-
1
-
-
66749098111
-
-
World Health Organization: Cancer. Available at Accessed November 22, 2008
-
World Health Organization: Cancer. Fact sheet no. 297. Available at http://www.who.int/mediacentre/factsheets/fs297/en/. Accessed November 22, 2008.
-
Fact Sheet No. 297
-
-
-
2
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al.: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004, 350: 2335-2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
3
-
-
20644432867
-
Bevacizumab in combination with fluorouracil and leucovorin: An active regimen for first-line metastatic colorectal cancer
-
Hurwitz HI, Fehrenbacher L, Hainsworth JD, et al.: Bevacizumab in combination with fluorouracil and leucovorin: An active regimen for first-line metastatic colorectal cancer. J Clin Oncol 2005, 23: 3502-3508.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3502-3508
-
-
Hurwitz, H.I.1
Fehrenbacher, L.2
Hainsworth, J.D.3
-
4
-
-
20544471876
-
Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
-
Kabbinavar FF, Hambleton J, Mass RD, et al.: Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol 2005, 23: 3706-3712.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3706-3712
-
-
Kabbinavar, F.F.1
Hambleton, J.2
Mass, R.D.3
-
6
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz LB, Meropol NJ, Loehrer PJ Sr, et al.: Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004, 22: 1201-1208.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer Sr., P.J.3
-
7
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecanrefractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, et al.: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecanrefractory metastatic colorectal cancer. N Engl J Med 2004, 351: 337-345.
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
8
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
-
Van Cutsem E, Peeters M, Siena S, et al.: Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007, 25: 1658-1664.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
-
9
-
-
20144381957
-
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
-
Chung KY, Shia J, Kemeny NE, et al.: Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 2005, 23: 1803-1810.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1803-1810
-
-
Chung, K.Y.1
Shia, J.2
Kemeny, N.E.3
-
10
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M, et al.: Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26: 1626-1634.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
11
-
-
51649120733
-
KRAS status and efficacy of first-line treatment of patients with metastatic colorectal cancer (mCRC) with FOLFOX with or without cetuximab: The OPUS experience
-
[abstract]
-
Bokemeyer C, Bondarenko I, Hartmann J, et al.: KRAS status and efficacy of first-line treatment of patients with metastatic colorectal cancer (mCRC) with FOLFOX with or without cetuximab: The OPUS experience [abstract]. J Clin Oncol 2008, 26(Suppl 15): 4000a.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL. 15
-
-
Bokemeyer, C.1
Bondarenko, I.2
Hartmann, J.3
-
12
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ, et al.: K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008, 359: 1757-1765.
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
13
-
-
38649099966
-
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
-
Lievre A, Bachet JB, Boige V, et al.: KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008, 26: 374-379.
-
(2008)
J Clin Oncol
, vol.26
, pp. 374-379
-
-
Lievre, A.1
Bachet, J.B.2
Boige, V.3
-
14
-
-
51649120733
-
KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer treated with FOLFIRI with or without cetuximab: The CRYSTAL experience
-
[abstract]
-
van Cutsem E Lang I, D'Haens G, et al.: KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer treated with FOLFIRI with or without cetuximab: The CRYSTAL experience [abstract]. J Clin Oncol 2008, 26(Suppl 15): 2.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL. 15
, pp. 2
-
-
van Cutsem, E.1
Lang, I.2
D'Haens, G.3
-
15
-
-
57449095367
-
Wildtype BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
Di Nicolantonio F, Martini M, Molinari F, et al.: Wildtype BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 2008, 26: 5705-5712.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
-
16
-
-
3242686833
-
The price tag on progress-chemotherapy for colorectal cancer
-
Schrag D: The price tag on progress-chemotherapy for colorectal cancer. N Engl J Med 2004, 351: 317-319.
-
(2004)
N Engl J Med
, vol.351
, pp. 317-319
-
-
Schrag, D.1
-
17
-
-
0037374498
-
The price of innovation: New estimates of drug development costs
-
DiMasi JA, Hansen RN, Grabowski HG: The price of innovation: new estimates of drug development costs. J Health Econ 2003, 22: 151-185.
-
(2003)
J Health Econ
, vol.22
, pp. 151-185
-
-
DiMasi, J.A.1
Hansen, R.W.2
Grabowski, H.G.3
-
18
-
-
0035338343
-
Risks in new drug development: Approval success rates for investigational drugs
-
Dimasi JA: Risks in new dAug development: approval success rates for investigational drugs. Clin Pharmacol Ther 2001, 69: 297-307.
-
(2001)
Clin Pharmacol Ther
, vol.69
, pp. 297-307
-
-
Dimasi, J.A.1
-
19
-
-
0141973782
-
The phase III trial in the era of targeted therapy: Unraveling the "go or no go" decision
-
Roberts TG Jr, Lynch TJ Jr, Chabner BA: The phase III trial in the era of targeted therapy: Unraveling the "go or no go" decision. J Clin Oncol 2003, 21: 3683-3695.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3683-3695
-
-
Roberts Jr., T.G.1
Lynch Jr., T.J.2
Chabner, B.A.3
-
20
-
-
65349154770
-
-
US Food and Drug Administration, US Department of Health and Human Services Bethesda, MD: US Department of Health and Human Services
-
US Food and Drug Administration, US Department of Health and Human Services: Critical Path Report. Bethesda, MD: US Department of Health and Human Services; 2004.
-
(2004)
Critical Path Report
-
-
-
21
-
-
65349131471
-
US Department of Health and Human Services
-
US Food and Drug Administration Bethesda, MD: US Department of Health and Human Services
-
US Food and Drug Administration, US Department of Health and Human Services: Critical Path Opportunities Report. Bethesda, MD: US Department of Health and Human Services; 2006.
-
(2006)
Critical Path Opportunities Report
-
-
-
22
-
-
42949104050
-
Systematic survey of therapeutic trials for metastatic colorectal cancer: Room for improvement in the critical pathway
-
Kopetz S, Overman M, Chang DZ, et al.: Systematic survey of therapeutic trials for metastatic colorectal cancer: Room for improvement in the critical pathway. J Clin Oncol 2008, 26: 2000-2005.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2000-2005
-
-
Kopetz, S.1
Overman, M.2
Chang, D.Z.3
-
23
-
-
34247491584
-
The development of novel agents for the treatment of colorectal cancer: A critical review of current practice and some suggestions for the future
-
Marshall JL, Gehan EA: The development of novel agents for the treatment of colorectal cancer: A critical review of current practice and some suggestions for the future. Clin Adv Hematol Oncol 2007, 5: 167-172.
-
(2007)
Clin Adv Hematol Oncol
, vol.5
, pp. 167-172
-
-
Marshall, J.L.1
Gehan, E.A.2
-
24
-
-
3342964433
-
Beyond fast track for drug approvals
-
Roberts TG Jr, Chabner BA: Beyond fast track for drug approvals. N Engl J Med 2004, 351: 501-505.
-
(2004)
N Engl J Med
, vol.351
, pp. 501-505
-
-
Roberts Jr., T.G.1
Chabner, B.A.2
-
25
-
-
44449090596
-
Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone
-
Freeman DJ, Juan T, Reiner M, et al.: Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone. Clin Colorectal Cancer 2008, 7: 184-190.
-
(2008)
Clin Colorectal Cancer
, vol.7
, pp. 184-190
-
-
Freeman, D.J.1
Juan, T.2
Reiner, M.3
-
26
-
-
34249738700
-
Rash as a surrogate marker for efficacy of epidermal growth factor receptor inhibitors in lung cancer
-
Perez-Soler R: Rash as a surrogate marker for efficacy of epidermal growth factor receptor inhibitors in lung cancer. Clin Lung Cancer 2006, 8(Suppl 1): S7-S14.
-
(2006)
Clin Lung Cancer
, vol.8
, Issue.SUPPL. 1
-
-
Perez-Soler, R.1
-
27
-
-
60549118166
-
Arterial hypertension correlates with clinical outcome in colorectal cancer patients treated with first-line bevacizumab
-
Scartozzi M, Galizia E, Chiorrini S, et al.: Arterial hypertension correlates with clinical outcome in colorectal cancer patients treated with first-line bevacizumab. Ann Oncol 2009, 20: 227-230.
-
(2009)
Ann Oncol
, vol.20
, pp. 227-230
-
-
Scartozzi, M.1
Galizia, E.2
Chiorrini, S.3
-
28
-
-
36949037220
-
Phase I/II study of cetuximab dose-escalation in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): Pharmacokinetic (PK), pharmacodynamic (PD) and efficacy data
-
[abstract]
-
Tejpar S, Peeters M, Humblet Y, et al.: Phase I/II study of cetuximab dose-escalation in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): Pharmacokinetic (PK), pharmacodynamic (PD) and efficacy data [abstract]. J Clin Oncol 2007, 25(Suppl 15): 4037.
-
(2007)
J Clin Oncol
, vol.25
, Issue.SUPPL. 15
, pp. 4037
-
-
Tejpar, S.1
Peeters, M.2
Humblet, Y.3
-
29
-
-
65349161734
-
Tumor burden endpoints and phase II clinical trial design
-
Alexandria, VA: American Society of Clinical Oncology
-
Stadler W: Tumor burden endpoints and phase II clinical trial design. In ASCO Educational Book. Alexandria, VA: American Society of Clinical Oncology; 2008:89-93.
-
(2008)
In ASCO Educational Book
, pp. 89-93
-
-
Stadler, W.1
-
30
-
-
34249030871
-
We should desist using RECIST, at least in GIST
-
Benjamin RS, Choi H, Macapinlac HA, et al.: We should desist using RECIST, at least in GIST. J Clin Oncol 2007, 25: 1760-1764.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1760-1764
-
-
Benjamin, R.S.1
Choi, H.2
Macapinlac, H.A.3
-
31
-
-
49249130844
-
Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer
-
Cohen SJ, Punt CJ, Iannotti N, et al.: Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26: 3213-3221.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3213-3221
-
-
Cohen, S.J.1
Punt, C.J.2
Iannotti, N.3
-
32
-
-
33749864510
-
Genomics and the impact of new technologies on the management of colorectal cancer
-
Harkin DP: Genomics and the impact of new technologies on the management of colorectal cancer. Oncologist 2006, 11: 988-991.
-
(2006)
Oncologist
, vol.11
, pp. 988-991
-
-
Harkin, D.P.1
-
33
-
-
0036727089
-
Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
-
Carmichael J, Popiela T, Radstone D, et al.: Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 2002, 20: 3617-3627.
-
(2002)
J Clin Oncol
, vol.20
, pp. 3617-3627
-
-
Carmichael, J.1
Popiela, T.2
Radstone, D.3
-
34
-
-
0036731818
-
Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
-
Douillard JY, Hoff PM, Skillings JR, et al.: Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 2002, 20: 3605-3616.
-
(2002)
J Clin Oncol
, vol.20
, pp. 3605-3616
-
-
Douillard, J.Y.1
Hoff, P.M.2
Skillings, J.R.3
-
35
-
-
0036057596
-
Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): A review
-
Malet-Martino M, Martino R: Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): A review. Oncologist 2002, 7: 288-323.
-
(2002)
Oncologist
, vol.7
, pp. 288-323
-
-
Malet-Martino, M.1
Martino, R.2
-
36
-
-
33845666953
-
A phase II trial of S-1 monotherapy in metastatic colorectal cancer after failure of irinotecan- and oxaliplatin-containing regimens
-
Jeung HC, Rha SY, Cho BC, et al.: A phase II trial of S-1 monotherapy in metastatic colorectal cancer after failure of irinotecan- and oxaliplatin-containing regimens. Br J Cancer 2006, 95: 1637-1641.
-
(2006)
Br J Cancer
, vol.95
, pp. 1637-1641
-
-
Jeung, H.C.1
Rha, S.Y.2
Cho, B.C.3
-
37
-
-
33847745417
-
Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels
-
Giovannetti E, Backus HH, Wouters D, et al.: Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels. Br J Cancer 2007, 96: 769-775.
-
(2007)
Br J Cancer
, vol.96
, pp. 769-775
-
-
Giovannetti, E.1
Backus, H.H.2
Wouters, D.3
-
38
-
-
39049164561
-
UFT as maintenance therapy in patients with advanced colorectal cancer responsive to the FOLFOX4 regimen
-
Scalamogna R, Brugnatelli S, Tinelli C, et al.: UFT as maintenance therapy in patients with advanced colorectal cancer responsive to the FOLFOX4 regimen. Oncology 2007, 72: 267-273.
-
(2007)
Oncology
, vol.72
, pp. 267-273
-
-
Scalamogna, R.1
Brugnatelli, S.2
Tinelli, C.3
-
39
-
-
6944255267
-
The novel highly lipophilic topoisomerase I inhibitor DB67 is effective in the treatment of liver metastases of murine CT-26 colon carcinoma
-
Lopez-Barcons LA, Zhang J, Siriwitayawan G, et al.: The novel highly lipophilic topoisomerase I inhibitor DB67 is effective in the treatment of liver metastases of murine CT-26 colon carcinoma. Neoplasia 2004, 6: 457-467.
-
(2004)
Neoplasia
, vol.6
, pp. 457-467
-
-
Lopez-Barcons, L.A.1
Zhang, J.2
Siriwitayawan, G.3
-
40
-
-
5144225469
-
Liposomal irinotecan: Formulation development and therapeutic assessment in murine xenograft models of colorectal cancer
-
Messerer CL, Ramsay EC, Waterhouse D, et al.: Liposomal irinotecan: formulation development and therapeutic assessment in murine xenograft models of colorectal cancer. Clin Cancer Res 2004, 10: 6638-6649.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6638-6649
-
-
Messerer, C.L.1
Ramsay, E.C.2
Waterhouse, D.3
-
41
-
-
59349105952
-
A multicenter, phase II study of CPX-1 liposome injection in patients (pts) with advanced colorectal cancer (CRC)
-
[abstract]
-
Batist G, Sawyer M, Gabrail N, et al.: A multicenter, phase II study of CPX-1 liposome injection in patients (pts) with advanced colorectal cancer (CRC) [abstract]. J Clin Oncol 2008, 26(Suppl 15): 4108.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL. 15
, pp. 4108
-
-
Batist, G.1
Sawyer, M.2
Gabrail, N.3
-
42
-
-
84869986234
-
-
[press release]. Available at Accessed December 2, 2008
-
Alchemia receives an open IND for HA-irinotecan from the U.S. FDA [press release]. Available at http://www.alchemia.com.au/IRM/Company/ShowPage.aspx?CPID= 1341&PageName=FDA%20approves%20open%20IND%20for%20HA- Irinotecan%20phase%203. Accessed December 2, 2008.
-
Alchemia Receives an Open IND for HA-irinotecan from the U.S. FDA
-
-
-
43
-
-
36048992408
-
Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy
-
Saltz LB, Rosen LS, Marshall JL, et al.: Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J Clin Oncol 2007, 25: 4793-4799.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4793-4799
-
-
Saltz, L.B.1
Rosen, L.S.2
Marshall, J.L.3
-
44
-
-
33645670595
-
Discovery and preclinical studies of (R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl pyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor
-
Bhide RS, Cai ZW, Zhang YZ, et al.: Discovery and preclinical studies of (R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl pyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J Med Chem 2006, 49: 2143-2146.
-
(2006)
J Med Chem
, vol.49
, pp. 2143-2146
-
-
Bhide, R.S.1
Cai, Z.W.2
Zhang, Y.Z.3
-
45
-
-
41149122199
-
Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-Fluoro-2-methyl-1H- indol-5-yloxy)-5-methylpyrrolo[2,1-f] [1,2,4]triazin-6-yloxy)propan-2- yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215)
-
Cai ZW, Zhang Y, Borzilleri RM, et al.: Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo [2,1-f] [1,2,4]triazin-6-yloxy)propan-2-yl 2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215). J Med Chem 2008, 51: 1976-1980.
-
(2008)
J Med Chem
, vol.51
, pp. 1976-1980
-
-
Cai, Z.W.1
Zhang, Y.2
Borzilleri, R.M.3
-
46
-
-
59349086005
-
A phase I study of brivanib alaninate (BMS-582664), an oral dual inhibitor of VEGFR and FGFR tyrosine kinases, in combination with full dose cetuximab (BC) in patients (pts) with advanced gastrointestinal malignancies (AGM) who failed prior therapy
-
[abstract]
-
Garrett CR Siu L, El-Khoueiry AB, et al.: A phase I study of brivanib alaninate (BMS-582664), an oral dual inhibitor of VEGFR and FGFR tyrosine kinases, in combination with full dose cetuximab (BC) in patients (pts) with advanced gastrointestinal malignancies (AGM) who failed prior therapy [abstract]. J Clin Oncol 2008, 26(Suppl 15): 4111.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL. 15
, pp. 4111
-
-
Garrett, C.R.1
Siu, L.2
El-Khoueiry, A.B.3
-
47
-
-
65349111509
-
A phase I study of BMS-582664 (brivanib alaninate), an oral dual inhibitor of VEGFR and FGFR tyrosine kinases, in patients (pts) with advanced/metastatic solid tumors: Safety, pharmacokinetic (PK), and pharmacodynamic (PD) findings
-
[abstract]
-
Jonker DJ Rosen LS, Sawyer M, et al.: A phase I study of BMS-582664 (brivanib alaninate), an oral dual inhibitor of VEGFR and FGFR tyrosine kinases, in patients (pts) with advanced/metastatic solid tumors: Safety, pharmacokinetic (PK), and pharmacodynamic (PD) findings [abstract]. J Clin Oncol 2007, 25(Suppl 18): 3559.
-
(2007)
J Clin Oncol
, vol.25
, Issue.SUPPL. 18
, pp. 3559
-
-
Jonker, D.J.1
Rosen, L.S.2
Sawyer, M.3
-
48
-
-
43149102244
-
Drug insight: Antiangiogenic therapies for gastrointestinal cancers-focus on monoclonal antibodies
-
Aug 12. [Epub ahead of print.]
-
ReinacheA-Schick A, Pohl M, Schmiegel W: Drug insight: antiangiogenic therapies for gastrointestinal cancers-focus on monoclonal antibodies. Nat Clin Pract Gastroenterol Hepatol 2008, Aug 12. [Epub ahead of print.]
-
Nat Clin Pract Gastroenterol Hepatol 2008
-
-
Reinacher-Schick, A.1
Pohl, M.2
Schmiegel, W.3
-
49
-
-
34447299692
-
EGFR targeting of solid tumors
-
Rocha-Lima CM, Soares HP, Raez LE, Singal R: EGFR targeting of solid tumors. Cancer Control 2007, 14: 295-304.
-
(2007)
Cancer Control
, vol.14
, pp. 295-304
-
-
Rocha-Lima, C.M.1
Soares, H.P.2
Raez, L.E.3
Singal, R.4
-
50
-
-
59049088446
-
Activation of notch signaling in human colon adenocarcinoma
-
Reedijk M, Odorcic S, Zhang H, et al.: Activation of notch signaling in human colon adenocarcinoma. Int J Oncol 2008, 33: 1223-1229.
-
(2008)
Int J Oncol
, vol.33
, pp. 1223-1229
-
-
Reedijk, M.1
Odorcic, S.2
Zhang, H.3
-
51
-
-
20544460148
-
Notch/gammasecretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
-
van Es JH, van Gijn ME, Riccio O, et al.: Notch/gammasecretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 2005, 435: 959-963.
-
(2005)
Nature
, vol.435
, pp. 959-963
-
-
van Es, J.H.1
van Gijn, M.E.2
Riccio, O.3
-
52
-
-
34548571130
-
Phase I pharmacokinetic (PK), and pharmacodynamic (PD) trial of the novel oral notch inhibitor MK-0752 in patients (pts) with advanced breast cancer (BC) and other solid tumors
-
[abstract]
-
Krop IE Kosh M, Fearen I, et al.: Phase I pharmacokinetic (PK), and pharmacodynamic (PD) trial of the novel oral notch inhibitor MK-0752 in patients (pts) with advanced breast cancer (BC) and other solid tumors [abstract]. J Clin Oncol 2006, 24(Suppl 18): 10574.
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL. 18
, pp. 10574
-
-
Krop, I.E.1
Kosh, M.2
Fearen, I.3
-
53
-
-
58149357574
-
Identification of the molecular mechanisms for dedifferentiation at the invasion front of colorectal cancer by a gene expression analysis
-
Oku Y, Shimoji T, Takifuji K, et al.: Identification of the molecular mechanisms for dedifferentiation at the invasion front of colorectal cancer by a gene expression analysis. Clin Cancer Res 2008, 14: 7215-7222.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7215-7222
-
-
Oku, Y.1
Shimoji, T.2
Takifuji, K.3
-
54
-
-
33745498412
-
Hedgehog Wnteraction in colorectal cancer
-
van den Brink GR, Hardwick JC: Hedgehog Wnteraction in colorectal cancer. Gut 2006, 55: 912-914.
-
(2006)
Gut
, vol.55
, pp. 912-914
-
-
van den Brink, G.R.1
Hardwick, J.C.2
-
55
-
-
27844485675
-
Notch and wnt inhibitors as potential new drugs for intestinal neoplastic disease
-
van Es JH, Clevers H: Notch and wnt inhibitors as potential new drugs for intestinal neoplastic disease. Trends Mol Med 2005, 11: 496-502.
-
(2005)
Trends Mol Med
, vol.11
, pp. 496-502
-
-
van Es, J.H.1
Clevers, H.2
-
56
-
-
52949100165
-
Cancer: Entangled pathways
-
BeEnards R: Cancer: entangled pathways. Nature 2008, 455: 479-480.
-
(2008)
Nature
, vol.455
, pp. 479-480
-
-
Bernards, R.1
-
57
-
-
55249090050
-
A first-in-human, first-in-class, phase I study of systemic hedgehog pathway antagonist, GDC-0449 in patients with advanced solid tumors
-
[abstract]
-
LoRusso PM Rudin CM, Borad MJ, et al.: A first-in-human, first-in-class, phase I study of systemic hedgehog pathway antagonist, GDC-0449 in patients with advanced solid tumors [abstract]. J Clin Oncol 2008, 26(Suppl 15): 3516.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL. 15
, pp. 3516
-
-
LoRusso, P.M.1
Rudin, C.M.2
Borad, M.J.3
-
58
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002, 2: 489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
59
-
-
65349162995
-
Elevated phosphorylated mammalian target of rapamycin (p-mtor) expression in human neoplasms
-
Ross JS Qian J, Sheehan C, et al.: Elevated phosphorylated mammalian target of rapamycin (p-mtor) expression in human neoplasms. J Clin Oncol 2007, 25(Suppl 18): 10571.
-
(2007)
J Clin Oncol
, vol.25
, Issue.SUPPL. 18
, pp. 10571
-
-
Ross, J.S.1
Qian, J.2
Sheehan, C.3
-
60
-
-
43249131245
-
Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: A phase I tumor pharmacodynamic study in patients with advanced solid tumors
-
Tabernero J, Rojo F, Calvo E, et al.: Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors. J Clin Oncol 2008, 26: 1603-1610.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1603-1610
-
-
Tabernero, J.1
Rojo, F.2
Calvo, E.3
-
61
-
-
28544444712
-
Type I insulin-like growth factor receptor as a therapeutic target in cancer
-
Miller BS, Yee D: Type I insulin-like growth factor receptor as a therapeutic target in cancer. Cancer Res 2005, 65: 10123-10127.
-
(2005)
Cancer Res
, vol.65
, pp. 10123-10127
-
-
Miller, B.S.1
Yee, D.2
-
62
-
-
40149098552
-
Growth inhibition of insulin-like growth factor I receptor monoclonal antibody to human colorectal cancer cells
-
Zhang Y: Growth inhibition of insulin-like growth factor I receptor monoclonal antibody to human colorectal cancer cells. Cancer Invest 2008, 26: 230-236.
-
(2008)
Cancer Invest
, vol.26
, pp. 230-236
-
-
Zhang, Y.1
-
63
-
-
49849098247
-
Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas
-
Piao W, Wang Y, Adachi Y, et al.: Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas. Mol Cancer Ther 2008, 7: 1483-1493.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1483-1493
-
-
Piao, W.1
Wang, Y.2
Adachi, Y.3
-
64
-
-
58149183124
-
Co-targeting the EGFR and IGF-IR with anti-EGFR monoclonal antibody ICR62 and the IGF-IR tyrosine kinase inhibitor NVP-AEW541 in colorectal cancer cells
-
Cunningham MP, Thomas H, Marks C, et al.: Co-targeting the EGFR and IGF-IR with anti-EGFR monoclonal antibody ICR62 and the IGF-IR tyrosine kinase inhibitor NVP-AEW541 in colorectal cancer cells. Int J Oncol 2008, 33: 1107-1113.
-
(2008)
Int J Oncol
, vol.33
, pp. 1107-1113
-
-
Cunningham, M.P.1
Thomas, H.2
Marks, C.3
-
65
-
-
36148953021
-
Phase I dose escalation study of the anti-IGF-1R monoclonal antibody CP-751,871 in patients with refractory solid tumors
-
[abstract]
-
Haluska P, Shaw H, Batzel GN, et al.: Phase I dose escalation study of the anti-IGF-1R monoclonal antibody CP-751,871 in patients with refractory solid tumors [abstract]. J Clin Oncol 2007, 25(Suppl 18): 3586.
-
(2007)
J Clin Oncol
, vol.25
, Issue.SUPPL. 18
, pp. 3586
-
-
Haluska, P.1
Shaw, H.2
Batzel, G.N.3
-
66
-
-
40849130815
-
Aurora kinase expression in colorectal adenocarcinoma: Correlations with clinicopathological features, p16 expression, and telomerase activity
-
Lam AK, Ong K, Ho YH: Aurora kinase expression in colorectal adenocarcinoma: Correlations with clinicopathological features, p16 expression, and telomerase activity. Hum Pathol 2008, 39: 599-604.
-
(2008)
Hum Pathol
, vol.39
, pp. 599-604
-
-
Lam, A.K.1
Ong, K.2
Ho, Y.H.3
-
67
-
-
34548253898
-
High copy amplification of the aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers
-
Nishida N, Nagasaka T, Kashiwagi K, et al.: High copy amplification of the aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers. Cancer Biol Ther 2007, 6: 525-533.
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 525-533
-
-
Nishida, N.1
Nagasaka, T.2
Kashiwagi, K.3
-
68
-
-
34250739960
-
AZD1152, a selective inhibitor of aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis
-
Wilkinson RW, Odedra R, Heaton SP, et al.: AZD1152, a selective inhibitor of aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res 2007, 13: 3682-3688.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3682-3688
-
-
Wilkinson, R.W.1
Odedra, R.2
Heaton, S.P.3
-
69
-
-
65349152111
-
Phase I study of the aurora kinases (AKs) inhibitor PHA-739358 administered as a 6 and 3-h IV infusion on days 1, 8, 15 every 4 wks in patients with advanced solid tumors
-
[abstract]
-
De Jonge M, Steeghs N, Verwiej J, et al.: Phase I study of the aurora kinases (AKs) inhibitor PHA-739358 administered as a 6 and 3-h IV infusion on days 1, 8, 15 every 4 wks in patients with advanced solid tumors [abstract]. J Clin Oncol 2008, 26(Suppl 15): 3554.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL. 15
, pp. 3554
-
-
De Jonge, M.1
Steeghs, N.2
Verwiej, J.3
-
70
-
-
33750322131
-
Phase I and pharmacologic study of the novel aurora kinase inhibitor AZD1152
-
Schellens JH, Boss D, Witteveen PO, et al.: Phase I and pharmacologic study of the novel aurora kinase inhibitor AZD1152. J Clin Oncol 2006, 24(Suppl 18): 3008.
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL. 18
, pp. 3008
-
-
Schellens, J.H.1
Boss, D.2
Witteveen, P.O.3
-
71
-
-
3442898528
-
A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer
-
Eng C, Kindler HL, Nattam S, et al.: A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer. Ann Oncol 2004, 15: 928-932.
-
(2004)
Ann Oncol
, vol.15
, pp. 928-932
-
-
Eng, C.1
Kindler, H.L.2
Nattam, S.3
-
72
-
-
0028941441
-
Inhibition of apoptosis during development of colorectal cancer
-
Bedi A, Pasricha PJ, Akhtar AJ, et al.: Inhibition of apoptosis during development of colorectal cancer. Cancer Res 1995, 55: 1811-1816.
-
(1995)
Cancer Res
, vol.55
, pp. 1811-1816
-
-
Bedi, A.1
Pasricha, P.J.2
Akhtar, A.J.3
-
73
-
-
10844223742
-
Elimination of hepatic metastases of colon cancer cells via p53-independent crosstalk between irinotecan and Apo2 ligand/TRAIL
-
Ravi R, Jain AJ, Schulick RD, et al.: Elimination of hepatic metastases of colon cancer cells via p53-independent crosstalk between irinotecan and Apo2 ligand/TRAIL. Cancer Res 2004, 64: 9105-9114.
-
(2004)
Cancer Res
, vol.64
, pp. 9105-9114
-
-
Ravi, R.1
Jain, A.J.2
Schulick, R.D.3
-
74
-
-
3242706005
-
The breakdown of apoptotic mechanism in the development and progression of colorectal carcinoma
-
Ogawa S, Nagao M, Kanehiro H, et al.: The breakdown of apoptotic mechanism in the development and progression of colorectal carcinoma. Anticancer Res 2004, 24: 1569-1579.
-
(2004)
Anticancer Res
, vol.24
, pp. 1569-1579
-
-
Ogawa, S.1
Nagao, M.2
Kanehiro, H.3
-
75
-
-
44849120686
-
A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes
-
Yada A, Yazawa M, Ishida S, et al.: A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes. Ann Oncol 2008, 19: 1060-1067.
-
(2008)
Ann Oncol
, vol.19
, pp. 1060-1067
-
-
Yada, A.1
Yazawa, M.2
Ishida, S.3
-
76
-
-
38849113981
-
DR5 receptor mediates anoikis in human colorectal carcinoma cell lines
-
Laguinge LM, Samara RN, Wang W, et al.: DR5 receptor mediates anoikis in human colorectal carcinoma cell lines. Cancer Res 2008, 68: 909-917.
-
(2008)
Cancer Res
, vol.68
, pp. 909-917
-
-
Laguinge, L.M.1
Samara, R.N.2
Wang, W.3
-
77
-
-
65349189148
-
Phase 1 trial of metronomic cyclophosphamide (CTX), bevacizumab (BV) and imatinib (IM) in patients (pts) with advanced solid tumors
-
[abstract]
-
Bergsland EK, Ko AH, Tempero MA, et al.: Phase 1 trial of metronomic cyclophosphamide (CTX), bevacizumab (BV) and imatinib (IM) in patients (pts) with advanced solid tumors [abstract]. J Clin Oncol 2008, 26(Suppl 15): 14620.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL. 15
, pp. 14620
-
-
Bergsland, E.K.1
Ko, A.H.2
Tempero, M.A.3
-
78
-
-
34047208542
-
Radioembolization of liver metastases from colorectal cancer using yttrium-90 microspheres with concomitant systemic oxaliplatin, fluorouracil, and leucovorin chemotherapy
-
Sharma RA, Van Hazel GA, Morgan B, et al.: Radioembolization of liver metastases from colorectal cancer using yttrium-90 microspheres with concomitant systemic oxaliplatin, fluorouracil, and leucovorin chemotherapy. J Clin Oncol 2007, 25: 1099-1106.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1099-1106
-
-
Sharma, R.A.1
Van Hazel, G.A.2
Morgan, B.3
-
79
-
-
45849097153
-
Pilot study of mutant ras peptide-based vaccine as an adjuvant treatment in pancreatic and colorectal cancers
-
Toubaji A, Achtar M, Provenzano M, et al.: Pilot study of mutant ras peptide-based vaccine as an adjuvant treatment in pancreatic and colorectal cancers. Cancer Immunol Immunother 2008, 57: 1413-1420.
-
(2008)
Cancer Immunol Immunother
, vol.57
, pp. 1413-1420
-
-
Toubaji, A.1
Achtar, M.2
Provenzano, M.3
|