The role of Th17 cells in adult patients with chronic idiopathic thrombocytopenic purpura

European Journal of Haematology

Volumn 82, Issue 6, 2009, Pages 488-489

  Guo, Zhen Xing ^a   Chen, Zhen Ping ^a   Zheng, Cui Ling ^a   Jia, Hai Rong ^a   Ge, Jing ^a   Gu, Dong Sheng ^a   Du, Wei Ting ^a   Wang, Xiao Yan ^a   Zhao, Hai Feng ^a   Yang, Ren Chi ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; INTERLEUKIN 17; INTERLEUKIN 2; MESSENGER RNA; PHYTOHEMAGGLUTININ; PREDNISOLONE;

BONE MARROW BIOPSY; CD8+ T LYMPHOCYTE; CELL FUNCTION; CHINESE; FLOW CYTOMETRY; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IN VITRO STUDY; LETTER; MEGAKARYOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH1 CELL; TH17 CELL; THROMBOCYTE COUNT;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CHRONIC DISEASE; FEMALE; HUMANS; INTERLEUKIN-17; LYMPHOCYTE COUNT; MALE; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RNA, MESSENGER; T-LYMPHOCYTE SUBSETS; YOUNG ADULT;

EID: 65349141382     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2009.01229.x     Document Type: Letter

References (10)

1. Cines DB, Blanchette VS. Immune thrombocytopenic purpura. N Engl J Med 2002 346 : 995 1008.
2. Zhou B, Zhao H, Yang RC, Han ZC. Multi-dysfunctional pathophysiology in ITP. Crit Rev Oncol/Hematol 2005 54 : 107 16.
3. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005 6 : 1123 32.
4. Park H, Li Z, Yang XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005 6 : 1133 41.
5. Wang T, Zhao H, Ren H, Guo J, Xu M, Yang R, Han ZC. Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura. Haematologica 2005 90 : 914 23.
6. Gupta S, Aggarwal S, Rashanravan B, Lee T. Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism. J Neuroimmunol 1998 85 : 106 9.
7. Becher B, Giacomini PS, Pelletier D, McCrea E, Prat A, Antel JP. Interferongamma secretion by peripheral blood T-cell subsets in multiple sclerosis: correlation with disease phase and interferon-beta therapy. Ann Neurol 1999 45 : 247 50.
8. Olsson B, Andersson PO, Jernas M, Jacobsson S, Carlsson B, Carlsson LM, Wadenvik H. T-cell-mediated cytotoxicity toward platelet in chronic idiopathic thrombocytopenic purpura. Nat Med 2003 9 : 1123 4.
9. Li S, Wang L, Zhao C, Li L, Peng J, Hou M. CD8+ T cells suppress autologous megakaryocyte apoptosis in idiopathic thrombocytopenic purpura. Br J Haematol 2007 139 : 605 11.
10. Ma D, Zhu X, Zhao P, et al. Profile of Th17 cytokines (IL-17, TGF-beta, IL-6) and Th1 cytokine (IFN-gamma) in patients with immune thrombocytopenic purpura. Ann Hematol 2008 87 : 899 904.