-104, 2003.
23. Yin, D. and X. Tang. Advances in the study on artificial cultivation of Cordyceps sinence. Zhongguo Zhong Yao Za Zhi 20: 707-709, 1995.