Involvement of UTP in protection of cardiomyocytes from hypoxic stress

Canadian Journal of Physiology and Pharmacology

Volumn 87, Issue 4, 2009, Pages 287-299

  Shainberg, Asher ^a   Yitzhaki, Smadar ^a   Golan, Or ^a   Jacobson, Kenneth A ^b   Hochhauser, Edith ^c  

^a BAR ILAN UNIVERSITY   (Israel)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Calcium; Cardiac cell culture; Cardioprotection; Heart; Hypoxia; Ischemia; Nucleotides; Preconditioning; Pyrimi Dines

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PURINERGIC P2 RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SURAMIN; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VALVE PROSTHESIS; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CELL HYPOXIA; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MITOCHONDRIA, HEART; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; URIDINE TRIPHOSPHATE;

EID: 65249183856     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-010     Document Type: Article

References (34)

1. Abbracchio, M.P., and Burnstock, G. 1998. Purinergic signalling: pathophysiological roles. Jpn. J. Pharmacol. 78: 113-145. doi:10.1254/jjp.78.113. PMID:9829617.
2. Anversa, P., and Kajstura, J. 1998. Ventricular myocytes are not terminally differentiated in the adult mammalian heart. Circ. Res. 83: 1-14. PMID:9670913.
3. 2 receptor activation: novel pathways for neuronal survival. J. Neurosci. 26: 3798-3804. doi:10. 1523/JNEUROSCI.5338-05.2006. PMID:16597733.
4. Burnstock, G. 1978. A basis for distinguishing two types of puri- nergic receptor. In Cell membrane receptors for drugs and hormones: a multidisciplinary approach. Edited by L. Bolis and R.W. Straub. Raven Press, New York. pp. 107-118.
5. El Ani, D., Jacobson, K.A., and Shainberg, A. 1994. Characterization of adenosine receptors in intact cultured heart cells. Bio- chem. Pharmacol. 48: 727-735. doi:10.1016/0006-2952(94) 90050-7. PMID:8080445.
6. Erlinge, D., Harnek, J., van Heusden, C., Olivecrona, G., Jern, S., and Lazarowski, E. 2005. Uridine triphosphate (UTP) is released during cardiac ischemia. Int. J. Cardiol. 100: 427-433. doi:10.1016/j.ijcard.2004.10. 005. PMID:15837087.
7. i relaxation in cardiomyocyte contraction following various drug treatments. Cell Calcium, 31: 279-287. doi:10.1016/S0143-4160(02)00056-8. PMID:12098217.
8. Hausenloy, D.J., and Yellon, D.M. 2006. Survival kinases in is- chemic preconditioning and postconditioning. Cardiovasc. Res. 70: 240-253. doi:10.1016/j.cardiores.2006.01.017. PMID: 16545352.
9. 2-receptor mRNA levels in congestive heart failure. Life Sci. 65: 1195-1206. doi:10.1016/S0024-3205(99)00353-7. PMID:10503935.
10. Huwiler, A., Rolz, W., Dorsch, S., Ren, S., and Pfeilschifter, J. 2002. Extracellular ATP and UTP activate the protein kinase B/ Akt cascade via the P2Y(2) purinoceptor in renal mesangial cells. Br. J. Pharmacol. 136: 520-529. doi:10.1038/sj.bjp. 0704748. PMID:12055130.
11. Jacobson, K.A., Ivanov, A.A., de Castro, S., Harden, T.K., and Ko, H. 2009. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 5: 75-89. doi:10.1007/ s11302-008-9106-2. PMID:18600475.
12. Jo, H., Noma, A., and Matsuoka, S. 2006. Calcium-mediated coupling between mitochondrial substrate dehydrogenation and cardiac workload in single guinea-pig ventricular myocytes. J. Mol. Cell. Cardiol. 40: 394-404. doi:10.1016/j.yjmcc.2005.12.012. PMID:16480740.
13. Kajstura, J., Cheng, W., Reiss, K., Clark, W.A., Sonnenblick, E.H., Krajewski, S., et al. 1996. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab. Invest. 74: 86-107. PMID:8569201.
14. Mazzola, A., Amoruso, E., Beltrami, E., Lecca, D., Ferrario, S., Cosentino, S., et al. 2008. Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes. J. Cell. Mol. Med. 12: 522-536. doi:10.1111/j.1582-4934.2007.00133.x. PMID:18419595.
15. Morgan, E.E., Faulx, M.D., McElfresh, T.A., Kung, T.A., Zawa- neh, M.S., Stanley, W.C., et al. 2004. Validation of echocardio- graphic methods for assessing left ventricular dysfunction in rats with myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 287: H2049-H2053. doi:10.1152/ajpheart. 00393.2004. PMID: 15475530.
16. Murry, C.E., Jennings, R.B., and Reimer, K.A. 1986. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation, 74: 1124-1136. PMID:3769170.
17. Nieminen, A.L., Gores, G.J., Bond, J.M., Imberti, R., Herman, B., and Lemasters, J.J. 1992. A novel cytotoxicity screening assay using a multiwell fluorescence scanner. Toxicol. Appl. Pharmacol. 115: 147-155. doi:10.1016/0041-008X(92)90317-L. PMID:1641848.
18. Pham, T.M., Morris, J.B., Arthur, J.F., Post, G.R., Brown, J.H., and Woodcock, E.A. 2003. UTP but not ATP causes hypertrophic growth in neonatal rat cardiomyocytes. J. Mol. Cell. Cardiol. 35:287-292. doi:10.1016/S0022- 2828(03)00009-9. PMID: 12676543.
19. Podrasky, E., Xu, D., and Liang, B.T. 1997. A novel phospholipase C- and cAMP-independent positive inotropic mechanism via a P2 purinoceptor. Am. J. Physiol. 273: H2380-H2387. PMID:9374775.
20. Puceat, M., and Vassort, G. 1996. Purinergic stimulation of rat car- diomyocytes induces tyrosine phosphorylation and membrane association of phospholipase C gamma: a major mechanism for InsP3 generation. Biochem. J. 318: 723-728. PMID:8809068.
21. Ralevic, V., and Burnstock, G. 1998. Receptors for purines and pyrimidines. Pharmacol. Rev. 50: 413-492. PMID:9755289.
22. Safran, N., Shneyvays, V., Balas, N., Jacobson, K.A., and Shain- berg, A. 2001. Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes. Mol. Cell. Biochem. 217: 143-152. doi:10.1023/ A:1007209321969. PMID:11269659.
23. Shneyvays, V., Nawrath, H., Jacobson, K.A., and Shainberg, A. 1998. Induction of apoptosis in cardiac myocytes by an A3 ade- nosine receptor agonist. Exp. Cell Res. 243: 383-397. doi:10.1006/excr.1998.4134. PMID:9743598.
24. Shneyvays, V., Safran, N., Halili-Rutman, I., and Shainberg, A. 2000. Insights into adenosine A1 and A3 receptors function: car- diotoxicity and cardioprotection. Drug Dev. Res. 50: 324-337. doi:10.1002/1098- 2299(200007/08)50:3/4〈324::AID-DDR16〉3. 0.CO;2-B.
25. Shneyvays, V., Mamedova, L., Zinman, T., Jacobson, K., and Shainberg, A. 2001. Activation of A3 adenosine receptor protects against doxorubicin- induced cardiotoxicity. J. Mol. Cell. Cardiol. 33: 1249-1261. doi:10.1006/jmcc.2001.1387. PMID: 11444927.
26. Shneyvays, V., Leshem, D., Mamedova, L.K., and Shainberg, A. 2003. Activation of adenosine A1 and A3 receptors protects mitochondria during hypoxia in cardiomyocytes by distinct me -chanisms. In Myocardial ischemia and preconditioning. Edited by N.S. Dhalla, N. Takeda, M. Singh, and A. Lukas. Kluwer Academic Publishers, Boston. pp. 347-364.
27. Sommerschild, H.T., and Kirkeboen, K.A. 2000. Adenosine and cardioprotection during ischaemia and reperfusion: an overview. Acta Anaesthesiol. Scand. 44: 1038-1055. doi:10.1034/j.1399- 6576.2000.440903.x. PMID:11028722.
28. Vassort, G. 2001. Adenosine 5'-triphosphate: a P2-purinergic agonist in the myocardium. Physiol. Rev. 81: 767-806. PMID:11274344.
29. von Kügelgen, I., and Wetter, A. 2000. Molecular pharmacology of P2Y-receptors. Naunyn Schmiedebergs Arch. Pharmacol. 362: 310-323. doi:10.1007/s002100000310. PMID:11111826.
30. Yitzhaki, S., Shneyvays, V., Jacobson, K.A., and Shainberg, A. 2005. Involvement of uracil nucleotides in protection of cardio- myocytes from hypoxic stress. Biochem. Pharmacol. 69: 1215-1223. doi:10.1016/j.bcp.2005.01. 018. PMID:15794942.
31. Yitzhaki, S., Shainberg, A., Cheporko, Y., Vidne, B.A., Sagie, A., Jacobson, K.A., and Hochhauser, E. 2006. Uridine-5'-tripho- sphate (UTP) reduces infarct size and improves rat heart function after myocardial infarct. Biochem. Pharmacol. 72: 949-955. doi:10.1016/j.bcp.2006.07.019. PMID:16939682.
32. Yitzhaki, S., Hochhauser, E., Porat, E., and Shainberg, A. 2007. Uridine-5'-triphosphate (UTP) maintains cardiac mitochondrial function following chemical and hypoxic stress. J. Mol. Cell. Cardiol. 43: 653-662. doi:10.1016/j.yjmcc.2007.07.060. PMID: 17880998.
33. Zaugg, M., and Schaub, M.C. 2003. Signaling and cellular mechanisms in cardiac protection by ischemic and pharmacological preconditioning. J. Muscle Res. Cell Motil. 24: 219-249. doi:10. 1023/A:1026021430091. PMID:14609033.
34. Zheng, J.S., Boluyt, M.O., Long, X., O'Neill, L., Lakatta, E.G., and Crow, M.T. 1996. Extracellular ATP inhibits adrenergic agonist- induced hypertrophy of neonatal cardiac myocytes. Circ. Res. 78: 525-535. PMID:8635209.