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Volumn 6, Issue 2, 2009, Pages 218-223

Emerging therapeutic targets in non-small cell lung cancer

Author keywords

Angiogenesis; Epidermal growth factor receptor; Non small cell lung cancer; Vaccine

Indexed keywords

3 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] 5 [1 (4 PIPERIDINYL) 1H PYRAZOL 4 YL] 2 PYRIDINYLAMINE; 5 (2,6 DICHLOROBENZYLSULFONYL) 3 [3,5 DIMETHYL 4 [2 (1 PYRROLIDINYLMETHYL) 1 PYRROLIDINYLCARBONYL] 1H PYRROL 2 YLMETHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; BEVACIZUMAB; BOSUTINIB; CANCER VACCINE; CARBOPLATIN; CETUXIMAB; CIMAVAX EPIDERMAL GROWTH FACTOR; CISPLATIN; CP 751871; CYCLOPHOSPHAMIDE; DASATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; EVEROLIMUS; GEFITINIB; LUCANIX; N (5 CHLORO 1,3 BENZODIOXOL 4 YL) 7 [2 (4 METHYL 1 PIPERAZINYL)ETHOXY] 5 (TETRAHYDRO 2H PYRAN 4 YLOXY) 4 QUINAZOLINAMINE; NAVELBINE; PACLITAXEL; PEMETREXED; PLACEBO; RECOMBINANT VACCINE; RECOMBINANT VASCULOTROPIN; SORAFENIB; STIMUVAX; SUNITINIB; TEMSIROLIMUS; UNCLASSIFIED DRUG;

EID: 65349149344     PISSN: 15463222     EISSN: None     Source Type: Journal    
DOI: 10.1513/pats.200808-099LC     Document Type: Conference Paper
Times cited : (13)

References (67)
  • 3
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N, Chang A, Parikh P, Rodrigues Pereira J, Ciuleanu T, von Pawel J, Thongprasert S, Tan EH, Pemberton K, Archer V, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005;366:1527-1537.
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3    Rodrigues Pereira, J.4    Ciuleanu, T.5    von Pawel, J.6    Thongprasert, S.7    Tan, E.H.8    Pemberton, K.9    Archer, V.10
  • 6
    • 45149102984 scopus 로고    scopus 로고
    • Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small cell lung cancer: SWOG S0023
    • Kelly K, Chansky K, Gaspar LE, Albain KS, Jett J, Ung YC, Lau DH, Crowley JJ, Gandara DR. Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small cell lung cancer: SWOG S0023. J Clin Oncol 2008;26:2450-2456.
    • (2008) J Clin Oncol , vol.26 , pp. 2450-2456
    • Kelly, K.1    Chansky, K.2    Gaspar, L.E.3    Albain, K.S.4    Jett, J.5    Ung, Y.C.6    Lau, D.H.7    Crowley, J.J.8    Gandara, D.R.9
  • 7
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • Eberhard DA, Johnson BE, Amler LC, Goddard AD, Heldens SL, Herbst RS, Ince WL, Janne PA, Januario T, Johnson DH, et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005;23:5900-5909.
    • (2005) J Clin Oncol , vol.23 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3    Goddard, A.D.4    Heldens, S.L.5    Herbst, R.S.6    Ince, W.L.7    Janne, P.A.8    Januario, T.9    Johnson, D.H.10
  • 10
    • 59749100191 scopus 로고    scopus 로고
    • Phase III randomised, open- label, first-line study of gefitinib vs carboplatin/paclitaxel in clinically selected patients with advanced non-small cell lung cancer (IPASS) [abstract]
    • Mok T, Wu YL, Thongprasert S, Yang CH, Chu D, Saijo N, Jiang H, Watkins C, Armour A, Fukuoka M. Phase III randomised, open- label, first-line study of gefitinib vs carboplatin/paclitaxel in clinically selected patients with advanced non-small cell lung cancer (IPASS) [abstract]. Ann Oncol 2008;19:viii1.
    • (2008) Ann Oncol , vol.19
    • Mok, T.1    Wu, Y.L.2    Thongprasert, S.3    Yang, C.H.4    Chu, D.5    Saijo, N.6    Jiang, H.7    Watkins, C.8    Armour, A.9    Fukuoka, M.10
  • 14
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small cell lung cancer
    • Herbst RS, Prager D, Hermann R, Fehrenbacher L, Johnson BE, Sandler A, Kris MG, Tran HT, Klein P, Li X, et al. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small cell lung cancer. J Clin Oncol 2005;23:5892-5899.
    • (2005) J Clin Oncol , vol.23 , pp. 5892-5899
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3    Fehrenbacher, L.4    Johnson, B.E.5    Sandler, A.6    Kris, M.G.7    Tran, H.T.8    Klein, P.9    Li, X.10
  • 15
    • 51349109631 scopus 로고    scopus 로고
    • FLEX: A randomized, multicenter, phase III study of cetuximab in combination with cisplatin/ vinorelbine (CV) versus CV alone in the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) [abstract]
    • Pirker R, Szczesna A, von Pawel J, et al. FLEX: A randomized, multicenter, phase III study of cetuximab in combination with cisplatin/ vinorelbine (CV) versus CV alone in the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol 2008;26:3a.
    • (2008) J Clin Oncol , vol.26
    • Pirker, R.1    Szczesna, A.2    von Pawel, J.3
  • 16
    • 65349189959 scopus 로고    scopus 로고
    • ImClone press release. August 29, 2008. (Accessed 2008 Oct 28) Available from http://www.drugs.com/clinica-trials/erbitux-phase-3-bms-099-lung-cancer- study-secondary-endpoint-update-overall-survival-results-5380.html
    • ImClone press release. August 29, 2008. (Accessed 2008 Oct 28) Available from http://www.drugs.com/clinica-trials/erbitux-phase-3-bms-099-lung-cancer- study-secondary-endpoint-update-overall-survival-results-5380.html
  • 17
    • 0032482939 scopus 로고    scopus 로고
    • Antiangiogenic gene therapy
    • Folkman J. Antiangiogenic gene therapy. Proc Natl Acad Sci USA 1998; 95:9064-9066.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9064-9066
    • Folkman, J.1
  • 18
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997;18:4-25.
    • (1997) Endocr Rev , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 20
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carbo- platin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, Herbst RS, Nemunaitis JJ, Jablons DM, Langer CJ, DeVore RF, 3rd, Gaudreault J, Damico LA, et al. Randomized phase II trial comparing bevacizumab plus carbo- platin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004;22:2184-2191.
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3    Herbst, R.S.4    Nemunaitis, J.J.5    Jablons, D.M.6    Langer, C.J.7    DeVore 3rd, R.F.8    Gaudreault, J.9    Damico, L.A.10
  • 22
    • 62349107301 scopus 로고    scopus 로고
    • B017704: A phase III randomized study of first-line bevacizumab combined with cisplatin/ gemcitabine (CG) in patients (pts) with advanced or recurrent non- squamous, non-small cell lung cancer (NSCLC) [abstract]
    • Manegold C, von Pawel J, Zaitloukal P, Ramlau R, Gorbounova V, Hirsh V, Leighl N, Mezger J, Archer V, Reck M. B017704: a phase III randomized study of first-line bevacizumab combined with cisplatin/ gemcitabine (CG) in patients (pts) with advanced or recurrent non- squamous, non-small cell lung cancer (NSCLC) [abstract]. Ann Oncol 2008;19:viii1.
    • (2008) Ann Oncol , vol.19
    • Manegold, C.1    von Pawel, J.2    Zaitloukal, P.3    Ramlau, R.4    Gorbounova, V.5    Hirsh, V.6    Leighl, N.7    Mezger, J.8    Archer, V.9    Reck, M.10
  • 23
    • 0036810227 scopus 로고    scopus 로고
    • Phase III randomised trial comparing paclitaxel/carboplatin with paclitaxel/cisplatin in patients with advanced non-small-cell lung cancer: A cooperative multinational trial
    • Rosell R, Gatzemeier U, Betticher DC, Keppler U, Macha HN, Pirker R, Berthet P, Breau JL, Lianes P, Nicholson M, et al. Phase III randomised trial comparing paclitaxel/carboplatin with paclitaxel/cisplatin in patients with advanced non-small-cell lung cancer: a cooperative multinational trial. Ann Oncol 2002;13:1539.
    • (2002) Ann Oncol , vol.13 , pp. 1539
    • Rosell, R.1    Gatzemeier, U.2    Betticher, D.C.3    Keppler, U.4    Macha, H.N.5    Pirker, R.6    Berthet, P.7    Breau, J.L.8    Lianes, P.9    Nicholson, M.10
  • 24
    • 0042413836 scopus 로고    scopus 로고
    • Randomized, multinational, phase III study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for advanced non- small-cell lung cancer: The TAX 326 study group
    • Fossella F, Pereira JR, von Pawel J, Pluzanska A, Gorbounova V, Kaukel E, Mattson KV, Ramlau R, Szczesna A, Fidias P, et al. Randomized, multinational, phase III study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for advanced non- small-cell lung cancer: the TAX 326 study group. J Clin Oncol 2003; 21:3016-3024.
    • (2003) J Clin Oncol , vol.21 , pp. 3016-3024
    • Fossella, F.1    Pereira, J.R.2    von Pawel, J.3    Pluzanska, A.4    Gorbounova, V.5    Kaukel, E.6    Mattson, K.V.7    Ramlau, R.8    Szczesna, A.9    Fidias, P.10
  • 25
    • 65349193290 scopus 로고    scopus 로고
    • Schiller JH, Lee JW, Hanna NH, Traynor AM, Carbone DP. A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501 [abstract]. JClinOncol2008;26: 8014a.
    • Schiller JH, Lee JW, Hanna NH, Traynor AM, Carbone DP. A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501 [abstract]. JClinOncol2008;26: 8014a.
  • 28
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
    • Luo J, Manning BD, Cantley LC. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 2003;4:257-262.
    • (2003) Cancer Cell , vol.4 , pp. 257-262
    • Luo, J.1    Manning, B.D.2    Cantley, L.C.3
  • 29
    • 38449090544 scopus 로고    scopus 로고
    • PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors
    • Noro R, Gemma A, Miyanaga A, Kosaihira S, Minegishi Y, Nara M, Kokubo Y, Seike M, Kataoka K, Matsuda K, et al. PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors. Int J Oncol 2007;31:1157-1163.
    • (2007) Int J Oncol , vol.31 , pp. 1157-1163
    • Noro, R.1    Gemma, A.2    Miyanaga, A.3    Kosaihira, S.4    Minegishi, Y.5    Nara, M.6    Kokubo, Y.7    Seike, M.8    Kataoka, K.9    Matsuda, K.10
  • 30
    • 0023721851 scopus 로고
    • Evidence for autocrine mitogenic stimulation by somatomedin-C/ insulin-like growth factor I on an established human lung cancer cell line
    • Minuto F, Del Monte P, Barreca A, Alama A, Cariola G, Giordano G. Evidence for autocrine mitogenic stimulation by somatomedin-C/ insulin-like growth factor I on an established human lung cancer cell line. Cancer Res 1988;48:3716-3719.
    • (1988) Cancer Res , vol.48 , pp. 3716-3719
    • Minuto, F.1    Del Monte, P.2    Barreca, A.3    Alama, A.4    Cariola, G.5    Giordano, G.6
  • 31
    • 0027237055 scopus 로고
    • Expression of insulin-like growth factor receptors I and II in normal human lung and in lung cancer
    • Kaiser U, Schardt C, Brandscheidt D, Wollmer E, Havemann K. Expression of insulin-like growth factor receptors I and II in normal human lung and in lung cancer. J Cancer Res Clin Oncol 1993;119: 665-668.
    • (1993) J Cancer Res Clin Oncol , vol.119 , pp. 665-668
    • Kaiser, U.1    Schardt, C.2    Brandscheidt, D.3    Wollmer, E.4    Havemann, K.5
  • 33
    • 33745307617 scopus 로고    scopus 로고
    • Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 2006;441:424-430.
    • Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 2006;441:424-430.
  • 34
    • 46149092748 scopus 로고    scopus 로고
    • Role of mTOR in anticancer drug resistance: Perspectives for improved drug treatment
    • Jiang BH, Liu LZ. Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug Resist Updat 2008; 11:63-76.
    • (2008) Drug Resist Updat , vol.11 , pp. 63-76
    • Jiang, B.H.1    Liu, L.Z.2
  • 35
    • 33748058820 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells
    • Wang MY, Lu KV, Zhu S, Dia EQ, Vivanco I, Shackleford GM, Cavenee WK, Mellinghoff IK, Cloughesy TF, Sawyers CL, et al. Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells. Cancer Res 2006;66:7864-7869.
    • (2006) Cancer Res , vol.66 , pp. 7864-7869
    • Wang, M.Y.1    Lu, K.V.2    Zhu, S.3    Dia, E.Q.4    Vivanco, I.5    Shackleford, G.M.6    Cavenee, W.K.7    Mellinghoff, I.K.8    Cloughesy, T.F.9    Sawyers, C.L.10
  • 37
    • 37349032876 scopus 로고    scopus 로고
    • Antagonists of growth-hormone- releasing hormone: An emerging new therapy for cancer
    • Schally AV, Varga JL, Engel JB. Antagonists of growth-hormone- releasing hormone: an emerging new therapy for cancer. Nat Clin Pract Endocrinol Metab 2008;4:33-43.
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , pp. 33-43
    • Schally, A.V.1    Varga, J.L.2    Engel, J.B.3
  • 39
    • 40349110085 scopus 로고    scopus 로고
    • A phase II NCCTG ''Window of Opportunity Front-line'' study of the mTOR inhibitor, CCI-779 (temsirolimus) given as a single agent in patients with advanced NSCLC [abstract]
    • Molina JR, Mandrekar SJ, Rowland KR, Reuter NF, Jett JR, Marks R, Schild SE, Adjei A. A phase II NCCTG ''Window of Opportunity Front-line'' study of the mTOR inhibitor, CCI-779 (temsirolimus) given as a single agent in patients with advanced NSCLC [abstract]. J Thorac Oncol 2007;2:S413.
    • (2007) J Thorac Oncol , vol.2
    • Molina, J.R.1    Mandrekar, S.J.2    Rowland, K.R.3    Reuter, N.F.4    Jett, J.R.5    Marks, R.6    Schild, S.E.7    Adjei, A.8
  • 40
    • 54949104315 scopus 로고    scopus 로고
    • A phase II study of RAD001 (everolimus) monotherapy in patients with advanced non-small cell lung cancer (NSCLC) failing prior platinum- based chemotherapy (C) or prior C and EGFR inhibitors [abstract]
    • 406s
    • Papadimitrakopoulou V, Soria JC, Douillard JY, Giaccone G, Wolf J, Crino L, Cappuzzo F, Sharma S, Gross SH, Shepherd FA. A phase II study of RAD001 (everolimus) monotherapy in patients with advanced non-small cell lung cancer (NSCLC) failing prior platinum- based chemotherapy (C) or prior C and EGFR inhibitors [abstract]. J Clin Oncol 2007;25:406s.
    • (2007) J Clin Oncol , vol.25
    • Papadimitrakopoulou, V.1    Soria, J.C.2    Douillard, J.Y.3    Giaccone, G.4    Wolf, J.5    Crino, L.6    Cappuzzo, F.7    Sharma, S.8    Gross, S.H.9    Shepherd, F.A.10
  • 41
    • 0037421205 scopus 로고    scopus 로고
    • PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration
    • Zeng L, Si X, Yu WP, et al. PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration. J Cell Biol 2003;160:137-146.
    • (2003) J Cell Biol , vol.160 , pp. 137-146
    • Zeng, L.1    Si, X.2    Yu, W.P.3
  • 42
    • 0034668172 scopus 로고    scopus 로고
    • Induction and regulation of epithelialmesenchymal transitions
    • Boyer B, Valles Am, Edme N. Induction and regulation of epithelialmesenchymal transitions. Biochem Pharmacol 2000;60:1091-1099.
    • (2000) Biochem Pharmacol , vol.60 , pp. 1091-1099
    • Boyer, B.1    Valles, A.2    Edme, N.3
  • 44
    • 0026611149 scopus 로고
    • Expression of pp60c-src in human small cell and non-small cell lung carcinomas
    • Mazurenko NN, Kogan EA, Zborovskaya IB, Kisseljov FL. Expression of pp60c-src in human small cell and non-small cell lung carcinomas. Eur J Cancer 1992;28:372-377.
    • (1992) Eur J Cancer , vol.28 , pp. 372-377
    • Mazurenko, N.N.1    Kogan, E.A.2    Zborovskaya, I.B.3    Kisseljov, F.L.4
  • 45
    • 0033393771 scopus 로고    scopus 로고
    • Selective requirement for Src kinases during VEGF-induced angio- genesis and vascular permeability
    • Eliceiri BP, Paul R, Schwartzberg PL, Hood JD, Leng J, Cheresh DA. Selective requirement for Src kinases during VEGF-induced angio- genesis and vascular permeability. Mol Cell 1999;4:915-924.
    • (1999) Mol Cell , vol.4 , pp. 915-924
    • Eliceiri, B.P.1    Paul, R.2    Schwartzberg, P.L.3    Hood, J.D.4    Leng, J.5    Cheresh, D.A.6
  • 46
    • 0037699512 scopus 로고    scopus 로고
    • Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells
    • Song L, Turkson J, Karras JG, Jove R, Haura EB. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. Oncogene 2003;22:4150-4165.
    • (2003) Oncogene , vol.22 , pp. 4150-4165
    • Song, L.1    Turkson, J.2    Karras, J.G.3    Jove, R.4    Haura, E.B.5
  • 47
    • 1842836011 scopus 로고    scopus 로고
    • Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphor- ylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tumour cells
    • Laird AD, Li G, Moss KG, Blake RA, Broome MA, Cherrington JM, Mendel DB. Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphor- ylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tumour cells. Mol Cancer Ther 2003;2:461-469.
    • (2003) Mol Cancer Ther , vol.2 , pp. 461-469
    • Laird, A.D.1    Li, G.2    Moss, K.G.3    Blake, R.A.4    Broome, M.A.5    Cherrington, J.M.6    Mendel, D.B.7
  • 48
    • 33745243692 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
    • Song L, Morris M, Bagui T, Lee FY, Jove R, Haura EB. Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res 2006;66:5542-5548.
    • (2006) Cancer Res , vol.66 , pp. 5542-5548
    • Song, L.1    Morris, M.2    Bagui, T.3    Lee, F.Y.4    Jove, R.5    Haura, E.B.6
  • 50
    • 33746504571 scopus 로고    scopus 로고
    • Invasive growth: A MET-driven genetic programme for cancer and stem cells
    • Boccacio C, Comoglio PM. Invasive growth: a MET-driven genetic programme for cancer and stem cells. Nat Rev Cancer 2006;6:637-645.
    • (2006) Nat Rev Cancer , vol.6 , pp. 637-645
    • Boccacio, C.1    Comoglio, P.M.2
  • 53
    • 0036121308 scopus 로고    scopus 로고
    • Fujita Y, Krause G, Scheffner M, Zechner D, Leddy HE, Behrens J, Sommer T, Birchmeier W. Hakai, a Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol 2002;4:222-231.
    • Fujita Y, Krause G, Scheffner M, Zechner D, Leddy HE, Behrens J, Sommer T, Birchmeier W. Hakai, a Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol 2002;4:222-231.
  • 54
    • 0036222482 scopus 로고    scopus 로고
    • E-cadherin and Hakai: Signaling, remodeling or destruction?
    • Pece S, Gutkind S. E-cadherin and Hakai: signaling, remodeling or destruction? Nat Cell Biol 2002;4:E72-E74.
    • (2002) Nat Cell Biol , vol.4
    • Pece, S.1    Gutkind, S.2
  • 55
    • 0000937789 scopus 로고
    • Contribution to the knowledge of sarcoma
    • Coley WB. Contribution to the knowledge of sarcoma. Ann Surg 1891; 14:199-220.
    • (1891) Ann Surg , vol.14 , pp. 199-220
    • Coley, W.B.1
  • 56
    • 41149131700 scopus 로고    scopus 로고
    • Are vaccines making a comeback in non-small cell lung cancer?
    • Nemunaitis JJ. Are vaccines making a comeback in non-small cell lung cancer? J Clin Oncol 2008;26:1402-1403.
    • (2008) J Clin Oncol , vol.26 , pp. 1402-1403
    • Nemunaitis, J.J.1
  • 57
    • 41949141343 scopus 로고    scopus 로고
    • Immune-potentiating effects of the chemotherapeutic drug cyclophosphamide
    • Brode S, Cooke A. Immune-potentiating effects of the chemotherapeutic drug cyclophosphamide. Crit Rev Immunol 2008;29:109-126.
    • (2008) Crit Rev Immunol , vol.29 , pp. 109-126
    • Brode, S.1    Cooke, A.2
  • 60
    • 65349149403 scopus 로고    scopus 로고
    • A multicentre phase IIB randomized controlled study of BLP25 liposome vaccine (L-BLP25 or Stimuvax) for active specific immunotherapy of non-small cell lung cancer (NSCLC): Updated survival analysis: B1-01 [abstract]
    • Butts CM, Maksymiuk A, Goss G, Soulieres D, Marshall E, Cormier Y, Ellis PM, Price A, Sawhney R, Murray NA. A multicentre phase IIB randomized controlled study of BLP25 liposome vaccine (L-BLP25 or Stimuvax) for active specific immunotherapy of non-small cell lung cancer (NSCLC): updated survival analysis: B1-01 [abstract]. J Thorac Oncol 2007;2:S332-S333.
    • (2007) J Thorac Oncol , vol.2
    • Butts, C.M.1    Maksymiuk, A.2    Goss, G.3    Soulieres, D.4    Marshall, E.5    Cormier, Y.6    Ellis, P.M.7    Price, A.8    Sawhney, R.9    Murray, N.A.10
  • 63
    • 42549106307 scopus 로고    scopus 로고
    • Final results of a multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of MAGE-A3 immunotherapeutic as adjuvant therapy in stage IB/II non-small cell lung cancer (NSCLC). [abstract]
    • Vansteenkiste J, Zielinski M, Linder A, Dahabre J, Esteban E, Malinowski W, Jassem J, Passlick B, Lehmann F, Brichard V. Final results of a multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of MAGE-A3 immunotherapeutic as adjuvant therapy in stage IB/II non-small cell lung cancer (NSCLC). [abstract]. J Clin Oncol 2007;25:398S.
    • (2007) J Clin Oncol , vol.25
    • Vansteenkiste, J.1    Zielinski, M.2    Linder, A.3    Dahabre, J.4    Esteban, E.5    Malinowski, W.6    Jassem, J.7    Passlick, B.8    Lehmann, F.9    Brichard, V.10
  • 65
  • 67
    • 65349084984 scopus 로고    scopus 로고
    • Kras status and efficacy in the CRYSTAL study: 1st-line treatment of patients with metastatic colorectal cancer (MCRC) receiving FOLFIRI with or without cetuximab [abstract]
    • Van Cutsem, Lang I, D'Haens G, Moiseyenko V, Zaluski J, Folprecht G, Tejpar S, Nippgen J, Stroh C, Rougier P. Kras status and efficacy in the CRYSTAL study: 1st-line treatment of patients with metastatic colorectal cancer (MCRC) receiving FOLFIRI with or without cetuximab [abstract]. Ann Oncol 2008;19(S8):viii44-viii45.
    • (2008) Ann Oncol , vol.19 , Issue.S8
    • Cutsem, V.1    Lang, I.2    D'Haens, G.3    Moiseyenko, V.4    Zaluski, J.5    Folprecht, G.6    Tejpar, S.7    Nippgen, J.8    Stroh, C.9    Rougier, P.10


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