The effect of amitriptyline on ectopic discharge of primary afferent fibers in the L5 dorsal root in a rat model of neuropathic pain

Anesthesia and Analgesia

Volumn 108, Issue 5, 2009, Pages 1671-1679

  Su, Xin ^a,b   Liang, Annie H ^a   Urban, Mark O ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MEDTRONIC INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; ANALGESIC AGENT; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DORSAL ROOT; DRUG EFFECT; MALE; NERVE FIBER; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; ACTION POTENTIAL; ANIMAL; DISEASE MODEL; DOSE RESPONSE; INTRAVENOUS DRUG ADMINISTRATION; LAMINECTOMY; LIGATION; LUMBAR VERTEBRA; METABOLISM; NEURALGIA; PAIN ASSESSMENT; PAIN THRESHOLD; PATHOPHYSIOLOGY; SENSORY NERVE CELL; SPINAL ROOT; SPRAGUE DAWLEY RAT; TIME;

ACTION POTENTIALS; AMITRIPTYLINE; ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAVENOUS; LAMINECTOMY; LIGATION; LUMBAR VERTEBRAE; MALE; NEURALGIA; NEURONS, AFFERENT; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SPINAL NERVE ROOTS; TIME FACTORS;

EID: 65349166698     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e31819b0271     Document Type: Article

References (41)

1. Yoon YW, Na HS, Chung JM. Contributions of injured and intact afferents to neuropathic pain in an experimental rat model. Pain 1996;64:27-36
2. Liu C-N, Wall PD, Ben-Dor E, Michaelis M, Amir R, Devor M. Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury. Pain 2000;85:503-21
3. Gold M. Spinal nerve ligation: what to blame for the pain and why. Pain 2000;84:117-20
4. Pan HL, Eisenach JC, Chen S R. Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. J Pharmacol Exp Ther 1999;288:1026-30
5. Abdi S, Lee DH, Chung JM. The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain. Anesth Analg 1998;87:1360-6
6. Tanner KD, Reichling DB, Gear RW, Paul SM, Levine JD. Altered temporal pattern of evoked afferent activity in a rat model of vincristine-induced painful peripheral neuropathy. Neuronscience 2003;118:809-17
7. Teng J, Mekhail N. Neuropathic pain: mechanisms and treatment options. Pain Pract 2003;3:8-21
8. Dick IE, Brochu RM, Purohit Y, Kaczorowski GJ, Martin WJ, Priest BT. Sodium channel blockade may contribute to the analgesic efficacy of antidepressants. J Pain 2007;8:315-24
9. Esser MJ, Sawynok J. Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects. Pain 1999;80:643-53
10. Gerner P, Mujtaba M, Khan M, Sudoh Y, Vlassakov K, Anthony D. Wang GK. N-phenylethyl amitriptyline in rat sciatic nerve blockade. Anesthesiol 2002;96:1435-42
11. Lynch ME, Clark AJ, Sawynok J, Sullivan MJ. Topical amitriptyline and ketamine in neuropathic pain syndromes: an open-label study. J Pain 2005;6:644-9
12. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994;53:55-63
13. Kim SH, Chung JM. An experimental model of peripheral neuropathy produced by segmental spinal nerve ligation. Pain 1992;50:355-63
14. Su X, Urban MO. Effect of metabotropic glutamate receptor subtype 5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine on mechanosensory afferents innervating rat hind paw following inflammation. Neurosci Lett 2005;390:123-8
15. Carter GT, Galer BS. Advances in the management of neuropathic pain. Phys Med Rehabil Clin N Am 2001;12:447-59
16. Gorodetskaya N, Constantin C, Janig W. Ectopic activity in cutaneous regenerating afferent nerve fibers following nerve lesion in the rat. Eur J Neurosci 2003;18:2487-97
17. Sun Q, Tu HY, Xing GG, Han JS, Wan Y. Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late stage in rats with spinal nerve ligation. Exp Neurol 2005;191:128-36
18. Amir R, Martin M, Devor M. Membrane potential oscillations in dorsal root ganglion neurons: role in normal electrogenesis and neuropathic pain. J Neurosci 1999;19:8589-96
19. Kretzberg J, Egelhaaf M, Warzecha A. Membrane potential fluctuations determine the precision of spike timing and synchronous activity: a model study. J Comput Neurosci 2001; 10:79-97
20. Everill B, Kocsis JF. Reduction in potassium currents in identified cutaneous afferent DRG neurons after axotomy. J Neurophysiol 1999;82:700-8
21. Cummins TR, Waxman SG Downregulation of tetrodotoxinresistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons following nerve injury. J Neurosci 1997;17:3503-14
22. Kim CH, Oh Y, Chung JM, Chung K. The changes in expression of three subtypes of TTX-sensitive sodium channels in sensory neurons after spinal nerve ligation. Mol Brain Res 2001; 95:153-61
23. Liu C-N, Devor M, Waxman SG, Kocsis JD. Subthreshold oscillations induced by spinal nerve injury in dissociated muscle and cutaneous afferents of mouse DRG J Neurophysiol 2002;87:2009-17
24. + channels. J Neurophysiol 1994;72:349-59
25. Tal M, Wall PD, Devor M. Myelinated afferent fiber types that become spontaneously active and mechanosensitive following nerve transaction in the rat. Brain Res 1999;824:218-23
26. Michaelis M, Liu X, Janig W. Axotomized and intact muscle afferents but no skin afferents develop ongoing discharges of dorsal root ganglion origin after peripheral nerve lesion. J Neurosci 2000;20:2742-8
27. Duan K, Yu X, Zhang C, Zhou Z. Control of secretion by temporal patterns of action potentials in adrenal chromaffin cells. J Neurosci 2003;23:11235-43
28. Wu G, Ringkamp M, Hartke TV, Murinson BB, Campbell JN, Griffin JW, Meyer RA. Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers. J Neurosci 2001;21:RC140
29. De-Doncker L, Picquet F, Petit J, Falempin M. Characterization of spindle afferents in rat soleus muscle using ramp-and-hold sinusoidal stretches. J Neurophysiol 2003;89:442-9
30. Leem JW, Willis WD, Chung JM. Cutaneous sensory receptors in the rat foot. J Neurophysiol 1993;69:1684-99
31. Perry PJ, Zeilmann C, Arndt S. Tricyclic antidepressant concentrations in plasma: an estimate of their sensitivity and specificity as a predictor of response. J Clin Psychopharmacol 1994; 14:230-40
32. + currents in rat sensory neurons. Anesthesiology 2001;94:137-44
33. Ritter AM, Ritchie C, Martin WJ. Relationship between the firing frequency of injured peripheral neurons and inhibition of firing by sodium channel blockers. J Pain 2007;8:287-95
34. Lai J, Hunter JC, Porreca F. The role of voltage-gated sodium channels in neuropathic pain. Curr Opin Neurobiol 2003; 13:291-7
35. + channels. J Pharmacol Exp Ther 2007;320:354-64
36. Matzner O, Devor M. Method for distinguishing between drug action on impulse propagation versus impulse generation. J Neurosci Methods 1993;49:23-31
37. Novakovic SD, Tzoumaka E, McGivern JG, Haraguchi M, Sangameswaran L, Gogas KR, Eglen RM, Hunter JC. Tetrodotoxin-resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions. J Neurosci 1998;18:2174-87
38. Elliott AA, Elliott JR. Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia. J Physiol 1993;463:39-56
39. + channels. J Membr Biol 2004;201:1-8
40. + channels by local anesthetics. Science 1994;265:1724-8
41. Angel A. Central neuronal pathways and the process of anaesthesia. Bri J Anaesthesia 1993;71:148-63