Identification and characterization of E-APC, a novel Drosophila homologue of the tumour suppressor APC

Genes to Cells

Volumn 4, Issue 8, 1999, Pages 465-474

  Hamada, Fumihiko ^a,b   Murata, Yoji ^a,c   Nishida, Ayumu ^c   Fujita, Fumitaka ^a   Tomoyasu, Yoshinori ^d   Nakamura, Makoto ^d   Toyoshima, Kumao ^e   Tabata, Tetsuya ^c   Ueno, Naoto ^d   Akiyama, Tetsu ^a,c  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^e OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BETA CATENIN; CELL PROTEIN; COMPLEMENTARY DNA; GLYCOGEN SYNTHASE; MESSENGER RNA; PIDOTIMOD;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LINE; COLON POLYPOSIS; COLORECTAL CANCER; COMPLEX FORMATION; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; DROSOPHILA; FUNCTIONAL ANATOMY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOMATOUS POLYPOSIS COLI PROTEIN; AMINO ACID SEQUENCE; ANIMALS; ARMADILLO DOMAIN PROTEINS; BETA CATENIN; CARRIER PROTEINS; CLONING, MOLECULAR; CYTOSKELETAL PROTEINS; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; HUMANS; INSECT PROTEINS; LYMPHOID ENHANCER-BINDING FACTOR 1; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PLASMIDS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TWO-HYBRID SYSTEM TECHNIQUES;

ANIMALIA; ARMADILLO;

EID: 6544276454     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.1999.00272.x     Document Type: Article

References (35)

1. Ahmed, Y., Hayashi, S., Levine, A., et al. (1998) Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. Cell 93, 1171-1182.
2. Baeg, G.H., Matsumine, A., Kuroda, T., et al. (1995) The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. EMBO J. 14, 5618-5625.
3. Behrens, J., Jerchow, B.A., Wurtele, M., et al. (1998) Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 280, 596-599.
4. Cadigan, K.M. & Nusse, R. (1997) Wnt signaling: a common theme in animal development. Genes Dev. 11, 3286-3305.
5. van Es, J.H., Kirkpatrick, C., van de Wetering, M., et al. (1999) Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Curr. Biol. 9, 105-108.
6. Hamada, F., Tomoyasu, Y., Takatsu, Y., et al. (1999) Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. Science 283, 1739-1742.
7. Hart, M.J., de los Santos, R., Albert, I.N., et al. (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr. Biol. 8, 573-581.
8. Hayashi, S., Rubinfeld, B., Souza, B., et al. (1997) A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo. Proc. Natl. Acad. Sci. USA 94, 242-247.
9. He, T.C., Sparks, A.B., Rago, C., et al. (1998) Identification of c-MYC as a target of the APC pathway. Science 281, 1509-1512.
10. Itoh, K., Krupnik, V.E. & Sokol, S.Y. (1998) Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin. Curr. Biol. 8, 591-594.
11. Joslyn, G., Richardson, D.S., White, R., et al. (1993) Dimer formation by an N-terminal coiled coil in the APC protein. Proc. Natl. Acad. Sci. USA 90, 11109-11113.
12. Kinzler, K.W. & Vogelstein, B. (1996) Lessons from hereditary colorectal cancer. Cell 87, 159-170.
13. Kishida, S., Yamamoto, H., Ikeda, S., et al. (1998) Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin. J. Biol. Chem. 273, 10823-10826.
14. Korinek, V., Barker, N., Morin, P.J., et al. (1997) Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 275, 1784-1787.
15. Matsumine, A., Ogai, A., Senda, T., et al. (1996) Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science 272, 1020-1023.
16. Miller, J.R. & Moon, R.T. (1996) Signal transduction through beta-catenin and specification of cell fate during embryogenesis. Genes Dev. 10, 2527-2539.
17. Miyashiro, I., Senda, T., Matsumine, A., et al. (1995) Subcellular localization of the APC protein: immunoelectron microscopic study of the association of the APC protein with catenin. Oncogene 11, 89-96.
18. Morin, P.J., Sparks, A.B., Korinek, V., et al. (1997) Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275, 1787-1790.
19. Morin, P.J., Vogelstein, B. & Kinzler, K.W. (1996) Apoptosis and APC in colorectal tumorigenesis. Proc. Natl. Acad. Sci. USA 93, 7950-7954.
20. Munemitsu, S., Albert, I., Souza, B., et al. (1995) Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. USA 92, 3046-3050.
21. Nakagawa, H., Murata, Y., Koyama, K., et al. (1998) Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin. Cancer Res. 58, 5176-5181.
22. Nakamura, T., Hamada, F., Ishidate, T., et al. (1998) Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. Genes Cells 3, 395-403.
23. Nathke, I.S., Adams, C.L., Polakis, P., et al. (1996) The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J. Cell Biol. 134, 165-179.
24. Polakis, P. (1997) The adenomatous polyposis coli (APC) tumor suppressor. Biochim. Biophys. Acta. 1332, F127-F147.
25. Rocheleau, C.E., Downs, W.D, Lin, R., et al. (1997) Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell 90, 707-716.
26. Rubinfeld, B., Albert, I., Porfiri, E., et al. (1997a) Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene. Cancer Res. 57, 4624-4630.
27. Rubinfeld, B., Robbins, P., El-Gamil, M., et al. (1997b) Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science 275, 1790-1792.
28. Rubinfeld, B., Souza, B., Albert, L., et al. (1993) Association of the APC gene product with beta-catenin. Science 262, 1731-1734.
29. Sakanaka, C., Weiss, J.B. & Williams, L.T. (1998) Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription. Proc. Natl. Acad. Sci. USA 95, 3020-3023.
30. Senda, T., Miyashiro, I., Matsumine, A., et al. (1996) The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells. Biochem. Biophys. Res. Commun. 223, 329-334.
31. Smith, K.J., Johnson, K.A., Bryan, T.M., et al. (1993) The APC gene product in normal and tumor cells. Proc. Natl. Acad. Sci. USA 90, 2846-2850.
32. Su, L.K., Burrell, M., Hill, D.E., et al. (1995) APC binds to the novel protein EB1. Cancer Res. 55, 2972-2977.
33. Su, L.K., Vogelstein, B. & Kinzler, K.W. (1993) Association of the APC tumor suppressor protein with catenins. Science 262, 1734-1737.
34. Tetsu, O. & McCormick, F. (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422-426.
35. Vleminckx, K., Wong, E., Guger, K., et al. (1997) Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis. J. Cell Biol. 136, 411-420.