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Volumn 2, Issue 3, 2009, Pages 220-231

MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN SULFATE; MEPRIN; MEPRIN ALPHA; MESSENGER RNA; PROTEIN MEP1A; UNCLASSIFIED DRUG;

EID: 65449141343     PISSN: 19330219     EISSN: None     Source Type: Journal    
DOI: 10.1038/mi.2009.3     Document Type: Article
Times cited : (67)

References (48)
  • 1
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier, R.J. & Podolsky, D.K. Unravelling the pathogenesis of inflammatory bowel disease. Nature 448, 427-434 (2007).
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 2
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura, Y. et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603-606 (2001).
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1
  • 3
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr R.H. et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314, 1461-1463 (2006).
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1
  • 4
    • 0033358520 scopus 로고    scopus 로고
    • Linkage of inflammatory bowel disease to human chromosome 6p
    • Hampe, J. et al. Linkage of inflammatory bowel disease to human chromosome 6p. Am. J. Hum. Genet. 65, 1647-1655 (1999).
    • (1999) Am. J. Hum. Genet , vol.65 , pp. 1647-1655
    • Hampe, J.1
  • 5
    • 0028826110 scopus 로고
    • Fine mapping of MEP1A, the gene encoding the alpha subunit of the metalloendopeptidase meprin, to human chromosome 6P21
    • Jiang, W. et al. Fine mapping of MEP1A, the gene encoding the alpha subunit of the metalloendopeptidase meprin, to human chromosome 6P21. Biochem. Biophys. Res. Commun. 216, 630-635 (1995).
    • (1995) Biochem. Biophys. Res. Commun , vol.216 , pp. 630-635
    • Jiang, W.1
  • 6
    • 0030200139 scopus 로고    scopus 로고
    • Expression and distribution of meprin protease subunits in mouse intestine
    • Bankus, J.M. & Bond, J.S. Expression and distribution of meprin protease subunits in mouse intestine. Arch. Biochem. Biophys. 331, 87-94 (1996).
    • (1996) Arch. Biochem. Biophys , vol.331 , pp. 87-94
    • Bankus, J.M.1    Bond, J.S.2
  • 7
    • 0001082248 scopus 로고    scopus 로고
    • Secretion of human meprin from intestinal epithelial cells depends on differential expression of the alpha and beta subunits
    • Lottaz, D., Hahn, D., Muller, S., Muller, C. & Sterchi, E.E. Secretion of human meprin from intestinal epithelial cells depends on differential expression of the alpha and beta subunits. Eur. J. Biochem. 259 496-504 (1999).
    • (1999) Eur. J. Biochem , vol.259 , pp. 496-504
    • Lottaz, D.1    Hahn, D.2    Muller, S.3    Muller, C.4    Sterchi, E.E.5
  • 8
    • 0033104363 scopus 로고    scopus 로고
    • Nonpolarized secretion of human meprin alpha in colorectal cancer generates an increased proteolytic potential in the stroma
    • Lottaz, D., Maurer, C.A., Hahn, D., Buchler, M.W. & Sterchi, E.E. Nonpolarized secretion of human meprin alpha in colorectal cancer generates an increased proteolytic potential in the stroma. Cancer Res. 59, 1127-1133 (1999).
    • (1999) Cancer Res , vol.59 , pp. 1127-1133
    • Lottaz, D.1    Maurer, C.A.2    Hahn, D.3    Buchler, M.W.4    Sterchi, E.E.5
  • 9
    • 33847665621 scopus 로고    scopus 로고
    • Compartmentalised expression of meprin in small intestinal mucosa: Enhanced expression in lamina propria in coeliac disease
    • Lottaz, D. et al. Compartmentalised expression of meprin in small intestinal mucosa: Enhanced expression in lamina propria in coeliac disease. Biol. Chem. 388, 337-341 (2007).
    • (2007) Biol. Chem , vol.388 , pp. 337-341
    • Lottaz, D.1
  • 10
    • 1642373361 scopus 로고    scopus 로고
    • Deletion of the mouse meprin beta metalloprotease gene diminishes the ability of leukocytes to disseminate through extracellular matrix
    • Crisman, J.M., Zhang, B., Norman, L.P. & Bond, J.S. Deletion of the mouse meprin beta metalloprotease gene diminishes the ability of leukocytes to disseminate through extracellular matrix. J. Immunol. 172, 4510-4519 (2004).
    • (2004) J. Immunol , vol.172 , pp. 4510-4519
    • Crisman, J.M.1    Zhang, B.2    Norman, L.P.3    Bond, J.S.4
  • 11
    • 0028969678 scopus 로고
    • The metzincins - topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases
    • Stocker, W. et al. The metzincins - topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases. Protein Sci. 4, 823-840 (1995).
    • (1995) Protein Sci , vol.4 , pp. 823-840
    • Stocker, W.1
  • 12
    • 20444376552 scopus 로고    scopus 로고
    • Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer
    • Bond, J.S., Matters, G.L., Banerjee, S. & Dusheck, R.E. Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer. FEBS Lett. 579, 3317-3322 (2005).
    • (2005) FEBS Lett , vol.579 , pp. 3317-3322
    • Bond, J.S.1    Matters, G.L.2    Banerjee, S.3    Dusheck, R.E.4
  • 13
    • 1642362446 scopus 로고    scopus 로고
    • Human meprin alpha and beta homo-oligomers: Cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors
    • Kruse, M. N. et al. Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Biochem. J. 378, 383-389 (2004).
    • (2004) Biochem. J , vol.378 , pp. 383-389
    • Kruse, M.N.1
  • 14
    • 23844493371 scopus 로고    scopus 로고
    • Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta
    • Hirano, M. et al. Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta. J. Immunol. 175, 3177-3185 (2005).
    • (2005) J. Immunol , vol.175 , pp. 3177-3185
    • Hirano, M.1
  • 15
    • 0028906545 scopus 로고
    • The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively
    • Bond, J.S., Rojas, K., Overhauser, J., Zoghbi, H.Y. & Jiang, W. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively. Genomics 25, 300-303 (1995).
    • (1995) Genomics , vol.25 , pp. 300-303
    • Bond, J.S.1    Rojas, K.2    Overhauser, J.3    Zoghbi, H.Y.4    Jiang, W.5
  • 16
    • 0030610342 scopus 로고    scopus 로고
    • Assignment of Mep 1a to mouse chromosome band 17C1-D1 by in situ hybridization
    • Jiang, W. & Beatty, B.G. Assignment of Mep 1a to mouse chromosome band 17C1-D1 by in situ hybridization. Cytogenet. Cell Genet. 76, 206-207 (1997).
    • (1997) Cytogenet. Cell Genet , vol.76 , pp. 206-207
    • Jiang, W.1    Beatty, B.G.2
  • 17
    • 0027495896 scopus 로고
    • Cloning, expression, and chromosomal localization of the mouse meprin beta subunit
    • Gorbea, C.M. et al. Cloning, expression, and chromosomal localization of the mouse meprin beta subunit. J. Biol. Chem. 268, 21035-21043 (1993).
    • (1993) J. Biol. Chem , vol.268 , pp. 21035-21043
    • Gorbea, C.M.1
  • 18
    • 0034652326 scopus 로고    scopus 로고
    • Human N benzoyl-L-tyrosyl- p -aminobenzoic acid hydrolase (human meprin): Genomic structure of the alpha and beta subunits
    • Hahn, D., Illisson, R., Metspalu, A. & Sterchi, E.E. Human N benzoyl-L-tyrosyl- p -aminobenzoic acid hydrolase (human meprin): Genomic structure of the alpha and beta subunits. Biochem. J. 346 (Part 1), 83-91 (2000).
    • (2000) Biochem. J , vol.346 , Issue.PART 1 , pp. 83-91
    • Hahn, D.1    Illisson, R.2    Metspalu, A.3    Sterchi, E.E.4
  • 19
    • 0035918152 scopus 로고    scopus 로고
    • Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity
    • Bertenshaw, G.P. et al. Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity. J. Biol. Chem. 276, 13248-13255 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 13248-13255
    • Bertenshaw, G.P.1
  • 20
    • 0033595116 scopus 로고    scopus 로고
    • Identification and localization of MEP1A-like sequences (MEP1AL1-4) in the human genome
    • Jiang, W. & Beatty, B.G. Identification and localization of MEP1A-like sequences (MEP1AL1-4) in the human genome. Biochem. Biophys. Res. Commun. 261, 163-168 (1999).
    • (1999) Biochem. Biophys. Res. Commun , vol.261 , pp. 163-168
    • Jiang, W.1    Beatty, B.G.2
  • 21
    • 0037317483 scopus 로고    scopus 로고
    • Targeted disruption of the meprin beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles
    • Norman, L.P., Jiang, W., Han, X., Saunders, T.L. & Bond, J.S. Targeted disruption of the meprin beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles. Mol. Cell. Biol. 23, 1221-1230 (2003).
    • (2003) Mol. Cell. Biol , vol.23 , pp. 1221-1230
    • Norman, L.P.1    Jiang, W.2    Han, X.3    Saunders, T.L.4    Bond, J.S.5
  • 23
    • 0033822405 scopus 로고    scopus 로고
    • Insights from mouse models of colitis
    • Boismenu, R. & Chen, Y. Insights from mouse models of colitis. J. Leukoc. Biol. 67, 267-278 (2000).
    • (2000) J. Leukoc. Biol , vol.67 , pp. 267-278
    • Boismenu, R.1    Chen, Y.2
  • 24
    • 0027224059 scopus 로고
    • Clinicopathologic study of dextran sulfate sodium experimental murine colitis
    • Cooper, H.S., Murthy, S.N., Shah, R.S. & Sedergran, D.J. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab. Invest. 69, 238-249 (1993).
    • (1993) Lab. Invest , vol.69 , pp. 238-249
    • Cooper, H.S.1    Murthy, S.N.2    Shah, R.S.3    Sedergran, D.J.4
  • 25
    • 0028006855 scopus 로고
    • Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice
    • Dieleman, L.A. et al. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 107, 1643-1652 (1994).
    • (1994) Gastroenterology , vol.107 , pp. 1643-1652
    • Dieleman, L.A.1
  • 26
    • 0033768784 scopus 로고    scopus 로고
    • Characterisation of acute murine dextran sodium sulphate colitis: Cytokine profile and dose dependency
    • Egger, B. et al. Characterisation of acute murine dextran sodium sulphate colitis: Cytokine profile and dose dependency. Digestion 62, 240-248 (2000).
    • (2000) Digestion , vol.62 , pp. 240-248
    • Egger, B.1
  • 27
    • 0029791910 scopus 로고    scopus 로고
    • Effects of dextran sulphate sodium on intestinal epithelial cells and intestinal lymphocytes
    • Ni, J., Chen, S. F. & Hollander, D. Effects of dextran sulphate sodium on intestinal epithelial cells and intestinal lymphocytes. Gut 39, 234-241 (1996).
    • (1996) Gut , vol.39 , pp. 234-241
    • Ni, J.1    Chen, S.F.2    Hollander, D.3
  • 28
    • 0035123651 scopus 로고    scopus 로고
    • Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone
    • Williams, K. L. et al. Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone. Gastroenterology 120, 925-937 (2001).
    • (2001) Gastroenterology , vol.120 , pp. 925-937
    • Williams, K.L.1
  • 29
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett, J.C. et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40, 955-962 (2008).
    • (2008) Nat. Genet , vol.40 , pp. 955-962
    • Barrett, J.C.1
  • 30
    • 35348983887 scopus 로고    scopus 로고
    • A second generation human haplotype map of over 3.1 million SNPs
    • Frazer, K.A. et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851-861 (2007).
    • (2007) Nature , vol.449 , pp. 851-861
    • Frazer, K.A.1
  • 31
    • 44349136821 scopus 로고    scopus 로고
    • Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    • Fisher, S.A. et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat. Genet. 40, 710-712 (2008).
    • (2008) Nat. Genet , vol.40 , pp. 710-712
    • Fisher, S.A.1
  • 32
    • 55049111426 scopus 로고    scopus 로고
    • Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
    • Franke, A. et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat. Genet. 40, 1319-1323 (2008).
    • (2008) Nat. Genet , vol.40 , pp. 1319-1323
    • Franke, A.1
  • 33
    • 0028148498 scopus 로고
    • Erythroid cell-specific determinants of alpha-globin mRNA stability
    • Weiss, I.M. & Liebhaber, S.A. Erythroid cell-specific determinants of alpha-globin mRNA stability. Mol. Cell. Biol. 14, 8123-8132 (1994).
    • (1994) Mol. Cell. Biol , vol.14 , pp. 8123-8132
    • Weiss, I.M.1    Liebhaber, S.A.2
  • 34
    • 0035282710 scopus 로고    scopus 로고
    • Ulcerative colitis and Crohn's disease: Distinctive gene expression profiles and novel susceptibility candidate genes
    • Lawrance, I.C., Fiocchi, C. & Chakravarti, S. Ulcerative colitis and Crohn's disease: Distinctive gene expression profiles and novel susceptibility candidate genes. Hum. Mol. Genet. 10, 445-456 (2001).
    • (2001) Hum. Mol. Genet , vol.10 , pp. 445-456
    • Lawrance, I.C.1    Fiocchi, C.2    Chakravarti, S.3
  • 35
    • 0031945843 scopus 로고    scopus 로고
    • Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis
    • Mahler, M. et al. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am. J. Physiol. 274, G544-G551 (1998).
    • (1998) Am. J. Physiol , vol.274
    • Mahler, M.1
  • 36
    • 0020608073 scopus 로고
    • Deficiency of a kidney metalloproteinase activity in inbred mouse strains
    • Beynon, R.J. & Bond, J.S. Deficiency of a kidney metalloproteinase activity in inbred mouse strains. Science 219, 1351-1353 (1983).
    • (1983) Science , vol.219 , pp. 1351-1353
    • Beynon, R.J.1    Bond, J.S.2
  • 37
    • 23944476094 scopus 로고    scopus 로고
    • Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer
    • Atreya, R. & Neurath, M.F. Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer. Clin. Rev. Allergy Immunol. 28, 187-196 (2005).
    • (2005) Clin. Rev. Allergy Immunol , vol.28 , pp. 187-196
    • Atreya, R.1    Neurath, M.F.2
  • 38
    • 37349050665 scopus 로고    scopus 로고
    • Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients
    • Pang, Y.H., Zheng, C.Q., Yang, X.Z. & Zhang, W.J. Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients. Cell. Immunol. 248, 115-120 (2007).
    • (2007) Cell. Immunol , vol.248 , pp. 115-120
    • Pang, Y.H.1    Zheng, C.Q.2    Yang, X.Z.3    Zhang, W.J.4
  • 39
    • 57649123150 scopus 로고    scopus 로고
    • Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation
    • Banerjee, S. & Bond, J.S. Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation. J. Biol. Chem. 283, 31371-31377 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 31371-31377
    • Banerjee, S.1    Bond, J.S.2
  • 40
    • 0037220898 scopus 로고    scopus 로고
    • Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease
    • Banks, C., Bateman, A., Payne, R., Johnson, P. & Sheron, N. Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease. J. Pathol. 199, 28-35 (2003).
    • (2003) J. Pathol , vol.199 , pp. 28-35
    • Banks, C.1    Bateman, A.2    Payne, R.3    Johnson, P.4    Sheron, N.5
  • 41
    • 22644431611 scopus 로고    scopus 로고
    • Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model
    • Pender, S.L. et al. Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model. Gut 54, 1114-1120 (2005).
    • (2005) Gut , vol.54 , pp. 1114-1120
    • Pender, S.L.1
  • 42
    • 23944491189 scopus 로고    scopus 로고
    • Generation of biologically active interleukin-1beta by meprin B
    • Herzog, C., Kaushal, G.P. & Haun, R.S. Generation of biologically active interleukin-1beta by meprin B. Cytokine 31, 394-403 (2005).
    • (2005) Cytokine , vol.31 , pp. 394-403
    • Herzog, C.1    Kaushal, G.P.2    Haun, R.S.3
  • 43
    • 0033933804 scopus 로고    scopus 로고
    • Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
    • von Lampe, B., Barthel, B., Coupland, S.E., Riecken, E.O. & Rosewicz, S. Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease. Gut 47, 63-73 (2000).
    • (2000) Gut , vol.47 , pp. 63-73
    • von Lampe, B.1    Barthel, B.2    Coupland, S.E.3    Riecken, E.O.4    Rosewicz, S.5
  • 44
    • 33745698756 scopus 로고    scopus 로고
    • Therapeutic implications of the specific inhibition of causative matrix metalloproteinases in experimental colitis induced by dextran sulphate sodium
    • Kobayashi, K. et al. Therapeutic implications of the specific inhibition of causative matrix metalloproteinases in experimental colitis induced by dextran sulphate sodium. J. Pathol. 209, 376-383 (2006).
    • (2006) J. Pathol , vol.209 , pp. 376-383
    • Kobayashi, K.1
  • 45
    • 33748477283 scopus 로고    scopus 로고
    • Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: Contrasting role of gelatinases in the pathogenesis of colitis
    • Garg, P. et al. Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: Contrasting role of gelatinases in the pathogenesis of colitis. J. Immunol. 177, 4103-4112 (2006).
    • (2006) J. Immunol , vol.177 , pp. 4103-4112
    • Garg, P.1
  • 46
    • 0027321548 scopus 로고
    • Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
    • Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W. & Roder, J.C. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90, 8424-8428 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8424-8428
    • Nagy, A.1    Rossant, J.2    Nagy, R.3    Abramow-Newerly, W.4    Roder, J.C.5
  • 47
    • 0036661048 scopus 로고    scopus 로고
    • Probing the active sites and mechanisms of rat metalloproteases meprin A and B
    • Bertenshaw, G.P., Villa, J.P., Hengst, J.A. & Bond, J.S. Probing the active sites and mechanisms of rat metalloproteases meprin A and B. Biol. Chem. 383, 1175-1183 (2002).
    • (2002) Biol. Chem , vol.383 , pp. 1175-1183
    • Bertenshaw, G.P.1    Villa, J.P.2    Hengst, J.A.3    Bond, J.S.4
  • 48
    • 0037229533 scopus 로고    scopus 로고
    • Increased activity and expression of matrix metalloproteinase-9 in a rat model of distal colitis
    • Medina, C. et al. Increased activity and expression of matrix metalloproteinase-9 in a rat model of distal colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 284, G116-G122 (2003).
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol , vol.284
    • Medina, C.1


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