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Volumn 103, Issue 1, 1998, Pages 168-175

Transcriptional silencing of the p16 gene in human myeloma-derived cell lines by hypermethylation

Author keywords

Methylation; Multiple myeloma; p15; p16; Transcriptional block

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; PROTEIN P15; PROTEIN P16; UNCLASSIFIED DRUG;

EID: 0031657575     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (39)

References (38)
  • 1
    • 0031014414 scopus 로고    scopus 로고
    • Reversal of loss of imprinting in tumor cells by 5-aza-2′-deoxycytidine
    • Barletta, J.M., Rainier, S. & Feinberg, A.P. (1997) Reversal of loss of imprinting in tumor cells by 5-aza-2′-deoxycytidine. Cancer Research, 57, 48-50.
    • (1997) Cancer Research , vol.57 , pp. 48-50
    • Barletta, J.M.1    Rainier, S.2    Feinberg, A.P.3
  • 2
    • 0031035406 scopus 로고    scopus 로고
    • Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia
    • Batova, A., Diccianni, M.B., Yu, J.C., Nobori, T., Link, M.P., Pullen, J. & Yu, A.L. (1997) Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia. Cancer Research, 57, 832-856.
    • (1997) Cancer Research , vol.57 , pp. 832-856
    • Batova, A.1    Diccianni, M.B.2    Yu, J.C.3    Nobori, T.4    Link, M.P.5    Pullen, J.6    Yu, A.L.7
  • 4
    • 0029915461 scopus 로고    scopus 로고
    • Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia
    • Cayuela, J.M., Madani, A., Sanhes, L., Stern, M.H. & Sigaux, F. (1996) Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia. Blood, 87, 2180-2186.
    • (1996) Blood , vol.87 , pp. 2180-2186
    • Cayuela, J.M.1    Madani, A.2    Sanhes, L.3    Stern, M.H.4    Sigaux, F.5
  • 6
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry, 162, 156-159.
    • (1987) Analytical Biochemistry , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 7
    • 0027229136 scopus 로고
    • Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
    • Ewen, M.E., Sluss, H.K., Sherr, C.J., Matsushime, H., Kato, J. & Livingston, D.M. (1993) Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell, 73, 487-497.
    • (1993) Cell , vol.73 , pp. 487-497
    • Ewen, M.E.1    Sluss, H.K.2    Sherr, C.J.3    Matsushime, H.4    Kato, J.5    Livingston, D.M.6
  • 10
    • 0028168242 scopus 로고
    • INK4B is a potential effector of TGF-β-induced cell cycle arrest
    • INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature, 371, 257-261.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 12
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman, J.G., Merlo, A., Mao, L., Lapidus, R.G., Issa, J-P.J., Davidson, N.E., Sidransky, D. & Baylin, S.B. (1995) Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Research, 54, 4525-4530.
    • (1995) Cancer Research , vol.54 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.-P.J.5    Davidson, N.E.6    Sidransky, D.7    Baylin, S.B.8
  • 13
    • 0030714115 scopus 로고    scopus 로고
    • Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemia
    • Iravani, M., Dhat, R. & Price, C.M. (1997) Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemia. Oncogene, 15, 2609-2614.
    • (1997) Oncogene , vol.15 , pp. 2609-2614
    • Iravani, M.1    Dhat, R.2    Price, C.M.3
  • 15
    • 0029898837 scopus 로고    scopus 로고
    • DNA methylation errors and cancer
    • Jones, P.A. (1996) DNA methylation errors and cancer. Cancer Research, 56, 2463-2467.
    • (1996) Cancer Research , vol.56 , pp. 2463-2467
    • Jones, P.A.1
  • 17
    • 0027288908 scopus 로고
    • Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4
    • Kato, J., Matsushime, H., Hiebert, S.W., Ewen, M.E. & Sherr, C.J. (1993) Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes and Development, 7, 331-342.
    • (1993) Genes and Development , vol.7 , pp. 331-342
    • Kato, J.1    Matsushime, H.2    Hiebert, S.W.3    Ewen, M.E.4    Sherr, C.J.5
  • 18
    • 0030941813 scopus 로고    scopus 로고
    • Homozygous deletion of the p16/ MTS1 gene in pediatric acute lymphoblastic leukemia is associated with unfavorable clinical outcome
    • Kees, U.R., Burton, P.R., Lu, C. & Baker, D.L. (1997) Homozygous deletion of the p16/ MTS1 gene in pediatric acute lymphoblastic leukemia is associated with unfavorable clinical outcome. Blood, 89, 4161-4166.
    • (1997) Blood , vol.89 , pp. 4161-4166
    • Kees, U.R.1    Burton, P.R.2    Lu, C.3    Baker, D.L.4
  • 19
    • 0029891539 scopus 로고    scopus 로고
    • Deletions of the p16 gene in pediatric leukemia and corresponding cell lines
    • Kees, U.R., Ranford, P.R. & Hatzis, M. (1996) Deletions of the p16 gene in pediatric leukemia and corresponding cell lines. Oncogene, 12, 2235-2239.
    • (1996) Oncogene , vol.12 , pp. 2235-2239
    • Kees, U.R.1    Ranford, P.R.2    Hatzis, M.3
  • 20
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo, A., Herman, J.G., Mao, L., Lee, D.J., Gabrielson, E., Burger, P.C., Baylin, S.B. & Sidransky, D. (1995) 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nature Medicine, 1, 686-692.
    • (1995) Nature Medicine , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 21
    • 0021359472 scopus 로고
    • 5-aza-2′-deoxycytidine therapy in patients with acute leukemia inhibits DNA methylation
    • Momparler, R.L., Bouchard, J., Onetto, N. & Rivard, G.E. (1984) 5-aza-2′-deoxycytidine therapy in patients with acute leukemia inhibits DNA methylation. Leukemia Research, 8, 181-185.
    • (1984) Leukemia Research , vol.8 , pp. 181-185
    • Momparler, R.L.1    Bouchard, J.2    Onetto, N.3    Rivard, G.E.4
  • 22
    • 0030974771 scopus 로고    scopus 로고
    • Pilot phase I-II study on 5-aza-2′-deoxycytidine (Decitabine) in patients with metastatic lung cancer
    • Momparler, R.L., Bouffard, D.Y., Momparler, L.F., Dionne, J., Belanger, K. & Ayoub, J. (1997) Pilot phase I-II study on 5-aza-2′-deoxycytidine (Decitabine) in patients with metastatic lung cancer. Anticancer Drugs, 8, 358-368.
    • (1997) Anticancer Drugs , vol.8 , pp. 358-368
    • Momparler, R.L.1    Bouffard, D.Y.2    Momparler, L.F.3    Dionne, J.4    Belanger, K.5    Ayoub, J.6
  • 23
    • 0022303520 scopus 로고
    • Clinical trial on 5-aza-2′-deoxycytidine in patients with acute leukaemia
    • Momparler, R.L., Rivard, G.E. & Gyer, M. (1985) Clinical trial on 5-aza-2′-deoxycytidine in patients with acute leukaemia. Pharmacology and Therapeutics, 30, 277-286.
    • (1985) Pharmacology and Therapeutics , vol.30 , pp. 277-286
    • Momparler, R.L.1    Rivard, G.E.2    Gyer, M.3
  • 24
    • 0030940091 scopus 로고    scopus 로고
    • Frequent hypermethylation of p16 and p15 genes in multiple myeloma
    • Ng, M.H.L., Chung, Y.F., Lo, K.W. Wickham, N.W.R., Lee, J.C.K. & Huang, D.P. (1997) Frequent hypermethylation of p16 and p15 genes in multiple myeloma. Blood, 89, 2500-2506.
    • (1997) Blood , vol.89 , pp. 2500-2506
    • Ng, M.H.L.1    Chung, Y.F.2    Lo, K.W.3    Wickham, N.W.R.4    Lee, J.C.K.5    Huang, D.P.6
  • 25
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • Nobori, T., Miura, K., Wu, D.J., Lois, A., Takabayashi, K. & Carson, D.A. (1994) Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature, 368, 753-756.
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3    Lois, A.4    Takabayashi, K.5    Carson, D.A.6
  • 27
    • 0029121279 scopus 로고
    • Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia
    • Ohnishi, H., Kawamura, M., Ida, K., Sheng, X.M., Hanada, R., Nobori, T., Yamamori, S. & Hayashi, Y. (1995) Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia. Blood, 86, 1269-1275.
    • (1995) Blood , vol.86 , pp. 1269-1275
    • Ohnishi, H.1    Kawamura, M.2    Ida, K.3    Sheng, X.M.4    Hanada, R.5    Nobori, T.6    Yamamori, S.7    Hayashi, Y.8
  • 31
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/ CDK4
    • Serrano, M., Hannon, G.J. & Beach, D. (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/ CDK4. Nature, 366, 704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 34
    • 0029008903 scopus 로고
    • Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood
    • Takeuchi, S., Bartram, C.R., Seriu, T., Miller, C.W., Tobler, A., Janssen, J.W., Reiter, A., Ludwig, W.D., Zimmermann, M. & Schwaller, J. (1995) Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood. Blood, 86, 755-760.
    • (1995) Blood , vol.86 , pp. 755-760
    • Takeuchi, S.1    Bartram, C.R.2    Seriu, T.3    Miller, C.W.4    Tobler, A.5    Janssen, J.W.6    Reiter, A.7    Ludwig, W.D.8    Zimmermann, M.9    Schwaller, J.10
  • 35
    • 0024792119 scopus 로고
    • Chromosomes in plasma-cell malignancies
    • Van den Berghe, H. (1989) Chromosomes in plasma-cell malignancies. European Journal of Haematology, 43, (Suppl. 51), 47-51.
    • (1989) European Journal of Haematology , vol.43 , Issue.51 SUPPL. , pp. 47-51
    • Van Den Berghe, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.