Terahertz spectroscopic techniques for the study of proteins in aqueous solutions

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 7215, Issue , 2009, Pages

  Brundermann, Erik ^a   Born, Benjamin ^a   Funkner, Stefan ^a   Kruger, Matthias ^a   Havenith, Martina ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Biomolecules; Semiconductors; Terahertz lasers; Terahertz spectroscopy

Indexed keywords

ABSOLUTE ABSORPTION COEFFICIENTS; ABSORPTION COEFFICIENTS; AQUEOUS BUFFER SOLUTIONS; AQUEOUS SOLUTIONS; COHERENT SYNCHROTRON RADIATIONS; DETECTION METHODS; GERMANIUM LASERS; HIGH STABILITIES; LASER SYSTEMS; LIQUID WATERS; REFERENCE SIGNALS; SAMPLE CELLS; SEMICONDUCTORS; SINGLE-POINT MUTATIONS; SPECTRAL RANGES; SPECTROSCOPIC TECHNIQUES; STATISTICAL ERRORS; TERAHERTZ; TERAHERTZ LASERS; TERAHERTZ SPECTROSCOPY; THZ FREQUENCIES; THZ SOURCES; THZ TIME-DOMAIN SPECTROSCOPIES; TIME-RESOLVED MEASUREMENTS; WATER DYNAMICS; PH VALUES;

ABSORPTION; BIOMOLECULES; CRYSTALS; ELECTRIC CONDUCTIVITY; GERMANIUM; HUMIDITY CONTROL; LASERS; LIQUIDS; PROTEIN FOLDING; SEMICONDUCTOR MATERIALS; SPECTROMETERS; SPECTROMETRY; SUGAR (SUCROSE); SUGARS; SYNCHROTRONS; SYSTEMATIC ERRORS;

SEMICONDUCTOR LASERS;

EID: 65349084461     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.808270     Document Type: Conference Paper

References (22)

1. Schmuttenmaer, C. A., "Exploring dynamics in the far-infrared with terahertz spectroscopy," Chem. Rev. 104, 1759-1779 (2004).
2. K̈ohler, R., Tredicucci, A., Beltram, F., Beere, H. E., Linfield, E. H., Davies, A. G., Ritchie, D. A., Iotti, R. C., and Rossi, F., "Terahertz semiconductor-heterostructure laser," Nature 417, 156-159 (2002).
3. Williams, B. S., "Terahertz quantum-cascade lasers," Nature Photonics 1, 517 - 525 (2007).
4. Br̈undermann, E., Havenith, M., Scalari, G., Giovannini, M., J'er̂ome Faist, Kunsch, J., Mechold, L., and Abraham, M., "Turn-key compact high temperature terahertz quantum cascade lasers: imaging and room temperature detection," Opt. Express 14, 1829-1841 (2006).
5. Plusquellic, D. F., Siegrist, K., Heilweil, E. J., and Esenturk, O., "Applications of terahertz spectroscopy in biosystems.," ChemPhysChem 8, 2412-2431 (2007).
6. Bergner, A., Heugen, U., Br̈undermann, E., Schwaab, G., Havenith, M., Chamberlin, D. R., and Haller, E. E., "New p-Ge THz spectrometer for the study of solutions: THz absorption spectroscopy of water," Rev. Sci. Instrum. 76, 063110/1-063110/5 (2005).
7. Haller, E. E. and Br̈undermann, E., "Doping of germanium and silicon crystals with non-hydrogenic acceptors for far infrared lasers." U.S. Patent No. 6011810 (4 January 2000).
8. Reichertz, L. A., Dubon, O. D., Sirmain, G., Brundermann, E., Hansen, W. L., Chamberlin, D. R., Linhart, A. M., Roser, H. P., and Haller, E. E., "Stimulated far-infrared emission from combined cyclotron resonances in germanium.," Physical Review B: Condensed Matter 56, 12069-12072 (1997).
9. Br̈undermann, E. and R̈oser, H. P., "First operation of a far-infrared p-germanium laser in a standard closed-cycle machine at 15 k.," Infrared Physics & Technology 38, 201-203 (1997).
10. Br̈undermann, E., R̈oser, H. P., Muravjov, A. V., Pavlov, S. G., and Shastin, V. N., "Mode fine structure of the p-Ge intervalence band laser measured by heterodyne mixing spectroscopy with an optically pumped ring gas laser.," Infrared Physics & Technology 36, 59-69 (1995).
11. Ebbinghaus, S., Kim, S. J., Heyden, M., Yu, X., Heugen, U., Gruebele, M., Leitner, D. M., and Havenith, M., "An extended dynamical hydration shell around proteins.," Proceedings of the National Academy of Sciences of the United States of America 104, 20749-20752 (2007).
12. Ebbinghaus, S., Kim, S. J., Heyden, M., Yu, X., Gruebele, M., Leitner, D. M., and Havenith, M., "Protein sequence- and pH-dependent hydration probed by terahertz spectroscopy.," Journal of the American Chemical Society 130, 2374-2375 (2008).
13. Heugen, U., Schwaab, G., Br̈undermann, E., Heyden, M., Yu, X., Leitner, D. M., and Havenith, M., "Solute-induced retardation of water dynamics probed directly by terahertz spectroscopy.," Proceedings of the National Academy of Sciences of the United States of America 103, 12301-12306 (2006).
14. Heyden, M., Br̈undermann, E., Heugen, U., Niehues, G., Leitner, D. M., and Havenith, M., "Long-range influence of carbohydrates on the solvation dynamics of water - answers from terahertz absorption measurements and molecular modeling simulations.," Journal of the American Chemical Society 130, 5773-5779 (2008).
15. Born, B., Kim, S. J., Ebbinghaus, S., Gruebele, M., and Havenith, M., "The terahertz dance of water with the proteins: the effect of protein flexibility on the dynamical hydration shell of ubiquitin.," Faraday Discussions 141, 161-173 (2009).
16. Ebbinghaus, S., Schr̈ock, K., Schauer, J., Br̈undermann, E., Heyden, M., Schwaab, G., B̈oke, M., Winter, J., Tani, M., and Havenith, M., "Terahertz time-domain spectroscopy as a new tool for the characterisation of dusty plasmas," Plasma Sources Sci. Technol. 15, 72-77 (2006).
17. Kim, S. J., Born, B., Havenith, M., and Gruebele, M., "Real-time detection of protein-water dynamics upon protein folding by terahertz absorption spectroscopy.," Angewandte Chemie, International Edition 47, 6486-6489 (2008).
18. Min, L. A. W. and Qing, H., "Real-time, continuous-wave terahertz imaging by use of a microbolometer focal-plane array," Opt Lett 30, 2563-5. (2005).
19. Br̈undermann, E., R̈ansch, J., Kraub, M., and Kunsch, J., "Erste THz-Videos mit einer Silizium-basierten IR-Kamera - in German," Photonik 6, 60-63 (2006).
20. M̈uller, A.-S., Birkel, I., Casalbuoni, S., Gasharova, B., Huttel, E., Mathis, Y.-L., Moss, D., Smale, N., Wesolowski, P., Br̈undermann, E., B̈uckle, T., and Klein, M., "Characterizing THz coherent synchrotron radiation at the ANKA storage ring," European Particle Accelerator Conference , 2091-2093 (2008).
21. Kopf, I., Samson, J.-S., Wollny, G., Grunwald, C., Br̈undermann, E., and Havenith, M., "Chemical imaging of microstructured self-assembled monolayers with nanometer resolution," J. Phys. Chem. C 111, 8166-8171 (2007).
22. Huber, A. J., Keilmann, F.,Wittborn, J., Aizpurua, J., and Hillenbrand, R., "Terahertz near-field nanoscopy of mobile carriers in single semiconductor nanodevices.," Nano Letters 8, 3766-3770 (2008).