Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys36

Journal of Biological Chemistry

Volumn 284, Issue 11, 2009, Pages 6934-6945

  Nogami, Keiji ^a   Nishiya, Katsumi ^a   Saenko, Evgueni L ^b   Takeyama, Masahiro ^a   Ogiwara, Kenichi ^a   Yoshioka, Akira ^a   Shima, Midori ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; COFACTOR; EXTENDED SURFACES; FACTOR IXA; FACTOR VIII; FACTOR VIIIA; LIGHT CHAIN; LYSINE RESIDUES; LYSINE-BINDING SITES; PROTEOLYTIC CLEAVAGE; SDS-PAGE ANALYSIS;

AMINES; AMINO ACIDS; BINDING ENERGY; DIFFUSERS (OPTICAL); SURFACE PLASMON RESONANCE;

BINDING SITES;

ARGININE; BLOOD CLOTTING FACTOR 8A; GLUTAMIC ACID; GLYCINE; LYSINE; PLASMIN; BLOOD CLOTTING FACTOR 9A;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVE SITE; LIGHT CHAIN; MOLECULAR DOCKING; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PEPTIDE MAPPING; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

BINDING SITES; FACTOR IXA; FACTOR VIIIA; HUMANS; LYSINE; PEPTIDE MAPPING; PLASMIN; PROTEIN STRUCTURE, TERTIARY; SURFACE PLASMON RESONANCE;

EID: 65449120759     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802224200     Document Type: Article

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