Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers

Clinical Cancer Research

Volumn 15, Issue 8, 2009, Pages 2703-2710

  Meyer, Rene ^a   Fofanov, Viacheslav ^b   Panigrahi, Anilk ^a   Merchant, Fatima ^c   Zhang, Nenggang ^a   Pati, Debananda ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Rice University   (United States)

^c UNIVERSITY OF HOUSTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEPARASE;

ARTICLE; BREAST CANCER; CANCER RECURRENCE; CANCER SURVIVAL; CHROMOSOMAL LOCALIZATION; CHROMOSOME SEGREGATION; COLORECTAL CANCER; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; METASTASIS; MULTIPLE CANCER; OSTEOSARCOMA; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE MICROARRAY;

CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMOSOME SEGREGATION; ENDOPEPTIDASES; HUMANS; LOGISTIC MODELS; NEOPLASMS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 65249183163     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-08-2454     Document Type: Article

References (46)

1. Zachariae W, Nasmyth K. Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev1999;13:2039-58.
2. Hauf S,Waizenegger IC, Peters JM. Cohesin cleavage by Separase required for anaphase and cytokinesis in human cells. Science 2001;293:1320-3.
3. Haering CH, Nasmyth K. Building and breaking bridges between sister chromatids. Bio Essays 2003; 25:1178-91.
4. Uhlmann F, Wernic D, Poupart MA, Koonin EV, Nasmyth K. Cleavage of cohesin by the CDclan protease separin triggers anaphase in yeast. Cell 2000; 103:375 -86.
5. Ciosk R, Zachariae W, Michaelis C, Shevchenko A, Mann M, Nasmyth K. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell 1998;93: 1067-76.
6. Cohen-Fix O, PetersJM, Kirschner MW, Koshland D. Anaphase initiation in Saccharomyces cerevisiaeis controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev 1996;10: 3081 -93.
7. Hornig NC,Knowles PP,McDonald NQ,Uhlmann F. The dual mechanism of Separase regulation by securin. Curr Biol 2002;12:973 -82.
8. Waizenegger I, Gimenez-Abian JF, Wernic D, Peters JM. Regulation of human Separase by securin binding and autocleavage. Curr Biol 2002;12:1368-78.
9. Stemmann O, Zou H, Gerber SA, Gygi SP, Kirschner MW. Dual inhibition of sister chromatid separation at metaphase. Cell 2001;107:715 -26.
10. Huang X, Andreu-Vieyra CV,YorkJP, et al. Inhibitory phosphorylation of Separase is essential for genome stability and viability of murine embryonic germ cells. PLoS Biol 2008;6:e15.
11. Pfleghaar K, Heubes S, Cox J, Stemmann O, Speicher MR. Securin is not required forchromosomal stabilityin human cells. PLoSBiol 2005;3:e416.
12. Pemberton HN, Franklyn JA, Boelaert K, et al. Sep- arase, securin and Rad21 in neural cell growth. J Cell Physiol 2007;213:45-53.
13. Kumada K,Yao R, Kawaguchi T, et al. The selective continued linkage of centromeres from mitosis to in- terphase in the absence of mammalian Separase. J Cell Biol 2006;172:835-46.
14. Aguilera A, Gomez-Gonzalez B. Genome instability: a mechanistic view of its causes and consequences. Nat Rev Genet 2008;9:204-17.
15. Wirth KG,Wutz G, Kudo NR, et al. Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. J Cell Biol 2006;172:847 -60.
16. Nagao K, Adachi Y,Yanagida M. Separase-mediated cleavage of cohesin at interphase is required for DNA repair. Nature 2004;430:1044-8.
17. Pati D, Haddad BR, Haegele A, et al. Hormone-induced chromosomal instability in p53-null mammary epithelium. Cancer Res 2004;64:5608-16.
18. Zhang N, Ge G, Meyer R, et al. Overexpression of Separase in mouse mammary epithelial cells induces aneuploidy and tumorigenesis. Proc Natl Acad Sci USA 2008;105:13033-8.
19. Duesberg P, Rausch C, Rasnick D, Hehlmann R. Genetic instability of cancer cells is proportional to their degree ofaneuploidy. Proc Natl Acad Sci U S A1998; 95:13692 -7.
20. Kearney TJ, Price EA, Lee S, Silberman AW. Tumor aneuploidy in young patients with colorectal cancer. Cancer1993;72:42-5.
21. van de Vijver MJ, He YD, van't Veer LJ, et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002;347: 1999 -2009.
22. Duesberg P. Are centrosomes oraneuploidy thekey to cancer? Science 1999;284:2091 -2.
23. Zimonjic D, Brooks MW, Popescu N,Weinberg RA, Hahn WC. Derivation of human tumor cells in vitrowithout widespread genomic instability. Cancer Res 2001;61:8838-44.
24. Weaver BA, Cleveland DW. Does aneuploidy cause cancer? CurrOpinCellBiol2006;18:658-67.
25. Merchant F. Fluorescence microscopy. Microscope image processing. Wu QJ, Merchant FA, Castleman KR, editors. 1st ed. San Diego (CA): Academic Press: 2008. p. 247 -90.
26. Merchant FA, Castleman KR. Computer assisted microscopy. Handbook of image and video processing. Bovik AC, editor. 2nd ed. San Diego (CA): Academic Press; 2005. p. 1311 -40.
27. Agresti A. Categorical data analysis. 2nd ed. Hoboken (NJ): John Wiley & Sons; 2002. (ISBN: 0-471-36093-7).
28. Conger A. Integration and generalisation of Kappas for multiple raters. Psychol Bull 1980;88:322-8.
29. van Diest PJ, van Dam P, Henzen-Logmans SC, et al. A scoring system for immunohistochemical staining: consensus report of the Task Force for Basic Research of the EORTC-GCCG. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Cooperative Group. J Clin Pathol 1997;50:801 -4.
30. Wang W, Bergh A, Damber JE. Chronic inflammation in benign prostate hyperplasia is associated with focal upregulation of cyclooxygenase-2, Bcl-2, and cell proliferation in the glandular epithelium. Prostate 2004;61:60-72.
31. Varambally S, Yu J, Laxman B, et al. Integrative ge- nomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell 2005;8:393-406.
32. Barclay WW, Woodruff RD,Hall MC, Cramer SD.A system for studying epithelial-stromal interactions reveals distinct inductive abilities of stromal cells from benign prostatic hyperplasia and prostate cancer. Endocrinology 2005;146:13 -8.
33. Ivshina AV, George J, Senko O, et al. Geneticreclassification of histologic grade delineates new clinical subtypes of breast cancer. Cancer Res 2006;66: 10292-301.
34. Pawitan Y, Bjohle J,Amler L, et al.Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts. Breast Cancer Res 2005;7:R953 -64.
35. Richardson AL, Wang ZC, De Nicolo A, et al. Xchromosomal abnormalities in basal-like human breast cancer. Cancer Cell 2006;9:121 -32.
36. Ginestier C, Cervera N, Finetti P, et al. Prognosis and gene expression profiling of 20q13-amplified breast cancers. Clin Cancer Res 2006;12:4533-44.
37. Desmedt C, Piette F, Loi S, et al. Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin Cancer Res2007;13:3207-14.
38. Sotiriou C,Wirapati P, Loi S, et al. Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst 2006;98:262 -72.
39. van't Veer LJ, Dai H, van de Vijver MJ, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002;415:530-6.
40. SunY,Yu H, Zou H. Nuclear exclusion of Separase prevents cohesin cleavage in interphase cells. Cell Cycle 2006;5:2537-42.
41. Adachi Y, Kokubu A, Ebe M, Nagao K,Yanagida M. Cut1/Separase-dependent roles of multiple phosphor- ylation of fission yeast cohesion subunit Rad21 in post-replicative damage repair and mitosis. Cell Cycle 2008;7:765-76.
42. Miller LD, Smeds J, George J, et al. An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc Natl Acad Sci U S A 2005;102:13550-5.
43. Shai R, Shi T, Kremen TJ, et al. Gene expression profiling identifies molecular subtypes of gliomas. Oncogene 2003;22:4918-23.
44. Lancaster JM, Dressman HK, Whitaker RS, et al. Gene expression patterns that characterize advanced stage serous ovarian cancers. J Soc Gynecol Investig 2004;11:51 -9.
45. Hendrix ND,Wu R, Kuick R, Schwartz DR, Fearon ER, Cho KR. Fibroblast growth factor 9 hasoncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas. Cancer Res 2006;66:1354-62.
46. Stransky N,Vallot C, Reyal F, et al. Regional copy number-independent deregulation of transcription in cancer. Nat Genet 2006;38:1386 -96.