Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes: In Focus: Heart

Journal of Cellular and Molecular Medicine

Volumn 12, Issue 2, 2008, Pages 522-536

  Mazzola, Alessia ^a,b   Amoruso, Emanuela ^a,b   Beltrami, Elena ^a   Lecca, Davide ^a   Ferrario, Silvia ^a   Cosentino, Simona ^a,b   Tremoli, Elena ^a,b   Ceruti, Stefania ^a   Abbracchio, Maria P ^a,c  

^a UNIVERSITY OF MILAN   (Italy)

^b CENTRO CARDIOLOGICO MONZINO   (Italy)

^c Department of Pharmacological Sciences   (Italy)

Author keywords

Apoptosis; Cytokines; Heart failure; P2Y receptors; Signal transduction

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE TRIPHOSPHATE; BISBENZIMIDE; PURINERGIC P2 RECEPTOR; PYRIMIDINE NUCLEOTIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL NUCLEUS; CELL SURVIVAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; FIBROSIS; HEART MUSCLE CELL; METABOLISM; RAT;

ADENINE NUCLEOTIDES; ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BISBENZIMIDE; CELL DEATH; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FIBROSIS; MYOCYTES, CARDIAC; RATS; RECEPTORS, PURINERGIC P2; TUMOR NECROSIS FACTOR-ALPHA; URACIL NUCLEOTIDES;

MURINAE; RODENTIA;

EID: 42349090153     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2007.00133.x     Document Type: Article

References (44)

1. Burnstock G, Knight GE. Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol. 2004 240 : 31 304.
2. Abbracchio MP, Burnstock G. Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol Ther. 1994 64 : 445 75.
3. Ralevic V, Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev. 1998 50 : 413 92.
4. North RA. Molecular physiology of P2X receptors. Physiol Rev. 2002 82 : 1013 67.
5. Abbracchio MP, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Miras-Portugal MT, King BF, Gachet C, Jacobson KA, Weisman GA, Burnstock G. Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. Trends Pharmacol Sci. 2003 24 : 52 5.
6. Ciana P, Fumagalli M, Trincavelli ML, Verderio C, Rosa P, Lecca D, Ferrario S, Parravicini C, Capra V, Gelosa P, Guerrini U, Belcredito S, Cimino M, Sironi L, Tremoli E, Rovati GE, Martini C, Abbracchio MP. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J. 2006 25 : 4615 27.
7. Egan TM, Khakh BS. Contribution of calcium ions to P2X channel responses. J Neurosci. 2004 24 : 3413 20.
8. Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev. 2006 58 : 281 341.
9. Pelleg A, Vassort G. P2 receptors in the cardiovascular system. In : Abbracchio MP, Williams M, eds. Purinergic and pyrimidergic signalling II. Berlin Heidelberg : Springer-Verlag 2001. pp. 73 100.
10. Drury A, Szent-Gyorgyi A. The physiological activity of adenine compounds with special reference to their action upon the mammalian heart. J Physiol. 1929 68 : 213 37.
11. Mantelli L, Amerini S, Filippi S, Ledda F. Blockade of adenosine receptors unmasks a stimulatory effect of ATP on cardiac contractility. Br J Pharmacol. 1993 109 : 1268 71.
12. Wihlborg AK, Balogh J, Wang L, Borna C, Dou Y, Joshi BV, Lazarowski E, Jacobson KA, Arner A, Erlinge D. Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction. Circ Res. 2006 98 : 970 6.
13. Froldi G, Galzignato G, Zanetti M, Montopoli M, Dorigo P, Caparrotta L. Are prostanoids related to positive inotropism by UTP and ATP? Pharmacology. 2005 73 : 140 5.
14. Magner JJ, Royston D. Heart failure. Br J Anaesth. 2004 93 : 74 85.
15. Towbin JA, Bowles NE. The failing heart. Nature. 2002 415 : 227 33.
16. Yitzhaki S, Shneyvays V, Jacobson KA, Shainberg A. Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress. Biochem Pharmacol. 2005 69 : 1215 23.
17. Yitzhaki S, Shainberg A, Cheporko Y, Vidne BA, Sagie A, Jacobson KA, Hochhauser E. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function after myocardial infarct. Biochem Pharmacol. 2006 72 : 949 55.
18. Banfi C, Ferrario S, De Vincenti O, Ceruti S, Fumagalli M, Mazzola A, D'Ambrosi N, Volonte C, Fratto P, Vitali E, Burnstock G, Beltrami E, Parolari A, Polvani G, Biglioli P, Tremoli E, Abbracchio MP. P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFalpha and potential role in myocardial cell death. J Mol Cell Cardiol. 2005 39 : 929 39.
19. Batista ML, Jr., Santos RV, Cunha LM, Mattos K, Oliveira EM, Seelaender MC, Costa Rosa LF. Changes in the pro-inflammatory cytokine production and peritoneal macrophage function in rats with chronic heart failure. Cytokine. 2006 34 : 284 90.
20. White SM, Constantin PE, Claycomb WC. Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function. Am J Physiol Heart Circ Physiol. 2004 286 : H823 9.
21. Simonetti M, Fabbro A, D'Arco M, Zweyer M, Nistri A, Giniatullin R, Fabbretti E. Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin. Mol Pain. 2006 2 : 11.
22. Bianco F, Fumagalli M, Pravettoni E, D'Ambrosi N, Volonte C, Matteoli M, Abbracchio MP, Verderio C. Pathophysiological roles of extracellular nucleotides in glial cells: differential expression of purinergic receptors in resting and activated microglia. Brain Res Brain Res Rev. 2005 48 : 144 56.
23. Ceruti S, Franceschi C, Barbieri D, Malorni W, Camurri A, Giammarioli AM, Ambrosini A, Racagni G, Cattabeni F, Abbracchio MP. Apoptosis induced by 2-chloro-adenosine and 2-chloro-2'-deoxy-adenosine in a human astrocytoma cell line: differential mechanisms and possible clinical relevance. J Neurosci Res. 2000 60 : 388 400.
24. Ceruti S, Beltrami E, Matarrese P, Mazzola A, Cattabeni F, Malorni W, Abbracchio MP. A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells. Mol Pharmacol. 2003 63 : 1437 47.
25. Ceruti S, Mazzola A, Abbracchio MP. Resistance of human astrocytoma cells to apoptosis induced by mitochondria-damaging agents: possible implications for anticancer therapy. J Pharmacol Exp Ther. 2005 314 : 825 37.
26. Jacobson KA, Costanzi S, Joshi BV, Besada P, Shin DH, Ko H, Ivanov AA, Mamedova L. Agonists and antagonists for P2 receptors. Novartis Found Symp. 2006 276 : 58 68.
27. Wildman SS, Unwin RJ, King BF. Extended pharmacological profiles of rat P2Y2 and rat P2Y4 receptors and their sensitivity to extracellular H+ and Zn2+ ions. Br J Pharmacol. 2003 140 : 1177 86.
28. Jacobson KA, Gao ZG. Adenosine receptors as therapeutic targets. Nat Rev Drug Discov. 2006 5 : 247 64.
29. Picano E, Abbracchio MP. Adenosine, the imperfect endogenous anti-ischemic cardio-neuroprotector. Brain Res Bull. 2000 52 : 75 82.
30. Sexl V, Mancusi G, Holler C, Gloria-Maercker E, Schutz W, Freissmuth M. Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells. J Biol Chem. 1997 272 : 5792 9.
31. Golembiowska K, Dziubina A. Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats. Neuropharmacology. 2004 47 : 414 26.
32. Goldenberg I, Shainberg A, Jacobson KA, Shneyvays V, Grossman E. Adenosine protects against angiotensin II-induced apoptosis in rat cardiocyte cultures. Mol Cell Biochem. 2003 252 : 133 9.
33. Ji X, Kim YC, Ahern DG, Linden J, Jacobson KA. [3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors. Biochem Pharmacol. 2001 61 : 657 63.
34. Abbracchio MP, Verderio C. Pathophysiological roles of P2 receptors in glial cells. Novartis Found Symp. 2006 276 : 91 103.
35. Clemens MG, Forrester T. Appearance of adenosine triphosphate in the coronary sinus effluent from isolated working rat heart in response to hypoxia. J Physiol. 1981 312 : 143 58.
36. Vial C, Owen P, Opie LH, Posel D. Significance of release of adenosine triphosphate and adenosine induced by hypoxia or adrenaline in perfused rat heart. J Mol Cell Cardiol. 1987 19 : 187 97.
37. Erlinge D, Harnek J, van Heusden C, Olivecrona G, Jern S, Lazarowski E. Uridine triphosphate (UTP) is released during cardiac ischemia. Int J Cardiol. 2005 100 : 427 33.
38. Aartsen WM, Schuijt MP, Danser AH, Daemen MJ, Smits JF. The role of locally expressed angiotensin converting enzyme in cardiac remodeling after myocardial infarction in mice. Cardiovasc Res. 2002 56 : 205 13.
39. Webb TE, Boluyt MO, Barnard EA. Molecular biology of P2Y purinoceptors: expression in rat heart. J Auton Pharmacol. 1996 16 : 303 7.
40. Bogdanov Y, Rubino A, Burnstock G. Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart. Life Sci. 1998 62 : 697 703.
41. Balogh J, Wihlborg AK, Isackson H, Joshi BV, Jacobson KA, Arner A, Erlinge D. Phospholipase C and cAMP-dependent positive inotropic effects of ATP in mouse cardiomyocytes via P2Y11-like receptors. J Mol Cell Cardiol. 2005 39 : 223 30.
42. Jiang L, Bardini M, Keogh A, dos Remedios CG, Burnstock G. P2X1 receptors are closely associated with connexin 43 in human ventricular myocardium. Int J Cardiol. 2005 98 : 291 7.
43. Saiag B, Bodin P, Shacoori V, Catheline M, Rault B, Burnstock G. Uptake and flow-induced release of uridine nucleotides from isolated vascular endothelial cells. Endothelium. 1995 2 : 279 85.
44. Hrafnkelsdottir T, Erlinge D, Jern S. Extracellular nucleotides ATP and UTP induce a marked acute release of tissue-type plasminogen activator in vivo in man. Thromb Haemost. 2001 85 : 875 81.