Limited impact of the thymus on immunological recovery during and after chemotherapy in patients with diffuse large b-cell lymphoma

Scandinavian Journal of Immunology

Volumn 69, Issue 6, 2009, Pages 547-554

  Vedel, S J ^b   Tholstrup, D ^c   Kolte, L ^b   Gaardbo, J ^b   Ryder, L P ^c   Ersboll A ^d   Albrecht Beste, E ^b   Jurlander, J ^c   Nielsen, J O ^b   Nielsen, S D ^a,b  

^a HVIDOVRE HOSPITAL   (Denmark)

^b Copenhagen University Hospital ^*  (Denmark)

^c International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYCLOPHOSPHAMIDE; DOXORUBICIN; PREDNISONE; RITUXIMAB; T LYMPHOCYTE RECEPTOR; VINCRISTINE;

ADULT; AGED; ARTICLE; B CELL LYMPHOMA; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONVALESCENCE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INFECTION COMPLICATION; INFECTION SENSITIVITY; LYMPHOCYTOPENIA; MULTIPLE CYCLE TREATMENT; ORGAN SIZE; PATIENT MONITORING; PRIORITY JOURNAL; PROSPECTIVE STUDY; THYMUS;

ADULT; AGED; ANTINEOPLASTIC AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL COUNT; FLOW CYTOMETRY; HUMANS; LYMPHOMA, LARGE B-CELL, DIFFUSE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THYMUS GLAND; TOMOGRAPHY, X-RAY COMPUTED;

EID: 65349175092     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2009.02252.x     Document Type: Article

References (38)

1. The Danish Lymphoma Study Group, LYFO. Recommendations 2005. http://www.lymphoma.dk. online
2. Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M. Report of the committee on Hodgkin's disease staging classification. Cancer Res 1971 31 : 1860 1.
3. McKelvey EM, Gottlieb JA, Wilson HE et al. Hydroxyldaunomycin (Adriamycin) combination chemotherapy in malignant lymphoma. Cancer 1976 38 : 1484 93.
4. Pfreundschuh M, Trumper L, Kloess M et al. Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL-B2 trial of the DSHNHL. Blood 2004 104 : 634 41. (Pubitemid 38970553)
5. Pfreundschuh M, Schubert J, Ziepert M et al. Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60). Lancet Oncol 2008 9 : 105 16.
6. Wunderlich A, Kloess M, Reiser M et al. Practicability and acute haematological toxicity of 2- and 3-weekly CHOP and CHOEP chemotherapy for aggressive non-Hodgkin's lymphoma: results from the NHL-B trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Ann Oncol 2003 14 : 881 93. (Pubitemid 36827204)
7. Trumper L, Zwick C, Ziepert M et al. Dose-escalated CHOEP for the treatment of young patients with aggressive non-Hodgkin's lymphoma: I. A randomized dose escalation and feasibility study with bi- and tri-weekly regimens. Ann Oncol 2008 19 : 538 44.
8. Coiffier B, Lepage E, Briere J et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 2002 346 : 235 42. (Pubitemid 34438862)
9. Pfreundschuh M, Trumper L, Osterborg A et al. CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol 2006 7 : 379 91.
10. Tholstrup D, de Nully BP, Jurlander J, Hansen M. Feasibility, efficacy and safety of CHOP-14 in elderly patients with very high-risk diffuse large B-cell lymphoma. Eur J Haematol 2007 79 : 100 6. (Pubitemid 47063255)
11. Brusamolino E, Rusconi C, Montalbetti L et al. Dose-dense R-CHOP-14 supported by pegfilgrastim in patients with diffuse large B-cell lymphoma: a phase II study of feasibility and toxicity. Haematologica 2006 91 : 496 502.
12. Borg C, Ray-Coquard I, Philip I et al. CD4 lymphopenia as a risk factor for febrile neutropenia and early death after cytotoxic chemotherapy in adult patients with cancer. Cancer 2004 101 : 2675 80. (Pubitemid 39532301)
13. Blay JY, Chauvin F, Le CA et al. Early lymphopenia after cytotoxic chemotherapy as a risk factor for febrile neutropenia. J Clin Oncol 1996 14 : 636 43. (Pubitemid 26051031)
14. Blay JY, Le CA, Mermet C et al. A risk model for thrombocytopenia requiring platelet transfusion after cytotoxic chemotherapy. Blood 1998 92 : 405 10. (Pubitemid 28323701)
15. Brunvand MW, Collins C, Livingston RB, Raghu G. Pneumocystis carinii pneumonia associated with profound lymphopenia and abnormal T-lymphocyte subset ratios during treatment for early-stage breast carcinoma. Cancer 1991 67 : 2407 9.
16. Haynes BF, Markert ML, Sempowski GD, Patel DD, Hale LP. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu Rev Immunol 2000 18 : 529 60. (Pubitemid 30365390)
17. Mackall CL, Fleisher TA, Brown MR et al. Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med 1995 332 : 143 9.
18. Douek DC, McFarland RD, Keiser PH et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998 396 : 690 5. (Pubitemid 29003949)
19. Douek DC, Vescio RA, Betts MR et al. Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet 2000 355 : 1875 81. (Pubitemid 30311880)
20. Cohen SJ, Hamann D, Borleffs J et al. Reconstitution of naive T cells during antiretroviral treatment of HIV-infected adults is dependent on age. AIDS 2002 16 : 2263 6. (Pubitemid 35449011)
21. Petridou E, Klimentopoulou AE, Moustaki M, Kostrikis LG, Hatzakis A, Trichopoulos D. Recent thymic emigrants and prognosis in T- and B-cell childhood hematopoietic malignancies. Int J Cancer 2002 101 : 74 7.
22. McCune JM, Loftus R, Schmidt DK et al. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J Clin Invest 1998 101 : 2301 8. (Pubitemid 28270424)
23. Kolte L, Dreves AM, Ersboll AK et al. Association between larger thymic size and higher thymic output in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy. J Infect Dis 2002 185 : 1578 85. (Pubitemid 34587519)
24. Nielsen SD, Jeppesen DL, Kolte L et al. Impaired progenitor cell function in HIV-negative infants of HIV-positive mothers results in decreased thymic output and low CD4 counts. Blood 2001 98 : 398 404.
25. De Rosa SC, Herzenberg LA, Herzenberg LA, Roederer M. 11-color, 13-parameter flow cytometry: identification of human naive T cells by phenotype, function, and T-cell receptor diversity. Nat Med 2001 7 : 245 8. (Pubitemid 32148494)
26. Smith KY, Valdez H, Landay A et al. Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy. J Infect Dis 2000 181 : 141 7. (Pubitemid 30049042)
27. McFarland RD, Douek DC, Koup RA, Picker LJ. Identification of a human recent thymic emigrant phenotype. Proc Natl Acad Sci USA 2000 97 : 4215 20. (Pubitemid 30226113)
28. Bell EB, Sparshott SM. Interconversion of CD45R subsets of CD4 T cells in vivo. Nature 1990 348 : 163 6. (Pubitemid 20368916)
29. Michie CA, McLean A, Alcock C, Beverley PC. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 1992 360 : 264 5.
30. Sprent J, Tough DF. Lymphocyte life-span and memory. Science 1994 265 : 1395 400. (Pubitemid 24306790)
31. Hazenberg MD, Borghans JA, de Boer RJ, Miedema F. Thymic output: a bad TREC record. Nat Immunol 2003 4 : 97 9. (Pubitemid 36193005)
32. Hazenberg MD, Otto SA, Cohen Stuart JW et al. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nat Med 2000 6 : 1036 42.
33. Harris JM, Hazenberg MD, Poulin JF et al. Multiparameter evaluation of human thymic function: interpretations and caveats. Clin Immunol 2005 115 : 138 46. (Pubitemid 40693083)
34. Svaldi M, Lanthaler AJ, Dugas M et al. T-cell receptor excision circles: a novel prognostic parameter for the outcome of transplantation in multiple myeloma patients. Br J Haematol 2003 122 : 795 801. (Pubitemid 37100306)
35. Chen X, Barfield R, Benaim E et al. Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients. Blood 2005 105 : 886 93. (Pubitemid 40070780)
36. Sfikakis PP, Gourgoulis GM, Moulopoulos LA, Kouvatseas G, Theofilopoulos AN, Dimopoulos MA. Age-related thymic activity in adults following chemotherapy-induced lymphopenia. Eur J Clin Invest 2005 35 : 380 7. (Pubitemid 40826837)
37. Mackall CL, Fleisher TA, Brown MR et al. Distinctions between CD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy. Blood 1997 89 : 3700 7. (Pubitemid 27227093)
38. Lyman GH, Delgado DJ. Risk and timing of hospitalization for febrile neutropenia in patients receiving CHOP, CHOP-R, or CNOP chemotherapy for intermediate-grade non-Hodgkin lymphoma. Cancer 2003 98 : 2402 9. (Pubitemid 37466655)